-
1
-
-
11844254469
-
The cAMP binding domain: An ancient signaling module
-
Berman, H. M. et al. The cAMP binding domain: an ancient signaling module. Proc Natl Acad Sci U S A 102, 45-50 (2005).
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 45-50
-
-
Berman, H.M.1
-
2
-
-
47549108691
-
Epac and PKA: A tale of two intracellular cAMP receptors
-
Cheng, X., Ji, Z., Tsalkova, T. & Mei, F. Epac and PKA: a tale of two intracellular cAMP receptors. Acta Biochim Biophys Sin (Shanghai) 40, 651-662 (2008).
-
(2008)
Acta Biochim Biophys Sin (Shanghai)
, vol.40
, pp. 651-662
-
-
Cheng, X.1
Ji, Z.2
Tsalkova, T.3
Mei, F.4
-
3
-
-
33645313112
-
CNG and HCN channels: Two peas, one pod
-
Craven, K. B. & Zagotta, W. N. CNG and HCN channels: two peas, one pod. Annu Rev Physiol 68, 375-401 (2006).
-
(2006)
Annu Rev Physiol
, vol.68
, pp. 375-401
-
-
Craven, K.B.1
Zagotta, W.N.2
-
4
-
-
0032480888
-
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
-
de Rooij, J. et al. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 396, 474-477 (1998).
-
(1998)
Nature
, vol.396
, pp. 474-477
-
-
De Rooij, J.1
-
5
-
-
0032545328
-
A family of cAMP-binding proteins that directly activate Rap1
-
Kawasaki, H. et al. A family of cAMP-binding proteins that directly activate Rap1. Science 282, 2275-2279 (1998).
-
(1998)
Science
, vol.282
, pp. 2275-2279
-
-
Kawasaki, H.1
-
6
-
-
0037192820
-
Differential signaling of cyclic AMP - Opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation
-
Mei, F. et al. Differential signaling of cyclic AMP - Opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation. J Biol Chem 277, 11497-11504 (2002).
-
(2002)
J Biol Chem
, vol.277
, pp. 11497-11504
-
-
Mei, F.1
-
7
-
-
64549105338
-
Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function
-
Niimura, M. et al. Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function. J Cell Physiol 219, 652-658 (2009).
-
(2009)
J Cell Physiol
, vol.219
, pp. 652-658
-
-
Niimura, M.1
-
8
-
-
77955629623
-
The interaction of Epac1 and Ran promotes Rap1 activation at the nuclear envelope
-
Liu, C. et al. The interaction of Epac1 and Ran promotes Rap1 activation at the nuclear envelope. Mol Cell Biol 30, 3956-3969 (2010).
-
(2010)
Mol Cell Biol
, vol.30
, pp. 3956-3969
-
-
Liu, C.1
-
9
-
-
78649543303
-
Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins
-
Gloerich, M. et al. Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins. Mol Cell Biol 30, 5421-5431 (2010).
-
(2010)
Mol Cell Biol
, vol.30
, pp. 5421-5431
-
-
Gloerich, M.1
-
10
-
-
79959395511
-
The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity
-
Gloerich, M. et al. The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity. J Cell Biol 193, 1009-1020 (2011).
-
(2011)
J Cell Biol
, vol.193
, pp. 1009-1020
-
-
Gloerich, M.1
-
11
-
-
84874732136
-
Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1
-
Yan, J. et al. Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1. Mol Cell Biol 33, 918-926 (2013).
-
(2013)
Mol Cell Biol
, vol.33
, pp. 918-926
-
-
Yan, J.1
-
12
-
-
84874472807
-
Epac2 mediates cardiac beta1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia
-
Pereira, L. et al. Epac2 mediates cardiac beta1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation 127, 913-922 (2013).
-
(2013)
Circulation
, vol.127
, pp. 913-922
-
-
Pereira, L.1
-
13
-
-
84890089485
-
Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain
-
Wang, H. et al. Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain. J Clin Invest 123, 5023-5034 (2013).
-
(2013)
J Clin Invest
, vol.123
, pp. 5023-5034
-
-
Wang, H.1
-
14
-
-
84902150096
-
Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses
-
Okumura, S. et al. Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses. J Clin Invest 124, 2785-2801 (2014).
-
(2014)
J Clin Invest
, vol.124
, pp. 2785-2801
-
-
Okumura, S.1
-
15
-
-
84892909254
-
Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways
-
Onodera, Y. Nam, J. M. & Bissell, M. J. Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways. J Clin Invest 124, 367-384 (2014).
-
(2014)
J Clin Invest
, vol.124
, pp. 367-384
-
-
Onodera, Y.1
Nam, J.M.2
Bissell, M.J.3
-
16
-
-
84892955099
-
Cyclic AMP sensor EPAC proteins and energy homeostasis
-
Almahariq, M. Mei, F. C. & Cheng, X. Cyclic AMP sensor EPAC proteins and energy homeostasis. Trends Endocrinol Metab 25, 60-71 (2014).
-
(2014)
Trends Endocrinol Metab
, vol.25
, pp. 60-71
-
-
Almahariq, M.1
Mei, F.C.2
Cheng, X.3
-
17
-
-
84856005294
-
A fluorescence-based high-throughput assay for the discovery of exchange protein directly activated by cyclic AMP (EPAC) antagonists
-
Tsalkova, T. Mei, F. C. & Cheng, X. A fluorescence-based high-throughput assay for the discovery of exchange protein directly activated by cyclic AMP (EPAC) antagonists. PLoS One 7, e30441 (2012).
-
(2012)
PLoS One
, vol.7
, pp. e30441
-
-
Tsalkova, T.1
Mei, F.C.2
Cheng, X.3
-
18
-
-
84868570315
-
Isoform-specific antagonists of exchange proteins directly activated by cAMP
-
Tsalkova, T. et al. Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc Natl Acad Sci U S A 109, 18613-18618 (2012).
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 18613-18618
-
-
Tsalkova, T.1
-
19
-
-
84871563190
-
A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion
-
Almahariq, M. et al. A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion. Mol Pharmacol 83, 122-128 (2013).
-
(2013)
Mol Pharmacol
, vol.83
, pp. 122-128
-
-
Almahariq, M.1
-
20
-
-
84888309422
-
Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses
-
Gong, B. et al. Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses. Proc Natl Acad Sci U S A 110, 19615-19620 (2013).
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 19615-19620
-
-
Gong, B.1
-
21
-
-
84920609728
-
Exchange Protein Directly Activated by cAMP (EPAC1) Modulates Regulatory T Cell-Mediated Immune Suppression
-
Almahariq, M. et al. Exchange Protein Directly Activated by cAMP (EPAC1) Modulates Regulatory T Cell-Mediated Immune Suppression. Biochem J 465, 295-303 (2015).
-
(2015)
Biochem J
, vol.465
, pp. 295-303
-
-
Almahariq, M.1
-
22
-
-
84889581761
-
Epac-inhibitors: Facts and artefacts
-
Rehmann, H. Epac-inhibitors: facts and artefacts. Sci Rep 3, 3032 (2013).
-
(2013)
Sci Rep
, vol.3
, pp. 3032
-
-
Rehmann, H.1
-
23
-
-
69949167518
-
Dynamically driven ligand selectivity in cyclic nucleotide binding domains
-
Das, R. et al. Dynamically driven ligand selectivity in cyclic nucleotide binding domains. J Biol Chem 284, 23682-23696 (2009).
-
(2009)
J Biol Chem
, vol.284
, pp. 23682-23696
-
-
Das, R.1
-
24
-
-
79955024796
-
Mapping allostery through the covariance analysis of NMR chemical shifts
-
Selvaratnam, R., Chowdhury, S., VanSchouwen, B. & Melacini, G. Mapping allostery through the covariance analysis of NMR chemical shifts. Proc Natl Acad Sci U S A 108, 6133-6138 (2011).
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 6133-6138
-
-
Selvaratnam, R.1
Chowdhury, S.2
VanSchouwen, B.3
Melacini, G.4
-
25
-
-
84856748688
-
The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants
-
Selvaratnam, R. et al. The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants. Biophys J 102, 630-639 (2012).
-
(2012)
Biophys J
, vol.102
, pp. 630-639
-
-
Selvaratnam, R.1
-
26
-
-
84869746585
-
The auto-inhibitory role of the EPAC hinge helix as mapped by NMR
-
Selvaratnam, R., Mazhab-Jafari, M. T., Das, R. & Melacini, G. The auto-inhibitory role of the EPAC hinge helix as mapped by NMR. PLoS One 7, e48707 (2012).
-
(2012)
PLoS One
, vol.7
, pp. e48707
-
-
Selvaratnam, R.1
Mazhab-Jafari, M.T.2
Das, R.3
Melacini, G.4
-
27
-
-
84892383028
-
Opposing roles of PKA and EPAC in the cAMP-dependent regulation of schwann cell proliferation and differentiation
-
corrected
-
Bacallao, K. & Monje, P. V. Opposing roles of PKA and EPAC in the cAMP-dependent regulation of schwann cell proliferation and differentiation [corrected]. PLoS One 8, e82354 (2013).
-
(2013)
PLoS One
, vol.8
, pp. e82354
-
-
Bacallao, K.1
Monje, P.V.2
-
28
-
-
84912024729
-
Activation of EPAC1/2 is essential for osteoclast formation by modulating NFkappaB nuclear translocation and actin cytoskeleton rearrangements
-
Mediero, A., Perez-Aso, M. & Cronstein, B. N. Activation of EPAC1/2 is essential for osteoclast formation by modulating NFkappaB nuclear translocation and actin cytoskeleton rearrangements. Faseb j 28, 4901-4913 (2014).
-
(2014)
Faseb J
, vol.28
, pp. 4901-4913
-
-
Mediero, A.1
Perez-Aso, M.2
Cronstein, B.N.3
-
29
-
-
84906921621
-
The adenylyl cyclase inhibitor MDL-12,330A potentiates insulin secretion via blockade of voltage-dependent K(+) channels in pancreatic beta cells
-
Li, X. et al. The adenylyl cyclase inhibitor MDL-12,330A potentiates insulin secretion via blockade of voltage-dependent K(+) channels in pancreatic beta cells. PLoS One 8, e77934 (2013).
-
(2013)
PLoS One
, vol.8
, pp. e77934
-
-
Li, X.1
-
30
-
-
84910636973
-
Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic beta cells
-
Zhang, M. et al. Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic beta cells. Mol Cell Proteomics 13, 3049-3062 (2014).
-
(2014)
Mol Cell Proteomics
, vol.13
, pp. 3049-3062
-
-
Zhang, M.1
-
31
-
-
84987643235
-
cAMP controls the restoration of endothelial barrier function after thrombin-induced hyperpermeability via Rac1 activation
-
Aslam, M. et al. cAMP controls the restoration of endothelial barrier function after thrombin-induced hyperpermeability via Rac1 activation. Physiol Rep 2, e12175 (2014).
-
(2014)
Physiol Rep
, vol.2
, pp. e12175
-
-
Aslam, M.1
-
32
-
-
84919683253
-
The Central Role of cAMP in Regulating Plasmodium falciparum Merozoite Invasion of Human Erythrocytes
-
Dawn, A. et al. The Central Role of cAMP in Regulating Plasmodium falciparum Merozoite Invasion of Human Erythrocytes. PLoS Pathog 10, e1004520 (2014).
-
(2014)
PLoS Pathog
, vol.10
, pp. e1004520
-
-
Dawn, A.1
-
33
-
-
84919624713
-
Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling
-
Ivonnet, P., Salathe, M. & Conner, G. E. Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling. Br J Pharmacol 172, 173-184 (2015).
-
(2015)
Br J Pharmacol
, vol.172
, pp. 173-184
-
-
Ivonnet, P.1
Salathe, M.2
Conner, G.E.3
-
34
-
-
84919778859
-
Pharmacological inhibition and genetic knockdown of exchange protein directly activated by cAMP 1 reduce pancreatic cancer metastasis in vivo
-
Almahariq, M. et al. Pharmacological inhibition and genetic knockdown of exchange protein directly activated by cAMP 1 reduce pancreatic cancer metastasis in vivo. Mol Pharmacol 87, 142-149 (2015).
-
(2015)
Mol Pharmacol
, vol.87
, pp. 142-149
-
-
Almahariq, M.1
-
35
-
-
84873716320
-
Efficient Synthesis of ESI-09, A Novel Non-cyclic Nucleotide EPAC Antagonist
-
Chen, H. et al. Efficient Synthesis of ESI-09, A Novel Non-cyclic Nucleotide EPAC Antagonist. Tetrahedron Lett 54, 1546-1549 (2013).
-
(2013)
Tetrahedron Lett
, vol.54
, pp. 1546-1549
-
-
Chen, H.1
-
36
-
-
84879588528
-
Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: Protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility
-
Ding, C. et al. Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility. J Med Chem 56, 5048-5058 (2013).
-
(2013)
J Med Chem
, vol.56
, pp. 5048-5058
-
-
Ding, C.1
-
37
-
-
27644580732
-
Interplay between exchange protein directly activated by cAMP (Epac) and microtubule cytoskeleton
-
Mei, F. C. & Cheng, X. Interplay between exchange protein directly activated by cAMP (Epac) and microtubule cytoskeleton. Mol Biosyst 1, 325-331 (2005).
-
(2005)
Mol Biosyst
, vol.1
, pp. 325-331
-
-
Mei, F.C.1
Cheng, X.2
-
38
-
-
79955961854
-
Mechanism of Intracellular cAMP Sensor Epac2 Activation cAMP-Induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS)
-
Li, S. et al. Mechanism of Intracellular cAMP Sensor Epac2 Activation cAMP-Induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS). J Biol Chem 286, 17889-17897 (2011).
-
(2011)
J Biol Chem
, vol.286
, pp. 17889-17897
-
-
Li, S.1
-
39
-
-
69949141505
-
Mechanism of Epac activation: Structural and functional analyses of Epac2 hinge mutants with constitutive and reduced activities
-
Tsalkova, T., Blumenthal, D. K., Mei, F. C., White, M. A. & Cheng, X. Mechanism of Epac activation: structural and functional analyses of Epac2 hinge mutants with constitutive and reduced activities. J Biol Chem 284, 23644-23651 (2009).
-
(2009)
J Biol Chem
, vol.284
, pp. 23644-23651
-
-
Tsalkova, T.1
Blumenthal, D.K.2
Mei, F.C.3
White, M.A.4
Cheng, X.5
-
40
-
-
37249005205
-
The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability
-
Niesen, F. H., Berglund, H. & Vedadi, M. The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability. Nat Protoc 2, 2212-2221 (2007).
-
(2007)
Nat Protoc
, vol.2
, pp. 2212-2221
-
-
Niesen, F.H.1
Berglund, H.2
Vedadi, M.3
-
41
-
-
0029400480
-
NMRPipe: A multidimensional spectral processing system based on UNIX pipes
-
Delaglio, F. et al. NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J Biomol NMR 6, 277-293 (1995).
-
(1995)
J Biomol NMR
, vol.6
, pp. 277-293
-
-
Delaglio, F.1
|