Decreased cord-blood phospholipids in young age-at-onset type 1 diabetes

Diabetes

Volumn 62, Issue 11, 2013, Pages 3951-3956

  La Torre, Daria ^a   Seppänen Laakso, Tuulikki ^b   Larsson, Helena E ^a   Hyötyläinen, Tuulia ^b   Ivarsson, Sten A ^a   Lernmark, Åke ^a   Orešič, Matej ^b  

^a LUND UNIVERSITY   (Sweden)

^b VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

LIPIDOME; LYSOPHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPID; TRIACYLGLYCEROL; AUTOANTIBODY;

ARTICLE; CASE CONTROL STUDY; CHILD; CHILDHOOD DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GESTATIONAL AGE; HIGH RISK PATIENT; HLA SYSTEM; HUMAN; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; INTRAUTERINE INFECTION; LIPIDOMICS; MAJOR CLINICAL STUDY; MALE; MATERNAL AGE; METABOLOMICS; PRESCHOOL CHILD; PRIORITY JOURNAL; RISK ASSESSMENT; SCHOOL CHILD; SEX DIFFERENCE; UMBILICAL CORD BLOOD; BLOOD; CHEMISTRY; FETUS BLOOD; FIRST TRIMESTER PREGNANCY; IMMUNOLOGY; NEWBORN; NEWBORN SCREENING; ONSET AGE; PANCREAS ISLET; PREGNANCY; PREGNANCY COMPLICATION; RISK; DIABETES MELLITUS, TYPE 1;

AGE OF ONSET; AUTOANTIBODIES; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; FETAL BLOOD; GESTATIONAL AGE; HUMANS; INFANT; INFANT, NEWBORN; ISLETS OF LANGERHANS; LYSOPHOSPHATIDYLCHOLINES; MALE; METABOLOMICS; NEONATAL SCREENING; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREGNANCY TRIMESTER, FIRST; RISK; SEX FACTORS;

EID: 84890747164     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-0215     Document Type: Article

References (41)

1. DIAMOND Project Group. Incidence and trends of childhood Type 1 diabetes worldwide 1990-1999. Diabet Med 2006;23:857-866
2. EURODIAB ACE Study Group. Variation and trends in incidence of childhood diabetes in Europe. Lancet 2000;355:873-876
3. Eisenbarth GS. Prediction of type 1 diabetes: the natural history of the prediabetic period. Adv Exp Med Biol 2004;552:268-290
4. La Torre D, Lernmark A. Immunology of beta-cell destruction. Adv Exp Med Biol 2010;654:537-583
5. Törn C, Mueller PW, Schlosser M, Bonifacio E, Bingley PJ; Participating Laboratories. Diabetes Antibody Standardization Program: evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2. Diabetologia 2008;51:846-852
6. DPT-1 Study Group The Diabetes Prevention Trial-Type 1 diabetes (DPT- 1): implementation of screening and staging of relatives. DPT-1 Study Group. Transplant Proc 1995;27:3377
7. Cucca F, Lampis R, Congia M, et al. A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins. Hum Mol Genet 2001;10:2025-2037
8. TEDDY Stydy Group. The Environmental Determinants of Diabetes in the Young (TEDDY) Study. Ann N Y Acad Sci 2008;1150:1-13
9. Gluckman PD, Hanson MA, Cooper C, Thornburg KL. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med 2008; 359:61-73
10. Dahlquist GG, Patterson C, Soltesz G. Perinatal risk factors for childhood type 1 diabetes in Europe. The EURODIAB Substudy 2 Study Group. Diabetes Care 1999;22:1698-1702
11. Elfving M, Svensson J, Oikarinen S, et al. Maternal enterovirus infection during pregnancy as a risk factor in offspring diagnosed with type 1 diabetes between 15 and 30 years of age. Exp Diabetes Res 2008;2008:271958
12. Lindehammer SR, Björck S, Lynch K, et al.; Diabetes and Celiac Disease Prediction in Scania Study Group. Early human pregnancy serum cytokine levels predict autoimmunity in offspring. Autoimmunity 2011;44:445-452
13. Bain JR, Stevens RD, Wenner BR, Ilkayeva O, Muoio DM, Newgard CB. Metabolomics applied to diabetes research: moving from information to knowledge. Diabetes 2009;58:2429-2443
14. Oresic M, Simell S, Sysi-Aho M, et al. Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J Exp Med 2008;205:2975-2984
15. Pflueger M, Seppänen-Laakso T, Suortti T, et al. Age- and islet autoimmunityassociated differences in amino acid and lipid metabolites in children at risk for type 1 diabetes. Diabetes 2011;60:2740-2747
16. Knip M, Veijola R, Virtanen SM, Hyöty H, Vaarala O, Akerblom HK. Environmental triggers and determinants of type 1 diabetes. Diabetes 2005;54 (Suppl. 2):S125-S136
17. Oresic M, Gopalacharyulu P, Mykkänen J, et al. Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes. Diabetes 29 April 2013 [Epub ahead of print]
18. Lynch KF, Lernmark B, Merlo J, Cilio CM, Ivarsson SA, Lernmark A; Diabetes Prediction in Skåne (DiPiS) Study Group. Cord blood islet autoantibodies and seasonal association with the type 1 diabetes high-risk genotype. J Perinatol 2008;28:211-217
19. Lindehammer SR, Hansson I, Midberg B, et al.; Diabetes Prediction in Skåne (DiPiS) Study Group. Seroconversion to islet autoantibodies between early pregnancy and delivery in non-diabetic mothers. J Reprod Immunol 2011;88:72-79
20. Nygren H, Seppänen-Laakso T, Castillo S, Hyötyläinen T, Orešic M. Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics for studies of body fluids and tissues. Methods Mol Biol 2011;708:247-257
21. Quehenberger O, Dennis EA. The human plasma lipidome. N Engl J Med 2011;365:1812-1823
22. Larsson HE, Lynch K, Lernmark B, et al.; DiPiS Study Group. Diabetesassociated HLA genotypes affect birthweight in the general population. Diabetologia 2005;48:1484-1491
23. Larsson HE, Hansson G, Carlsson A, et al.; DiPiS Study Group. Children developing type 1 diabetes before 6 years of age have increased linear growth independent of HLA genotypes. Diabetologia 2008;51:1623-1630
24. Larsson K, Elding-Larsson H, Cederwall E, et al. Genetic and perinatal factors as risk for childhood type 1 diabetes. Diabetes Metab Res Rev 2004; 20:429-437
25. Wiklund S, Johansson E, Sjöström L, et al. Visualization of GC/TOF-MSbased metabolomics data for identification of biochemically interesting compounds using OPLS class models. Anal Chem 2008;80:115-122
26. Käll L, Storey JD, MacCoss MJ, Noble WS. Posterior error probabilities and false discovery rates: two sides of the same coin. J Proteome Res 2008;7:40-44
27. Rodie VA, Caslake MJ, Stewart F, et al. Fetal cord plasma lipoprotein status in uncomplicated human pregnancies and in pregnancies complicated by pre-eclampsia and intrauterine growth restriction. Atherosclerosis 2004;176:181-187
28. Herrera E. Lipid metabolism in pregnancy and its consequences in the fetus and newborn. Endocrine 2002;19:43-55
29. Kilby MD, Neary RH, Mackness MI, Durrington PN. Fetal and maternal lipoprotein metabolism in human pregnancy complicated by type I diabetes mellitus. J Clin Endocrinol Metab 1998;83:1736-1741
30. Li Z, Vance DE. Phosphatidylcholine and choline homeostasis. J Lipid Res 2008;49:1187-1194
31. Treede I, Braun A, Sparla R, et al. Anti-inflammatory effects of phosphatidylcholine. J Biol Chem 2007;282:27155-27164
32. Chow SN, Chen HY, Ouyang PC, Lee TY, Wei PY, Chen JS. Serum triglyceride levels in newborns and mothers at parturition. Int J Biol Res Pregnancy 1982;3:30-32
33. Christensen NC. Concentrations of triglycerides, free fatty acids and glycerol in cord blood of newborn infants with a birth weight of less than or equal to 2700 grams. Acta Paediatr Scand 1977;66:43-48
34. Svensson J, Carstensen B, Mortensen HB, Borch-Johnsen K; Danish Study Group of Childhood Diabetes. Early childhood risk factors associated with type 1 diabetes-is gender important? Eur J Epidemiol 2005;20:429-434
35. Kaijser M, Bonamy AK, Akre O, et al. Perinatal risk factors for diabetes in later life. Diabetes 2009;58:523-526
36. Andersson C, Larsson K, Vaziri-Sani F, et al. The three ZNT8 autoantibody variants together improve the diagnostic sensitivity of childhood and adolescent type 1 diabetes. Autoimmunity 2011;44:394-405
37. Varmus H. Ten years on-the human genome and medicine. N Engl J Med 2010;362:2028-2029
38. Fuchs B, Muller K, Paasch U, Schiller J. Lysophospholipids: potential markers of diseases and infertility? Mini Rev Med Chem 2012;12:74-86
39. Lissauer E, Johnson B, Shi S, Gentle T, Scalea M. Decreased lysophosphatidylcholine levels are associated with sepsis compared to uninfected inflammation prior to onset of sepsis. J Surg Res 2007;137:206
40. Cardwell CR, Stene LC, Joner G, et al. Maternal age at birth and childhood type 1 diabetes: a pooled analysis of 30 observational studies. Diabetes 2010;59:486-494
41. Zivkovic AM, Wiest MM, Nguyen UT, Davis R, Watkins SM, German JB. Effects of sample handling and storage on quantitative lipid analysis in human serum. Metabolomics 2009;5:507-516