A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion

Molecular Pharmacology

Volumn 83, Issue 1, 2013, Pages 122-128

  Almahariq, Muayad ^a   Tsalkova, Tamara ^a   Mei, Fang C ^a   Chen, Haijun ^a   Zhou, Jia ^a   Sastry, Sarita K ^a   Schwede, Frank ^b   Cheng, Xiaodong ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b Forschungslabor und Biochemica Vertrieb GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 (5 TERT BUTYL ISOXAZOL 3 YL) 2 [(3 CHLOROPHENYL)HYDRAZONO] 3 OXO PROPIONITRILE; ANTINEOPLASTIC AGENT; ESI 09; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP; PEPTIDES AND PROTEINS; PROTEIN KINASE B; RAP1 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER INVASION; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; METASTASIS; MOLECULAR DOCKING; PANCREAS CANCER; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CELL MOVEMENT; CYCLIC AMP; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; HYDRAZONES; INSULIN; INSULIN-SECRETING CELLS; ISOXAZOLES; MOLECULAR DOCKING SIMULATION; NEOPLASM INVASIVENESS; PANCREATIC NEOPLASMS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RAP1 GTP-BINDING PROTEINS;

EID: 84871563190     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.080689     Document Type: Article

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