Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men

Diabetes Care

Volumn 36, Issue 11, 2013, Pages 3732-3738

  Mahendran, Yuvaraj ^a   Cederberg, Henna ^b   Vangipurapu, Jagadish ^a   Kangas, Antti J ^c   Soininen, Pasi ^a,c   Kuusisto, Johanna ^b   Uusitupa, Matti ^a,b   Ala Korpela, Mika ^a,c,d,e   Laakso, Markku ^b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF OULU   (Finland)

^d OULU UNIVERSITY HOSPITAL   (Finland)

^e UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE; GLYCEROL; LINOLEIC ACID; MONOUNSATURATED FATTY ACID; MONOUNSATURATED N 7 FATTY ACID; MONOUNSATURATED N 9 FATTY ACID; OMEGA 6 FATTY ACID; SATURATED FATTY ACID; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CROSS-SECTIONAL STUDY; FATTY ACID BLOOD LEVEL; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; GLYCEROL BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; LIPID COMPOSITION; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PREDICTION; PROTON NUCLEAR MAGNETIC RESONANCE; RISK FACTOR; RISK REDUCTION; BLOOD; CAUCASIAN; DIABETES MELLITUS, TYPE 2; FINLAND; MIDDLE AGED;

AGED; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; FATTY ACIDS; FATTY ACIDS, MONOUNSATURATED; FATTY ACIDS, NONESTERIFIED; FINLAND; GLYCEROL; HUMANS; HYPERGLYCEMIA; MALE; MIDDLE AGED;

EID: 84891451520     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc13-0800     Document Type: Article

References (38)

1. Eckel RH, Alberti KG, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2010;375:181-183
2. Hagen JH, Moorhouse JA, Steinberg J. Effect of insulin on plasma glycerol in man. Metabolism 1963;12:346-351
3. Funahashi T, Nagasawa A, Hibuse T, Maeda N. Impact of glycerol gateway molecule in adipocytes. Cell Mol Biol (Noisy-le-grand) 2006;52:40-45
4. Salgin B, Ong KK, Thankamony A, Emmett P, Wareham NJ, Dunger DB. Higher fasting plasma free fatty acid levels are associated with lower insulin secretion in children and adults and a higher incidence of type 2 diabetes. J Clin Endocrinol Metab 2012;97:3302-3309
5. Paolisso G, Tataranni PA, Foley JE, Bogardus C, Howard BV, Ravussin E. A high concentration of fasting plasma nonesterified fatty acids is a risk factor for the development of NIDDM. Diabetologia 1995;38:1213-1217
6. Pankow JS, Duncan BB, SchmidtMI, et al.; Atherosclerosis Risk in Communities Study. Fasting plasma free fatty acids and risk of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes Care 2004;27:77-82
7. Charles MA, Eschwège E, Thibult N, et al. The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: results of the Paris Prospective Study. Diabetologia 1997;40: 1101-1106
8. Hjellvik V, Sakshaug S, Strøm H. Body mass index, triglycerides, glucose, and blood pressure as predictors of type 2 diabetes in a middle-aged Norwegian cohort of men and women. Clin Epidemiol 2012; 4:213-224
9. Baylin A, Campos H. The use of fatty acid biomarkers to reflect dietary intake. Curr Opin Lipidol 2006;17:22-27
10. Feskens EJ, van Dam RM. Dietary fat and the etiology of type 2 diabetes: an epidemiological perspective. Nutr Metab Cardiovasc Dis 1999;9:87-95
11. Zheng JS, Huang T, Yang J, Fu YQ, Li D. Marine N-3 polyunsaturated fatty acids are inversely associated with risk of type 2 diabetes in Asians: a systematic reviewand meta-analysis. PLoS ONE 2012;7:e44525
12. Djoussé L, Biggs ML, Lemaitre RN, et al. Plasma omega-3 fatty acids and incident diabetes in older adults. Am J Clin Nutr 2011;94:527-533
13. Hodge AM, English DR, O'Dea K, et al. Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: interpreting the role of linoleic acid. Am J Clin Nutr 2007;86:189-197
14. Patel PS, Sharp SJ, Jansen E, et al. Fatty acids measured in plasma and erythrocytemembrane phospholipids and derived by food-frequency questionnaire and the risk of new-onset type 2 diabetes: a pilot study in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohort. Am J Clin Nutr 2010;92: 1214-1222
15. Huang T, Wahlqvist ML, Xu T, Xu A, Zhang A, Li D. Increased plasma n-3 polyunsaturated fatty acid is associated with improved insulin sensitivity in type 2 diabetes in China. Mol Nutr Food Res 2010;54(Suppl. 1):S112-S119
16. Nigam A, Frasure-Smith N, Lespérance F, Julien P. Relationship between n-3 and n-6 plasma fatty acid levels and insulin resistance in coronary patients with and without metabolic syndrome. Nutr Metab Cardiovasc Dis 2009;19:264-270
17. Haag M, Dippenaar NG. Dietary fats, fatty acids and insulin resistance: short review of a multifaceted connection. Med Sci Monit 2005;11:RA359-RA367
18. Wang L, Folsom AR, Zheng ZJ, Pankow JS, Eckfeldt JH; ARIC Study Investigators. Plasma fatty acid composition and incidence of diabetes in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) study. Am J Clin Nutr 2003;78: 91-98
19. Vessby B, Aro A, Skarfors E, Berglund L, Salminen I, Lithell H. The risk to develop NIDDM is related to the fatty acid composition of the serum cholesterol esters. Diabetes 1994;43:1353-1357
20. Laaksonen DE, Lakka TA, Lakka HM, et al. Serum fatty acid composition predicts development of impaired fasting glycaemia and diabetes in middle-aged men. Diabet Med 2002;19:456-464
21. Würtz P, Tiainen M, Mäkinen VP, et al. Circulating metabolite predictors of glycemia in middle-aged men and women. Diabetes Care 2012;35:1749-1756
22. Vessby B, Uusitupa M, Hermansen K, et al.; KANWU Study. Substituting dietary saturated formonounsaturated fat impairs insulin sensitivity in healthy men and women: the KANWU Study. Diabetologia 2001;44:312-319
23. Lichtenstein AH, Schwab US. Relationship of dietary fat to glucose metabolism. Atherosclerosis 2000;150:227-243
24. Corella D, Ordovás JM. Interactions between dietary n-3 fatty acids and genetic variants and risk of disease. Br J Nutr 2012;107(Suppl. 2):S271-S283
25. Stancáková A, Javorský M, Kuulasmaa T, Haffner SM, Kuusisto J, Laakso M. Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men. Diabetes 2009;58: 1212-1221
26. American Diabetes Association. Standards of medical care in diabetes. Diabetes Care 2004;27(Suppl. 1):S15-S35
27. Soininen P, Kangas AJ, Würtz P, et al. High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism. Analyst (Lond) 2009; 134:1781-1785
28. Tukiainen T, Tynkkynen T, Mäkinen VP, et al. A multi-metabolite analysis of serum by 1H NMR spectroscopy: early systemic signs of Alzheimer's disease. Biochem Biophys Res Commun 2008;375:356-361
29. Kettunen J, Tukiainen T, Sarin AP, et al. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet 2012;44: 269-276
30. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999;22:1462-1470
31. Sundström J, Lind L, Vessby B, Andrén B, Aro A, Lithell H. Dyslipidemia and an unfavorable fatty acid profile predict left ventricular hypertrophy 20 years later. Circulation 2001;103:836-841
32. Kouki R, Schwab U, Hassinen M, et al. Food consumption, nutrient intake and the risk of having metabolic syndrome: the DR's EXTRA Study. Eur J Clin Nutr 2011;65:368-377
33. Lovejoy JC, Champagne CM, Smith SR, et al. Relationship of dietary fat and serum cholesterol ester and phospholipid fatty acids to markers of insulin resistance inmen and women with a range of glucose tolerance. Metabolism 2001; 50:86-92
34. Vessby B, Tengblad S, Lithell H. Insulin sensitivity is related to the fatty acid composition of serum lipids and skeletal muscle phospholipids in 70-year-old men. Diabetologia 1994;37:1044-1050
35. Rizos EC, Ntzani EE, Bika E, Kostapanos MS, Elisaf MS. Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. JAMA 2012;308:1024-1033
36. Jeppesen C, Schiller K, Schulze MB. Omega-3 and omega-6 fatty acids and type 2 diabetes. Curr Diab Rep 2013;13: 279-288
37. Czernichow S, Thomas D, Bruckert E. n-6 Fatty acids and cardiovascular health: a review of the evidence for dietary intake recommendations. Br J Nutr 2010;104: 788-796
38. Bosch J, Gerstein HC, Dagenais GR, et al.; ORIGIN Trial Investigators. n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia. N Engl J Med 2012;367:309-318