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Volumn 32, Issue 2, 2016, Pages 127-137

Understanding the Genetic Mechanisms of Cancer Drug Resistance Using Genomic Approaches

Author keywords

Cancer genome; Drug resistance mechanisms; Functional genomic screening

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CETUXIMAB; CRIZOTINIB; CYCLIN E; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; ESTROGEN RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 3; FOCAL ADHESION KINASE; GEFITINIB; MAMMALIAN TARGET OF RAPAMYCIN; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; NEU DIFFERENTIATION FACTOR; NOTCH1 RECEPTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PROTEIN TYROSINE KINASE; SCATTER FACTOR; SOMATOMEDIN RECEPTOR; TEMOZOLOMIDE; TRANSCRIPTION FACTOR GATA 2; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

EID: 84958619618     PISSN: 01689525     EISSN: 13624555     Source Type: Journal    
DOI: 10.1016/j.tig.2015.11.003     Document Type: Review
Times cited : (69)

References (92)
  • 1
    • 84875758730 scopus 로고    scopus 로고
    • Lessons from the cancer genome
    • Garraway L.A., Lander E.S. Lessons from the cancer genome. Cell 2013, 153:17-37.
    • (2013) Cell , vol.153 , pp. 17-37
    • Garraway, L.A.1    Lander, E.S.2
  • 2
    • 84884407337 scopus 로고    scopus 로고
    • Tumour heterogeneity in the clinic
    • Bedard P.L., et al. Tumour heterogeneity in the clinic. Nature 2013, 501:355-364.
    • (2013) Nature , vol.501 , pp. 355-364
    • Bedard, P.L.1
  • 3
    • 84879088863 scopus 로고    scopus 로고
    • Acquired resistance to crizotinib from a mutation in CD74-ROS1
    • Awad M.M., et al. Acquired resistance to crizotinib from a mutation in CD74-ROS1. N. Engl. J. Med. 2013, 368:2395-2401.
    • (2013) N. Engl. J. Med. , vol.368 , pp. 2395-2401
    • Awad, M.M.1
  • 4
    • 84856717005 scopus 로고    scopus 로고
    • Identification of a mutation in the extracellular domain of the epidermal growth factor receptor conferring cetuximab resistance in colorectal cancer
    • Montagut C., et al. Identification of a mutation in the extracellular domain of the epidermal growth factor receptor conferring cetuximab resistance in colorectal cancer. Nat. Med. 2012, 18:221-223.
    • (2012) Nat. Med. , vol.18 , pp. 221-223
    • Montagut, C.1
  • 5
    • 33749435816 scopus 로고    scopus 로고
    • Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer
    • Engelman J.A., et al. Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer. J. Clin. Invest. 2006, 116:2695-2706.
    • (2006) J. Clin. Invest. , vol.116 , pp. 2695-2706
    • Engelman, J.A.1
  • 6
    • 79953118839 scopus 로고    scopus 로고
    • Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
    • 75ra26
    • Sequist L.V., et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci. Transl. Med. 2011, 3:75ra26.
    • (2011) Sci. Transl. Med. , vol.3
    • Sequist, L.V.1
  • 7
    • 84885816283 scopus 로고    scopus 로고
    • Bypass mechanisms of resistance to receptor tyrosine kinase inhibition in lung cancer
    • Niederst M.J., Engelman J.A. Bypass mechanisms of resistance to receptor tyrosine kinase inhibition in lung cancer. Sci. Signal. 2013, 6:re6.
    • (2013) Sci. Signal. , vol.6 , pp. re6
    • Niederst, M.J.1    Engelman, J.A.2
  • 8
    • 84938917325 scopus 로고    scopus 로고
    • Activation of the BMP-BMPR pathway conferred resistance to EGFR-TKIs in lung squamous cell carcinoma patients with EGFR mutations
    • Wang Z., et al. Activation of the BMP-BMPR pathway conferred resistance to EGFR-TKIs in lung squamous cell carcinoma patients with EGFR mutations. Proc. Natl. Acad. Sci. U.S.A. 2015, 112:9990-9995.
    • (2015) Proc. Natl. Acad. Sci. U.S.A. , vol.112 , pp. 9990-9995
    • Wang, Z.1
  • 9
    • 84905726946 scopus 로고    scopus 로고
    • Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells
    • Lee H.J., et al. Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells. Cancer Cell 2014, 26:207-221.
    • (2014) Cancer Cell , vol.26 , pp. 207-221
    • Lee, H.J.1
  • 10
    • 84864402225 scopus 로고    scopus 로고
    • Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer
    • Zhang Z., et al. Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer. Nat. Genet. 2012, 44:852-860.
    • (2012) Nat. Genet. , vol.44 , pp. 852-860
    • Zhang, Z.1
  • 11
    • 84904070924 scopus 로고    scopus 로고
    • A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors
    • Konieczkowski D.J., et al. A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors. Cancer Discov. 2014, 4:816-827.
    • (2014) Cancer Discov. , vol.4 , pp. 816-827
    • Konieczkowski, D.J.1
  • 12
    • 84864285794 scopus 로고    scopus 로고
    • Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
    • Straussman R., et al. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature 2012, 487:500-504.
    • (2012) Nature , vol.487 , pp. 500-504
    • Straussman, R.1
  • 13
    • 84928008693 scopus 로고    scopus 로고
    • Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin beta1/FAK signaling
    • Hirata E., et al. Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin beta1/FAK signaling. Cancer cell 2015, 27:574-588.
    • (2015) Cancer cell , vol.27 , pp. 574-588
    • Hirata, E.1
  • 14
    • 77950809059 scopus 로고    scopus 로고
    • A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
    • Sharma S.V., et al. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell 2010, 141:69-80.
    • (2010) Cell , vol.141 , pp. 69-80
    • Sharma, S.V.1
  • 15
    • 84867743287 scopus 로고    scopus 로고
    • Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling
    • Zeller C., et al. Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling. Oncogene 2012, 31:4567-4576.
    • (2012) Oncogene , vol.31 , pp. 4567-4576
    • Zeller, C.1
  • 16
    • 84901806616 scopus 로고    scopus 로고
    • Integrated analysis of DNA methylation and mRNA expression profiling reveals candidate genes associated with cisplatin resistance in non-small cell lung cancer
    • Zhang Y.W., et al. Integrated analysis of DNA methylation and mRNA expression profiling reveals candidate genes associated with cisplatin resistance in non-small cell lung cancer. Epigenetics 2014, 9:896-909.
    • (2014) Epigenetics , vol.9 , pp. 896-909
    • Zhang, Y.W.1
  • 17
    • 84884818865 scopus 로고    scopus 로고
    • A phase I/II study of decitabine in combination with panitumumab in patients with wild-type (wt) KRAS metastatic colorectal cancer
    • Garrido-Laguna I., et al. A phase I/II study of decitabine in combination with panitumumab in patients with wild-type (wt) KRAS metastatic colorectal cancer. Inves. New Drugs 2013, 31:1257-1264.
    • (2013) Inves. New Drugs , vol.31 , pp. 1257-1264
    • Garrido-Laguna, I.1
  • 18
    • 84895813472 scopus 로고    scopus 로고
    • Phase I study of panobinostat and imatinib in patients with treatment-refractory metastatic gastrointestinal stromal tumors
    • Bauer S., et al. Phase I study of panobinostat and imatinib in patients with treatment-refractory metastatic gastrointestinal stromal tumors. Br. J. Cancer 2014, 110:1155-1162.
    • (2014) Br. J. Cancer , vol.110 , pp. 1155-1162
    • Bauer, S.1
  • 19
    • 84884812613 scopus 로고    scopus 로고
    • Methylation and histone deacetylase inhibition in combination with platinum treatment in patients with advanced malignancies
    • Falchook G.S., et al. Methylation and histone deacetylase inhibition in combination with platinum treatment in patients with advanced malignancies. Inves. New Drugs 2013, 31:1192-1200.
    • (2013) Inves. New Drugs , vol.31 , pp. 1192-1200
    • Falchook, G.S.1
  • 20
    • 84901828394 scopus 로고    scopus 로고
    • A randomised, phase II trial of the DNA-hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in combination with carboplatin vs carboplatin alone in patients with recurrent, partially platinum-sensitive ovarian cancer
    • Glasspool R.M., et al. A randomised, phase II trial of the DNA-hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in combination with carboplatin vs carboplatin alone in patients with recurrent, partially platinum-sensitive ovarian cancer. Br. J. Cancer 2014, 110:1923-1929.
    • (2014) Br. J. Cancer , vol.110 , pp. 1923-1929
    • Glasspool, R.M.1
  • 21
    • 84875490185 scopus 로고    scopus 로고
    • Cancer genome landscapes
    • Vogelstein B., et al. Cancer genome landscapes. Science 2013, 339:1546-1558.
    • (2013) Science , vol.339 , pp. 1546-1558
    • Vogelstein, B.1
  • 22
    • 79959480919 scopus 로고    scopus 로고
    • Towards systematic functional characterization of cancer genomes
    • Boehm J.S., Hahn W.C. Towards systematic functional characterization of cancer genomes. Nat. Rev. Genet. 2011, 12:487-498.
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 487-498
    • Boehm, J.S.1    Hahn, W.C.2
  • 23
    • 84880861468 scopus 로고    scopus 로고
    • The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology
    • Abaan O.D., et al. The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology. Cancer Res. 2013, 73:4372-4382.
    • (2013) Cancer Res. , vol.73 , pp. 4372-4382
    • Abaan, O.D.1
  • 24
    • 77952202405 scopus 로고    scopus 로고
    • MRNA and microRNA expression profiles of the NCI-60 integrated with drug activities
    • Liu H., et al. mRNA and microRNA expression profiles of the NCI-60 integrated with drug activities. Mol. Cancer Ther. 2010, 9:1080-1091.
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 1080-1091
    • Liu, H.1
  • 25
    • 76649106091 scopus 로고    scopus 로고
    • Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NCI 60 cancer cell line set
    • Park E.S., et al. Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NCI 60 cancer cell line set. Mol. Cancer Ther. 2010, 9:257-267.
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 257-267
    • Park, E.S.1
  • 26
    • 84904490528 scopus 로고    scopus 로고
    • NCI-60 whole exome sequencing and pharmacological CellMiner analyses
    • Reinhold W.C., et al. NCI-60 whole exome sequencing and pharmacological CellMiner analyses. PLoS ONE 2014, 9:e101670.
    • (2014) PLoS ONE , vol.9 , pp. e101670
    • Reinhold, W.C.1
  • 27
    • 84899932161 scopus 로고    scopus 로고
    • High resolution copy number variation data in the NCI-60 cancer cell lines from whole genome microarrays accessible through CellMiner
    • Varma S., et al. High resolution copy number variation data in the NCI-60 cancer cell lines from whole genome microarrays accessible through CellMiner. PLoS ONE 2014, 9:e92047.
    • (2014) PLoS ONE , vol.9 , pp. e92047
    • Varma, S.1
  • 28
    • 38049097938 scopus 로고    scopus 로고
    • Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling
    • McDermott U., et al. Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling. Proc. Nat. Acad. Sci. U.S.A. 2007, 104:19936-19941.
    • (2007) Proc. Nat. Acad. Sci. U.S.A. , vol.104 , pp. 19936-19941
    • McDermott, U.1
  • 29
    • 67651006061 scopus 로고    scopus 로고
    • Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions
    • Sos M.L., et al. Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions. J. Clin. Invest. 2009, 119:1727-1740.
    • (2009) J. Clin. Invest. , vol.119 , pp. 1727-1740
    • Sos, M.L.1
  • 30
    • 79961062492 scopus 로고    scopus 로고
    • Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer
    • Cheung H.W., et al. Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. Proc. Nat. Acad. Sci. U.S.A. 2011, 108:12372-12377.
    • (2011) Proc. Nat. Acad. Sci. U.S.A. , vol.108 , pp. 12372-12377
    • Cheung, H.W.1
  • 31
    • 84864286442 scopus 로고    scopus 로고
    • Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
    • Wilson T.R., et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature 2012, 487:505-509.
    • (2012) Nature , vol.487 , pp. 505-509
    • Wilson, T.R.1
  • 32
    • 77951717316 scopus 로고    scopus 로고
    • Molecular target class is predictive of in vitro response profile
    • Greshock J., et al. Molecular target class is predictive of in vitro response profile. Cancer Res. 2010, 70:3677-3686.
    • (2010) Cancer Res. , vol.70 , pp. 3677-3686
    • Greshock, J.1
  • 33
    • 84859169877 scopus 로고    scopus 로고
    • The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
    • Barretina J., et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 2012, 483:603-607.
    • (2012) Nature , vol.483 , pp. 603-607
    • Barretina, J.1
  • 34
    • 84859187259 scopus 로고    scopus 로고
    • Systematic identification of genomic markers of drug sensitivity in cancer cells
    • Garnett M.J., et al. Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature 2012, 483:570-575.
    • (2012) Nature , vol.483 , pp. 570-575
    • Garnett, M.J.1
  • 35
    • 84924407460 scopus 로고    scopus 로고
    • A comprehensive transcriptional portrait of human cancer cell lines
    • Klijn C., et al. A comprehensive transcriptional portrait of human cancer cell lines. Nat. Biotechnol. 2015, 33:306-312.
    • (2015) Nat. Biotechnol. , vol.33 , pp. 306-312
    • Klijn, C.1
  • 36
    • 79960987021 scopus 로고    scopus 로고
    • A public genome-scale lentiviral expression library of human ORFs
    • Yang X., et al. A public genome-scale lentiviral expression library of human ORFs. Nat. Methods 2011, 8:659-661.
    • (2011) Nat. Methods , vol.8 , pp. 659-661
    • Yang, X.1
  • 37
    • 84924266469 scopus 로고    scopus 로고
    • A functional landscape of resistance to ALK inhibition in lung cancer
    • Wilson F.H., et al. A functional landscape of resistance to ALK inhibition in lung cancer. Cancer cell 2015, 27:397-408.
    • (2015) Cancer cell , vol.27 , pp. 397-408
    • Wilson, F.H.1
  • 38
    • 84889606709 scopus 로고    scopus 로고
    • A melanocyte lineage program confers resistance to MAP kinase pathway inhibition
    • Johannessen C.M., et al. A melanocyte lineage program confers resistance to MAP kinase pathway inhibition. Nature 2013, 504:138-142.
    • (2013) Nature , vol.504 , pp. 138-142
    • Johannessen, C.M.1
  • 39
    • 78650309875 scopus 로고    scopus 로고
    • COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
    • Johannessen C.M., et al. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature 2010, 468:968-972.
    • (2010) Nature , vol.468 , pp. 968-972
    • Johannessen, C.M.1
  • 40
    • 84924325933 scopus 로고    scopus 로고
    • Genetic modifiers of EGFR dependence in non-small cell lung cancer
    • Sharifnia T., et al. Genetic modifiers of EGFR dependence in non-small cell lung cancer. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:18661-18666.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 18661-18666
    • Sharifnia, T.1
  • 41
    • 84878587532 scopus 로고    scopus 로고
    • RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer
    • Serra V., et al. RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer. J. Clin. Invest. 2013, 123:2551-2563.
    • (2013) J. Clin. Invest. , vol.123 , pp. 2551-2563
    • Serra, V.1
  • 42
    • 84939885519 scopus 로고    scopus 로고
    • PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling
    • Moody S.E., et al. PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling. Oncogene 2015, 34:2061-2071.
    • (2015) Oncogene , vol.34 , pp. 2061-2071
    • Moody, S.E.1
  • 43
    • 84919983240 scopus 로고    scopus 로고
    • Systematic identification of signaling pathways with potential to confer anticancer drug resistance
    • Martz C.A., et al. Systematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci. Signal. 2014, 7:ra121.
    • (2014) Sci. Signal. , vol.7 , pp. ra121
    • Martz, C.A.1
  • 44
    • 84920029560 scopus 로고    scopus 로고
    • RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis
    • Winter P.S., et al. RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis. Sci. Signal. 2014, 7:ra122.
    • (2014) Sci. Signal. , vol.7 , pp. ra122
    • Winter, P.S.1
  • 45
    • 38549141939 scopus 로고    scopus 로고
    • Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer
    • Iorns E., et al. Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer. Cancer Cell 2008, 13:91-104.
    • (2008) Cancer Cell , vol.13 , pp. 91-104
    • Iorns, E.1
  • 46
    • 35148885729 scopus 로고    scopus 로고
    • A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
    • Berns K., et al. A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 2007, 12:395-402.
    • (2007) Cancer Cell , vol.12 , pp. 395-402
    • Berns, K.1
  • 47
    • 84857377978 scopus 로고    scopus 로고
    • Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen
    • Mendes-Pereira A.M., et al. Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:2730-2735.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 2730-2735
    • Mendes-Pereira, A.M.1
  • 48
    • 84894552468 scopus 로고    scopus 로고
    • Identification of novel determinants of resistance to lapatinib in ERBB2-amplified cancers
    • Wetterskog D., et al. Identification of novel determinants of resistance to lapatinib in ERBB2-amplified cancers. Oncogene 2014, 33:966-976.
    • (2014) Oncogene , vol.33 , pp. 966-976
    • Wetterskog, D.1
  • 49
    • 84899698299 scopus 로고    scopus 로고
    • Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer
    • de Bruin E.C., et al. Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer. Cancer Discov. 2014, 4:606-619.
    • (2014) Cancer Discov. , vol.4 , pp. 606-619
    • de Bruin, E.C.1
  • 50
    • 77955038485 scopus 로고    scopus 로고
    • NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome
    • Holzel M., et al. NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome. Cell 2010, 142:218-229.
    • (2010) Cell , vol.142 , pp. 218-229
    • Holzel, M.1
  • 51
    • 84870020040 scopus 로고    scopus 로고
    • MED12 controls the response to multiple cancer drugs through regulation of TGF-beta receptor signaling
    • Huang S., et al. MED12 controls the response to multiple cancer drugs through regulation of TGF-beta receptor signaling. Cell 2012, 151:937-950.
    • (2012) Cell , vol.151 , pp. 937-950
    • Huang, S.1
  • 52
    • 84897531613 scopus 로고    scopus 로고
    • Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma
    • Sun C., et al. Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma. Nature 2014, 508:118-122.
    • (2014) Nature , vol.508 , pp. 118-122
    • Sun, C.1
  • 53
    • 34147198467 scopus 로고    scopus 로고
    • Synthetic lethal screen identification of chemosensitizer loci in cancer cells
    • Whitehurst A.W., et al. Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature 2007, 446:815-819.
    • (2007) Nature , vol.446 , pp. 815-819
    • Whitehurst, A.W.1
  • 54
    • 79953814654 scopus 로고    scopus 로고
    • RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5
    • Zhu Y.X., et al. RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5. Blood 2011, 117:3847-3857.
    • (2011) Blood , vol.117 , pp. 3847-3857
    • Zhu, Y.X.1
  • 55
    • 77954299059 scopus 로고    scopus 로고
    • + leukemia cells upon inhibition of Bcr-Abl
    • + leukemia cells upon inhibition of Bcr-Abl. Cancer Cell 2010, 18:74-87.
    • (2010) Cancer Cell , vol.18 , pp. 74-87
    • Gregory, M.A.1
  • 56
    • 84863230465 scopus 로고    scopus 로고
    • Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
    • Prahallad A., et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 2012, 483:100-103.
    • (2012) Nature , vol.483 , pp. 100-103
    • Prahallad, A.1
  • 57
    • 84872387485 scopus 로고    scopus 로고
    • Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models
    • Corcoran R.B., et al. Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models. Cancer Cell 2013, 23:121-128.
    • (2013) Cancer Cell , vol.23 , pp. 121-128
    • Corcoran, R.B.1
  • 58
    • 80053465657 scopus 로고    scopus 로고
    • Functional viability profiles of breast cancer
    • Brough R., et al. Functional viability profiles of breast cancer. Cancer Discov. 2011, 1:260-273.
    • (2011) Cancer Discov. , vol.1 , pp. 260-273
    • Brough, R.1
  • 59
    • 79952220731 scopus 로고    scopus 로고
    • Parallel high-throughput RNA interference screens identify PINK1 as a potential therapeutic target for the treatment of DNA mismatch repair-deficient cancers
    • Martin S.A., et al. Parallel high-throughput RNA interference screens identify PINK1 as a potential therapeutic target for the treatment of DNA mismatch repair-deficient cancers. Cancer Res. 2011, 71:1836-1848.
    • (2011) Cancer Res. , vol.71 , pp. 1836-1848
    • Martin, S.A.1
  • 60
    • 84885229945 scopus 로고    scopus 로고
    • Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3-mutant cancer
    • Herrera-Abreu M.T., et al. Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3-mutant cancer. Cancer Discov. 2013, 3:1058-1071.
    • (2013) Cancer Discov. , vol.3 , pp. 1058-1071
    • Herrera-Abreu, M.T.1
  • 61
    • 84856069665 scopus 로고    scopus 로고
    • A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis
    • Kessler J.D., et al. A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science 2012, 335:348-353.
    • (2012) Science , vol.335 , pp. 348-353
    • Kessler, J.D.1
  • 62
    • 84860319361 scopus 로고    scopus 로고
    • The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer
    • Kumar M.S., et al. The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer. Cell 2012, 149:642-655.
    • (2012) Cell , vol.149 , pp. 642-655
    • Kumar, M.S.1
  • 63
    • 84933277263 scopus 로고    scopus 로고
    • Applications of the CRISPR-Cas9 system in cancer biology
    • Sanchez-Rivera F.J., Jacks T. Applications of the CRISPR-Cas9 system in cancer biology. Nat. Rev. Cancer 2015, 15:387-395.
    • (2015) Nat. Rev. Cancer , vol.15 , pp. 387-395
    • Sanchez-Rivera, F.J.1    Jacks, T.2
  • 64
    • 80051625929 scopus 로고    scopus 로고
    • Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling
    • Wagle N., et al. Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. J. Clin. Oncol. 2011, 29:3085-3096.
    • (2011) J. Clin. Oncol. , vol.29 , pp. 3085-3096
    • Wagle, N.1
  • 65
    • 84891894051 scopus 로고    scopus 로고
    • The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma
    • Van Allen E.M., et al. The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma. Cancer Discov. 2014, 4:94-109.
    • (2014) Cancer Discov. , vol.4 , pp. 94-109
    • Van Allen, E.M.1
  • 66
    • 84933040790 scopus 로고    scopus 로고
    • Clinical acquired resistance to RAF inhibitor combinations in BRAF-mutant colorectal cancer through MAPK pathway alterations
    • Ahronian L.G., et al. Clinical acquired resistance to RAF inhibitor combinations in BRAF-mutant colorectal cancer through MAPK pathway alterations. Cancer discov. 2015, 5:358-367.
    • (2015) Cancer discov. , vol.5 , pp. 358-367
    • Ahronian, L.G.1
  • 67
    • 84891899026 scopus 로고    scopus 로고
    • MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibition
    • Wagle N., et al. MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibition. Cancer Discov. 2014, 4:61-68.
    • (2014) Cancer Discov. , vol.4 , pp. 61-68
    • Wagle, N.1
  • 68
    • 84930638395 scopus 로고    scopus 로고
    • Whole-genome characterization of chemoresistant ovarian cancer
    • Patch A.M., et al. Whole-genome characterization of chemoresistant ovarian cancer. Nature 2015, 521:489-494.
    • (2015) Nature , vol.521 , pp. 489-494
    • Patch, A.M.1
  • 69
    • 84892373020 scopus 로고    scopus 로고
    • Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma
    • Johnson B.E., et al. Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science 2014, 343:189-193.
    • (2014) Science , vol.343 , pp. 189-193
    • Johnson, B.E.1
  • 70
    • 84890553061 scopus 로고    scopus 로고
    • Inconsistency in large pharmacogenomic studies
    • Haibe-Kains B., et al. Inconsistency in large pharmacogenomic studies. Nature 2013, 504:389.
    • (2013) Nature , vol.504 , pp. 389
    • Haibe-Kains, B.1
  • 71
    • 84905454959 scopus 로고    scopus 로고
    • Enhancing reproducibility in cancer drug screening: how do we move forward?
    • Hatzis C., et al. Enhancing reproducibility in cancer drug screening: how do we move forward?. Cancer Res. 2014, 74:4016-4023.
    • (2014) Cancer Res. , vol.74 , pp. 4016-4023
    • Hatzis, C.1
  • 72
    • 84862908154 scopus 로고    scopus 로고
    • ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells
    • Liu X., et al. ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells. Am. J. Pathol. 2012, 180:599-607.
    • (2012) Am. J. Pathol. , vol.180 , pp. 599-607
    • Liu, X.1
  • 73
    • 84919443958 scopus 로고    scopus 로고
    • Patient-derived models of acquired resistance can identify effective drug combinations for cancer
    • Crystal A.S., et al. Patient-derived models of acquired resistance can identify effective drug combinations for cancer. Science 2014, 346:1480-1486.
    • (2014) Science , vol.346 , pp. 1480-1486
    • Crystal, A.S.1
  • 74
    • 84861719757 scopus 로고    scopus 로고
    • Patient-derived tumour xenografts as models for oncology drug development
    • Tentler J.J., et al. Patient-derived tumour xenografts as models for oncology drug development. Nat. Rev. Clin. Oncol. 2012, 9:338-350.
    • (2012) Nat. Rev. Clin. Oncol. , vol.9 , pp. 338-350
    • Tentler, J.J.1
  • 75
    • 84906895091 scopus 로고    scopus 로고
    • Patient-derived xenograft models: an emerging platform for translational cancer research
    • Hidalgo M., et al. Patient-derived xenograft models: an emerging platform for translational cancer research. Cancer Discov. 2014, 4:998-1013.
    • (2014) Cancer Discov. , vol.4 , pp. 998-1013
    • Hidalgo, M.1
  • 76
    • 84884559238 scopus 로고    scopus 로고
    • Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts
    • Li S., et al. Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts. Cell Rep. 2013, 4:1116-1130.
    • (2013) Cell Rep. , vol.4 , pp. 1116-1130
    • Li, S.1
  • 77
    • 84925682623 scopus 로고    scopus 로고
    • Prioritizing therapeutic targets using patient-derived xenograft models
    • Lodhia K.A., et al. Prioritizing therapeutic targets using patient-derived xenograft models. Bioch. Biophys. Acta 2015, 1855:223-234.
    • (2015) Bioch. Biophys. Acta , vol.1855 , pp. 223-234
    • Lodhia, K.A.1
  • 78
    • 84866923492 scopus 로고    scopus 로고
    • Characterization of a large panel of patient-derived tumor xenografts representing the clinical heterogeneity of human colorectal cancer
    • Julien S., et al. Characterization of a large panel of patient-derived tumor xenografts representing the clinical heterogeneity of human colorectal cancer. Clin. Cancer Res. 2012, 18:5314-5328.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 5314-5328
    • Julien, S.1
  • 79
    • 84922067781 scopus 로고    scopus 로고
    • Single luminal epithelial progenitors can generate prostate organoids in culture
    • 951-954
    • Chua C.W., et al. Single luminal epithelial progenitors can generate prostate organoids in culture. Nat. Cell Biol. 2014, 16:951-961. 951-954.
    • (2014) Nat. Cell Biol. , vol.16 , pp. 951-961
    • Chua, C.W.1
  • 80
    • 84928974420 scopus 로고    scopus 로고
    • Prospective derivation of a living organoid biobank of colorectal cancer patients
    • van de Wetering M., et al. Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell 2015, 161:933-945.
    • (2015) Cell , vol.161 , pp. 933-945
    • van de Wetering, M.1
  • 81
    • 67349123408 scopus 로고    scopus 로고
    • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    • Sato T., et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 2009, 459:262-265.
    • (2009) Nature , vol.459 , pp. 262-265
    • Sato, T.1
  • 82
    • 84878835012 scopus 로고    scopus 로고
    • Intestinal organoids as tissue surrogates for toxicological and pharmacological studies
    • Kuratnik A., Giardina C. Intestinal organoids as tissue surrogates for toxicological and pharmacological studies. Biochem. Pharmacol. 2013, 85:1721-1726.
    • (2013) Biochem. Pharmacol. , vol.85 , pp. 1721-1726
    • Kuratnik, A.1    Giardina, C.2
  • 83
    • 84907554319 scopus 로고    scopus 로고
    • Organoid cultures derived from patients with advanced prostate cancer
    • Gao D., et al. Organoid cultures derived from patients with advanced prostate cancer. Cell 2014, 159:176-187.
    • (2014) Cell , vol.159 , pp. 176-187
    • Gao, D.1
  • 84
    • 84907552531 scopus 로고    scopus 로고
    • Identification of multipotent luminal progenitor cells in human prostate organoid cultures
    • Karthaus W.R., et al. Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Cell 2014, 159:163-175.
    • (2014) Cell , vol.159 , pp. 163-175
    • Karthaus, W.R.1
  • 85
    • 84920983131 scopus 로고    scopus 로고
    • Organoid models of human and mouse ductal pancreatic cancer
    • Boj S.F., et al. Organoid models of human and mouse ductal pancreatic cancer. Cell 2015, 160:324-338.
    • (2015) Cell , vol.160 , pp. 324-338
    • Boj, S.F.1
  • 86
    • 84923375991 scopus 로고    scopus 로고
    • Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy
    • Montero J., et al. Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy. Cell 2015, 160:977-989.
    • (2015) Cell , vol.160 , pp. 977-989
    • Montero, J.1
  • 87
    • 77956274693 scopus 로고    scopus 로고
    • Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis
    • Iadevaia S., et al. Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis. Cancer Res. 2010, 70:6704-6714.
    • (2010) Cancer Res. , vol.70 , pp. 6704-6714
    • Iadevaia, S.1
  • 88
    • 77951134093 scopus 로고    scopus 로고
    • A formal model for analyzing drug combination effects and its application in TNF-alpha-induced NFkappaB pathway
    • Yan H., et al. A formal model for analyzing drug combination effects and its application in TNF-alpha-induced NFkappaB pathway. BMC Sys. Biol. 2010, 4:50.
    • (2010) BMC Sys. Biol. , vol.4 , pp. 50
    • Yan, H.1
  • 89
    • 84885811004 scopus 로고    scopus 로고
    • Drug synergy screen and network modeling in dedifferentiated liposarcoma identifies CDK4 and IGF1R as synergistic drug targets
    • Miller M.L., et al. Drug synergy screen and network modeling in dedifferentiated liposarcoma identifies CDK4 and IGF1R as synergistic drug targets. Sci. Signal. 2013, 6:ra85.
    • (2013) Sci. Signal. , vol.6 , pp. ra85
    • Miller, M.L.1
  • 90
    • 84885722700 scopus 로고    scopus 로고
    • Profiles of Basal and stimulated receptor signaling networks predict drug response in breast cancer lines
    • Niepel M., et al. Profiles of Basal and stimulated receptor signaling networks predict drug response in breast cancer lines. Sci. Signal. 2013, 6:ra84.
    • (2013) Sci. Signal. , vol.6 , pp. ra84
    • Niepel, M.1
  • 91
    • 84909606346 scopus 로고    scopus 로고
    • Timing and heterogeneity of mutations associated with drug resistance in metastatic cancers
    • Bozic I., Nowak M.A. Timing and heterogeneity of mutations associated with drug resistance in metastatic cancers. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:15964-15968.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 15964-15968
    • Bozic, I.1    Nowak, M.A.2
  • 92
    • 84896727479 scopus 로고    scopus 로고
    • Addressing genetic tumor heterogeneity through computationally predictive combination therapy
    • Zhao B., et al. Addressing genetic tumor heterogeneity through computationally predictive combination therapy. Cancer Discov. 2014, 4:166-174.
    • (2014) Cancer Discov. , vol.4 , pp. 166-174
    • Zhao, B.1


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