Mechanism of Epac activation. Structural and functional analyses of Epac2 hinge mutants with constitutive and reduced activities

Journal of Biological Chemistry

Volumn 284, Issue 35, 2009, Pages 23644-23651

  Tsalkova, Tamara ^a   Blumenthal, Donald K ^b   Mei, Fang C ^a   White, Mark A ^a   Cheng, Xiaodong ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALIGNMENT ANALYSIS; CATALYTIC ACTIVITY; CONFORMATIONAL CHANGE; CONSERVED RESIDUES; CONSTITUTIVELY ACTIVES; EXCHANGE PROTEINS; MOTION CORRELATION; NORMAL MODES; NUCLEOTIDE EXCHANGE; OPTIMAL SIZE; SIDE CHAINS; SMALL ANGLE X-RAY SCATTERING; STRUCTURAL PARAMETER;

AMINO ACIDS;

FETAL MONITORING;

ANTIPORTER; CYCLIC AMP; EPAC2; GLYCINE; MUTANT PROTEIN; NUCLEOTIDE; PHENYLALANINE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; HINGE REGION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; CYCLIC AMP; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTAGENESIS, SITE-DIRECTED; MUTATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 69949141505     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.024950     Document Type: Article

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