cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 10, 2012, Pages 3814-3819

  Consonni, Sarah V ^a   Gloerich, Martijn ^a   Spanjaard, Emma ^a   Bos, Johannes L ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Lipid anchor; Membrane translocation; Small GTPases

Indexed keywords

CYCLIC AMP; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PHOSPHATIDIC ACID; PHOSPHOLIPASE D1; PROTEIN EPAC1; RAP PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN LIPID INTERACTION; PROTEIN TRANSPORT; REGULATORY MECHANISM;

CELL MEMBRANE; CYCLIC AMP; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HEK293 CELLS; HUMANS; LIPIDS; LIPOSOMES; PHOSPHATIDIC ACIDS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RAP1 GTP-BINDING PROTEINS; RECOMBINANT PROTEINS;

EID: 84857947890     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1117599109     Document Type: Article

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