Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes

Nature Communications

Volumn 7, Issue , 2016, Pages

  Bacos, Karl ^a   Gillberg, Linn ^b,c   Volkov, Petr ^a   Olsson, Anders H ^b   Hansen, Torben ^d   Pedersen, Oluf ^d   Gjesing, Anette Prior ^d   Eiberg, Hans ^c   Tuomi, Tiinamaija ^e,f   Almgren, Peter ^a   Groop, Leif ^a,f   Eliasson, Lena ^a   Vaag, Allan ^b,c   Dayeh, Tasnim ^a   Ling, Charlotte ^a  

^a LUND UNIVERSITY DIABETES CENTRE   (Sweden)

^b Rigshospitalet   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d Capital Region   (Denmark)

^e HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^f UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; INSULIN;

AGE STRUCTURE; BIOMARKER; BLOOD; DIABETES; DNA; HORMONE; METHYLATION;

ADULT; AGED; AGING; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DNA METHYLATION; FAM123C GENE; FEMALE; FHL2 GENE; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENE SILENCING; HUMAN; IN VIVO STUDY; INSULIN RELEASE; KLF14 GENE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET; ZNF518B GENE; AGE; BLOOD; EPIGENETICS; GENE EXPRESSION REGULATION; METABOLISM; PHYSIOLOGY; SECRETION (PROCESS);

ADULT; AGE FACTORS; AGED; BIOMARKERS; DIABETES MELLITUS, TYPE 2; DNA METHYLATION; EPIGENOMICS; GENE EXPRESSION REGULATION; GENE SILENCING; HUMANS; INSULIN; ISLETS OF LANGERHANS; MIDDLE AGED;

EID: 84962885566     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms11089     Document Type: Article

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