X-ray crystallographic analysis of IMP-1 metallo-β-lactamase complexed with a 3-aminophthalic acid derivative, structure-based drug design, and synthesis of 3,6-disubstituted phthalic acid derivative inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 20, 2014, Pages 4891-4894

  Hiraiwa, Yukiko ^a   Saito, Jun ^a   Watanabe, Takashi ^a   Yamada, Mototsugu ^a   Morinaka, Akihiro ^a   Fukushima, Takayoshi ^a   Kudo, Toshiaki ^a  

^a MEIJI SEIKA KAISHA LTD   (Japan)

Author keywords

IMP 1; Metallo lactamase; Pseudomonas aeruginosa

Indexed keywords

3-(4-HYDROXYPIPERIDINE-1-YL)PHTHALIC ACID; ANTIINFECTIVE AGENT; BETA LACTAMASE; BETA-LACTAMASE IMP-1; ENZYME INHIBITOR; PHTHALIC ACID DERIVATIVE; PIPERIDINE DERIVATIVE;

CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DESIGN; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MULTIDRUG RESISTANCE; PSEUDOMONAS AERUGINOSA; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHTHALIC ACIDS; PIPERIDINES; PSEUDOMONAS AERUGINOSA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84908691597     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.08.039     Document Type: Article

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