Predictors of progression from the appearance of islet autoantibodies to early childhood diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY)

Diabetes Care

Volumn 38, Issue 5, 2015, Pages 808-813

  Steck, Andrea K ^a   Vehik, Kendra ^b   Bonifacio, Ezio ^c   Lernmark, Ake ^d   Ziegler, Anette G ^e,f,g   Hagopian, William A ^h   She, Jinxiong ⁱ   Simell, Olli ^j   Akolkar, Beena ^k   Krischer, Jeffrey ^b   Schatz, Desmond ^l   Rewers, Marian J ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d LUND UNIVERSITY   (Sweden)

^e INSTITUTE OF EPIDEMIOLOGY   (Germany)

^f TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^g Forschergruppe Diabetes eV   (Germany)

^h PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

ⁱ MEDICAL COLLEGE OF GEORGIA   (United States)

^j UNIVERSITY OF TURKU   (Finland)

^k NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^l UNIVERSITY OF FLORIDA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; GLUTAMATE DECARBOXYLASE 65 ANTIBODY; HLA DQ ANTIGEN; HLA DR ANTIGEN; INSULIN ANTIBODY; INSULINOMA ASSOCIATED PROTEIN 2 ANTIBODY; PROTEIN ANTIBODY; UNCLASSIFIED DRUG; GLUTAMATE DECARBOXYLASE; RECEPTOR LIKE PROTEIN TYROSINE PHOSPHATASE;

ARTICLE; AUTOIMMUNITY; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; GENETIC RISK; HIGH RISK PATIENT; HUMAN; INCIDENCE; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; PRESCHOOL CHILD; PROSPECTIVE STUDY; PROTEIN EXPRESSION; SENSITIVITY AND SPECIFICITY; SEROCONVERSION; SURVIVAL RATE; CLINICAL TRIAL; GENOTYPE; IMMUNOLOGY; METABOLISM; MULTICENTER STUDY; PANCREAS ISLET; RISK FACTOR;

AUTOANTIBODIES; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; DISEASE PROGRESSION; FEMALE; GENOTYPE; GLUTAMATE DECARBOXYLASE; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; INFANT; INSULIN ANTIBODIES; ISLETS OF LANGERHANS; MALE; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 8; RISK FACTORS;

EID: 84928811876     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc14-2426     Document Type: Article

References (38)

1. Palmer JP, Asplin CM, Clemons P, et al. Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 1983;222:1337-1339
2. Baekkeskov S, Aanstoot H-J, Christgau S, et al. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 1990;347:151-156
3. Gianani R, Rabin DU, Verge CF, et al. ICA512 autoantibody radioassay. Diabetes 1995;44:1340-1344
4. Wenzlau JM, Juhl K, Yu L, et al. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci U S A 2007;104:17040-17045
5. Bingley PJ, Bonifacio E, Ziegler AG, Schatz DA, Atkinson MA, Eisenbarth GS; Immunology of Diabetes Society. Proposed guidelines on screening for risk of type 1 diabetes. Diabetes Care 2001;24:398
6. Verge CF, Gianani R, Kawasaki E, et al. Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 1996;45:926-933
7. LaGasse JM, Brantley MS, Leech NJ, et al, .; Washington State Diabetes Prediction Study. Successful prospective prediction of type 1 diabetes in schoolchildren through multiple defined autoantibodies: an 8-year follow-up of the Washington State Diabetes Prediction Study. Diabetes Care 2002;25:505-511
8. Maclaren NK, Lan MS, Schatz D, Malone J, Notkins AL, Krischer J. Multiple autoantibodies as predictors of type 1 diabetes in a general population. Diabetologia 2003;46:873-874
9. Bingley PJ, Bonifacio E, Williams AJ, Genovese S, Bottazzo GF, Gale EA. Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers. Diabetes 1997;46:1701-1710
10. Samuelsson U, Sundkvist G, Borg H, Fernlund P, Ludvigsson J. Islet autoantibodies in the prediction of diabetes in school children. Diabetes Res Clin Pract 2001;51:51-57
11. Knip M, Korhonen S, Kulmala P, et al. Prediction of type 1 diabetes in the general population. Diabetes Care 2010;33:1206-1212
12. Ziegler AG, Rewers M, Simell O, et al. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA 2013;309:2473-2479
13. Steck AK, Johnson K, Barriga KJ, et al. Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: Diabetes Autoimmunity Study in the Young. Diabetes Care 2011;34:1397-1399
14. TEDDY Study Group. The Environmental Determinants of Diabetes in the Young (TEDDY) study. Ann N Y Acad Sci 2008;1150:1-13
15. Kiviniemi M, Hermann R, Nurmi J, et al, .; TEDDY Study Group. A high-throughput population screening system for the estimation of genetic risk for type 1 diabetes: an application for the TEDDY (The Environmental Determinants of Diabetes in the Young) study. Diabetes Technol Ther 2007;9:460-472
16. Hagopian WA, Erlich H, Lernmark A, et al, .; TEDDY Study Group. The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421000 infants. Pediatr Diabetes 2011;12:733-743
17. Bonifacio E, Yu L, Williams AK, et al. Harmonization of glutamic acid decarboxylase and islet antigen-2 autoantibody assays for National Institute of Diabetes and Digestive and Kidney Diseases consortia. J Clin Endocrinol Metab 2010;95:3360-3367
18. Babaya N, Yu L, Miao D, et al. Comparison of insulin autoantibody: polyethylene glycol and micro-IAA 1-day and 7-day assays. Diabetes Metab Res Rev 2009;25:665-670
19. Yu L, Robles DT, Abiru N, et al. Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes. Proc Natl Acad Sci U S A 2000;97:1701-1706
20. Törn C, Mueller PW, Schlosser M, Bonifacio E, Bingley PJ. Diabetes Antibody Standardization Program: evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2. Diabetologia 2008;51:846-852
21. Vehik K, Fiske SW, Logan CA, et al, .; TEDDY Study Group. Methods, quality control and specimen management in an international multicentre investigation of type 1 diabetes: TEDDY. Diabetes Metab Res Rev 2013;29:557-567
22. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2014;37(Suppl. 1):S81-S90
23. Ziegler AG, Hummel M, Schenker M, Bonifacio E. Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB study. Diabetes 1999;48:460-468
24. Kukko M, Kimpimäki T, Korhonen S, et al. Dynamics of diabetes-associated autoantibodies in young children with human leukocyte antigen-conferred risk of type 1 diabetes recruited from the general population. J Clin Endocrinol Metab 2005;90:2712-2717
25. Elding Larsson H, Vehik K, Gesualdo P, et al, .; TEDDY Study Group. Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease. Pediatr Diabetes 2014;15:118-126
26. Bingley PJ, Gale EA; European Nicotinamide Diabetes Intervention Trial (ENDIT) Group. Progression to type 1 diabetes in islet cell antibody-positive relatives in the European Nicotinamide Diabetes Intervention Trial: the role of additional immune, genetic and metabolic markers of risk. Diabetologia 2006;49:881-890
27. Mrena S, Virtanen SM, Laippala P, et al. Models for predicting type 1 diabetes in siblings of affected children. Diabetes Care 2006;29:662-667
28. Orban T, Sosenko JM, Cuthbertson D, et al, .; Diabetes Prevention Trial-Type 1 Study Group. Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes Care 2009;32:2269-2274
29. Walter M, Albert E, Conrad M, et al. IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of type 1 diabetes and associated autoimmunity. Diabetologia 2003;46:712-720
30. Steck AK, Bugawan TL, Valdes AM, et al. Association of non-HLA genes with type 1 diabetes autoimmunity. Diabetes 2005;54:2482-2486
31. Bonifacio E, Hummel M, Walter M, Schmid S, Ziegler AG. IDDM1 and multiple family history of type 1 diabetes combine to identify neonates at high risk for type 1 diabetes. Diabetes Care 2004;27:2695-2700
32. Siljander HT, Simell S, Hekkala A, et al. Predictive characteristics of diabetes-associated autoantibodies among children with HLA-conferred disease susceptibility in the general population. Diabetes 2009;58:2835-2842
33. Achenbach P, Warncke K, Reiter J, et al. Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics. Diabetes 2004;53:384-392
34. Sosenko JM, Palmer JP, Greenbaum CJ, et al, .; Diabetes Prevention Trial-Type 1 Study Group. Increasing the accuracy of oral glucose tolerance testing and extending its application to individuals with normal glucose tolerance for the prediction of type 1 diabetes: the Diabetes Prevention Trial-Type 1. Diabetes Care 2007;30:38-42
35. Stene LC, Barriga K, Hoffman M, et al. Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY). Pediatr Diabetes 2006;7:247-253
36. Sosenko JM, Krischer JP, Palmer JP, et al, .; Diabetes Prevention Trial-Type 1 Study Group. A risk score for type 1 diabetes derived from autoantibody-positive participants in the Diabetes Prevention Trial-Type 1. Diabetes Care 2008;31:528-533
37. Sosenko JM, Skyler JS, Mahon J, et al, .; Type 1 Diabetes TrialNet Study Group, ; Diabetes Prevention Trial-Type 1 Study Group. The application of the Diabetes Prevention Trial-Type 1 risk score for identifying a preclinical state of type 1 diabetes. Diabetes Care 2012;35:1552-1555
38. Schlosser M, Strebelow M, Wassmuth R, et al. The Karlsburg type 1 diabetes risk study of a normal schoolchild population: association of beta-cell autoantibodies and human leukocyte antigen-DQB1 alleles in antibody-positive individuals. J Clin Endocrinol Metab 2002;87:2254-2261