Disappearance of an advanced adenomatous colon polyp after intratumoural injection with viscum album (european mistletoe) extract: A case report

Journal of Gastrointestinal and Liver Diseases

Volumn 23, Issue 4, 2014, Pages 449-452

  Von Schoen Angerer, Tido ^a,d   Goyert, Andreas ^b   Vagedes, Jan ^a,e   Kiene, Helmut ^c   Merckens, Harald ^b   Kienle, Gunver S ^c  

^a ARCIM Institute   (Germany)

^b Filderklinik ^*  (Germany)

^c UNIVERSITY OF WITTEN HERDECKE   (Germany)

^d Clinique d'Ophtalmologie de Fribourg   (Switzerland)

^e UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Colon polyp; Colorectal adenoma; European mistletoe; Tumour regression; Viscum album

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; HERBACEOUS AGENT; VISCUM ALBUM EXTRACT; ANTINEOPLASTIC AGENT; PLANT EXTRACT; VEGETABLE PROTEIN; VISCUM ALBUM PEPTIDE;

ADENOMATOUS POLYP; AGED; ARTICLE; BIOPSY; BLOOD CELL COUNT; CANCER INHIBITION; CANCER STAGING; CASE REPORT; COLON ADENOMA; COLON CANCER; COLON POLYP; COLONOSCOPY; DYSPLASIA; EMPHYSEMA; GRAPE; HEMICOLECTOMY; HERBAL MEDICINE; HUMAN; HUMAN TISSUE; LIVER FUNCTION TEST; MALE; MENTAL STRESS; MULTIPLE CYCLE TREATMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; STRAWBERRY; THORAX RADIOGRAPHY; TUMOR VOLUME; ADENOMATOUS POLYPS; COLONIC NEOPLASMS; COLONIC POLYPS; INTRALESIONAL DRUG ADMINISTRATION; MEDICINAL PLANT; PATHOLOGY; PHYTOTHERAPY; REMISSION; TIME; TREATMENT OUTCOME; VISCUM ALBUM;

ADENOMATOUS POLYPS; AGED; ANTINEOPLASTIC AGENTS, PHYTOGENIC; COLONIC NEOPLASMS; COLONIC POLYPS; COLONOSCOPY; HUMANS; INJECTIONS, INTRALESIONAL; MALE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT PROTEINS; PLANTS, MEDICINAL; REMISSION INDUCTION; TIME FACTORS; TREATMENT OUTCOME; VISCUM ALBUM;

EID: 84914690375     PISSN: 18418724     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Heitman SJ, Ronksley PE, Hilsden RJ, Manns BJ, Rostom A, Hemmelgarn BR. Prevalence of adenomas and colorectal cancer in average risk individuals: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 2009;7:1272-1278.
2. Kedia P, Waye JD. Colon polypectomy: a review of routine and advanced techniques. J Clin Gastroenterol 2013;47:657-665.
3. Kienle GS, Kiene H. Review article: Influence of Viscum album L (European mistletoe) extracts on quality of life in cancer patients: a systematic review of controlled clinical studies. Integr Cancer Ther 2010;9:142-157.
4. Horneber MA, Bueschel G, Huber R, Linde K, Rostock M. Mistletoe therapy in oncology. Cochrane Database Syst Rev 2008;(2):CD003297.
5. Tröger W, Galun D, Reif M, Schumann A, Stankovic N, Milicevic M. Viscum album [L.] extract therapy in patients with locally advanced or metastatic pancreatic cancer: A randomised clinical trial on overall survival. Eur J Cancer 2013;49:3788-3797.
6. Orange M, Lace A, Fonseca MP, von Laue BH, Geider S, Kienle GS. Durable Regression of Primary Cutaneous B-Cell Lymphoma Following Fever-inducing Mistletoe Treatment: Two Case Reports. Glob Adv Health Med 2012;1:18-25.
7. Werthmann PG, Strater G, Friesland H, Kienle GS. Durable response of cutaneous squamous cell carcinoma following high-dose peri-lesional injections of Viscum album extracts--a case report. Phytomedicine 2013;20:324-327.
8. Kirsch A. Successful treatment of metastatic malignant melanoma with Viscum album extract (Iscador M). J Altern Complement Med 2007;13:443-445.
9. Zänker KS, Matthes H, Bock PR, Hanisch J. A specific mistletoe preparation (Iscador-Qu®) in colorectal cancer (CRC) patients: more than just supportive care? J Cancer Sci Ter 2012;4:264-270.
10. Cazacu M, Oniu T, Lungoci C, et al. The influence of isorel on the advanced colorectal cancer. Cancer Biother Radiopharm 2003;18:27-34.
11. Schink M, Troger W, Dabidian A, et al. Mistletoe extract reduces the surgical suppression of natural killer cell activity in cancer patients. a randomized phase III trial. Forsch Komplementmed 2007;14:9-17.
12. Park WB, Lyu SY, Kim JH, et al. Inhibition of tumor growth and metastasis by Korean mistletoe lectin is associated with apoptosis and antiangiogenesis. Cancer Biother Radiopharm 2001;16:439-447.
13. Kienle GS, Grugel R, Kiene H. Safety of higher dosages of Viscum album L. in animals and humans--systematic review of immune changes and safety parameters. BMC Complement Altern Med 2011;11:72.
14. Kienle GS KH. Die Mistel in der Onkologie: Fakten und konzeptionelle Grundlagen. New York: Schattauer; 2003.
15. Urech K, Schaller G, Jaggy C. Viscotoxins, mistletoe lectins and their isoforms in mistletoe (Viscum album L.) extracts Iscador. Arzneimittelforschung 2006;56:428-434.
16. Gagnier JJ, Kienle G, Altman DG, et al. The CARE guidelines: consensus-based clinical case reporting guideline development. J Med Case Rep 2013;7:223.
17. Sakamoto S, Fu K, Kobayashi O, et al. Spontaneous complete regression of a rectal cancer. Endoscopy 2009;41:910-912.
18. Filippakis GM, Zografos G, Pararas N, Lanitis S, Georgiadou D, Filippakis MG. Spontaneous regression of rectal polyps following abdominal colectomy and ileorectal anastomosis for familial adenomatous polyposis, without sulindac treatment: report of four cases. Endoscopy 2007;39:665-668.
19. Bersentes K, Fennerty MB, Sampliner RE, Garewal HS. Lack of spontaneous regression of tubular adenomas in two years of follow-up. Am J Gastroenterol 1997;92:1117-1120.
20. Edge SB, American Joint Committee on Cancer. AJCC cancer staging manual. 7th ed. New York: Springer; 2010.
21. Kobayashi N, Saito Y, Sano Y, et al. Determining the treatment strategy for colorectal neoplastic lesions: endoscopic assessment or the non-lifing sign for diagnosing invasion depth? Endoscopy 2007;39:701-705.
22. Harrison JD, Solomon MJ, Young JM, et al. Patient and physician preferences for surgical and adjuvant treatment options for rectal cancer. Arch Surg 2008;143:389-394.