HbA1c Predicts time to diagnosis of type 1 diabetes in children at risk

Diabetes

Volumn 64, Issue 5, 2015, Pages 1719-1727

  Helminen, Olli ^a   Aspholm, Susanna ^b,c   Pokka, Tytti ^a   Hautakangas, Milla Riikka ^a   Haatanen, Nora ^a   Lempainen, Johanna ^d   Ilonen, Jorma ^d,e   Simell, Olli ^d   Knip, Mikael ^c,f,g,h   Veijola, Riitta ^a  

^a OULU UNIVERSITY HOSPITAL   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

^d UNIVERSITY OF TURKU   (Finland)

^e UNIVERSITY OF EASTERN FINLAND   (Finland)

^f UNIVERSITY OF HELSINKI AND HELSINKI UNIVERSITY HOSPITAL   (Finland)

^g UNIVERSITY OF HELSINKI   (Finland)

^h FOLKHÄLSAN RESEARCH CENTER   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; HEMOGLOBIN A1C; HLA ANTIGEN CLASS 2; HLA DRB1 ANTIGEN; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN; HLA ANTIGEN;

ARTICLE; CHILD; FEMALE; FINLAND; FOLLOW UP; GENETIC PREDISPOSITION; GENETIC RISK; GENOTYPE; HIGH RISK POPULATION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; UMBILICAL CORD BLOOD; BLOOD; DIABETES MELLITUS, TYPE 1; EPIDEMIOLOGY; FETUS BLOOD; GENE EXPRESSION REGULATION; GENETICS; INFANT; METABOLISM; NEWBORN; PRESCHOOL CHILD;

AUTOANTIBODIES; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; FETAL BLOOD; FINLAND; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEMOGLOBIN A, GLYCOSYLATED; HLA ANTIGENS; HUMANS; INFANT; INFANT, NEWBORN; MALE;

EID: 84933519614     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-0497     Document Type: Article

References (33)

1. DIAMOND Project Group. Incidence and trends of childhood type 1 diabetes worldwide 1990-1999. Diabet Med 2006;23:857-866.
2. Patterson CC, Gyürüs E, Rosenbauer J, et al. Trends in childhood type 1 diabetes incidence in Europe during 1989-2008: Evidence of non-uniformity over time in rates of increase. Diabetologia 2012;55:2142-2147.
3. Harjutsalo V, Sjöberg L, Tuomilehto J. Time trends in the incidence of type 1 diabetes in Finnish children: A cohort study. Lancet 2008;371:1777- 1782.
4. Cooper JD, Howson JM, Smyth D, et al.; Type 1 Diabetes Genetics Consortium. Confirmation of novel type 1 diabetes risk loci in families. Diabetologia 2012;55:996-1000.
5. Ilonen J, Sjöroos M, Knip M, et al. Estimation of genetic risk for type 1 diabetes. Am J Med Genet 2002;115:30-36.
6. Knip M, Veijola R, Virtanen SM, Hyöty H, Vaarala O, Akerblom HK. Environmental triggers and determinants of type 1 diabetes. Diabetes 2005;54(Suppl. 2):S125-S136.
7. Gillespie KM, Bain SC, Barnett AH, et al. The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. Lancet 2004;364:1699-1700.
8. Siljander HT, Simell S, Hekkala A, et al. Predictive characteristics of diabetesassociated autoantibodies among children with HLA-conferred disease susceptibility in the general population. Diabetes 2009;58:2835-2842.
9. Ziegler AG, Rewers M, Simell O, et al. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA 2013;309: 2473-2479.
10. Sosenko JM, Palmer JP, Rafkin-Mervis L, et al.; Diabetes Prevention Trial- Type 1 Study Group. Incident dysglycemia and progression to type 1 diabetes among participants in the Diabetes Prevention Trial-Type 1. Diabetes Care 2009; 32:1603-1607.
11. Sosenko JM, Skyler JS, Mahon J, et al.; Type 1 Diabetes TrialNet Study Group; Diabetes Prevention Trial-Type 1 Study Group. The application of the diabetes prevention trial- Type 1 risk score for identifying a preclinical state of type 1 diabetes. Diabetes Care 2012;35:1552-1555.
12. Jeffcoate SL. Diabetes control and complications: The role of glycated haemoglobin, 25 years on. Diabet Med 2004;21:657-665.
13. Rohlfing CL, Wiedmeyer HM, Little RR, England JD, Tennill A, Goldstein DE. Defining the relationship between plasma glucose and HbA(1c): Analysis of glucose profiles and HbA(1c) in the Diabetes Control and Complications Trial. Diabetes Care 2002;25:275-278.
14. International Expert Committee. International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care 2009;32: 1327-1334.
15. Vehik K, Cuthbertson D, Boulware D, et al.; TEDDY, TRIGR, Diabetes Prevention Trial-Type 1, and Type 1 Diabetes TrialNet Natural History Study Groups. Performance of HbA1c as an early diagnostic indicator of type 1 diabetes in children and youth. Diabetes Care 2012;35:1821-1825.
16. Stene LC, Barriga K, Hoffman M, et al. Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY). Pediatr Diabetes 2006;7: 247-253.
17. Parikka V, Näntö-Salonen K, Saarinen M, et al. Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk. Diabetologia 2012;55:1926-1936.
18. Näntö-Salonen K, Kupila A, Simell S, et al. Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: A double-blind, randomised controlled trial. Lancet 2008;372: 1746-1755.
19. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998;15:539-553.
20. Hermann R, Knip M, Veijola R, et al.; FinnDiane Study Group. Temporal changes in the frequencies of HLA genotypes in patients with type 1 diabetes- indication of an increased environmental pressure? Diabetologia 2003;46:420- 425.
21. Hekkala A, Ilonen J, Knip M, Veijola R.; Finnish Paediatric Diabetes Register. Family history of diabetes and distribution of class II HLA genotypes in children with newly diagnosed type 1 diabetes: Effect on diabetic ketoacidosis. Eur J Endocrinol 2011;165:813-817.
22. Siekmann L. Requirements for reference (calibration) laboratories in laboratory medicine. Clin Biochem Rev 2007;28:149-154.
23. Braga F, Dolci A, Montagnana M, et al. Revaluation of biological variation of glycated hemoglobin (HbA(1c)) using an accurately designed protocol and an assay traceable to the IFCC reference system. Clin Chim Acta 2011;412:1412-1416.
24. Choi SH, Kim TH, Lim S, Park KS, Jang HC, Cho NH. Hemoglobin A1c as a diagnostic tool for diabetes screening and new-onset diabetes prediction: A 6-year community-based prospective study. Diabetes Care 2011;34:944-949.
25. Braga F, Dolci A, Mosca A, Panteghini M. Biological variability of glycated hemoglobin. Clin Chim Acta 2010;411:1606-1610.
26. Aly TA, Ide A, Jahromi MM, et al. Extreme genetic risk for type 1A diabetes. Proc Natl Acad Sci U S A 2006;103:14074-14079.
27. Siljander HT, Veijola R, Reunanen A, Virtanen SM, Akerblom HK, Knip M. Prediction of type 1 diabetes among siblings of affected children and in the general population. Diabetologia 2007;50:2272-2275.
28. Sosenko JM, Krischer JP, Palmer JP, et al.; Diabetes Prevention Trial-Type 1 Study Group. A risk score for type 1 diabetes derived from autoantibody-positive participants in the diabetes prevention trial- Type 1. Diabetes Care 2008;31:528-533.
29. Sosenko JM, Skyler JS, Krischer JP, et al.; Diabetes Prevention Trial-Type 1 Study Group. Glucose excursions between states of glycemia with progression to type 1 diabetes in the diabetes prevention trial- Type 1 (DPT-1). Diabetes 2010;59: 2386-2389.
30. Sosenko JM, Skyler JS, Herold KC, Palmer JP.; Type 1 Diabetes TrialNet and Diabetes Prevention Trial-Type 1 Study Groups. The metabolic progression to type 1 diabetes as indicated by serial oral glucose tolerance testing in the Diabetes Prevention Trial- Type 1. Diabetes 2012;61:1331-1337.
31. Sosenko JM, Skyler JS, Palmer JP, et al.; Type 1 Diabetes TrialNet Study Group; Diabetes Prevention Trial-Type 1 Study Group. The prediction of type 1 diabetes by multiple autoantibody levels and their incorporation into an autoantibody risk score in relatives of type 1 diabetic patients. Diabetes Care 2013; 36:2615-2620.
32. Barker JM, Goehrig SH, Barriga K, et al.; DAISY study. Clinical characteristics of children diagnosed with type 1 diabetes through intensive screening and follow-up. Diabetes Care 2004;27:1399-1404.
33. Ziegler AG, Hummel M, Schenker M, Bonifacio E. Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: The 2-year analysis of the German BABYDIAB Study. Diabetes 1999;48: 460-468.