Recombinant VAA-I from viscum album induces apoptotic cell death of hepatocellular carcinoma SMMC7721 cells

Molecules

Volumn 17, Issue 10, 2012, Pages 11435-11446

  Yang, Xueliang ^a,b   Jiang, Shuang ^b   Liu, Yahui ^a   Zhang, Ping ^a   Xie, Shuli ^a   Wang, Guangyi ^a  

^a JILIN UNIVERSITY   (China)

^b BEIHUA UNIVERSITY   (China)

Author keywords

Apoptosis; Phosphoinositide 3 kinase; rVAA I; Viscum album

Indexed keywords

ANTINEOPLASTIC AGENT; CALCIUM; CASPASE; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE INHIBITOR; RECOMBINANT PROTEIN; RIBOSOME INACTIVATING PROTEIN; TOXIN; VAA I PROTEIN, VISCUM ALBUM; VAA-I PROTEIN, VISCUM ALBUM;

APOPTOSIS; ARTICLE; CHEMISTRY; DRUG EFFECT; GENETICS; HUMAN; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; MITOCHONDRION; PICHIA; SIGNAL TRANSDUCTION; TIME; TUMOR CELL LINE; VISCUM ALBUM;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CALCIUM; CARCINOMA, HEPATOCELLULAR; CASPASES; CELL LINE, TUMOR; CYTOCHROMES C; HUMANS; LIVER NEOPLASMS; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PICHIA; PROTEIN KINASE INHIBITORS; RECOMBINANT PROTEINS; RIBOSOME INACTIVATING PROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS; TOXINS, BIOLOGICAL; VISCUM ALBUM;

EID: 84868159209     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules171011435     Document Type: Article

References (22)

1. Hajto, T.; Hostanska, K. Modulatory potency of the β- galactosidespecific lectin from mistletoe extract (Iscador) on the host defense system in vivo in rabbits and patients. Cancer Res. 1989, 49, 4803-4808.
2. Lavastre, V.; Chiasson, S. Viscum album agglutinin-I (VAA-I) induces apoptosis and degradation of cytoskeletal proteins in human leukemia PLB-985 and X-CGD cells via caspases: Lamin B1 is a novel target of VAA-I. Leuk. Res. 2005, 29, 1443-1453.
3. Lacadena, J.; Aderra, M. Fungal ribotoxins: Molecular dissection of a family of natural killers. FEMS Microbiol. Rev. 2007, 31, 212-237.
4. Hajto, T.; Gabius, H.J. Increased secretion of tumor necrosis factor a, interleukin 1, and interleukin 6 by human mononuclear cells exposed to β-galactoside-specific lectin from clinically applied misletoe extract. Cancer Res. 1990, 50, 3322-3326.
5. Janssen, O.; Kabelitz, D. In vitro effects of mistletoe extracts and mistletoe lectins. Cytotoxicity towards tumor cells due to the induction of programmed cell death (apoptosis). Drug Res. 1993, 43, 1221-1227.
6. Müeller, E.A.; Anderer, F.A. A Viscum album oligosaccharide activating human natural cytotoxicity is an interferon-gamma inducer. Cancer Immunol. Immunother. 1990, 32, 221-227.
7. Büssing, A.; Schweizer, K. Induction of apoptosis in human lymphocytes treated with Viscum album L is mediated by mistletoe lectins. Cancer Lett. 1996, 99, 59-72.
8. 2+)i, and induces cell death. Naunyn Schmiedebergs Arch. Pharmacol. 1997, 355, 190-197.
9. Scott, M.G.; Storez, H. Cooperative regulation of extracellular signal-regulated kinase activation and cell shape change by Filamin A and β-Arrestins. Mol. Cell Biol. 2006, 26, 3432-3445.
10. Soothill, J.S.; Girling, A.J. The IC50: An exactly defined measure of antibiotic sensitivity. J. Antimicrob. Chemother. 1992, 29, 137-139.
11. Momoi, T. Caspases involved in ER stress-mediated cell death. J. Chem. Neuroanat. 2004, 28, 101-105.
12. Koyama, Y.; Tohyama, M. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced. J. Cell Biol. 2004, 165, 347-356.
13. Salvesen, G.S. Caspases and apoptosis. Essays Biochem. 2002, 38, 9-19.
14. Huyen, J.D.; Kaveri, S.V. Induction of Apoptosis of Endothelial Cells by Viscum album: A Role for Anti-Tumoral Properties of Mistletoe Lectins. Mol. Med. 2002, 8, 600-606.
15. Kim, H.; Glogauer, M. Filamin A regulates cell spreading and survival via β1 integrins. Exp. Cell Res. 2008, 314, 834-846.
16. Marti, A.; Cunningham, C. Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells. J. Biol. Chem. 1997, 272, 2620-2628.
17. Woo, M.S.; Rabinovitz, I. Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site. Mol. Cell. Biol. 2004, 24, 3025-3035.
18. Cullere, X.; Andersson, L. Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase. Blood 2005, 105, 1950-1955.
19. Gillis, P.A.; Rice, S.A. Herpes simplex virus type 1 ICP27 induces p38 mitogen-activated protein kinase signaling and apoptosis in HeLa cells. J. Virol. 2009, 83, 1767-1777.
20. Pei, B.; Guo, X. Arsenite-induced germline apoptosis through a MAPK-dependent, p53-independent pathway in Caenorhabditis elegans. Chem. Res. Toxicol. 2008, 21, 1530-1535.
21. Mylonis, I.; Paraskeva, E. A typical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1alpha by MAPK. J. Biol. Chem. 2008, 283, 27620-27627.
22. δδCt method. Methods. 2001, 25, 402-408.