Progression from single to multiple islet autoantibodies often occurs soon after seroconversion: implications for early screening

Diabetologia

Volumn 58, Issue 2, 2015, Pages 411-413

  Chmiel, Ruth ^a   Giannopoulou, Eleni Z ^a,b   Winkler, Christiane ^a,b   Achenbach, Peter ^a,b   Ziegler, Anette Gabriele ^a,b   Bonifacio, Ezio ^c,d,e  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b Forschergruppe Diabetes EV   (Germany)

^c CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

^d GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^e INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Incidence; Multiple islet autoantibodies; Type 1 diabetes

Indexed keywords

AUTOANTIBODY; HLA DR3 ANTIGEN; HLA DR4 ANTIGEN; INSULIN ANTIBODY;

ANTIBODY SCREENING; ASYMPTOMATIC DISEASE; DISEASE COURSE; GENETIC RISK; GENOTYPE; HLA SYSTEM; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; KETOACIDOSIS; LETTER; METABOLIC DISORDER; PRIORITY JOURNAL; SEROCONVERSION; BLOOD; CHILD; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; IMPAIRED GLUCOSE TOLERANCE; INCIDENCE; ONSET AGE; PANCREAS ISLET; PRESCHOOL CHILD;

AGE OF ONSET; AUTOANTIBODIES; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; DISEASE PROGRESSION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INCIDENCE; INSULIN ANTIBODIES; ISLETS OF LANGERHANS; PREDIABETIC STATE;

EID: 84925503990     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3443-1     Document Type: Letter

References (5)

1. Ziegler AG, Rewers M, Simell O et al (2013) Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA 309:2473–2479
2. Ziegler AG, Bonifacio E, BABYDIAB-BABYDIET Study Group (2012) Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes. Diabetologia 55:1937–1943
3. Hummel M, Bonifacio E, Schmid S, Walter M, Knopff A, Ziegler AG (2004) Brief communication: early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents. Ann Intern Med 140:882–886
4. Parikka V, Näntö-Salonen K, Saarinen M et al (2012) Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk. Diabetologia 55:1926–1936
5. Hummel S, Pflüger M, Hummel M, Bonifacio E, Ziegler AG (2011) Primary dietary intervention study to reduce the risk of islet autoimmunity in children at increased risk for type 1 diabetes: the BABYDIET study. Diabetes Care 34:1301–1305