Natural products are the future of anticancer therapy: Preclinical and clinical advancements of viscum album phytometabolites

Cellular and Molecular Biology

Volumn 61, Issue 6, 2015, Pages 62-68

  Attar, R ^a   Tabassum, S ^b   Fayyaz, S ^c   Ahmad, M S ^d   Nogueira, D R ^e   Yaylim, I ^f   Timirci Kahraman, O ^f   Kucukhuseyin, O ^f   Cacina, C ^f   Farooqi, Ammad Ahmad ^g   Ismail, M ^g  

^a YEDITEPE UNIVERSITY   (Turkey)

^b INTERNATIONAL ISLAMIC UNIVERSITY   (Pakistan)

^c RLMC   (Pakistan)

^d PMAS ARID AGRICULTURE UNIVERSITY   (Pakistan)

^e FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^f ISTANBUL UNIVERSITY   (Turkey)

^g INSTITUTE OF BIOMEDICAL AND GENETIC ENGINEERING IBGE   (Pakistan)

Author keywords

Apoptosis; Cancer; Death receptor; Signaling; TRAIL

Indexed keywords

CYTOSKELETON PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NATURAL PRODUCT; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR; VISCUM ALBUM EXTRACT; PLANT EXTRACT;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER RESISTANCE; CANCER THERAPY; CYTOSKELETON; ENDOPLASMIC RETICULUM STRESS; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; INTRACELLULAR SIGNALING; METABOLITE; NONHUMAN; ONCOGENE; PERSONALIZED MEDICINE; VISCUM ALBUM; ANIMAL; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; GENETICS; NEOPLASMS; PATHOLOGY; PHYSIOLOGY;

ANIMALS; DRUG RESISTANCE, NEOPLASM; ENDOPLASMIC RETICULUM STRESS; HUMANS; NEOPLASMS; PLANT EXTRACTS; VISCUM ALBUM;

EID: 84962173208     PISSN: 01455680     EISSN: 1165158X     Source Type: Journal    
DOI: 10.14715/cmb/2015.61.6.9     Document Type: Article

References (58)

1. Jones, C., Baker, S.J. Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma. Nat Rev Cancer, 2014,14(10): 651-661. doi: 10.1038/nrc3811.
2. Brown, R, Curry, E, Magnani, L, Wilhelm-Benartzi, CS, Borley, J. Poised epigenetic states and acquired drug resistance in cancer. Nat Rev Cancer, 2014, 14(11):747-53. doi: 10.1038/nrc3819.
3. Mertens, F., Johansson, B., Fioretos, T., Mitelman, F. The emerging complexity of gene fusions in cancer. Nat Rev Cancer, 2015, 15(6):371-81. doi: 10.1038/nrc3947.
4. Buchheit, C.L., Weigel, K.J., Schafer, Z.T. Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression. Nat Rev Cancer, 2014, 14(9):632-41. doi: 10.1038/nrc3789.
5. Knowles, M.A., Hurst, C.D. Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity. Nat Rev Cancer, 2015, 15(1):25-41. doi: 10.1038/nrc3817.
6. Roberts, S.A., Gordenin, D.A. Hypermutation in human cancer genomes: footprints and mechanisms. Nat Rev Cancer, 2014, 14(12):786-800. doi:10.1038/nrc3816
7. Shu, L., Cheung., K.L., Khor, T.O., Chen, C., Kong, A.N. Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis. Cancer Metastasis Rev, 2010, 29(3):483-502. doi: 10.1007/s10555-010-9239-y.
8. Ribereau-Gayon, G., Dumont, S., Muller, C., Jung, M-L., Poindron, P., Anton, R. Mistletoe lectins I, II and III induce the production of cytokines by cultured human monocytes. Cancer Lett, 1996,109(1-2):33-38. doi:10.1016/S0304-3835 (96)04401-1.
9. Jager, S., Winkler, K., Pfuller, U., Scheffler, A. Solubility studies of oleanolic acid and betulinic acid in aqueous solutions and plant extracts of Viscum album L. Planta Med, 2007, 73:157-162. DOI: 10.1055/s-2007-967106
10. Strüh, C.M., Jäger, S., Schempp, C.M., Scheffler, A., Martin, S.F. A novel triterpene extract from mistletoe induces rapid apoptosis in murine B16.F10 melanoma cells. Phytother Res, 2012, 26(10):1507-12. doi: 10.1002/ptr.4604.
11. Klingbeil, M.F., Xavier, F.C., Sardinha, L.R., Severino, P., Mathor, M.B., Rodrigues, R.V., Pinto, D.S. Jr. Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines. Oncol Rep, 2013, 30(5):2316-22. doi: 10.3892/or.2013.2732
12. Park, Y.K., Do, Y.R., Jang, B.C. Apoptosis of K562 leukemia cells by Abnobaviscum F®, a European mistletoe extract. Oncol Rep, 2012, 28(6):2227-32. doi: 10.3892/or.2012.2026.
13. Choi, S.H., Lyu, S.Y., Park, W.B. Mistletoe lectin induces apoptosis and telomerase inhibition in human A253 cancer cells through dephosphorylation of Akt. Arch Pharm Res, 2004, 27(1):68-76.
14. Igney, F.H., Krammer, P.H. Death and anti-death: tumour resistance to apoptosis. Nat Rev Cancer, 2002, 2(4):277-88. doi:10.1038/nrc776
15. Cotter, T.G. Apoptosis and cancer: the genesis of a research field. Nat Rev Cancer, 2009, 9(7):501-7. doi: 10.1038/nrc2663
16. Brown, J.M., Attardi, L.D. The role of apoptosis in cancer development and treatment response. Nat Rev Cancer, 2005,5(3):231-7. doi:10.1038/nrc1560
17. Bantel, H., Engels, I.H., Voelter, W., Schulze-Osthoff, K., Wesselborg, S. Mistletoe lectin activates caspase-8/FLICE independently of death receptor signaling and enhances anticancer drug-induced apoptosis. Cancer Res, 1999,59(9):2083-90.
18. Delebinski, C.I., Jaeger, S., Kemnitz-Hassanin, K., Henze, G., Lode, H.N., Seifert, G.J. A new development of triterpene acid-containing extracts from Viscum album L. displays synergistic induction of apoptosis in acute lymphoblastic leukaemia. Cell Prolif, 2012, 45(2):176-87. doi: 10.1111/j.1365-2184.2011.00801.x
19. Lavastre, V., Chiasson, S., Cavalli, H., Girard, D. Viscum album agglutinin-I (VAA-I) induces apoptosis and degradation of cytoskeletal proteins in human leukemia PLB-985 and X-CGD cells via caspases: lamin B1 is a novel target of VAA-I. Leuk Res, 2005, 29(12):1443-53. doi:10.1016/j.leukres.2005.05.014
20. Yang, X., Jiang, S., Liu Y., Zhang, P., Xie, S., Wang, G. Recombinant VAA-I from Viscum album induces apoptotic cell death of hepatocellular carcinoma SMMC7721 cells. Molecules, 2012, 17(10):11435-46. doi: 10.3390/molecules171011435.
21. Uçar, E.Ö., Arda, N., Aitken, A. Extract from mistletoe, Viscum album L., reduces Hsp27 and 14-3-3 protein expression and induces apoptosis in C6 rat glioma cells. Genet Mol Res, 2012, 11(3):2801-13. DOI http://dx.doi.org/10.4238/2012.August.24.5
22. Wetzker, R., Böhmer, F.D. Transactivation joins multiple tracks to the ERK/MAPK cascade. Nat Rev Mol Cell Biol, 2003, 4(8):651-7. doi:10.1038/nrm1173
23. Jeffrey, K.L., Camps, M., Rommel, C., Mackay, C.R. Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses. Nat Rev Drug Discov,2007, 6(5):391-403. doi:10.1038/nrd2289
24. Kim, W.H., Park, W.B., Gao, B., Jung, M.H. Critical role of reactive oxygen species and mitochondrial membrane potential in Korean mistletoe lectin-induced apoptosis in human hepatocarcinoma cells. Mol Pharmacol, 2004 66(6):1383-96. doi: 10.1124/mol.104.001347
25. Wang, M., Kaufman, R.J. The impact of the endoplasmic reticulum protein-folding environment on cancer development. Nat Rev Cancer, 2014, 14(9):581-97. doi: 10.1038/nrc3800
26. Todd, D.J., Lee, A.H., Glimcher, L.H. The endoplasmic reticulum stress response in immunity and autoimmunity. Nat Rev Immunol, 2008 8(9):663-74. doi: 10.1038/nri2359.
27. Haze, K., Yoshida, H., Yanagi, H., Yura, T., Mori, K. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol Biol Cell, 1999,10(11):3787-99. doi: 10.1091/mbc.10.11.3787
28. Vicente-Manzanares, M., Ma, X., Adelstein, R.S., Horwitz, A.R. Non-muscle myosin II takes centre stage in cell adhesion and migration. Nat Rev Mol Cell Biol, 2009, 10(11):778-90. doi: 10.1038/nrm2786.
29. Lavastre, V., Binet, F., Moisan, E., Chiasson, S., Girard, D. Viscum album agglutinin-I induces degradation of cytoskeletal proteins in leukaemia PLB-985 cells differentiated toward neutrophils: cleavage of non-muscle myosin heavy chain-IIA by caspases. Br J Haematol, 2007, 138(4):545-54. doi:10.1111/j.1365-2141.2007.06692.x
30. Zarkovic, N., Vukovic, T., Loncaric, I., Miletic, M., Zarkovic, K., Borovic, S., Cipak, A., Sabolovic, S., Konitzer, M., Mang, S. An overview on anticancer activities of the Viscum album extract. Cancer Biotherapy & Radiopharmaceuticals, 2001, 16(1): 55-62. doi:10.1089/108497801750096041.
31. Podlech, O., Harter, P.N., Mittelbronn, M., Pöschel, S., Naumann, U. Fermented mistletoe extract as a multimodal antitumoral agent in gliomas. Evid Based Complement Alternat Med, 2012, 2012:501796. doi: 10.1155/2012/501796.
32. Strüh, C.M., Jäger, S., Kersten, A., Schempp, C.M., Scheffler, A., Martin, S.F. Triterpenoids amplify anti-tumoral effects of mistletoe extracts on murine B16.f10 melanoma in vivo. PLoS One, 2013, 8(4):e62168. doi: 10.1371/journal.pone.0062168.
33. Delebinski, C.I., Twardziok, M., Kleinsimon, S., Hoff, F., Mulsow, K., Rolff, J., Jäger, S., Eggert, A., Seifert, G. A Natural Combination Extract of Viscum album L. Containing Both Triterpene Acids and Lectins Is Highly Effective against AML In Vivo. PLoS One, 2015, 10(8):e0133892. doi: 10.1371/journal.pone.0133892
34. Han, S.Y., Hong, C.E., Kim, H.G., Lyu, S.Y. Anti-cancer effects of enteric-coated polymers containing mistletoe lectin in murine melanoma cells in vitro and in vivo. Mol Cell Biochem, 2015, 408(1-2):73-87. doi: 10.1007/s11010-015-2484-1
35. Aparicio, S., Hidalgo, M., Kung, A.L. Examining the utility of patient-derived xenograft mouse models. Nat Rev Cancer, 2015, 15(5):311-6. doi: 10.1038/nrc3944.
36. Von Schoen-Angerer, T., Goyert, A., Vagedes, J., Kiene, H., Merckens, H., Kienle, G.S. Disappearance of an advanced adenomatous colon polyp after intratumoural injection with Viscum album (European mistletoe) extract: a case report. J Gastrointestin Liver Dis, 2014, 23(4):449-52. DOI: http://dx.doi.org/10.15403/jgld.2014.1121.234
37. Werthmann, P.G., Helling, D., Heusser, P., Kienle, G.S. Tumour response following high-dose intratumoural application of Viscum album on a patient with adenoid cystic carcinoma. BMJ Case Rep, 2014, Jul 31:2014. doi: 10.1136/bcr-2013-203180.
38. Longhi, A., Reif, M., Mariani, E., Ferrari, S. A Randomized Study on Postrelapse Disease-Free Survival with Adjuvant Mistletoe versus Oral Etoposide in Osteosarcoma Patients. Evid Based Complement Alternat Med, 2014, 2014:210198. doi: 10.1155/2014/210198.
39. Mansky, P.J., Wallerstedt, D.B., Sannes, T.S., Stagl, J., Johnson, L.L., Blackman, M.R., Grem, J.L., Swain, S.M., Monahan, B.P. NCCAM/NCI Phase 1 Study of Mistletoe Extract and Gemcitabine in Patients with Advanced Solid Tumors. Evid Based Complement Alternat Med, 2013; 2013:964592. doi: 10.1155/2013/964592.
40. Tröger, W., Galun, D., Reif, M., Schumann, A., Stanković, N., Milićević, M. Viscum album [L.] extract therapy in patients with locally advanced or metastatic pancreatic cancer: a randomised clinical trial on overall survival. Eur J Cancer, 2013, 49(18):3788-97. doi: 10.1016/j.ejca.2013.06.043.
41. Werthmann, P.G., Sträter, G., Friesland, H., Kienle, G.S. Durable response of cutaneous squamous cell carcinoma following high-dose peri-lesional injections of Viscum album extracts--a case report. Phytomedicine, 2013, 20(3-4):324-7. doi: 10.1016/j.phymed.2012.11.001
42. Steele, M.L., Axtner, J., Happe, A., Kröz, M., Matthes, H., Schad, F. Use and Safety of Intratumoral Application of European Mistletoe (Viscum album L) Preparations in Oncology. Integr Cancer Ther, 2015, 14(2):140-8. doi: 10.1177/1534735414563977.
43. Barker, H.E., Paget, J.T., Khan, A.A., Harrington, K.J. The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Nat Rev Cancer, 2015, 15(7):409-25. doi: 10.1038/nrc3958.
44. Sosa, M.S., Bragado, P., Aguirre-Ghiso, J.A. Mechanisms of disseminated cancer cell dormancy: an awakening field. Nat Rev Cancer, 2014, 14(9):611-22. doi: 10.1038/nrc3793.
45. Ghajar, C.M. Metastasis prevention by targeting the dormant niche. Nat Rev Cancer, 2015, 15(4):238-47. doi: 10.1038/nrc3910.
46. Lin, S., Gregory, R.I. MicroRNA biogenesis pathways in cancer. Nat Rev Cancer, 2015, 15(6):321-33. doi: 10.1038/nrc3932.
47. Li, Y., Ahmad, A., Sarkar and F. H., ASPP and iASPP: Implication in cancer development and progression. Cell. Mol. Biol. 2015, 61(6): 2-8.
48. Masood, N., Qureshi, M. Z. and Yasmin, A., Association of NOTCH with different microRNAs in head and neck cancer. Cell. Mol. Biol. 2015, 61(6): 9-16.
49. Amirkhah, R., Farazmand, A., Irfan-Maqsood, M., Wolkenhauerand, O. and Schmitz, U., The role of microRNAs in the resistance to colorectal cancer treatments. Cell. Mol. Biol. 2015, 61(6): 17-23.
50. Wang, Z., Chen, J. and Capobianco, A. J., The Notch signaling pathway in esophageal adenocarcinoma. Cell. Mol. Biol. 2015, 61(6): 24-32.
51. Limami, Y., Pinon, A., Riaz, A. and Simon, A., TRAIL and targeting cancer cells: between promises and obstacles. Cell. Mol. Biol. 2015, 61(6): 33-38.
52. Silva Galbiatti-Dias, A. L., Pavarino, É. C., Kawasaki-Oyama, R. S., Maniglia, J. V., Maniglia, E. J. V. and Goloni Bertollo, E. M., Cancer stem cells in head and neck cancer: A Mini Review. Cell. Mol. Biol. 2015, 61(6): 39-43.
53. Musella, A., Marchetti, C., Gasparri, M. L., Salerno, L., Casorelli, A., Domenici, L., Imperiale, L., Ruscito, I., Abdul Halim, T., Palaia, I., Di Donato, V., Pecorini, F., Monti, M., Muzii, L. and Panici, P. B., PARP inhibition: A promising therapeutic target in ovarian cancer. Cell. Mol. Biol. 2015, 61(6): 44-61.
54. Hsu, Y-C., Hsieh, Y-H., Liao, C-C., Chong, L-W., Lee, C-Y., Yu, Y-L. and Chou, R-H., Targeting post-translational modifications of histones for cancer therapy. Cell. Mol. Biol. 2015, 61(6): 69-84.
55. Chong, L-W., Chou, R-H., Liao, C-C., Lee, T-F., Lin, Y., Yang, K-C. and Hsu, Y-C. Saturated fatty acid induces cancer stem cell-like properties in human hepatoma cells. Cell. Mol. Biol. 2015, 61(6): 85-91.
56. Smina, T. P., Mohan, A., Ayyappa, K. A., Sethuraman, S. and Krishnan, U. M., Hesperetin exerts apoptotic effect on A431 skin carcinoma cells by regulating mitogen activated protein kinases and cyclins. Cell. Mol. Biol. 2015, 61(6): 92-99.
57. Ahmadi, M., Jafari, R., Marashi, S. A. and Farazmand, A., Indirect role of microRNAs and transcription factors in the regulation of important cancer genes: A network biology approach. Cell. Mol. Biol. 2015, 61(6): 100-107.
58. Zahoor, A., Mansoor, Q., Farooqi, A. A., Fayyaz, S., Naz, G. and Ismail, M., Genetic variants in the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and death receptor (DR4) genes contribute to susceptibility to colorectal cancer in pakistani population. Cell. Mol. Biol. 2015, 61(6): 108-112.