Mistletoe lectin activates caspase-8/FLICE independently of death receptor signaling and enhances anticancer drug-induced apoptosis

Cancer Research

Volumn 59, Issue 9, 1999, Pages 2083-2090

  Bantel, Heike ^a   Engels, Ingo H ^a   Voelter, Wolfgang ^a   Schulze Osthoff, Klaus ^a   Wesselborg, Sebastian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; LECTIN; PLANT EXTRACT;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER ADJUVANT THERAPY; CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REGULATORY MECHANISM; VISCUM ALBUM;

AMINO ACID CHLOROMETHYL KETONES; ANTIBIOTICS, ANTINEOPLASTIC; ANTIGENS, CD95; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; ARABIDOPSIS PROTEINS; BREFELDIN A; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CYSTEINE PROTEINASE INHIBITORS; CYTOCHROME C GROUP; DRUG SYNERGISM; ENZYME ACTIVATION; ENZYME PRECURSORS; ETOPOSIDE; FATTY ACID DESATURASES; HUMANS; JURKAT CELLS; LEUKEMIA, B-CELL; LEUKEMIA, T-CELL, ACUTE; MITOCHONDRIA; MITOMYCIN; NEOPLASM PROTEINS; PLANT PREPARATIONS; PLANT PROTEINS; PROTEINS; TOXINS, BIOLOGICAL; TUMOR CELLS, CULTURED;

EID: 0033135490     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Hajto, T., Hostanska, K., Frei, K., Rordorf, C., and Gabius, H. J. Increased secretion of tumor necrosis factor-α, interleukin-1, and interleukin-6 by human mononuclear cells exposed to β-galactoside-specific lectin from clinically applied mistletoe extract. Cancer Res., 50: 3322-3326, 1990.
2. Beuth, J., Ko, H. L., Gabius, H. J., Burrichter, H., Oette, K., and Pulverer, G. Behavior of lymphocyte subsets and expression of activation markers in response to immunotherapy with galactoside-specific lectin from mistletoe in breast cancer patients. Clin. Investig., 70: 658-661, 1992.
3. Peumans, W. J., Verhaert, P., Pfuller, U., and Van Damme, E. J. Isolation and partial characterization of a small chitin-binding lectin from mistletoe (Viscum album). FEBS Lett., 396: 261-265, 1996.
4. Franz, H. Mistletoe lectins and their A and B chains. Oncology, 43: 23-34, 1986.
5. Franz, H., Ziska, P., and Kindt, A. Isolation and properties of three lectins from mistletoe (Viscum album L.). Biochem. J., 195: 481-484, 1981.
6. Hajto, T., Hostanska, K., and Gabius, H. J. Modulatory potency of the β-galactoside-specific lectin from mistletoe extract (Iscador) on the host defense system in vivo in rabbits and patients. Cancer Res., 49: 4803-4808, 1989.
7. Soler, M. H., Stoeva, S., Schwamborn, C., Wilhelm, S., Stiefel, T., and Voelter, W. Complete amino acid sequence of the A-chain of mistletoe lectin I. FEBS Lett., 399: 153-157, 1996.
8. Soler, M. H., Stoeva, S., and Voelter, W. Complete amino acid sequence of the B-chain of mistletoe lectin I. Biochem. Biophys. Res. Commun., 246: 596-601, 1998.
9. Endo, Y., Tsurugi, K., and Franz, H. The site of action of the A-chain of mistletoe lectin I on eukaryotic ribosomes. The RNA N-glycosidase activity of the protein. FEBS Lett., 231: 378-380, 1988.
10. Beuth, J. Clinical relevance of immunoactive mistletoe lectin-I. Anticancer Drugs, 8: S53-S55, 1997.
11. Ribereau-Gayon, G., Dumont, S., Muller, C., Jung, M. L., Poindron, P., and Anton, R. Mistletoe lectins I, II and III induce the production of cytokines by cultured human monocytes. Cancer Lett., 109: 33-38, 1996.
12. Stein, G. M., and Berg, P. A. Mistletoe extract-induced effects on immunocompetent cells: in vitro studies. Anticancer Drugs, 8: S39-S42, 1997.
13. Heiny, B. M., and Beuth, J. Mistletoe extract standardized for the galactoside-specific tectin (ML-1) induces β-endorphin release and immunopotentiation in breast cancer patients. Anticancer Res., 14: 1339-1342, 1994.
14. Falconer, J., Chan, E. C., Madsen, G., Thomson, M., Davies, J., and Smith, R. Secretion of β-endorphin into the maternal circulation by uteroplacental tissues in response to hypoglycaemic stress. J. Endocrinol., 118: 5-8, 1988.
15. Janssen, O., Scheffler, A., and Kabelitz, D. In vitro effects of mistletoe extracts and mistletoe lectins. Cytotoxicity towards tumor cells due to the induction of programmed cell death (apoptosis). Arzneim-Forsch./Drug Res., 43: 1221-1227, 1993.
16. Büssing, A., Suzart, K., Bergmann, J., Pfuller, U., Schietzel, M., and Schweizer, K. Induction of apoptosis in human lymphocytes treated with Viscum album L. is mediated by the mistletoe lectins. Cancer Lett., 99: 59-72, 1996.
17. Möckel, B., Schwarz, T., Zinke, H., Eck, J., Langer, M., and Lentzen, H. Effects of mistletoe lectin I on human blood cell lines and peripheral blood cells. Cytotoxicity, apoptosis and induction of cytokines. Arzneim-Forsch./Drug Res., 47: 1145-1151, 1997.
18. Cohen, G. M. Caspases: the executioners of apoptosis. Biochem. J., 326: 1-16, 1997.
19. Nicholson, D. N., and Thornberry, N. A. Caspases: killer proteases. Trends Biochem. Sci., 22: 299-306, 1997.
20. Stroh, C., and Schulze-Osthoff, K. Death by a thousand cuts: an ever increasing list of caspase substrates. Cell Death Differ., 5: 977-1000, 1998.
21. Enari, M., Sakahiera, H., Yokoyama, H., Okawa, K., Iwamatsu, A., and Nagata, S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature (Lond.), 391: 43-50, 1998.
22. Nagata, S. Apoptosis by death factor. Cell, 88: 355-365, 1997.
23. Schulze-Osthoff, K., Ferrari, D., Los, M., Wesselborg, S., and Peter, M. E. Apoptosis signaling by death receptors. Eur. J. Biochem., 254: 439-459, 1998.
24. Kischkel, F. C., Hellbardt, S., Behrmann, I., Germer, M., Pawlita, M., Krammer, P. H., and Peter, M. E. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J., 14: 5579-5588, 1995.
25. Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., Mann, M., Krammer, P. H., Peter, M. E., and Dixit, V. M. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell, 85: 817-827, 1996.
26. Kluck, R. M., Bossy Wetzel, E., Green, D. R., and Newmeyer, D. D. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science (Washington DC), 275: 1132-1136, 1997.
27. Yang, J., Liu, X., Bhalla, K., Kim, C. N., Ibrado, A. M., Cai, J., Peng, T. I., Jones, D. P., and Wang, X. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science (Washington DC), 275: 1129-1132, 1997.
28. Zou, H., Henzel, W. J., Liu, X., Lutschg, A., and Wang, X. Apaf-1, a human protein, homologous to C. elegans Ced-4, participates in cytochrome c-dependent activation of caspase-3. Cell, 90: 405-413, 1997.
29. Krippner, A., Matsuno-Yagi, A., Gottlieb, R. A., and Babior, B. M. Loss of function of cytochrome c in Jurkat cells undergoing fas-mediated apoptosis. J. Biol. Chem., 271: 21629-21636, 1996.
30. Adachi, S., Cross, A. R., Babior, B. M., and Gotllieb, R. A. Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome c during Fas-mediated apoptosis. J. Biol. Chem., 272: 21878-21882, 1997.
31. Li, H., Zhu, H., Xu, C J., and Yuan, J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell, 94: 491-501, 1998.
32. Luo, X., Budihardjo, I., Zou, H., Slaughter, C., and Wang, X. Bid, a Bcl2 interacting protein, mediates cy tochrome c release from mitochondria in response to activation of cell surface death receptors. Cell, 94: 481-490, 1998.
33. Friesen, C., Herr, I., Krammer, P. H., and Debatin, K. M. Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nat. Med., 2: 574-577, 1996.
34. Müller, M., Strand, S., Hug, H., Heinemann, E. M., Walczak, H., Hofmann, W. J., Stremmel, W., Krammer, P. H., and Galle, P. R. Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53. J. Clin. Invest., 99: 403-413, 1997.
35. Aragane, Y., Kulms, D., Metze, D., Wilkes, G., Poeppelmann, B., Luger, T. A., and Schwarz, T. Ultraviolet light induces apoptosis via activation of CD95 (Fas/APO-1) independently from its ligand CD95L. J. Cell Biol., 140: 171-182, 1998.
36. Chinnaiyan, A. M., O'Rourke, K., Tewari, M., and Dixit, V. M. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell, 81: 505-512, 1995.
37. Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F., and Riccardi, C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods, 139: 271-279, 1991.
38. Berenbaum, M. C. Criteria for analyzing interactions between biologically active agents. Adv. Cancer Res., 35: 269-335, 1981.
39. Zamzami, N., Marchetti, P., Castedo, M., Decaudin, D., Macho, A., Hirsch, T., Susin, S. A., Petit, P. X., Mignotte, B., and Kroemer, G. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J. Exp. Med., 182: 367-377, 1995.
40. Fearnhead, H. O., Rodriguez, J., Govek, E-E., Guo, W., Kobayashi, R., Hannon, G., and Lazebnik, Y. A. Oncogene-dependent apoptosis is mediated by caspase-9. Proc. Natl. Acad. Sci. USA, 95: 13664-13669, 1998.
41. Medema, J. P., Scaffidi, C., Kischkel, F. C., Shevchenko, A., Mann, M., Krammer, P. H., and Peter, M. E. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J., 16: 2794-2804, 1997.
42. Scaffidi, C., Medema, J. P., Krammer, P. H., and Peter, M. E. FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b. J. Biol. Chem., 272: 26953-26958, 1997.
43. Boldin, M. P., Goncharov, T. M., Goltsev, Y. V., and Wallach, D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell, 85: 803-815, 1996.
44. Chinnaiyan, A. M., O'Rourke, K., Yu, G. L., Lyons, R. H., Garg, M., Duan, D. R., Xing, L., Gentz, R., Ni, J., and Dixit, V. M. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science (Washington DC), 274: 990-992, 1996.
45. Schneider, P., Thome, M., Burs, K., Bodmer, J. L., Hofman, K., Kataoka, T., Holler, N., and Tschopp, J. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-κB. Immunity, 7: 831-836, 1997.
46. Pan, G., O'Rourke, K., Chinnaiyan, A. M., Gentz, R., Ebner, R., Ni, J., and Dixit, V. M. The receptor for the cytotoxic ligand TRAIL. Science (Washington DC), 276: 111-113, 1997.
47. Sandvig, K., Prydz, K., Hansen, S. H., and van Deurs, B. Ricin transport in brefeldin A-treated cells: correlation between Golgi structure and toxic effect. J. Cell Biol., 115: 971-981, 1991.
48. Susin, S. A., Zamzami, N., and Kroemer, G. Mitochondria as regulators of apoptosis: doubt no more. Biochim. Biophys. Acta, 1366: 151-165, 1998.
49. Doser, C., Doser, M., Hulsen, H., and Mechelke, F. Influence of carbohydrates on the cytotoxicity of an aqueous mistletoe drug and of purified mistletoe lectins tested on human T-leukemia cells. Arzneim-Forsch./Drug Res., 39: 547-651, 1989.
50. Ribereau-Gayon, G., Jung, M. L., Baudino, S., Salle, G., and Beck, J. P. Effects of mistletoe (Viscum album L.) extracts on cultured tumor cells. Experientia, 42: 594-599, 1986.
51. Dietrich, J. B., Ribereau-Gayon, G., Jung, M. L., Franz, H., Beck, J. P., and Anton, R. Identity of the N-terminal sequences of the three A chains of mistletoe (Viscum album L.) lectins: homology with ricin-like plant toxins and single-chain ribosome-inhibiting proteins. Anticancer Drugs, 3: 507-511, 1992.
52. Beuth, J., Ko, H. L., Gabius, H. J., and Pulverer, G. Influence of treatment with the immunomodulatory effective dose of the β-galactoside-specificl lectin from mistletoe on tumor colonization in BALB/c-mice for two experimental model systems. In Vivo (Athens), 5: 29-32, 1991.
53. Antony, S., Kuttan, R., and Kuttan, G. Effect of Viscum album in the inhibition of lung metastasis in mice induced by B16F10 melanoma cells. J. Exp. Clin. Cancer Res., 16: 159-162, 1997.
54. Hajto, T., Hostanska, K., Fornalski, M., and Kirsch, A. Antitumor activity of β-galactoside specific mistletoe lectin as immunomodulator applied by mistletoe extracts (Iscador). Dtsch. Zschr. Onkol., 23: 1-6, 1991.
55. Fulda, S., Sieverts, H., Friesen, C., Herr, I., and Debatin, K. M. The CD95 (APO-1/ Fas) system mediates drug-induced apoptosis in neuroblastoma cells. Cancer Res., 57: 3823-3829, 1997.
56. Perillo, N. L., Pace, K. E., Seilhamer, J. J., and Baum, L. G. Apoptosis of T cells mediated by galectin-1. Nature (Lond.), 378: 736-739, 1995.
57. Vander Heiden, M. G., Chandel, N. S., Williamson, E. K., Schumacker, P. T., and Thompson, C. G. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell, 91: 627-637, 1997.
58. Bossy-Wetzel, E., Newmeyer, D. D., and Green, D. R. Mitochondrial cytochrome c release occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J., 17: 37-49, 1998.
59. Zhuang, J., Dinsdale, D., and Cohen, G. M. Apoptosis, in human monocytic THP.1 cells, results in the release of cytochrome c from mitochondria prior to their ultra-condensation, formation of outer membrane discontinuities and reduction in inner membrane potential. Cell Death Differ., 5: 953-962, 1998.
60. Rossé, T., Olivier, R., Monney, L., Rager, M., Conus, S., Fellay, I., Jansen, B., and Borner, C. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c. Nature (Lond.), 391: 496-499, 1998.
61. Deveraux, Q. L., Roy, N., Stennicke, H. R., Van Arsdale, T., Zhou, Q., Srinivasula, S. M., Alnemri, E. S., Salvesen, G. S., and Reed, J. C. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J., 17: 2215-2223, 1998.
62. Baichwal, V. R., and Baeuerle, P. A. Activate NF-κB or die? Curr. Biol., 7. R94-R96, 1997.