-
1
-
-
81255135837
-
Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes
-
DeRose, Y. S. et al. Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes. Nature Med. 17, 1514-1520 (2011).
-
(2011)
Nature Med.
, vol.17
, pp. 1514-1520
-
-
Derose, Y.S.1
-
2
-
-
84881415504
-
A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models
-
Zhang, X. et al. A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models. Cancer Res. 73, 4885-4897 (2013).
-
(2013)
Cancer Res.
, vol.73
, pp. 4885-4897
-
-
Zhang, X.1
-
3
-
-
84860378325
-
Global gene expression profiling confirms the molecular fidelity of primary tumor-based orthotopic xenograft mouse models of medulloblastoma
-
Zhao, X. et al. Global gene expression profiling confirms the molecular fidelity of primary tumor-based orthotopic xenograft mouse models of medulloblastoma. Neuro Oncol. 14, 574-583 (2012).
-
(2012)
Neuro Oncol.
, vol.14
, pp. 574-583
-
-
Zhao, X.1
-
4
-
-
4644266467
-
Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity
-
Loukopoulos, P. et al. Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity. Pancreas 29, 193-203 (2004).
-
(2004)
Pancreas
, vol.29
, pp. 193-203
-
-
Loukopoulos, P.1
-
5
-
-
84866557855
-
Patient-derived luminal breast cancer xenografts retain hormone receptor heterogeneity and help define unique estrogen-dependent gene signatures
-
Kabos, P. et al. Patient-derived luminal breast cancer xenografts retain hormone receptor heterogeneity and help define unique estrogen-dependent gene signatures. Breast Cancer Res. Treat. 135, 415-432 (2012).
-
(2012)
Breast Cancer Res. Treat.
, vol.135
, pp. 415-432
-
-
Kabos, P.1
-
6
-
-
84925229458
-
Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution
-
Eirew, P. et al. Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution. Nature 518, 422-426 (2015).
-
(2015)
Nature
, vol.518
, pp. 422-426
-
-
Eirew, P.1
-
7
-
-
84862526929
-
The clonal and mutational evolution spectrum of primary triple-negative breast cancers
-
Shah, S. P. et al. The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature 486, 395-399 (2012).
-
(2012)
Nature
, vol.486
, pp. 395-399
-
-
Shah, S.P.1
-
8
-
-
84897954204
-
PyClone: Statistical inference of clonal population structure in cancer
-
Roth, A. et al. PyClone: statistical inference of clonal population structure in cancer. Nature Meth. 11, 396-398 (2014).
-
(2014)
Nature Meth.
, vol.11
, pp. 396-398
-
-
Roth, A.1
-
9
-
-
77951139631
-
Genome remodelling in a basal-like breast cancer metastasis and xenograft
-
Ding, L. et al. Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature 464, 999-1005 (2010).
-
(2010)
Nature
, vol.464
, pp. 999-1005
-
-
Ding, L.1
-
10
-
-
84906895091
-
Patient-derived xenograft models: An emerging platform for translational cancer research
-
Hidalgo, M. et al. Patient-derived xenograft models: an emerging platform for translational cancer research. Cancer Discov. 4, 998-1013 (2014).
-
(2014)
Cancer Discov.
, vol.4
, pp. 998-1013
-
-
Hidalgo, M.1
-
11
-
-
84855784479
-
Molecular profiling of patient-derived breast cancer xenografts
-
Reyal, F. et al. Molecular profiling of patient-derived breast cancer xenografts. Breast Cancer Res. 14, R11 (2012).
-
(2012)
Breast Cancer Res.
, vol.14
, pp. R11
-
-
Reyal, F.1
-
12
-
-
80052470635
-
Tumor engraftment in nude mice and enrichment in stroma-related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer
-
Garrido-Laguna, I. et al. Tumor engraftment in nude mice and enrichment in stroma-related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer. Clin. Cancer Res. 17, 5793-5800 (2011).
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 5793-5800
-
-
Garrido-Laguna, I.1
-
13
-
-
84900020778
-
Transcriptional dissection of pancreatic tumors engrafted in mice
-
Martinez-Garcia, R. et al. Transcriptional dissection of pancreatic tumors engrafted in mice. Genome Med. 6, 27 (2014).
-
(2014)
Genome Med.
, vol.6
, pp. 27
-
-
Martinez-Garcia, R.1
-
14
-
-
33845206491
-
Practices and pitfalls of mouse cancer models in drug discovery
-
Kung, A. L. Practices and pitfalls of mouse cancer models in drug discovery. Adv. Cancer Res. 96, 191-212 (2007).
-
(2007)
Adv. Cancer Res.
, vol.96
, pp. 191-212
-
-
Kung, A.L.1
-
15
-
-
2042458747
-
Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials
-
Johnson, J. I. et al. Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials. Br. J. Cancer 84, 1424-1431 (2001).
-
(2001)
Br. J. Cancer
, vol.84
, pp. 1424-1431
-
-
Johnson, J.I.1
-
16
-
-
84862772839
-
A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer
-
Bertotti, A. et al. A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer. Cancer Discov. 1, 508-523 (2011).
-
(2011)
Cancer Discov.
, vol.1
, pp. 508-523
-
-
Bertotti, A.1
-
17
-
-
34447123764
-
A new model of patient tumor-derived breast cancer xenografts for preclinical assays
-
Marangoni, E. et al. A new model of patient tumor-derived breast cancer xenografts for preclinical assays. Clin. Cancer Res. 13, 3989-3998 (2007).
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 3989-3998
-
-
Marangoni, E.1
-
18
-
-
58149186087
-
Establishment of patient-derived non-small cell lung cancer xenografts as models for the identification of predictive biomarkers
-
Fichtner, I. et al. Establishment of patient-derived non-small cell lung cancer xenografts as models for the identification of predictive biomarkers. Clin. Cancer Res. 14, 6456-6468 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 6456-6468
-
-
Fichtner, I.1
-
19
-
-
84862145477
-
A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma
-
Sivanand, S. et al. A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma. Sci. Transl. Med. 4, 137ra75 (2012).
-
(2012)
Sci. Transl. Med.
, vol.4
, pp. 137ra75
-
-
Sivanand, S.1
-
20
-
-
84866923492
-
Characterization of a large panel of patient-derived tumor xenografts representing the clinical heterogeneity of human colorectal cancer
-
Julien, S. et al. Characterization of a large panel of patient-derived tumor xenografts representing the clinical heterogeneity of human colorectal cancer. Clin. Cancer Res. 18, 5314-5328 (2012).
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 5314-5328
-
-
Julien, S.1
-
21
-
-
1942422737
-
Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development
-
Peterson, J. K. & Houghton, P. J. Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development. Eur. J. Cancer 40, 837-844 (2004).
-
(2004)
Eur. J. Cancer
, vol.40
, pp. 837-844
-
-
Peterson, J.K.1
Houghton, P.J.2
-
22
-
-
80051588648
-
A pilot clinical study of treatment guided by personalized tumorgrafts in patients with advanced cancer
-
Hidalgo, M. et al. A pilot clinical study of treatment guided by personalized tumorgrafts in patients with advanced cancer. Mol. Cancer Ther. 10, 1311-1316 (2011).
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 1311-1316
-
-
Hidalgo, M.1
-
23
-
-
84856695586
-
Prioritizing phase i treatment options through preclinical testing on personalized tumorgraft
-
Morelli, M. P. et al. Prioritizing phase I treatment options through preclinical testing on personalized tumorgraft. J. Clin. Oncol. 30, e45-e48 (2012).
-
(2012)
J. Clin. Oncol.
, vol.30
, pp. e45-e48
-
-
Morelli, M.P.1
-
24
-
-
84928539909
-
Integrated next generation sequencing and avatar mouse models for personalized cancer treatment
-
Garralda, E. Integrated next generation sequencing and avatar mouse models for personalized cancer treatment. J. Clin. Oncol. 13, 2476-2484 (2013).
-
(2013)
J. Clin. Oncol.
, vol.13
, pp. 2476-2484
-
-
Garralda, E.1
-
25
-
-
84919443958
-
Patient-derived models of acquired resistance can identify effective drug combinations for cancer
-
Crystal, A. S. et al. Patient-derived models of acquired resistance can identify effective drug combinations for cancer. Science 346, 1480-1486 (2014).
-
(2014)
Science
, vol.346
, pp. 1480-1486
-
-
Crystal, A.S.1
-
26
-
-
0026452172
-
Phase II preclinical drug screening in human tumor xenografts: A first European multicenter collaborative study
-
Boven, E. et al. Phase II preclinical drug screening in human tumor xenografts: a first European multicenter collaborative study. Cancer Res. 52, 5940-5947 (1992).
-
(1992)
Cancer Res.
, vol.52
, pp. 5940-5947
-
-
Boven, E.1
-
27
-
-
77649122679
-
Comparative profiling of the novel epothilone, sagopilone, in xenografts derived from primary non-small cell lung cancer
-
Hammer, S. et al. Comparative profiling of the novel epothilone, sagopilone, in xenografts derived from primary non-small cell lung cancer. Clin. Cancer Res. 16, 1452-1465 (2010).
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 1452-1465
-
-
Hammer, S.1
-
28
-
-
84920983131
-
Organoid models of human and mouse ductal pancreatic cancer
-
Boj, S. F. et al. Organoid models of human and mouse ductal pancreatic cancer. Cell 160, 324-338 (2015).
-
(2015)
Cell
, vol.160
, pp. 324-338
-
-
Boj, S.F.1
-
29
-
-
84907554319
-
Organoid cultures derived from patients with advanced prostate cancer
-
Gao, D. et al. Organoid cultures derived from patients with advanced prostate cancer. Cell 159, 176-187 (2014).
-
(2014)
Cell
, vol.159
, pp. 176-187
-
-
Gao, D.1
-
30
-
-
84907552531
-
Identification of multipotent luminal progenitor cells in human prostate organoid cultures
-
Karthaus, W. R. et al. Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Cell 159, 163-175 (2014).
-
(2014)
Cell
, vol.159
, pp. 163-175
-
-
Karthaus, W.R.1
-
31
-
-
84904066077
-
Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture
-
Li, X. et al. Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture. Nature Med. 20, 769-777 (2014).
-
(2014)
Nature Med.
, vol.20
, pp. 769-777
-
-
Li, X.1
-
32
-
-
84880270290
-
Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay
-
Baccelli, I. et al. Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nature Biotech. 31, 539-544 (2013).
-
(2013)
Nature Biotech.
, vol.31
, pp. 539-544
-
-
Baccelli, I.1
-
33
-
-
84866921954
-
Lurbinectedin (PM01183), a new DNA minor groove binder, inhibits growth of orthotopic primary graft of cisplatin-resistant epithelial ovarian cancer
-
Vidal, A. et al. Lurbinectedin (PM01183), a new DNA minor groove binder, inhibits growth of orthotopic primary graft of cisplatin-resistant epithelial ovarian cancer. Clin. Cancer Res. 18, 5399-5411 (2012).
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 5399-5411
-
-
Vidal, A.1
-
34
-
-
20544434435
-
Preclinical testing of antileukemic drugs using an in vivo model of systemic disease
-
Lock, R. B., Liem, N. L. & Papa, R. A. Preclinical testing of antileukemic drugs using an in vivo model of systemic disease. Methods Mol. Med. 111, 323-334 (2005).
-
(2005)
Methods Mol. Med.
, vol.111
, pp. 323-334
-
-
Lock, R.B.1
Liem, N.L.2
Papa, R.A.3
-
35
-
-
84863380530
-
A model for personalized in vivo analysis of human immune responsiveness
-
Kalscheuer, H. et al. A model for personalized in vivo analysis of human immune responsiveness. Sci. Transl. Med. 4, 125ra30 (2012).
-
(2012)
Sci. Transl. Med.
, vol.4
, pp. 125ra30
-
-
Kalscheuer, H.1
-
36
-
-
84873084388
-
Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer
-
Kreso, A. et al. Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science 339, 543-548 (2013).
-
(2013)
Science
, vol.339
, pp. 543-548
-
-
Kreso, A.1
-
37
-
-
84908032167
-
Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity
-
Marusyk, A. et al. Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity. Nature 514, 54-58 (2014).
-
(2014)
Nature
, vol.514
, pp. 54-58
-
-
Marusyk, A.1
-
38
-
-
84878862323
-
Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer
-
Bardelli, A. et al. Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer. Cancer Discov. 3, 658-673 (2013).
-
(2013)
Cancer Discov.
, vol.3
, pp. 658-673
-
-
Bardelli, A.1
-
39
-
-
84883143193
-
Stromal disrupting effects of nab-paclitaxel in pancreatic cancer
-
Alvarez, R. et al. Stromal disrupting effects of nab-paclitaxel in pancreatic cancer. Br. J. Cancer 109, 926-933 (2013).
-
(2013)
Br. J. Cancer
, vol.109
, pp. 926-933
-
-
Alvarez, R.1
-
40
-
-
83355169753
-
Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: A phase I/II trial
-
Von Hoff, D. D. et al. Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. J. Clin. Oncol. 29, 4548-4554 (2011).
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 4548-4554
-
-
Von Hoff, D.D.1
-
41
-
-
84886741654
-
Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
-
Von Hoff, D. D. et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N. Engl. J. Med. 369, 1691-1703 (2013).
-
(2013)
N. Engl. J. Med.
, vol.369
, pp. 1691-1703
-
-
Von Hoff, D.D.1
-
42
-
-
79955525586
-
Primary resistance to cetuximab in a panel of patient-derived tumour xenograft models: Activation of MET as one mechanism for drug resistance
-
Krumbach, R. et al. Primary resistance to cetuximab in a panel of patient-derived tumour xenograft models: activation of MET as one mechanism for drug resistance. Eur. J. Cancer 47, 1231-1243 (2011).
-
(2011)
Eur. J. Cancer
, vol.47
, pp. 1231-1243
-
-
Krumbach, R.1
|