Tumour response following high-dose intratumoural application of Viscum album on a patient with adenoid cystic carcinoma

BMJ Case Reports

Volumn , Issue , 2014, Pages

  Werthmann, Paul Georg ^a   Helling, Dieter ^b   Heusser, Peter ^a   Kienle, Gunver Sophia ^a  

^a UNIVERSITY OF WITTEN HERDECKE   (Germany)

^b Medical Practice for General Medicine   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

VISCUM ALBUM EXTRACT;

ADENOID CYSTIC CARCINOMA; AGED; ARTICLE; CANCER CLASSIFICATION; CANCER STAGING; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DRUG DOSE INCREASE; DRUG MEGADOSE; FEVER; FOLLOW UP; FRAXINUS; HARD PALATE; HEART ARREST; HUMAN; INJECTION SITE INFLAMMATION; INJECTION SITE PAIN; INJECTION SITE SWELLING; MALE; MEDICAL HISTORY; OAK; ORAL SURGERY; PRIORITY JOURNAL; PROSTATE TUMOR; PROSTATECTOMY; PUNCH BIOPSY; QUALITY OF LIFE; SUDDEN DEATH; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT REFUSAL; TREATMENT RESPONSE; TUMOR GROWTH; TUMOR LOCALIZATION; TUMOR REGRESSION; TUMOR VOLUME; VERY ELDERLY; VISCUM ALBUM;

EID: 84905104331     PISSN: None     EISSN: 1757790X     Source Type: Journal    
DOI: 10.1136/bcr-2013-203180     Document Type: Article

References (30)

1. Tian Z, Li L, Wang L, et al. Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg 2010;39:235-42.
2. Bradley PJ. Adenoid cystic carcinoma of the head and neck: a review. Curr Opin Otolaryngol Head Neck Surg 2004;12:127-32. (Pubitemid 38420202)
3. Garden AS, Weber RS, Ang KK, et al. Postoperative radiation therapy for malignant tumors of minor salivary glands. Outcome and patterns of failure. Cancer 1994;73:2563-9. (Pubitemid 24155534)
4. Oates JA, Kinsella DC, Gutowski NJ. Neurological picture. Fast-growing adenoid cystic carcinoma: a neurotropic malignancy. J Neurol Neurosurg Psychiatry 2006;77:1039. (Pubitemid 44338525)
5. Irish J, Sandhu N, Simpson C, et al. Quality of life in patients with maxillectomy prostheses. Head Neck 2009;31:813-21.
6. Kaufman J. A guide to systemic therapy for patients with progressive adenoid cystic carcinoma. Adenoid Cystic Carcinoma Research Foundation, 2010.
7. O'Regan B, Hirshberg C. Spontaneous remission - an annonted bibliography. Institute of Noetic Sciences, 1993.
8. Grillet B, Demedts M, Roelens J, et al. Spontaneous regression of lung metastases of adenoid cystic carcinoma. Chest 1984;85:289-91. (Pubitemid 14192524)
9. Molassiotis A, Fernadez-Ortega P, Pud D, et al. Use of complementary and alternative medicine in cancer patients: a European survey. Ann Oncol 2005;16:655-63. (Pubitemid 40613334)
10. Kienle GS, Kiene H. Complementary cancer therapy: a systematic review of prospective clinical trials on anthroposophic mistletoe extracts. Eur J Med Res 2007;12:103-19. (Pubitemid 46564000)
11. Kienle GS, Kiene H. Die Mistel in der Onkologie - Fakten und konzeptionelle Grundlagen. Stuttgart, New York: Schattauer Verlag, 2003.
12. Büssing A, ed. Mistletoe. The genus Viscum. Amsterdam: Hardwood Academic Publishers, 2000.
13. Kienle GS, Kiene H. Influence of Viscum album L (European mistletoe) extracts on quality of life in cancer patients: a systematic review of controlled clinical studies. Integr Cancer Ther 2010;9:142-57.
14. Troger W, Galun D, Reif M, et al. Viscum album [L.] extract therapy in patients with locally advanced or metastatic pancreatic cancer: a randomised clinical trial on overall survival. Eur J Cancer 2013;49:3788-97.
15. Scheffler A, Mast H, Fischer S, et al. Komplette Remission eines Mundhöhlenkarzinoms nach alleiniger Mistelbehandlung. In: Scheer R, Becker H, Berg PA, eds. Grundlagen der Misteltherapie. Aktueller Stand der Forschung und klinische Anwendung. Stuttgart: Hippokrates Verlag GmbH, 1996:453-66.
16. Orange M, Fonseca M, Lace A, et al. Durable tumour responses following primary high-dose induction with mistletoe extracts: two case reports. Eur J Integr Med 2010;1:227.
17. Orange M, Lace A, Fonseca M, et al. Durable regression of primary cutaneous B-cell lymphoma following fever-inducing mistletoe treatment - two case reports. Glob Adv Health Med 2012;1:18-25.
18. Werthmann PG, Strater G, Friesland H, et al. Durable response of cutaneous squamous cell carcinoma following high-dose peri-lesional injections of Viscum album extracts - a case report. Phytomedicine 2013;20:324-7.
19. Kienle GS, Grugel R, Kiene H. Safety of higher dosages of Viscum album L. in animals and humans - systematic review of immune changes and safety parameters. BMC Complement Altern Med 2011;11:72.
20. Gagnier JJ, Riley D, Altman DG, et al. The CARE guidelines: consensus-based clinical case reporting guideline development. Dtsch Arztebl Int 2013;110:603-8.
21. Ya-Juan L, Hong-Lan Z. Inhibitory effect of mistletoe alkali on adenoid cystic carcinoma cells. J Jilin Univ 2008;34:601-4.
22. Klingbeil MF, Xavier FC, Sardinha LR, et al. Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines. Oncol Rep 2013;30:2316-22.
23. Steuer-Vogt MK, Bonkowsky V, Scholz M, et al. [Influence of ML-1 standardized mistletoe extract on the quality of life in head and neck cancer patients]. HNO 2006;54:277-86.
24. Kienle GS, Glockmann A, Schink M, et al. Viscum album L. extracts in breast and gynaecological cancers: a systematic review of clinical and preclinical research. J Exp Clin Cancer Res 2009;28:79.
25. Geir W. [The mistletoe preparation ISOREL in the treatment of laryngeal cancer - case report of a complete remission] Das Mistelpräparat ISOREL bei Larynxkarzinom - Fallbericht von einer Totalremission. Krebsgeschehen 1982;1982:1-12.
26. Orange M, Lace A, von Laue B. The importance of the primary dosage in mistletoe therapy. In: Scheer R, Alban S, Becker H, Holzgrabe U, Kemper FH, Kreis W, et al., eds. Die Mistel in der Tumortherapie 2. Essen: KVC Verlag, 2009:385-400.
27. Metelmann HR, Hyckel P, Podmelle F. Oral cancer treatment and immune targets - a role for dendritic cells? J Craniomaxillofac Surg 2012;40:103-4.
28. Papaspyrou G, Hoch S, Rinaldo A, et al. Chemotherapy and targeted therapy in adenoid cystic carcinoma of the head and neck: a review. Head Neck 2011;33:905-11.
29. Vikram B, Strong EW, Shah JP, et al. Radiation therapy in adenoid-cystic carcinoma. Int J Radiat Oncol Biol Phys 1984;10:221-3. (Pubitemid 14131624)
30. Jensen AD, Krauss J, Weichert W, et al. RadioImmunotherapy for adenoid cystic carcinoma: a single-institution series of combined treatment with cetuximab. Radiat Oncol 2010;5:102.