A novel tyrosine-modified low molecular weight polyethylenimine (P10Y) for efficient siRNA delivery in vitro and in vivo

Journal of Controlled Release

Volumn 230, Issue , 2016, Pages 13-25

  Ewe, Alexander ^a   Przybylski, Susanne ^b   Burkhardt, Jana ^b   Janke, Andreas ^c   Appelhans, Dietmar ^c   Aigner, Achim ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b FRAUNHOFER INSTITUTE FOR CELL THERAPY AND IMMUNOLOGY   (Germany)

^c LEIBNIZ INSTITUTE OF POLYMER RESEARCH DRESDEN   (Germany)

Author keywords

P10Y; Polyethlyenimine; RNAi in vivo; siRNA transfection; Therapeutic siRNA delivery; Tyrosine modification

Indexed keywords

AMINO ACIDS; BIOACTIVITY; CELL CULTURE; CELLS; CHEMICAL MODIFICATION; CYTOLOGY; GENE THERAPY; GENE TRANSFER; GENES; MAMMALS; MOLECULAR WEIGHT; NUCLEIC ACIDS; TUMORS;

IN-VIVO; P10Y; POLYETHLYENIMINE; SIRNA DELIVERY; SIRNA TRANSFECTION; TYROSINE MODIFICATION;

RNA;

GAMMA INTERFERON; POLYETHYLENEIMINE DERIVATIVE; SMALL INTERFERING RNA; SURVIVIN; TUMOR NECROSIS FACTOR ALPHA; TYROSINE DERIVATIVE; BIRC5 PROTEIN, MOUSE; INHIBITOR OF APOPTOSIS PROTEIN; POLYETHYLENEIMINE; REPRESSOR PROTEIN; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; ATOMIC FORCE MICROSCOPY; BIOCOMPATIBILITY; CANCER GENE THERAPY; CANCER SIZE; CARCINOMA CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG STABILITY; DRUG STORAGE; ENDOCYTOSIS; ERYTHROCYTE AGGREGATION; FLOW CYTOMETRY; FREEZE DRYING; GENE SILENCING; GENE TARGETING; IMMUNOPHENOTYPING; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; LIGHT SCATTERING; MELANOMA; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; ONCOGENE; OVARY CARCINOMA; PHOTON CORRELATION SPECTROSCOPY; PRIORITY JOURNAL; PROSTATE CARCINOMA; REAL TIME POLYMERASE CHAIN REACTION; TUMOR XENOGRAFT; WESTERN BLOTTING; ZETA POTENTIAL; ANIMAL; CHEMISTRY; GENE TRANSFER; GENETICS; HUMAN; NUDE MOUSE; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; GENE TRANSFER TECHNIQUES; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; MELANOMA; MICE, NUDE; MOLECULAR WEIGHT; POLYETHYLENEIMINE; REPRESSOR PROTEINS; RNA, SMALL INTERFERING; TYROSINE;

EID: 84962650827     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2016.03.034     Document Type: Article

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