Association of NOTCH with different microRNAs in head and neck cancer

Cellular and Molecular Biology

Volumn 61, Issue 6, 2015, Pages 9-16

  Masood, Nosheen ^a   Qureshi, M Z ^b   Yasmin, A ^a  

^a FATIMA JINNAH WOMEN UNIVERSITY   (Pakistan)

^b GCU   (Pakistan)

Author keywords

Head and neck cancer; MicroRNA; Mutations; NOTCH1; P16

Indexed keywords

MICRORNA; MK 0752; N (6,7 DIHYDRO 6 OXO 5H DIBENZ[B,D]AZEPIN 7 YL) 2,2 DIMETHYL N' (2,2,3,3,3 PENTAFLUOROPROPYL)PROPANEDIAMIDE; NOTCH RECEPTOR; PROTEIN P16; NOTCH1 PROTEIN, HUMAN; NOTCH1 RECEPTOR; P16 PROTEIN, HUMAN; TUMOR PROTEIN;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CLINICAL TRIAL (TOPIC); GENE MUTATION; HEAD AND NECK CANCER; HUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; ANIMAL; GENETICS; HEAD AND NECK NEOPLASMS; METABOLISM;

ANIMALS; HEAD AND NECK NEOPLASMS; HUMANS; MICRORNAS; NEOPLASM PROTEINS; RECEPTOR, NOTCH1;

EID: 84962175330     PISSN: 01455680     EISSN: 1165158X     Source Type: Journal    
DOI: 10.14715/cmb/2015.61.6.3     Document Type: Article

References (98)

1. Bose, P., Brockton, N.T. and Dort, J.C., Head and neck cancer from anatomy to biology. Int.J.Cancer. 2013,133: 2013-2023.
2. Maier, H., Dietz, A., Gewelke, U., Heller, W.,D. and Weidauer, H., Tobacco and alcohol and the risk of head and neck cancer. Clin. Investig. 1992, 70:320-327.
3. Liu, X., Chen, Z., Yu, J., Xia, J. and Zhou, X., MicroRNA profiling and head and neck cancer.Comp.Func. Genom. 2009, doi: 10.1155/2009/837514.
4. Toru, H., Masaharu, Y. and Shinji, T., Genetic polymorphisms and head and neck cancer risk. Int. J. Oncol. 2008, 32: 945-73.
5. McWilliams, J.,E., Evans, A.,J., Beer, T.,M., Andersen, P.,E., Cohen, J.,I., Everts, E.,C. andHenner, W.,D., Genetic polymorphisms in head and neck cancer risk. Head Neck. 2000, 22(6):609-17.
6. Chen, D., Cabay, J.R., Wang, A., Lu, Y., Khan, S.M. and Zhou, X.,MicroRNA deregulations in head and neck squamous cell carcinomas. J. Oral.Maxillofac. Res.2013, 4: e2.
7. Bentwich, I., Avniel, A., Karov Y., Aharonov, R., Gilad, S., Barad, O., Barzilai, A., Einat, P., Einav, U., Meiri, E., Sharon, E., Spector, Y. and Bentwich Z., Identification of hundreds of conserved and nonconserved human microRNAs.Nature Genetics. 2005,37(7): 766-770.
8. Tran, N., McLean, T., Zhang, X., Zhao, C.J., Thomson, J.M., Brien, C. and Rose, B., MicroRNA expression profiles in head and neck cancer cell lines. Biochem.Biophy. Res. Comm.2007, 358: 12-17.
9. Avissar, M., Christensen, B.C., Kelsey, K.T. and Marsit, C.J., A MicroRNA Expression Ratio is Predictive of Head and Neck Squamous Cell Carcinoma. Clin. Cancer Res. 2009,15(8): 2850-2855.
10. Liu, X., Jiang, L., Wang, A., Yu, J., Shi, F. and Zhou X., MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines. Cancer Lett.2009, 286(2): 217-222.
11. Hui, A.B.Y., Lenarduzzi, M., Krushel, T., Waldron, L., Pintille, M., Shi, W., Ordonnez, B., Jurisica, I., Sullivan, B., Waldron, J., Gullane, P., Cummings, B. and Liu, F., Comprehensive microRNA profiling for head and neck squamous cell carcinomas.Clin. Cancer Res.2010, 16: 1129-1139.
12. Orang, A.V., Safaralizadeh, R. and Kazemzadeh-Bavili, M., Mechanisms of miRNA-mediated gene regulation from common downregulation to mRNA-specific upregulation.Int. J. Genom. 2014, 2014: 970607.doi: 10.1155/2014/970607.
13. Wald, A.I., Hoskins, E.E., Wells, S.I., Ferris, R.L. and Khan, S.A., Human papillomavirus alters microRNA profiles in squamous cell carcinoma of the head and neck (SCCHN) cell lines. Head Neck. 2011,33(4): 504-512.
14. Hebert, C., Norris, K., Scheper, M.A., Nikitakis, N. and Sauk, J.J., High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma. Mol. Cancer.2007, 6(5): 1-11.
15. Kozaki, K.I., Imoto, I., Mogi, S., Omura, K. and Inazawa, J., Exploration of tumor suppressive microRNAs silenced by DNA hypermethylation in oral cancer.Cancer Res.2008, 68(7): 2094-2105.
16. Wong, T.S., Liu, X.B., Wong, B.Y., Ng, R.W., Yuen, A.P., Wei, W.I., Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue. Clin. Cancer Res.2008, 14: 2588-2592.
17. Yu, T., Wang, X.Y., Gong, R.G., Li, A., Yang, S., Cao, Y.T., Wen, Y.M., Wang, C.M., Yi, X.Z.,The expression profile of microRNAs in a model of 7,12-dimethyl-benz[a]anthrance-induced oral carcinogenesis in Syrian hamster. J. Exp. Clin. Cancer Res. 2009, 28: 64.
18. Yeun, P.W., Man, M., Lam, K.Y. and Kwong, Y.L.,Clinicopathological significance of p16 gene expression in in the surgical treatment of head and neck squamous cell carcinomas.J. Clin. Pathol.2002, 55: 58-60.
19. Perez-Ordonez, P.,Beauchemin, M. and Jordan R.C.K., Molecular biology of squamous cell carcinoma of the head and neck.J. Clin. Pathol.2009, 59:445-453.
20. Patrick, K.H., Chang, S.S., Glazer, C.A., Califano, J.A. and Sidransky, D., Molecular techniques and genetic alterations in head and neck cancer.Oral Oncol.2009, 45(4): 335-339.
21. Tohda, S., NOTCH signaling roles in acute myeloid leukemia cell growth and interaction with other stemness-related signals.Anticancer Res. 2014, 34(11):6259-64.
22. Takebe, N., Miele, L., Harris, P.J., Jeong, W., Bando, H., Kahn, M., Yang, S.X. and Ivy, S.P.,Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update.Nat Rev Clin Oncol.2015, doi: 10.1038/nrclinonc.2015.61.
23. Flores, A.N., McDermott, N., Meunier, A. and Marignol, L.,NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer.Nat Rev Urol. 2014, 11(9):499-507.
24. Cama, A., Verginelli, F., Lotti, L.V., Napolitano, F., Morgano, A., D'Orazio, A., Vacca, M., Perconti, S., Pepe, F., Romani, F., Vitullo, F., di Lella, F., Visone, R., Mannelli, M., Neumann, H.P., Raiconi, G., Paties, C., Moschetta, A., Tagliaferri, R., Veronese, A., Sanna, M. and Mariani-Costantini, R., Integrative genetic, epigenetic and pathological analysis of paraganglioma reveals complex dysregulation of NOTCH signaling.Acta Neuropathol. 2013, 126(4):575-94.
25. Song, Y., Li, L., Ou, Y., Gao, Z., Li, E., Li, X., Zhang, W., Wang, J., Xu, L., Zhou, Y., Ma, X., Liu, L., Zhao, Z., Huang, X., Fan, J., Dong, L., Chen, G., Ma, L., Yang, J., Chen, L., He, M., Li, M., Zhuang, X., Huang, K., Qiu, K., Yin, G., Guo, G., Feng, Q., Chen, P., Wu, Z., Wu, J., Ma, L., Zhao, J., Luo, L., Fu, M., Xu, B., Chen, B., Li, Y., Tong, T., Wang, M., Liu, Z., Lin, D., Zhang, X., Yang, H., Wang, J. and Zhan, Q., Identification of genomic alterations in oesophageal squamous cell cancer.Nature. 2014, 509(7498):91-5.
26. Agrawal, N., Frederick, M.J., Pickering, C.R., Bettegowda, C. and Chang, K., Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science.2011, 333: 1154-1157.
27. Leethanakul, C., Patel, V., Gillespie, J., Pallente, M., Ensley, J.F., Koontongkaew, S., Liotta, L.A., Emmert-Buck, M. and Gutkind, J.S., Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays. Oncogene.2000, 19: 3220-3224.
28. Stransky, N., Egloff, A.M., Tward, A.D., Kostic, A.D., Cibulskis, K., The mutational landscape of head and neck squamous cell carcinoma. Science.2011, 333: 1157-1160.
29. Baldus, C.D., Thibaut, J., Goekbuget, N., Stroux, A., Schlee, C., Mossner, M., Burmeister, T., Schwartz, S., Bloomfield, C.D., Hoelzer, D., Thiel, E. and Hofmann, W.K., Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia. Haematologic. 2009, 94: 1383-1390.
30. Pickering, C.R., Zhang, J., Yoo, S.Y., Bengtsson, L., Moorthy, S., Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers. Cancer Discov.2013, 3: 770-781.
31. South, A.P., Purdie, K.J., Watt, S.A., Haldenby, S., NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis. J. Invest.Dermatol.2014, 134: 2630-2638.
32. Hijioka, H., Setoguchi, T., Miyawaki, A., Gao, H., Ishida, T., Komiya, S. and Nakamura, N., Upregulation of Notch pathway molecules in oral squamous cell carcinoma. Int. J.Oncol.2010, 36: 817-822.
33. Yao, J., Duan, L., Fan, M. and Wu, X., Gamma-secretase inhibitors exerts antitumor activity via down-regulation of Notch and Nuclear factor kappa B in human tongue carcinoma cells. Oral Dis.2007, 13: 555-563.
34. Pang, T.K., Leung, O.N., Ye, T.M., Liu, W., Chiu, P.N., Lam, K.W., Lee, K. andYeung, S.B., MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells.Carcinogenesis. 2010, 31(6): 1037-1044.
35. Zhang, L., Dong, Y., Zhu, N., Tsoi, H., Zhao, Z., Wu, C., Wang, K., Zheng, S., Ng, S.M., Chan, F.K.L., Sung, J.Y. and Yu, J., MicroRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer. Mol. Cancer. 2014, 13:124.
36. Capuano, M., Iaffaldano, L., Tinto, N., Montanaro, D., Capobianco, V., Izzo, V., Tucci, F., Troncone, G., Greco, L. andSacchetti, L. MicroRNA-449a Overexpression, Reduced NOTCH1 Signals and Scarce Goblet Cells Characterize the Small Intestine of Celiac Patients. PLoS ONE. 2011,6(12): 1-10.
37. Hatziapostolou, M., Polytarchou, C., Aggelidou, E., Drakaki, A., Poultsides, G.A. and Jaeger, S.A., Ogata H, Karin M, Struhl F K, Hadzopoulou-Cladaras M, Iliopoulos D. An HNF4a-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell2011, 147:1233-1247.
38. Lin, S.C., Liu, C.J., Lin, J.A., Chiang, W.F., Hung, P.S. and Chang, K.W., miR-24 up-regulation inoral carcinoma: Positive association from clinical and in vitro analysis. Oral Oncol. 2010,46:204-208.
39. Wu, Q., Wang, C., Lu, Z., Guo, L. andGe, Q., Analysis of serum genome-wide microRNAs forbreast cancer detection. Clin.Chim. Acta.2012, 413:1058-1065.
40. Nymark, P., Guled, M., Borze, I., Faisal, A., Lahti, L., Salmenkivi, K., Kettunen, E., Anttila, S. andKnuutila, S., Integrative analysis of microRNA, mRNA and aCGH data revealsasbestos- and histology related changes in lung cancer. Gene.Chrom. Cancer.2011, 50:585-597.
41. Giglio, S., Cirombella, R., Amodeo, R., Portaro, C., Lavra, L. and Vecchione, A. MicroRNA miR-24 Promotes Cell Proliferation by Targeting the CDKs Inhibitors p27Kip1 and p16INK4a. J. Cell. Physiol. 2013, 228: 2015-2023.
42. Lee, S., Jung, J.W., Park, S.B., Roh, K., Lee, S.Y., Kim, J.H., Kang, S.K. and Kang, K.S., Histone deacetylase regulates high mobility group A2-targeting microRNAs in human cord blood-derived multipotent stem cell aging. Cell. Mol. Life Sci. 2011,68:325-336.
43. Fu, W.M., Zhu, X., Wang, W.M., Lu, Y.F., Hu, B.G., Wang, H., Liang, W.C., Wang, S.S., Ko, C.H., Waye, M.M., Kung, H.F., Li, G. and Zhang, J.F.,Hotair Mediates Hepatocarcinogenesis through Suppressing MiRNA-218 Expression and Activating P14 and P16 Signaling.J Hepatol. 2015,. pii: S0168-8278(15)00343-8.
44. Diaz-Padilla, I., Wilson, M.K., Clarke, B.A., Hirte, H.W., Welch, S.A., Mackay, H.J., Biagi, J.J., Reedijk, M., Weberpals, J.I., Fleming, G.F., Wang, L., Liu, G., Zhou, C., Blattler, C., Ivy, S.P. and Oza, A.M., A phase II study of single-agent RO4929097, a gamma-secretase inhibitor of Notch signaling, in patients with recurrent platinum-resistant epithelial ovarian cancer: A study of the Princess Margaret, Chicago and California phase II consortia.GynecolOncol. 2015, 137(2):216-22.
45. Lee, S.M., Moon, J., Redman, B.G., Chidiac, T., Flaherty, L.E., Zha, Y., Othus, M., Ribas, A., Sondak, V.K., Gajewski, T.F. and Margolin, K.A., Phase 2 study of RO4929097, a gamma-secretase inhibitor, in metastatic melanoma: SWOG 0933.Cancer. 2015, 121(3):432-40.
46. Richter, S., Bedard, P.L., Chen, E.X., Clarke, B.A., Tran, B., Hotte, S.J., Stathis, A., Hirte, H.W., Razak, A.R., Reedijk, M., Chen, Z., Cohen, B., Zhang, W.J., Wang, L., Ivy, S.P., Moore, M.J., Oza, A.M., Siu, L.L. and McWhirter, E., A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575).Invest New Drugs. 2014, 32(2):243-9.
47. Brana, I., Berger, R., Golan, T., Haluska, P., Edenfield, J., Fiorica, J., Stephenson, J., Martin, L.P., Westin, S., Hanjani, P., Jones, M.B., Almhanna, K., Wenham, R.M., Sullivan, D.M., Dalton, W.S., Gunchenko, A., Cheng, J.D., Siu, L.L. and Gray, J.E., A parallel-arm phase I trial of the humanised anti-IGF-1R antibody dalotuzumab in combination with the AKT inhibitor MK-2206, the mTOR inhibitor ridaforolimus, or the NOTCH inhibitor MK-0752, in patients with advanced solid tumours.Br J Cancer. 2014, 111(10):1932-44.
48. Andersson, E.R. and Lendahl, U., Therapeutic modulation of Notch signalling--are we there yet?Nat Rev Drug Discov. 2014, 13(5):357-78.
49. Golan T, Messer AR, Amitai-Lange A, Melamed Z, Ohana R, Bell RE, Kapitansky O, Lerman G, Greenberger S, Khaled M, Amar N, Albrengues J, Gaggioli C, Gonen P, Tabach Y, Sprinzak D, Shalom-Feuerstein R, Levy C. Interactions of Melanoma Cells with Distal Keratinocytes Trigger Metastasis via Notch Signaling Inhibition of MITF. Mol Cell. 2015 Jul 29. pii: S1097-2765(15)00500-6.
50. Xiao W, Gao Z, Duan Y, Yuan W, Ke Y. Downregulation of miR-19a exhibits inhibitory effects on metastatic renal cell carcinoma by targeting PIK3CA and inactivating Notch signaling in vitro. Oncol Rep. 2015 Aug;34(2):739-46.
51. Mohammadi-Yeganeh S, Mansouri A, Paryan M. Targeting Of miR9/NOTCH1 Interaction Reduces Metastatic Behavior in Triple-negative Breast Cancer. Chem Biol Drug Des. 2015 May 11. doi: 10.1111/cbdd.12584.
52. Ma J, Fang B, Zeng F, Ma C, Pang H, Cheng L, Shi Y, Wang H, Yin B, Xia J, Wang Z. Down-regulation of miR-223 reverses epithelial-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells. Oncotarget. 2015 Jan 30;6(3):1740-9.
53. Yang G, Gong Y, Wang Q, Wang Y, Zhang X. The role of miR-100-mediated Notch pathway in apoptosis of gastric tumor cells. Cell Signal. 2015 Jun;27(6):1087-101.
54. Fayyaz S, Farooqi AA. miRNA and TMPRSS2-ERG do not mind their own business in prostate cancer cells. Immunogenetics. 2013 May;65(5):315-32.
55. Farooqi AA, Nawaz A, Javed Z, Bhatti S, Ismail M. While at Rome miRNA and TRAIL do whatever BCR-ABL commands to do. Arch Immunol Ther Exp (Warsz). 2013 Feb;61(1):59-74.
56. Farooqi AA, Fayyaz S, Shatynska-Mytsyk I, Javed Z, Jabeen S, Yaylim I, Gasparri ML, Panici PB. Is miR-34a a Well Equipped swordsman to Conquer Temple of Molecular Oncology? Chem Biol Drug Des. 2015 Aug 11. doi: 10.1111/cbdd.12634.
57. Misso G, Di Martino MT, De Rosa G, Farooqi AA, Lombardi A, Campani V, Zarone MR, Gullà A, Tagliaferri P, Tassone P, Caraglia M. Mir-34: a new weapon against cancer? Mol Ther Nucleic Acids. 2014 Sep 23;3:e194.
58. Farooqi AA, De Rosa G. TRAIL and microRNAs in the treat ment of prostate cancer: therapeutic potential and role of nanotechnology. Appl Microbiol Biotechnol. 2013 Oct;97(20):8849-57.
59. Farooqi AA, Naqi A, Qureshi MZ, Rana A, Khan A, Riaz AM, Afzal SM, Rasheed N, Bhatti S. Prostate cancer is known by the companionship with ATM and miRNA it keeps: craftsmen of translation have dual behaviour with tailors of life thread. Cell Biochem Funct. 2012 Oct;30(7):611-7.
60. Farooqi AA, Qureshi MZ, Coskunpinar E, Naqvi SK, Yaylim I, Ismail M. MiR-421, miR-155 and miR-650: emerging trends of regulation of cancer and apoptosis. Asian Pac J Cancer Prev. 2014;15(5):1909-12.
61. An, F., Zhang, Z., Xia, M., and Xing, L. Subpath analysis of each subtype of head and neck cancer based on the regulatory relationship between miRNAs and biological pathways. Oncol Rep. 2015, 34:1745-1754, doi: 10.3892/or.2015.4150
62. Zhao, L., Tang, M., Hu, Z., Yan, B., Pi, W., Li, Z., Zhang, J., Zhang, L., Jiang, W., Li, G., Qiu, Y., Hu, F., Liu, F., Lu, J., Chen, X., Xiao, L., Xu, Z., Tao, Y., Yang, L., Bode, A.M., Dong, Z., Zhou, J., Fan, J., Sun, L., and Cao, Y. miR-504 mediated down-regulation of nuclear respiratory factor 1 leads to radio-resistance in nasopharyngeal carcinoma. Oncotarget, 2015, 6:15995-16018
63. Hu, A., Huang, J.J., Xu, W.H., Jin, X.J., Li,J. P., Tang, Y.J, Huang, X.F., Cui, H.J., Sun, G,B., Li, R.L., Duan, J.L., and Duan, J.L. MiR-21/miR-375 ratio is an independent prognostic factor in patients with laryngeal squamous cell carcinoma. Am J Cancer Res, 2015, 5:1775-1785
64. Zhu, H., Xiaoyuan, Z., Genyang, C., Minghui, Z., and Weihua, L. Downregulation of microRNA-21 enhances radiosensitivity in nasopharyngeal carcinoma. Exp Ther Med, 2015, 9: 2185-2189
65. Xu, L, Zhifeng, C., Fei, X., Wei, C., Ruina, M., Shiyin, C., and Pengcheng, C. MicroRNA-24 inhibits growth, induces apoptosis, and reverses radioresistance in laryngeal squamous cell carcinoma by targeting X-linked inhibitor of apoptosis protein. Cancer Cell Int, 2015, 15:61, doi: 10.1186/s12935-015-0217-x
66. Chang, Y., Chia-Ing, J., Chih-Yu, P., Yu-Chi, L., Fang-Wei, H., and Cheng-Chia, Y. Activation of microRNA-494-targeting Bmi1 and ADAM10 by silibinin ablates cancer stemness and predicts favourable prognostic value in head and neck squamous cell carcinomas. Oncotarget, 2015
67. Coutinho-Camillo, C.M., Lourenço, S.V., de Araújo Lima, L., Kowalski, L.P., and Soares, F.A. Expression of apoptosis-regulating miRNAs and target mRNAs in oral squamous cell carcinoma. Cancer Genet, 2015, 208:382-9, doi: 10.1016/j.cancergen.2015.04.004
68. Cheng, Y., Yang, L., Yuanyuan, N., Dong, L., Fei D., and Jun, Z. STAT3 is involved in miR-124-mediated suppressive effects on esophageal cancer cells. BMC cancer, 2015, 15:306
69. Ratovitski, E.A. Phospho-ΔNp63α-responsive microRNAs contribute to the regulation of necroptosis in squamous cell carcinoma upon cisplatin exposure. FEBS lett, 589:1352-1358, doi: 10.1016/j.febslet.2015.04.020
70. Kalfert, D., Pesta, M., Kulda, V., Topolcan, O., Ryska, A., Celakovsky, P., Laco, J., and Ludvikova, M. MicroRNA Profile in Site-specific Head and Neck Squamous Cell Cancer. Anticancer Res, 2015, 35: 2455-2463
71. Darda, L., Hakami, F., Morgan, R., Murdoch, C., Lambert, D. W., and Hunter, K.D. The role of HOXB9 and miR-196a in head and neck squamous cell carcinoma. PloS One, 2015, 10:e0122285, doi: 10.1371/journal.pone.0122285
72. Fan, S., Chen, W.X., Lv, X.B., Tang, Q.L., Sun, L.J., Liu, B.D., Zhong, J.L., Lin, Z.Y., Wang, Y.Y., Li, Q.X., Yu, X., Zhang, H.Q., Li, Y.L., Wen, B., Zhang, Z., Chen, W.L., and Li, J.S. miR-483-5p determines mitochondrial fission and cisplatin sensitivity in tongue squamous cell carcinoma by targeting FIS1. Cancer lett, 2015, 362: 183-191, doi: 10.1016/j.canlet.2015.03.045 Esopha ment
73. Xu, Y., He, J., Wang, Y., Zhu, X., Pan, Q., Xie, Q., and Sun, F. miR-889 promotes proliferation of esophageal squamous cell carcinomas through DAB2IP. FEBS lett, 2015, 589:1127-1135, doi: 10.1016/j.febslet.2015.03.027
74. Wang, R., Fang, J., Ma, H., Feng, L., Lian, M., Yang, F., Wang, H., Wang, Q., and Chen, X. Effect of microRNA-203 on tumor growth in human hypopharyngeal squamous cell carcinoma. Mol Cell Biochem, 2015, 405:97-104, doi: 10.1007/s11010-015-2401-7
75. Hauser, B., Zhao, Y., Pang, X., Ling, Z., Myers, E., Wang, P., Califano, J., and Gu, X. Functions of MiRNA-128 on the Regulation of Head and Neck Squamous Cell Carcinoma Growth and Apoptosis. PloS One, 2015, 10:e0116321, doi: 10.1371/journal.pone.0116321
76. Peng, X., Cao, P., Li, J., He, D., Han, S., Zhou, J., Tan, G., Li, W., Yu, F., Yu, J., Li, Z., and Cao, K. MiR-1204 sensitizes nasopharyngeal carcinoma cells to paclitaxel both in vitro and in vivo. Cancer Biol Ther, 2015, 16:261-267, doi: 10.1080/15384047.2014.1001287
77. Ide, S., Toiyama, Y., Shimura, T., Kawamura, M., Yasuda, H., Saigusa, S., Ohi, M., Tanaka, K., Mohri, Y., and Kusunoki, M. MicroRNA-503 Promotes Tumor Progression and Acts as a Novel Biomarker for Prognosis in Oesophageal Cancer. Anticancer Res, 2015, 35:1447-1451.
78. Veit, J.A., Scheckenbach, K., Schuler, P.J., Laban, S., Wiggenhauser, S.P., Thierauf, J,. Klussmann J.P., and Hoffmann, T.K. MicroRNA Expression in Differentially Metastasizing Tumors of the Head and Neck: Adenoid Cystic Versus Squamous Cell Carcinoma. Anticancer Res, 2015, 35:1271-1277
79. Xu, Y.F., Li, Y.Q., Guo, R., He, Q.M., Ren, X.Y., Tang, X.R., Jia, W.H., Kang, T.B., Zeng, M.S., Sun, Y., Ma, J., and Liu, N. Identification of miR-143 as a tumour suppressor in nasopharyngeal carcinoma based on microRNA expression profiling. Int J Biochem Cell Biol, 2015, 61:120-128, doi: 10.1016/j.biocel.2015.02.006
80. Fukumoto, I., Hanazawa, T., Kinoshita, T., Kikkawa, N., Koshizuka, K., Goto, Y., Nishikawa, R., Chiyomaru, T., Enokida, H., Nakagawa, M., Okamoto, Y., and Seki, N. MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways. Br J Cancer, 2015, 112:891-900, doi: 10.1038/bjc.2015.19
81. Stanitz, E., Juhasz, K., Gombos, K., Gocze, K., Toth, C., and Kiss, I. Alteration of miRNA Expression Correlates with Lifestyle, Social and Environmental Determinants in Esophageal Carcinoma. Anticancer Res, 2015, 35:1091-1097
82. Li, G., Ren, S., Su, Z., Liu, C., Deng, T., Huang, D., Tian, Y., Qiu, Y., and Liu, Y. Increased expression of miR-93 is associated with poor prognosis in head and neck squamous cell carcinoma. Tumor Biol, 2015, 36:3949-3956, doi: 10.1007/s13277-015-3038-6
83. Wang, X., Li, M., Wang, Z., Han, S., Tang, X., Ge, Y., Zhou, L., Zhou, C., Yuan, Q., and Yang, M. Silencing of long noncoding rna malat1 by mir-101 and mir-217 inhibits proliferation, migration, and invasion of esophageal squamous cell carcinoma cells. J Biol Chem, 2015, 290:3925-3935, doi: 10.1074/jbc.M114.596866
84. Suh, Y.E., Raulf, N., Gäken, J., Lawler, K., Urbano, T.G., Bullenkamp, J., Gobeil, S., Huot, J., Odell, E., and Tavassoli, M. MicroRNA-196a promotes an oncogenic effect in head and neck cancer cells by suppressing annexin A1 and enhancing radioresistance. Int J Cancer, 2015, doi: 10.1002/ijc.29397
85. Boufraqech, M., Nilubol, N., Zhang, L., Gara, S.K., Sadowski, S.M., Mehta, A., He, M., Davis, S., Dreiling, J., Copland, J.A., Smallridge, R.C., Quezado, M.M., and Kebebew, E. miR30a Inhibits LOX Expression and Anaplastic Thyroid Cancer Progression. Cancer Res, 2015, 75:367-377, doi: 10.1158/0008-5472.CAN-14-2304
86. Zhang, R., Chen, X., Zhang, S., Zhang, X., Li, T., Liu, Z., Wang, J., Zang, W., Wang, Y., Du, Y., and Zhao, G. Upregulation of miR-494 Inhibits Cell Growth and Invasion and Induces Cell Apoptosis by Targeting Cleft Lip and Palate Transmembrane 1-Like in Esopha geal Squamous Cell Carcinoma. Dig Dis Sci, 2015, 60:1247-1255, doi: 10.1007/s10620-014-3433-7
87. Li, Y., Ahmad, A., Sarkar and F. H., ASPP and iASPP: Implication in cancer development and progression. Cell. Mol. Biol. 201561, (6): 2-8.
88. Amirkhah, R., Farazmand, A., Irfan-Maqsood, M., Wolkenhauerand, O. and Schmitz, U., The role of microRNAs in the resistance to colorectal cancer treatments. Cell. Mol. Biol. 2015, 61(6): 17-23.
89. Wang, Z., Chen, J. and Capobianco, A. J., The Notch signaling pathway in esophageal adenocarcinoma. Cell. Mol. Biol. 201561, (6): 24-32.
90. Limami, Y., Pinon, A., Riaz, A. and Simon, A., TRAIL and targeting cancer cells: between promises and obstacles. Cell. Mol. Biol. 201561, (6): 33-38.
91. Silva Galbiatti-Dias, A. L., Pavarino, É. C., Kawasaki-Oyama, R. S., Maniglia, J. V., Maniglia, E. J. V. and Goloni Bertollo, E. M., Cancer stem cells in head and neck cancer: A Mini Review. Cell. Mol. Biol. 2015, 61(6): 39-43.
92. Musella, A., Marchetti, C., Gasparri, M. L., Salerno, L., Casorelli, A., Domenici, L., Imperiale, L., Ruscito, I., Abdul Halim, T., Palaia, I., Di Donato, V., Pecorini, F., Monti, M., Muzii, L. and Panici, P. B., PARP inhibition: A promising therapeutic target in ovarian cancer. Cell. Mol. Biol. 201561, (6): 44-61.
93. Attar, R., Tabassum, S., Fayyaz, S., Ahmad, M. S., Nogueira, D. R., Yaylim, I., Timirci-Kahraman, O., Kucukhuseyin, O., Cacina, C., Farooqi, A. A. and Ismail, M., Natural products are the future of anticancer therapy: Preclinical and clinical advancements of Viscum album phytometabolites. Cell. Mol. Biol. 2015, 61(6): 62-68.
94. Hsu, Y-C., Hsieh, Y-H., Liao, C-C., Chong, L-W., Lee, C-Y., Yu, Y-L. and Chou, R-H., Targeting post-translational modifications of histones for cancer therapy. Cell. Mol. Biol. 2015, 61(6): 69-84.
95. Chong, L-W., Chou, R-H., Liao, C-C., Lee, T-F., Lin, Y., Yang, K-C. and Hsu, Y-C. Saturated fatty acid induces cancer stem cell-like properties in human hepatoma cells. Cell. Mol. Biol. 201561, (6): 85-91.
96. Smina, T. P., Mohan, A., Ayyappa, K. A., Sethuraman, S. and Krishnan, U. M., Hesperetin exerts apoptotic effect on A431 skin carcinoma cells by regulating mitogen activated protein kinases and cyclins. Cell. Mol. Biol. 2015, 61(6): 92-99.
97. Ahmadi, M., Jafari, R., Marashi, S. A. and Farazmand, A., Indirect role of microRNAs and transcription factors in the regulation of important cancer genes: A network biology approach. Cell. Mol. Biol. 2015, 61(6): 100-107.
98. Zahoor, A., Mansoor, Q., Farooqi, A. A., Fayyaz, S., Naz, G. and Ismail, M., Genetic variants in the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and death receptor (DR4) genes contribute to susceptibility to colorectal cancer in pakistani population. Cell. Mol. Biol. 2015, 61(6): 108-112.