Multifunctional mercapto-tacrine derivatives for treatment of age-related neurodegenerative diseases

Journal of Medicinal Chemistry

Volumn 55, Issue 7, 2012, Pages 3588-3592

  Wang, Yue ^a   Guan, Xin Lei ^a   Wu, Peng Fei ^a   Wang, Can Ming ^a   Cao, Hui ^a   Li, Lei ^a   Guo, Xiao Juan ^a   Wang, Fang ^a,b,c   Xie, Na ^a,b,c   Jiang, Feng Chao ^a,c   Chen, Jian Guo ^a,b,c  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; TACRINE DERIVATIVE; TROLOX C;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BRAIN SLICE; CHOLINERGIC TRANSMISSION; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG DESIGN; DRUG EFFICACY; EXCITATORY POSTSYNAPTIC POTENTIAL; HUMAN; HUMAN CELL; IC 50; LIVER TOXICITY; LONG TERM POTENTIATION; NERVE CELL PLASTICITY; NEUROBLASTOMA CELL; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; RAT; STRUCTURE ACTIVITY RELATION; TREATMENT RESPONSE;

ACETYLCHOLINESTERASE; AGING; ANIMALS; BUTYRYLCHOLINESTERASE; CA1 REGION, HIPPOCAMPAL; CELL LINE, TUMOR; CHOLINESTERASE INHIBITORS; HUMANS; LIVER; LONG-TERM POTENTIATION; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS; TACRINE;

EID: 84859790482     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300124p     Document Type: Article

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