Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 11, 2016, Pages 3036-3041

  Singhmar, Pooja ^a   Huo, Xiaojiao ^a   Eijkelkamp, Niels ^b   Berciano, Susana Rojo ^c,d   Baameur, Faiza ^a   Mei, Fang C ^e   Zhu, Yingmin ^e   Cheng, Xiaodong ^e   Hawke, David ^a   Mayor, Federico ^c,d   Murga, Cristina ^c,d   Heijnen, Cobi J ^a   Kavelaars, Annemieke ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^d Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas   (Spain)

^e UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Chronic pain; Epac1; Epac1 translocation; GRK2; Piezo2

Indexed keywords

G PROTEIN COUPLED RECEPTOR KINASE 2; PLECKSTRIN; ADRBK1 PROTEIN, MOUSE; EPAC PROTEIN, MOUSE; FREUND ADJUVANT; GUANINE NUCLEOTIDE EXCHANGE FACTOR; ION CHANNEL; NERVE PROTEIN; PHOSPHOSERINE; PIEZO2 PROTEIN, MOUSE; RAP1 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYPERALGESIA; INFLAMMATORY PAIN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPINAL GANGLION; AMINO ACID SEQUENCE; ANIMAL; CHEMICALLY INDUCED; CHRONIC DISEASE; COMPLICATION; DEFICIENCY; GENETICS; INFLAMMATION; KNOCKOUT MOUSE; MECHANORECEPTOR; METABOLISM; MOLECULAR GENETICS; NOCICEPTION; PAIN; PAIN THRESHOLD; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN ANALYSIS; PROTEIN PROCESSING; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; CHRONIC DISEASE; FREUND'S ADJUVANT; G-PROTEIN-COUPLED RECEPTOR KINASE 2; GANGLIA, SPINAL; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HYPERALGESIA; INFLAMMATION; ION CHANNELS; MECHANORECEPTORS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NOCICEPTION; PAIN; PAIN THRESHOLD; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN INTERACTION MAPPING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; RAP1 GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 84962583653     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1516036113     Document Type: Article

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