Acidosis mediates the switching of Gs-PKA and Gi-PKCε dependence in prolonged hyperalgesia induced by inflammation

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Huang, Wei Yu ^a   Dai, Shih Ping ^a   Chang, Yan Ching ^a   Sun, Wei Hsin ^a  

^a NATIONAL CENTRAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CARRAGEENAN; CYCLIC AMP DEPENDENT PROTEIN KINASE; FREUND ADJUVANT; G PROTEIN COUPLED RECEPTOR; G2A PROTEIN; PROSTAGLANDIN E2; PROTEIN KINASE C EPSILON; PROTON; SEROTONIN; TDAG8 PROTEIN; UNCLASSIFIED DRUG; GPR68 PROTEIN, MOUSE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN KINASE INHIBITOR; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ACIDOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME DEPENDENCE; ENZYME MECHANISM; GENE EXPRESSION; HYPERALGESIA; INHIBITION KINETICS; MOUSE; NOCICEPTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SOFT TISSUE INFLAMMATION; SWITCHING TIME; ANIMAL; COMPLICATION; DRUG EFFECTS; INFLAMMATION; METABOLISM; PH;

RATTUS;

ACIDOSIS; ANIMALS; CARRAGEENAN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FREUND'S ADJUVANT; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HYDROGEN-ION CONCENTRATION; HYPERALGESIA; INFLAMMATION; MICE; PROTEIN KINASE C-EPSILON; PROTEIN KINASE INHIBITORS; PROTEIN TRANSPORT; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84929103983     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0125022     Document Type: Article

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