Molecular signatures differentiate immune states in type 1 diabetic families

Diabetes

Volumn 63, Issue 11, 2014, Pages 3960-3973

  Chen, Yi Guang ^a,b   Cabrera, Susanne M ^a,b   Jia, Shuang ^a,b   Kaldunski, Mary L ^a,b   Kramer, Joanna ^a,b   Cheong, Sami ^c   Geoffrey, Rhonda ^a,b   Roethle, Mark F ^a,b   Woodliff, Jeffrey E ^d   Greenbaum, Carla J ^e   Wang, Xujing ^f   Hessner, Martin J ^a  

^a CHILDREN S HOSPITAL OF WISCONSIN   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^d PURDUE UNIVERSITY   (United States)

^e BENAROYA RESEARCH INSTITUTE   (United States)

^f NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD4 ANTIGEN; CD45RA ANTIGEN; HLA DR3 ANTIGEN; HLA DR4 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; INTERLEUKIN 1; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA;

AGE; ALGORITHM; ANTIBODY TITER; ARTICLE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ONTOLOGY; DISEASE PREDISPOSITION; FAMILIAL DISEASE; HUMAN; IMMUNE STATUS; IMMUNOREGULATION; INFLAMMATION; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; REGULATORY T LYMPHOCYTE; SIBLING; T LYMPHOCYTE ACTIVATION; ADOLESCENT; ADULT; BLOOD; CHILD; CROSS-SECTIONAL STUDY; FEMALE; IMMUNOLOGY; LONGITUDINAL STUDY; MALE; METABOLISM; YOUNG ADULT;

ADOLESCENT; ADULT; CHEMOKINE CCL2; CHEMOKINE CCL3; CHEMOKINE CCL4; CHILD; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 1; FEMALE; HUMANS; INTERLEUKIN-1; INTERLEUKIN-10; INTERLEUKIN-12 SUBUNIT P40; LONGITUDINAL STUDIES; MALE; T-LYMPHOCYTES, REGULATORY; YOUNG ADULT;

EID: 84906086651     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-0214     Document Type: Article

References (49)

1. Steck AK, Rewers MJ. Genetics of type 1 diabetes. Clin Chem 2011;57: 176-185
2. Stene LC, Oikarinen S, Hyöty H, et al. Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY). Diabetes 2010;59:3174-3180
3. Hober D, Sauter P. Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host. Nat Rev Endocrinol 2010;6:279-289
4. Erlich H, Valdes AM, Noble J, et al.; Type 1 Diabetes Genetics Consortium. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes 2008;57:1084-1092
5. Unwin N, Gan D, Whiting D. The IDF Diabetes Atlas: providing evidence, raising awareness and promoting action. Diabetes Res Clin Pract 2010;87:2-3
6. Vehik K, Dabelea D. The changing epidemiology of type 1 diabetes: why is it going through the roof? Diabetes Metab Res Rev 2011;27:3-13
7. Atkinson MA, Chervonsky A. Does the gut microbiota have a role in type 1 diabetes? Early evidence from humans and animal models of the disease. Diabetologia 2012;55:2868-2877
8. Fourlanos S, Varney MD, Tait BD, et al. The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypes. Diabetes Care 2008;31:1546-1549
9. Todd JA. Etiology of type 1 diabetes. Immunity 2010;32:457-467
10. Wang X, Jia S, Geoffrey R, Alemzadeh R, Ghosh S, Hessner MJ. Identification of a molecular signature in human type 1 diabetes mellitus using serum and functional genomics. J Immunol 2008;180:1929-1937
11. Zhang Q, Fillmore TL, Schepmoes AA, et al. Serum proteomics reveals systemic dysregulation of innate immunity in type 1 diabetes. J Exp Med 2013;210:1912203
12. Greenbaum CJ, Palmer JP, Kuglin B, Kolb H. Insulin autoantibodies measured by radioimmunoassay methodology are more related to insulindependent diabetes mellitus than those measured by enzyme-linked immunosorbent assay: results of the Fourth International Workshop on the Standardization of Insulin Autoantibody Measurement. J Clin Endocrinol Metab 1992;74:1040-1044
13. Wenzlau JM, Juhl K, Yu L, et al. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci USA 2007;104:17040-17045
14. Gianani R, Rabin DU, Verge CF, et al. ICA512 autoantibody radioassay. Diabetes 1995;44:1340-1344
15. Eizirik DL, Colli ML, Ortis F. The role of inflammation in insulitis and betacell loss in type 1 diabetes. Nat Rev Endocrinol 2009;5:219-226
16. Knip M. Natural course of preclinical type 1 diabetes. Horm Res 2002;57 (Suppl. 1):6-11
17. Bingley PJ, Bonifacio E, Williams AJ, Genovese S, Bottazzo GF, Gale EA. Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers. Diabetes 1997;46:1701-1710
18. Bingley PJ, Bonifacio E, Ziegler AG, Schatz DA, Atkinson MA, Eisenbarth GS; Immunology of Diabetes Society. Proposed guidelines on screening for risk of type 1 diabetes. Diabetes Care 2001;24:398
19. Atkinson MA, Eisenbarth GS. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 2001;358:221-229
20. Devendra D, Liu E, Eisenbarth GS. Type 1 diabetes: recent developments. BMJ 2004;328:750-754
21. Skyler JS. Prediction and prevention of type 1 diabetes: progress, problems, and prospects. Clin Pharmacol Ther 2007;81:768-771
22. Kaldunski M, Jia S, Geoffrey R, et al. Identification of a serum-induced transcriptional signature associated with type 1 diabetes in the BioBreeding rat. Diabetes 2010;59:2375-2385
23. Jia S, Kaldunski M, Jailwala P, et al. Use of transcriptional signatures induced in lymphoid and myeloid cell lines as an inflammatory biomarker in type 1 diabetes. Physiol Genomics 2011;43:697-709
24. Levy H, Wang X, Kaldunski M, et al. Transcriptional signatures as a diseasespecific and predictive inflammatory biomarker for type 1 diabetes. Genes Immun 2012;13:593-604
25. Chen YG, Mordes JP, Blankenhorn EP, et al. Temporal induction of immunoregulatory processes coincides with age-dependent resistance to viral-induced type 1 diabetes. Genes Immun 2013;14:387-400
26. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998; 15:539-553
27. Woo W, LaGasse JM, Zhou Z, et al. A novel high-throughput method for accurate, rapid, and economical measurement of multiple type 1 diabetes autoantibodies. J Immunol Methods 2000;244:91-103
28. Klitz W, Maiers M, Spellman S, et al. New HLA haplotype frequency reference standards: high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans. Tissue Antigens 2003;62:296-307
29. Huang W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009;4: 44-57
30. Sturn A, Quackenbush J, Trajanoski Z. Genesis: cluster analysis of microarray data. Bioinformatics 2002;18:207-208
31. Edgar R, Domrachev M, Lash AE. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 2002;30: 207-210
32. Aly TA, Ide A, Humphrey K, et al. Genetic prediction of autoimmunity: initial oligogenic prediction of anti-islet autoimmunity amongst DR3/DR4-DQ8 relatives of patients with type 1A diabetes. J Autoimmun 2005;25(Suppl.):40-45
33. Miyara M, Yoshioka Y, Kitoh A, et al. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 2009;30:899-911
34. Chatzigeorgiou A, Harokopos V, Mylona-Karagianni C, Tsouvalas E, Aidinis V, Kamper EF. The pattern of inflammatory/anti-inflammatory cytokines and chemokines in type 1 diabetic patients over time. Ann Med 2010;42:426-438
35. Hussain MJ, Maher J, Warnock T, Vats A, Peakman M, Vergani D. Cytokine overproduction in healthy first degree relatives of patients with IDDM. Diabetologia 1998;41:343-349
36. Svensson J, Eising S, Hougaard DM, et al.; Danish Childhood Diabetes Registry. Few differences in cytokines between patients newly diagnosed with type 1 diabetes and their healthy siblings. Hum Immunol 2012;73:1116-1126
37. Carratù R, Secondulfo M, de Magistris L, et al. Altered intestinal permeability to mannitol in diabetes mellitus type I. J Pediatr Gastroenterol Nutr 1999;28:264-269
38. Kuitunen M, Saukkonen T, Ilonen J, Akerblom HK, Savilahti E. Intestinal permeability to mannitol and lactulose in children with type 1 diabetes with the HLA-DQB1-02 allele. Autoimmunity 2002;35:365-368
39. Bosi E, Molteni L, Radaelli MG, et al. Increased intestinal permeability precedes clinical onset of type 1 diabetes. Diabetologia 2006;49:2824-2827
40. Secondulfo M, Iafusco D, Carratù R, et al. Ultrastructural mucosal alterations and increased intestinal permeability in non-celiac, type I diabetic patients. Dig Liver Dis 2004;36:35-45
41. Sapone A, de Magistris L, Pietzak M, et al. Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives. Diabetes 2006;55:1443-1449
42. Gough SC, Simmonds MJ. The HLA region and autoimmune disease: associations and mechanisms of action. Curr Genomics 2007;8:453-465
43. Mangalam AK, Taneja V, David CS. HLA class II molecules influence susceptibility versus protection in inflammatory diseases by determining the cytokine profile. J Immunol 2013;190:513-518
44. Brusko T, Wasserfall C, McGrail K, et al. No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes. Diabetes 2007;56:604-612
45. van Loosdregt J, Fleskens V, Fu J, et al. Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity. Immunity 2013;39:259-271
46. Chen Z, Barbi J, Bu S, et al. The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. Immunity 2013;39:272-285
47. Petrich de Marquesini LG, Fu J, Connor KJ, et al. IFN-gamma and IL-10 islet-antigen-specific T cell responses in autoantibody-negative first-degree relatives of patients with type 1 diabetes. Diabetologia 2010;53:1451-1460
48. Tree TI, Lawson J, Edwards H, et al. Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppression. Diabetes 2010;59:1451-1460
49. Yang C, Jurczyk A, diIorio P, et al. Salicylate prevents virus-induced type 1 diabetes in the BBDR rat. PLoS One 2013;8:e78050