Direct measurement of DNA affinity landscapes on a high-throughput sequencing instrument

Nature Biotechnology

Volumn 29, Issue 7, 2011, Pages 659-664

  Nutiu, Razvan ^a   Friedman, Robin C ^a   Luo, Shujun ^b   Khrebtukova, Irina ^b   Silva, David ^b   Li, Robin ^b   Zhang, Lu ^b   Schroth, Gary P ^b   Burge, Christopher B ^a,c  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b ILLUMINA INC   (United States)

^c Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROAD APPLICATION; DIRECT MEASUREMENT; DISSOCIATION CONSTANT; DNA AFFINITY; DNA-PROTEIN INTERACTION; FLOW CELLS; HIGH-THROUGHPUT; IN-VITRO; IN-VIVO; LIGAND INTERACTIONS; MASTER REGULATORS; PROTEIN-DNA BINDING; QUANTITATIVE MEASUREMENT; STARVATION RESPONSE; SUB-MICROMOLAR AFFINITY;

AMINO ACIDS; BINDING ENERGY; BINDING SITES; DEPTH PROFILING; DISSOCIATION; DNA; PROTEINS; THROUGHPUT; TRANSCRIPTION;

GENE ENCODING;

DNA; TRANSCRIPTION FACTOR GCN4;

ARTICLE; BINDING SITE; DISSOCIATION CONSTANT; DNA BINDING; DNA DETERMINATION; DNA SEQUENCE; FLUORESCENT LIGAND INTERACTION PROFILING; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; IN VIVO STUDY; MEASUREMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; PROTEIN MALNUTRITION; QUANTITATIVE ANALYSIS; YEAST;

CHROMATOGRAPHY, AFFINITY; DNA; DNA-BINDING PROTEINS; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; PROTEIN INTERACTION MAPPING; SEQUENCE ANALYSIS, DNA; SPECTROMETRY, FLUORESCENCE;

EID: 79960277492     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.1882     Document Type: Article

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