Co-infections and pathogenesis of KSHV-associated malignancies

Frontiers in Microbiology

Volumn 7, Issue FEB, 2016, Pages

  Thakker, Suhani ^a   Verma, Subhash C ^a  

^a UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

Herpesviruses; KSHV; Polymicrobial infections

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 6;

ANGIOFOLLICULAR LYMPH NODE HYPERPLASIA; ARTICLE; CANCER GROWTH; CD4 LYMPHOCYTE COUNT; CELL PROLIFERATION; CELL SURVIVAL; CYTOMEGALOVIRUS INFECTION; DISEASE ASSOCIATION; DISEASE TRANSMISSION; EPSTEIN BARR VIRUS INFECTION; HERPES VIRUS INFECTION; HUMAN; HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNE DEFICIENCY; KAPOSI SARCOMA; LIFE EXPECTANCY; MALARIA FALCIPARUM; MIXED INFECTION; NONHUMAN; PRIMARY EFFUSION LYMPHOMA; VIRUS GENOME;

EID: 84962074524     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2016.00151     Document Type: Article

References (170)

1. Abbas, W., Tariq, M., Iqbal, M., Kumar, A., and Herbein, G. (2015). Eradication of HIV-1 from the macrophage reservoir: an uncertain goal? Viruses 7, 1578-1598. doi: 10.3390/v7041578
2. Ablashi, D., Agut, H., Alvarez-Lafuente, R., Clark, D. A., Dewhurst, S., DiLuca, D., et al. (2014). Classification of HHV-6A and HHV-6B as distinct viruses. Arch. Virol. 159, 863-870. doi: 10.1007/s00705-013-1902-5
3. Adland, E., Klenerman, P., Goulder, P., and Matthews, P. C. (2015). Ongoing burden of disease and mortality from HIV/CMV coinfection in Africa in the antiretroviral therapy era. Front. Microbiol. 6:1016. doi: 10.3389/fmicb.2015.01016
4. Albini, A., Soldi, R., Giunciuglio, D., Giraudo, E., Benelli, R., Primo, L., et al. (1996). The angiogenesis induced by HIV-1 tat protein is mediated by the Flk-1/KDR receptor on vascular endothelial cells. Nat. Med. 2, 1371-1375. doi: 10.1038/nm1296-1371
5. Ambroziak, J. A., Blackbourn, D. J., Herndier, B. G., Glogau, R. G., Gullett, J. H., McDonald, A. R., et al. (1995). Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patients. Science 268, 582-583. doi: 10.1126/science.7725108
6. An, F. Q., Folarin, H. M., Compitello, N., Roth, J., Gerson, S. L., McCrae, K. R., et al. (2006). Long-term-infected telomerase-immortalized endothelial cells: a model for Kaposi's sarcoma-associated herpesvirus latency in vitro and in vivo. J. Virol. 80, 4833-4846. doi: 10.1128/JVI.80.10.4833-4846.2006
7. Aoki, Y., and Tosato, G. (2004). HIV-1 Tat enhances Kaposi sarcoma-associated herpesvirus (KSHV) infectivity. Blood 104, 810-814. doi: 10.1182/blood-2003-07-2533
8. Aoki, Y., and Tosato, G. (2007). Interactions between HIV-1 Tat and KSHV. Curr. Top. Microbiol. Immunol. 312, 309-326.
9. Arias, C., Weisburd, B., Stern-Ginossar, N., Mercier, A., Madrid, A. S., Bellare, P., et al. (2014). KSHV 2.0: a comprehensive annotation of the Kaposi's sarcoma-associated herpesvirus genome using next-generation sequencing reveals novel genomic and functional features. PLoS Pathog. 10:e1003847. doi: 10.1371/journal.ppat.1003847
10. Ariyoshi, K., Schim van der Loeff, M., Cook, P., Whitby, D., Corrah, T., Jaffar, S., et al. (1998). Kaposi's sarcoma in the Gambia, West Africa is less frequent in human immunodeficiency virus type 2 than in human immunodeficiency virus type 1 infection despite a high prevalence of human herpesvirus 8. J. Hum. Virol. 1, 193-199.
11. Asou, H., Tasaka, T., Said, J. W., Daibata, M., Kamada, N., and Koeffler, H. P. (2000). Co-infection of HHV-6 and HHV-8 is rare in primary effusion lymphoma. Leuk. Res. 24, 59-61. doi: 10.1016/S0145-2126(99)00144-7
12. Ballon, G., Akar, G., and Cesarman, E. (2015). Systemic expression of Kaposi sarcoma herpesvirus (KSHV) Vflip in endothelial cells leads to a profound proinflammatory phenotype and myeloid lineage remodeling in vivo. PLoS Pathog. 11:e1004581. doi: 10.1371/journal.ppat.1004581
13. Bhutani, M., Polizzotto, M. N., Uldrick, T. S., and Yarchoan, R. (2015). Kaposi sarcoma-associated herpesvirus-associated malignancies: epidemiology, pathogenesis, and advances in treatment. Semin. Oncol. 42, 223-246. doi: 10.1053/j.seminoncol.2014.12.027
14. Biggar, R. J., Chaturvedi, A. K., Goedert, J. J., and Engels, E. A. (2007). AIDS-related cancer and severity of immunosuppression in persons with AIDS. J. Natl. Cancer Inst. 99, 962-972. doi: 10.1093/jnci/djm010
15. Blasig, C., Zietz, C., Haar, B., Neipel, F., Esser, S., Brockmeyer, N. H., et al. (1997). Monocytes in Kaposi's sarcoma lesions are productively infected by human herpesvirus 8. J. Virol. 71, 7963-7968.
16. Bonnet, F., Lewden, C., May, T., Heripret, L., Jougla, E., Bevilacqua, S., et al. (2004). Malignancy-related causes of death in human immunodeficiency virus-infected patients in the era of highly active antiretroviral therapy. Cancer 101, 317-324. doi: 10.1002/cncr.20354
17. Boshoff, C., Gao, S. J., Healy, L. E., Matthews, S., Thomas, A. J., Coignet, L., et al. (1998). Establishing a KSHV+ cell line (BCP-1) from peripheral blood and characterizing its growth in Nod/SCID mice. Blood 91, 1671-1679.
18. Boulanger, E., Gerard, L., Gabarre, J., Molina, J. M., Rapp, C., Abino, J. F., et al. (2005). Prognostic factors and outcome of human herpesvirus 8-associated primary effusion lymphoma in patients with AIDS. J. Clin. Oncol. 23, 4372-4380. doi: 10.1200/JCO.2005.07.084
19. Bovenzi, P., Mirandola, P., Secchiero, P., Strumia, R., Cassai, E., and Di Luca, D. (1993). Human herpesvirus 6 (variant A) in Kaposi's sarcoma. Lancet 341, 1288-1289. doi: 10.1016/0140-6736(93)91198-U
20. Cai, Q., Verma, S. C., Lu, J., and Robertson, E. S. (2010). Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis. Adv. Virus Res. 78, 87-142. doi: 10.1016/B978-0-12-385032-4.00003-3
21. Campadelli-Fiume, G., Mirandola, P., and Menotti, L. (1999). Human herpesvirus 6: an emerging pathogen. Emerg. Infect. Dis. 5, 353-366. doi: 10.3201/eid0503.990306
22. Caselli, E., Galvan, M., Cassai, E., Caruso, A., Sighinolfi, L., and Di Luca, D. (2005). Human herpesvirus 8 enhances human immunodeficiency virus replication in acutely infected cells and induces reactivation in latently infected cells. Blood 106, 2790-2797. doi: 10.1182/blood-2005-04-1390
23. Caselli, E., Galvan, M., Santoni, F., Rotola, A., Caruso, A., Cassai, E., et al. (2003). Human herpesvirus-8 (Kaposi's sarcoma-associated virus) ORF50 increases in vitro cell susceptibility to human immunodeficiency virus type 1 infection. J. Gen. Virol. 84, 1123-1131. doi: 10.1099/vir.0.18799-0
24. Caselli, E., Menegazzi, P., Bracci, A., Galvan, M., Cassai, E., and Di Luca, D. (2001). Human herpesvirus-8 (Kaposi's sarcoma-associated herpesvirus) ORF50 interacts synergistically with the tat gene product in transactivating the human immunodeficiency virus type 1 LTR. J. Gen. Virol. 82, 1965-1970. doi: 10.1099/0022-1317-82-8-1965
25. Cesarman, E., Chang, Y., Moore, P. S., Said, J. W., and Knowles, D. M. (1995). Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N. Engl. J. Med. 332, 1186-1191. doi: 10.1056/NEJM199505043321802
26. Chang, H., Gwack, Y., Kingston, D., Souvlis, J., Liang, X., Means, R. E., et al. (2005). Activation of CD21 and CD23 gene expression by Kaposi's sarcoma-associated herpesvirus RTA. J. Virol. 79, 4651-4663. doi: 10.1128/JVI.79.8.4651-4663.2005
27. Chang, Y., Cesarman, E., Pessin, M. S., Lee, F., Culpepper, J., Knowles, D. M., et al. (1994). Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266, 1865-1869. doi: 10.1126/science.7997879
28. Chen, C. J., Hsu, W. L., Yang, H. I., Lee, M. H., Chen, H. C., Chien, Y. C., et al. (2014). Epidemiology of virus infection and human cancer. Recent Results Cancer Res. 193, 11-32. doi: 10.1007/978-3-642-38965-8_2
29. Chen, X., Cheng, L., Jia, X., Zeng, Y., Yao, S., Lv, Z., et al. (2009). Human immunodeficiency virus type 1 Tat accelerates Kaposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice. Neoplasia 11, 1272-1284. doi: 10.1593/neo.09494
30. Coluzzi, M., Calabro, M. L., Manno, D., Chieco-Bianchi, L., Schulz, T. F., and Ascoli, V. (2003). Reduced seroprevalence of Kaposi's sarcoma-associated herpesvirus (KSHV), human herpesvirus 8 (HHV8), related to suppression of Anopheles density in Italy. Med. Vet. Entomol. 17, 461-464. doi: 10.1111/j.1365-2915.2003.00465.x
31. Conant, K. L., Marinelli, A., and Kaleeba, J. A. (2013). Dangerous liaisons: molecular basis for a syndemic relationship between Kaposi's sarcoma and P. falciparum malaria. Front. Microbiol. 4:35. doi: 10.3389/fmicb.2013.00035
32. Crane, G. M., Xian, R. R., Burns, K. H., Borowitz, M. J., Duffield, A. S., and Taube, J. M. (2014). Primary effusion lymphoma presenting as a cutaneous intravascular lymphoma. J. Cutan. Pathol. 41, 928-935. doi: 10.1111/cup.12405
33. Crispo, A., Tamburini, M., De Marco, M. R., Ascierto, P., Silvestro, P., Ronga, D., et al. (2001). HHV-8 prevalence, immunosuppression and Kaposi's sarcoma in South Italy. Int. J. Mol. Med. 7, 535-538.
34. Dai, L., DeFee, M. R., Cao, Y., Wen, J., Wen, X., Noverr, M. C., et al. (2014). Lipoteichoic acid (LTA) and lipopolysaccharides (LPS) from periodontal pathogenic bacteria facilitate oncogenic herpesvirus infection within primary oral cells. PLoS ONE 9:e101326. doi: 10.1371/journal.pone.0101326
35. Dai, L., Qin, Z., Defee, M., Toole, B. P., Kirkwood, K. L., and Parsons, C. (2012). Kaposi sarcoma-associated herpesvirus (KSHV) induces a functional tumor-associated phenotype for oral fibroblasts. Cancer Lett. 318, 214-220. doi: 10.1016/j.canlet.2011.12.019
36. Daly, M. L., Fogo, A., McDonald, C., and Morris-Jones, R. (2014). Kaposi sarcoma: no longer an AIDS-defining illness? A retrospective study of Kaposi sarcoma cases with CD4 counts above 300/mm(3) at presentation. Clin. Exp. Dermatol. 39, 7-12. doi: 10.1111/ced.12163
37. Damania, B., and Dittmer, D. P. (2014). What lies within: coinfections and immunity. Cell Host Microbe 16, 145-147. doi: 10.1016/j.chom.2014.07.014
38. Debaisieux, S., Rayne, F., Yezid, H., and Beaumelle, B. (2012). The ins and outs of HIV-1 Tat. Traffic 13, 355-363. doi: 10.1111/j.1600-0854.2011.01286.x
39. Deloose, S. T., Smit, L. A., Pals, F. T., Kersten, M. J., van Noesel, C. J., and Pals, S. T. (2005). High incidence of Kaposi sarcoma-associated herpesvirus infection in HIV-related solid immunoblastic/plasmablastic diffuse large B-cell lymphoma. Leukemia 19, 851-855. doi: 10.1038/sj.leu.2403709
40. Douglas, J. L., Gustin, J. K., Moses, A. V., Dezube, B. J., and Pantanowitz, L. (2010). Kaposi sarcoma pathogenesis: a triad of viral infection, oncogenesis and chronic inflammation. Transl. Biomed. 1, 172.
41. Dourmishev, L. A., Dourmishev, A. L., Palmeri, D., Schwartz, R. A., and Lukac, D. M. (2003). Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis. Microbiol. Mol. Biol. Rev. 67, 175-212. doi: 10.1128/MMBR.67.2.175-212.2003
42. Drexler, H. G., Uphoff, C. C., Gaidano, G., and Carbone, A. (1998). Lymphoma cell lines: in vitro models for the study of HHV-8+ primary effusion lymphomas (body cavity-based lymphomas). Leukemia 12, 1507-1517. doi: 10.1038/sj.leu.2401160
43. Edelman, D. C. (2005). Human herpesvirus 8-a novel human pathogen. Virol. J. 2, 78. doi: 10.1186/1743-422X-2-78
44. Engels, E. A., Biggar, R. J., Hall, H. I., Cross, H., Crutchfield, A., Finch, J. L., et al. (2008). Cancer risk in people infected with human immunodeficiency virus in the United States. Int. J. Cancer 123, 187-194. doi: 10.1002/ijc.23487
45. Ensoli, B., Barillari, G., Salahuddin, S. Z., Gallo, R. C., and Wong-Staal, F. (1990). Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients. Nature 345, 84-86. doi: 10.1038/345084a0
46. Fajgenbaum, D. C., van Rhee, F., and Nabel, C. S. (2014). HHV-8-negative, idiopathic multicentric Castleman disease: novel insights into biology, pathogenesis, and therapy. Blood 123, 2924-2933. doi: 10.1182/blood-2013-12-545087
47. Fatahzadeh, M., and Schwartz, R. A. (2013). Oral Kaposi's sarcoma: a review and update. Int. J. Dermatol. 52, 666-672. doi: 10.1111/j.1365-4632.2012.05758.x
48. Ferreira, D. C., Paiva, S. S., Carmo, F. L., Rocas, I. N., Rosado, A. S., Santos, K. R., et al. (2011). Identification of herpesviruses types 1 to 8 and human papillomavirus in acute apical abscesses. J. Endod. 37, 10-16. doi: 10.1016/j.joen.2010.09.009
49. Fiume, G., Scialdone, A., Albano, F., Rossi, A., Maria Tuccillo, F., Rea, D., et al. (2015). Impairment of T cell development and acute inflammatory response in HIV-1 Tat transgenic mice. Sci. Rep. 5, 13864. doi: 10.1038/srep13864
50. Flamand, L., Gosselin, J., D'Addario, M., Hiscott, J., Ablashi, D. V., Gallo, R. C., et al. (1991). Human herpesvirus 6 induces interleukin-1 beta and tumor necrosis factor alpha, but not interleukin-6, in peripheral blood mononuclear cell cultures. J. Virol. 65, 5105-5110.
51. Flore, O., Rafii, S., Ely, S., O'Leary, J. J., Hyjek, E. M., and Cesarman, E. (1998). Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus. Nature 394, 588-592. doi: 10.1038/29093
52. Gallo, R. C. (1998). The enigmas of Kaposi's sarcoma. Science 282, 1837-1839. doi: 10.1126/science.282.5395.1837
53. Ganem, D. (2006). KSHV infection and the pathogenesis of Kaposi's sarcoma. Annu. Rev. Pathol. 1, 273-296. doi: 10.1146/annurev.pathol.1.110304.100133
54. Ganem, D. (2007). "KSHV-induced oncogenesis, "in Source Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis, eds A. Arvin, G. Campadelli-Fiume, E. Mocarski, P. S. Moore, B. Roizman, R. Whitley, et al. (Cambridge: Cambridge University Press).
55. Giffin, L., and Damania, B. (2014). KSHV: pathways to tumorigenesis and persistent infection. Adv. Virus Res. 88, 111-159. doi: 10.1016/B978-0-12-800098-4.00002-7
56. Gottwein, E., Corcoran, D. L., Mukherjee, N., Skalsky, R. L., Hafner, M., Nusbaum, J. D., et al. (2011). Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines. Cell Host Microbe 10, 515-526. doi: 10.1016/j.chom.2011.09.012
57. Gowda, N. M., Wu, X., Kumar, S., Febbraio, M., and Gowda, D. C. (2013). CD36 contributes to malaria parasite-induced pro-inflammatory cytokine production and NK and T cell activation by dendritic cells. PLoS ONE 8:e77604. doi: 10.1371/journal.pone.0077604
58. Greene, W., Kuhne, K., Ye, F., Chen, J., Zhou, F., Lei, X., et al. (2007). Molecular biology of KSHV in relation to AIDS-associated oncogenesis. Cancer Treat. Res. 133, 69-127. doi: 10.1007/978-0-387-46816-7_3
59. Grulich, A. E., van Leeuwen, M. T., Falster, M. O., and Vajdic, C. M. (2007). Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet 370, 59-67. doi: 10.1016/S0140-6736(07)61050-2
60. Guito, J., and Lukac, D. M. (2015). KSHV reactivation and novel implications of protein isomerization on lytic switch control. Viruses 7, 72-109. doi: 10.3390/v7010072
61. Guo, H. G., Pati, S., Sadowska, M., Charurat, M., and Reitz, M. (2004). Tumorigenesis by human herpesvirus 8 vGPCR is accelerated by human immunodeficiency virus type 1 Tat. J. Virol. 78, 9336-9342. doi: 10.1128/JVI.78.17.9336-9342.2004
62. Haecker, I., and Renne, R. (2014). HITS-CLIP and PAR-CLIP advance viral miRNA targetome analysis. Crit. Rev. Eukaryot. Gene Expr. 24, 101-116. doi: 10.1615/CritRevEukaryotGeneExpr.2014006367
63. Haldar, K., and Mohandas, N. (2009). Malaria, erythrocytic infection, and anemia. Hematology Am. Soc. Hematol. Educ. Program 1, 87-93. doi: 10.1182/asheducation-2009.1.87
64. Hu, J., Yang, Y., Turner, P. C., Jain, V., McIntyre, L. M., and Renne, R. (2014). LANA binds to multiple active viral and cellular promoters and associates with the H3K4methyltransferase hSET1 complex. PLoS Pathog. 10:e1004240. doi: 10.1371/journal.ppat.1004240
65. Hu, M., Wang, C., Li, W., Lu, W., Bai, Z., Qin, D., et al. (2015). A KSHV microRNA directly targets G protein-coupled receptor kinase 2 to promote the migration and invasion of endothelial cells by inducing CXCR2 and activating AKT signaling. PLoS Pathog. 11:e1005171. doi: 10.1371/journal.ppat.1005171
66. Huang, L. M., Chao, M. F., Chen, M. Y., Shih, H., Chiang, Y. P., Chuang, C. Y., et al. (2001). Reciprocal regulatory interaction between human herpesvirus 8 and human immunodeficiency virus type 1. J. Biol. Chem. 276, 13427-13432. doi: 10.1074/jbc. M011314200
67. Hughes, D. J., Wood, J. J., Jackson, B. R., Baquero-Perez, B., and Whitehouse, A. (2015). NEDDylation is essential for Kaposi's sarcoma-associated herpesvirus latency and lytic reactivation and represents a novel anti-KSHV target. PLoS Pathog. 11:e1004771. doi: 10.1371/journal.ppat.1004771
68. Hyun, T. S., Subramanian, C., Cotter, M. A. II, Thomas, R. A., and Robertson, E. S. (2001). Latency-associated nuclear antigen encoded by Kaposi's sarcoma-associated herpesvirus interacts with Tat and activates the long terminal repeat of human immunodeficiency virus type 1 in human cells. J. Virol. 75, 8761-8771. doi: 10.1128/JVI.75.18.8761-8771.2001
69. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2012). Biological agents. Volume 100 B. A review of human carcinogens. IARC Monogr. Eval. Carcinog. Risks Hum. 100, 1-441.
70. Ignatovich, I. A., Dizhe, E. B., Akif'ev, B. N., Burov, S. V., Boiarchuk, E. A., and Perevozchikov, A. P. (2002). [Delivery of "suicide" thymidine kinase gene of herpes virus in the complex with cationic peptide into human hepatoma cells in vitro]. Tsitologiia 44, 455-462.
71. Jarviluoma, A., and Ojala, P. M. (2006). Cell signaling pathways engaged by KSHV. Biochim. Biophys. Acta 1766, 140-158. doi: 10.1016/j.bbcan.2006.05.001
72. Jiang, Y., Xu, D., Zhao, Y., and Zhang, L. (2008). Mutual inhibition between Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus lytic replication initiators in dually-infected primary effusion lymphoma. PLoS ONE 3:e1569. doi: 10.1371/journal.pone.0001569
73. Jones, T., Ye, F., Bedolla, R., Huang, Y., Meng, J., Qian, L., et al. (2012). Direct and efficient cellular transformation of primary rat mesenchymal precursor cells by KSHV. J. Clin. Invest. 122, 1076-1081. doi: 10.1172/JCI58530
74. Kalt, I., Masa, S. R., and Sarid, R. (2009). Linking the Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to human malignancies. Methods Mol. Biol. 471, 387-407. doi: 10.1007/978-1-59745-416-2_19
75. Karijolich, J., Zhao, Y., Peterson, B., Zhou, Q., and Glaunsinger, B. (2014). Kaposi's sarcoma-associated herpesvirus ORF45 mediates transcriptional activation of the HIV-1 long terminal repeat via RSK2. J. Virol. 88, 7024-7035. doi: 10.1128/JVI.00931-14
76. Kempf, W., Adams, V., Wey, N., Moos, R., Schmid, M., Avitabile, E., et al. (1997). CD68+ cells of monocyte/macrophage lineage in the environment of AIDS-associated and classic-sporadic Kaposi sarcoma are singly or doubly infected with human herpesviruses 7 and 6B. Proc. Natl. Acad. Sci. U.S.A. 94, 7600-7605. doi: 10.1073/pnas.94.14.7600
77. Kempkes, B., and Robertson, E. S. (2015). Epstein-Barr virus latency: current and future perspectives. Curr. Opin. Virol. 14, 138-144. doi: 10.1016/j.coviro.2015.09.007
78. Kim, Y., Park, C. J., Roh, J., and Huh, J. (2014). Current concepts in primary effusion lymphoma and other effusion-based lymphomas. Korean J. Pathol. 48, 81-90. doi: 10.4132/KoreanJPathol.2014.48.2.81
79. King, C. A., Li, X., Barbachano-Guerrero, A., and Bhaduri-McIntosh, S. (2015). STAT3 regulates lytic activation of Kaposi's sarcoma-associated herpesvirus. J. Virol. 89, 11347-11355. doi: 10.1128/JVI.02008-15
80. Knowlton, E. R., Rappocciolo, G., Piazza, P., Lepone, L. M., Nadgir, S. V., Bullotta, A., et al. (2014). Human herpesvirus 8 induces polyfunctional B lymphocytes that drive Kaposi's sarcoma. MBio 5, e01277-14. doi: 10.1128/mBio.01277-14
81. Krause, J. R., Robinson, S. D., and Vance, E. A. (2014). Multicentric Castleman's disease and HIV. Proc. (Bayl. Univ. Med. Cent.) 27, 28-30.
82. Krithivas, A., Young, D. B., Liao, G., Greene, D., and Hayward, S. D. (2000). Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells. J. Virol. 74, 9637-9645. doi: 10.1128/JVI.74.20.9637-9645.2000
83. Krown, S. E., Lee, J. Y., and Dittmer, D. P. (2008). More on HIV-associated Kaposi's sarcoma. N. Engl. J. Med. 358, 535-536; author reply 536. doi: 10.1056/NEJMc072994
84. Kumar, A., Darcis, G., Van Lint, C., and Herbein, G. (2015). Epigenetic control of HIV-1 post integration latency: implications for therapy. Clin. Epigenetics 7, 103. doi: 10.1186/s13148-015-0137-6
85. Labo, N., Miley, W., Benson, C. A., Campbell, T. B., and Whitby, D. (2015). Epidemiology of Kaposi's sarcoma-associated herpesvirus in HIV-1-infected US persons in the era of combination antiretroviral therapy. AIDS 29, 1217-1225. doi: 10.1097/QAD.0000000000000682
86. Letang, E., Lewis, J. J., Bower, M., Mosam, A., Borok, M., Campbell, T. B., et al. (2013). Immune reconstitution inflammatory syndrome associated with Kaposi sarcoma: higher incidence and mortality in Africa than in the UK. AIDS 27, 1603-1613. doi: 10.1097/QAD.0b013e328360a5a1
87. Li, C. J., Friedman, D. J., Wang, C., Metelev, V., and Pardee, A. B. (1995). Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science 268, 429-431. doi: 10.1126/science.7716549
88. Loesche, W. J., and Grossman, N. S. (2001). Periodontal disease as a specific, albeit chronic, infection: diagnosis and treatment. Clin. Microbiol. Rev. 14, 727-752. doi: 10.1128/CMR.14.4.727-752.2001
89. Longnecker, R., and Neipel, F. (2007). "Introduction to the human gamma-herpesviruses, "in Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis, eds A. Arvin, G. Campadelli-Fiume, E. Mocarski, P. S. Moore, B. Roizman, R. Whitley, et al. (Cambridge: Cambridge University Press).
90. Lu, C., Zeng, Y., Huang, Z., Huang, L., Qian, C., Tang, G., et al. (2005). Human herpesvirus 6 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus. Am. J. Pathol. 166, 173-183. doi: 10.1016/S0002-9440(10)62242-0
91. Lui, V. W., Wong, E. Y., Ho, Y., Hong, B., Wong, S. C., Tao, Q., et al. (2009). STAT3 activation contributes directly to Epstein-Barr virus-mediated invasiveness of nasopharyngeal cancer cells in vitro. Int. J. Cancer 125, 1884-1893. doi: 10.1002/ijc.24567
92. Lukac, D. M., and Yuan, Y. (2007). "Reactivation and lytic replication of KSHV, "in Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis, eds A. Arvin, G. Campadelli-Fiume, E. Mocarski, P. S. Moore, B. Roizman, R. Whitley, et al. (Cambridge: Cambridge University Press), 434-460.
93. Mani, D., Neil, N., Israel, R., and Aboulafia, D. M. (2009). A retrospective analysis of AIDS-associated Kaposi's sarcoma in patients with undetectable HIV viral loads and CD4 counts greater than 300 cells/mm(3). J. Int. Assoc. Physicians AIDS Care (Chic.) 8, 279-285. doi: 10.1177/1545109709341852
94. Martin, J. N. (2007). "The epidemiology of KSHV and its association with malignant disease, "in Source Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis, eds A. Arvin, G. Campadelli-Fiume, E. Mocarski, P. S. Moore, B. Roizman, R. Whitley, et al. (Cambridge: Cambridge University).
95. Maurer, T., Ponte, M., and Leslie, K. (2007). HIV-associated Kaposi's sarcoma with a high CD4 count and a low viral load. N. Engl. J. Med. 357, 1352-1353. doi: 10.1056/NEJMc070508
96. Mbulaiteye, S. M., Biggar, R. J., Goedert, J. J., and Engels, E. A. (2003). Immune deficiency and risk for malignancy among persons with AIDS. J. Acquir. Immune Defic. Syndr. 32, 527-533. doi: 10.1097/00126334-200304150-00010
97. Meeuwsen, S., Persoon-Deen, C., Bsibsi, M., Bajramovic, J. J., Ravid, R., De Bolle, L., et al. (2005). Modulation of the cytokine network in human adult astrocytes by human herpesvirus-6A. J. Neuroimmunol. 164, 37-47. doi: 10.1016/j.jneuroim.2005.03.013
98. Merat, R., Amara, A., Lebbe, C., de The, H., Morel, P., and Saib, A. (2002). HIV-1 infection of primary effusion lymphoma cell line triggers Kaposi's sarcoma-associated herpesvirus (KSHV) reactivation. Int. J. Cancer 97, 791-795. doi: 10.1002/ijc.10086
99. Mercader, M., Nickoloff, B. J., and Foreman, K. E. (2001). Induction of human immunodeficiency virus 1 replication by human herpesvirus 8. Arch. Pathol. Lab. Med. 125, 785-789.
100. Mercader, M., Taddeo, B., Panella, J. R., Chandran, B., Nickoloff, B. J., and Foreman, K. E. (2000). Induction of HHV-8 lytic cycle replication by inflammatory cytokines produced by HIV-1-infected T cells. Am. J. Pathol. 156, 1961-1971. doi: 10.1016/S0002-9440(10)65069-9
101. Miller, G., Heston, L., Grogan, E., Gradoville, L., Rigsby, M., Sun, R., et al. (1997). Selective switch between latency and lytic replication of Kaposi's sarcoma herpesvirus and Epstein-Barr virus in dually infected body cavity lymphoma cells. J. Virol. 71, 314-324.
102. Moore, P. S., and Chang, Y. (2010). Why do viruses cause cancer? Highlights of the first century of human tumour virology. Nat. Rev. Cancer 10, 878-889. doi: 10.1038/nrc2961
103. Mori, J., Kawabata, A., Tang, H., Tadagaki, K., Mizuguchi, H., Kuroda, K., et al. (2015). Human herpesvirus-6 U14 induces cell-cycle arrest in G2/M phase by associating with a cellular protein, EDD. PLoS ONE 10:e0137420. doi: 10.1371/journal.pone.0137420
104. Morris, T. L., Arnold, R. R., and Webster-Cyriaque, J. (2007). Signaling cascades triggered by bacterial metabolic end products during reactivation of Kaposi's sarcoma-associated herpesvirus. J. Virol. 81, 6032-6042. doi: 10.1128/JVI.02504-06
105. Murata, T. (2014). Regulation of Epstein-Barr virus reactivation from latency. Microbiol. Immunol. 58, 307-317. doi: 10.1111/1348-0421.12155
106. Mutlu, A. D., Cavallin, L. E., Vincent, L., Chiozzini, C., Eroles, P., Duran, E. M., et al. (2007). In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma. Cancer Cell 11, 245-258. doi: 10.1016/j.ccr.2007.01.015
107. Mylona, E. E., Baraboutis, I. G., Lekakis, L. J., Georgiou, O., Papastamopoulos, V., and Skoutelis, A. (2008). Multicentric Castleman's disease in HIV infection: a systematic review of the literature. AIDS Rev. 10, 25-35.
108. Myoung, J., and Ganem, D. (2011). Infection of primary human tonsillar lymphoid cells by KSHV reveals frequent but abortive infection of T cells. Virology 413, 1-11. doi: 10.1016/j.virol.2010.12.036
109. Nalwoga, A., Cose, S., Wakeham, K., Miley, W., Ndibazza, J., Drakeley, C., et al. (2015). Association between malaria exposure and Kaposi's sarcoma-associated herpes virus seropositivity in Uganda. Trop. Med. Int. Health 20, 665-672. doi: 10.1111/tmi.12464
110. Nascimento, M. C. (2014). Malaria may influence the transmission of Kaposi sarcoma associated herpesvirus in endemic areas. J. Acquir. Immune Defic. Syndr. 67, e41-e43. doi: 10.1097/QAI.0000000000000229
111. Newton, R., Ziegler, J., Bourboulia, D., Casabonne, D., Beral, V., Mbidde, E., et al. (2003). Infection with Kaposi's sarcoma-associated herpesvirus (KSHV) and human immunodeficiency virus (HIV) in relation to the risk and clinical presentation of Kaposi's sarcoma in Uganda. Br. J. Cancer 89, 502-504. doi: 10.1038/sj.bjc.6601113
112. Okada, S., Goto, H., and Yotsumoto, M. (2014). Current status of treatment for primary effusion lymphoma. Intractable Rare Dis. Res. 3, 65-74. doi: 10.5582/irdr.2014.01010
113. Oksenhendler, E., Carcelain, G., Aoki, Y., Boulanger, E., Maillard, A., Clauvel, J. P., et al. (2000). High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric castleman disease in HIV-infected patients. Blood 96, 2069-2073.
114. Orem, J., Otieno, M. W., and Remick, S. C. (2004). AIDS-associated cancer in developing nations. Curr. Opin. Oncol. 16, 468-476. doi: 10.1097/00001622-200409000-00010
115. Ota, Y., Hishima, T., Mochizuki, M., Kodama, Y., Moritani, S., Oyaizu, N., et al. (2014). Classification of AIDS-related lymphoma cases between 1987 and 2012 in Japan based on the WHO classification of lymphomas, fourth edition. Cancer Med. 3, 143-153. doi: 10.1002/cam4.178
116. Paiardini, M., and Muller-Trutwin, M. (2013). HIV-associated chronic immune activation. Immunol. Rev. 254, 78-101. doi: 10.1111/imr.12079
117. Pan, Z. G., Zhang, Q. Y., Lu, Z. B., Quinto, T., Rozenvald, I. B., Liu, L. T., et al. (2012). Extracavitary KSHV-associated large B-Cell lymphoma: a distinct entity or a subtype of primary effusion lymphoma? Study of 9 cases and review of an additional 43 cases. Am. J. Surg. Pathol. 36, 1129-1140. doi: 10.1097/PAS.0b013e31825b38ec
118. Pantanowitz, L., Khammissa, R. A., Lemmer, J., and Feller, L. (2013). Oral HIV-associated Kaposi sarcoma. J. Oral Pathol. Med. 42, 201-207. doi: 10.1111/j.1600-0714.2012.01180.x
119. Pantry, S. N., and Medveczky, P. G. (2009). Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus replication. Semin. Cancer Biol. 19, 153-157. doi: 10.1016/j.semcancer.2009.02.010
120. Park, M. Y., Kim, Y. E., Seo, M. R., Lee, J. R., Lee, C. H., and Ahn, J. H. (2006). Interactions among four proteins encoded by the human cytomegalovirus UL112-113 region regulate their intranuclear targeting and the recruitment of UL44 to prereplication foci. J. Virol. 80, 2718-2727. doi: 10.1128/JVI.80.6.2718-2727.2006
121. Parravicini, C., Chandran, B., Corbellino, M., Berti, E., Paulli, M., Moore, P. S., et al. (2000). Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Am. J. Pathol. 156, 743-749. doi: 10.1016/S0002-9440(10)64940-1
122. Pinzone, M. R., Berretta, M., Cacopardo, B., and Nunnari, G. (2015). Epstein-barr virus-and Kaposi sarcoma-associated herpesvirus-related malignancies in the setting of human immunodeficiency virus infection. Semin. Oncol. 42, 258-271. doi: 10.1053/j.seminoncol.2014.12.026
123. Polizzotto, M. N., Uldrick, T. S., Hu, D., and Yarchoan, R. (2012). Clinical manifestations of Kaposi sarcoma herpesvirus lytic activation: multicentric Castleman disease (KSHV-MCD) and the KSHV inflammatory cytokine syndrome. Front. Microbiol. 3:73. doi: 10.3389/fmicb.2012.00073
124. Powles, T., Stebbing, J., Bazeos, A., Hatzimichael, E., Mandalia, S., Nelson, M., et al. (2009). The role of immune suppression and HHV-8 in the increasing incidence of HIV-associated multicentric Castleman's disease. Ann. Oncol. 20, 775-779. doi: 10.1093/annonc/mdn697
125. Purushothaman, P., Uppal, T., and Verma, S. C. (2015). Molecular biology of KSHV lytic reactivation. Viruses 7, 116-153. doi: 10.3390/v7010116
126. Riley, K. J., Rabinowitz, G. S., Yario, T. A., Luna, J. M., Darnell, R. B., and Steitz, J. A. (2012). EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency. EMBO J. 31, 2207-2221. doi: 10.1038/emboj.2012.63
127. Rodriguez Salazar, M. J., Raya Sanchez, J. M., Rodriguez Sanchez, R., Alonso Socas, M. M., Brito Barroso, M. L., and Hernandez Nieto, L. (2004). HIV-associated primary body-cavity-based lymphoma: clinico-biologic features in three patients diagnosed at the same institution. An. Med. Interna 21, 175-178.
128. Rohner, E., Wyss, N., Heg, Z., Faralli, Z., Mbulaiteye, S. M., Novak, U., et al. (2015). HIV and human herpesvirus 8 co-infection across the globe: systematic review and meta-analysis. Int. J. Cancer 138, 45-54. doi: 10.1002/ijc.29687
129. Rohner, E., Wyss, N., Trelle, S., Mbulaiteye, S. M., Egger, M., Novak, U., et al. (2014). HHV-8 seroprevalence: a global view. Syst. Rev. 3, 11. doi: 10.1186/2046-4053-3-11
130. Ruocco, V., Ruocco, E., Schwartz, R. A., and Janniger, C. K. (2011). Kaposi sarcoma and quinine: a potentially overlooked triggering factor in millions of Africans. J. Am. Acad. Dermatol. 64, 434-436. doi: 10.1016/j.jaad.2009.12.016
131. Rusnati, M., and Presta, M. (2002). HIV-1 Tat protein and endothelium: from protein/cell interaction to AIDS-associated pathologies. Angiogenesis 5, 141-151. doi: 10.1023/A:1023892223074
132. Russo, J. J., Bohenzky, R. A., Chien, M. C., Chen, J., Yan, M., Maddalena, D., et al. (1996). Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc. Natl. Acad. Sci. U.S.A. 93, 14862-14867. doi: 10.1073/pnas.93.25.14862
133. Sastry, K. J., Marin, M. C., Nehete, P. N., McConnell, K., el-Naggar, A. K., and McDonnell, T. J. (1996). Expression of human immunodeficiency virus type I tat results in down-regulation of bcl-2 and induction of apoptosis in hematopoietic cells. Oncogene 13, 487-493.
134. Schafer, G., Blumenthal, M. J., and Katz, A. A. (2015). Interaction of human tumor viruses with host cell surface receptors and cell entry. Viruses 7, 2592-2617. doi: 10.3390/v7052592
135. Schmidt, C. Q., Kennedy, A. T., and Tham, W. H. (2015). More than just immune evasion: hijacking complement by Plasmodium falciparum. Mol. Immunol. 67, 71-84. doi: 10.1016/j.molimm.2015.03.006
136. Schulz, T. F., and Cesarman, E. (2015). Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis. Curr. Opin. Virol. 14, 116-128. doi: 10.1016/j.coviro.2015.08.016
137. Serraino, D., Corona, R. M., Giuliani, M., Farchi, F., Sarmati, L., Uccella, I., et al. (2003). Infection with human herpesvirus type 8 and kaposi's sarcoma in a central Italian area formerly endemic for malaria. Infection 31, 47-50. doi: 10.1007/s15010-002-3107-9
138. Shelburne, S. A. III, Hamill, R. J., Rodriguez-Barradas, M. C., Greenberg, S. B., Atmar, R. L., Musher, D. W., et al. (2002). Immune reconstitution inflammatory syndrome: emergence of a unique syndrome during highly active antiretroviral therapy. Medicine (Baltimore) 81, 213-227. doi: 10.1097/00005792-200205000-00005
139. Shiboski, C. H., and Winkler, J. R. (1993). Gingival Kaposi's sarcoma and periodontitis. A case report and suggested treatment approach to the combined lesions. Oral Surg. Oral Med. Oral Pathol. 76, 49-53. doi: 10.1016/0030-4220(93)90293-D
140. Simonelli, C., Spina, M., Cinelli, R., Talamini, R., Tedeschi, R., Gloghini, A., et al. (2003). Clinical features and outcome of primary effusion lymphoma in HIV-infected patients: a single-institution study. J. Clin. Oncol. 21, 3948-3954. doi: 10.1200/JCO.2003.06.013
141. Sinzger, C., Digel, M., and Jahn, G. (2008). Cytomegalovirus cell tropism. Curr. Top. Microbiol. Immunol. 325, 63-83.
142. Soulier, J., Grollet, L., Oksenhendler, E., Cacoub, P., Cazals-Hatem, D., Babinet, P., et al. (1995). Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 86, 1276-1280.
143. Spadavecchia, S., Gonzalez-Lopez, O., Carroll, K. D., Palmeri, D., and Lukac, D. M. (2010). Convergence of Kaposi's sarcoma-associated herpesvirus reactivation with Epstein-Barr virus latency and cellular growth mediated by the notch signaling pathway in coinfected cells. J. Virol. 84, 10488-10500. doi: 10.1128/JVI.00894-10
144. Stolka, K., Ndom, P., Hemingway-Foday, J., Iriondo-Perez, J., Miley, W., Labo, N., et al. (2014). Risk factors for Kaposi's sarcoma among HIV-positive individuals in a case control study in Cameroon. Cancer Epidemiol. 38, 137-143. doi: 10.1016/j.canep.2014.02.006
145. Suda, T., Katano, H., Delsol, G., Kakiuchi, C., Nakamura, T., Shiota, M., et al. (2001). HHV-8 infection status of AIDS-unrelated and AIDS-associated multicentric Castleman's disease. Pathol. Int. 51, 671-679. doi: 10.1046/j.1440-1827.2001.01266.x
146. Tamburro, K. M., Yang, D., Poisson, J., Fedoriw, Y., Roy, D., Lucas, A., et al. (2012). Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and human herpesvirus 6A. Virology 433, 220-225. doi: 10.1016/j.virol.2012.08.014
147. Tarrant-Elorza, M., Rossetto, C. C., and Pari, G. S. (2014). Maintenance and replication of the human cytomegalovirus genome during latency. Cell Host Microbe 16, 43-54. doi: 10.1016/j.chom.2014.06.006
148. Toth, Z., Maglinte, D. T., Lee, S. H., Lee, H. R., Wong, L. Y., Brulois, K. F., et al. (2010). Epigenetic analysis of KSHV latent and lytic genomes. PLoS Pathog. 6:e1001013. doi: 10.1371/journal.ppat.1001013
149. Trivedi, P., Takazawa, K., Zompetta, C., Cuomo, L., Anastasiadou, E., Carbone, A., et al. (2004). Infection of HHV-8+ primary effusion lymphoma cells with a recombinant Epstein-Barr virus leads to restricted EBV latency, altered phenotype, and increased tumorigenicity without affecting TCL1 expression. Blood 103, 313-316. doi: 10.1182/blood-2003-05-1710
150. Ueda, K., Ohsaki, E., Nakano, K., and Zheng, X. (2011). Characterization of Kaposi's sarcoma-associated herpesvirus-related lymphomas by DNA microarray analysis. Leuk. Res. Treatment 2011, 726964. doi: 10.4061/2011/726964
151. Uldrick, T. S., Wang, V., O'Mahony, D., Aleman, K., Wyvill, K. M., Marshall, V., et al. (2010). An interleukin-6-related systemic inflammatory syndrome in patients co-infected with Kaposi sarcoma-associated herpesvirus and HIV but without Multicentric Castleman disease. Clin. Infect. Dis. 51, 350-358. doi: 10.1086/654798
152. Uppal, T., Banerjee, S., Sun, Z., Verma, S. C., and Robertson, E. S. (2014). KSHV LANA-the master regulator of KSHV latency. Viruses 6, 4961-4998. doi: 10.3390/v6124961
153. Varthakavi, V., Browning, P. J., and Spearman, P. (1999). Human immunodeficiency virus replication in a primary effusion lymphoma cell line stimulates lytic-phase replication of Kaposi's sarcoma-associated herpesvirus. J. Virol. 73, 10329-10338.
154. Varthakavi, V., Smith, R. M., Deng, H., Sun, R., and Spearman, P. (2002). Human immunodeficiency virus type-1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus through induction of KSHV Rta. Virology 297, 270-280. doi: 10.1006/viro.2002.1434
155. Veettil, M. V., Bandyopadhyay, C., Dutta, D., and Chandran, B. (2014). Interaction of KSHV with host cell surface receptors and cell entry. Viruses 6, 4024-4046. doi: 10.3390/v6104024
156. Vieira, J., O'Hearn, P., Kimball, L., Chandran, B., and Corey, L. (2001). Activation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) lytic replication by human cytomegalovirus. J. Virol. 75, 1378-1386. doi: 10.1128/JVI.75.3.1378-1386.2001
157. Wakeham, K., Webb, E. L., Sebina, I., Muhangi, L., Miley, W., Johnson, W. T., et al. (2011). Parasite infection is associated with Kaposi's sarcoma associated herpesvirus (KSHV) in Ugandan women. Infect. Agent Cancer 6, 15. doi: 10.1186/1750-9378-6-15
158. Wakeham, K., Webb, E. L., Sebina, I., Nalwoga, A., Muhangi, L., Miley, W., et al. (2013). Risk factors for seropositivity to Kaposi sarcoma-associated herpesvirus among children in Uganda. J. Acquir. Immune Defic. Syndr. 63, 228-233. doi: 10.1097/QAI.0b013e31828a7056
159. Wang, P., Rennekamp, A. J., Yuan, Y., and Lieberman, P. M. (2009). Topoisomerase I and RecQL1 function in Epstein-Barr virus lytic reactivation. J. Virol. 83, 8090-8098. doi: 10.1128/JVI.02379-08
160. Wells, R., Stensland, L., and Vieira, J. (2009). The human cytomegalovirus UL112-113 locus can activate the full Kaposi's sarcoma-associated herpesvirus lytic replication cycle. J. Virol. 83, 4695-4699. doi: 10.1128/JVI.02241-08
161. Xu, D., Coleman, T., Zhang, J., Fagot, A., Kotalik, C., Zhao, L., et al. (2007). Epstein-Barr virus inhibits Kaposi's sarcoma-associated herpesvirus lytic replication in primary effusion lymphomas. J. Virol. 81, 6068-6078. doi: 10.1128/JVI.02743-06
162. Xue, M., Yao, S., Hu, M., Li, W., Hao, T., Zhou, F., et al. (2014). HIV-1 Nef and KSHV oncogene K1 synergistically promote angiogenesis by inducing cellular miR-718 to regulate the PTEN/AKT/mTOR signaling pathway. Nucleic Acids Res. 42, 9862-9879. doi: 10.1093/nar/gku583
163. Yamanishi, K., Okuno, T., Shiraki, K., Takahashi, M., Kondo, T., Asano, Y., et al. (1988). Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet 1, 1065-1067. doi: 10.1016/S0140-6736(88)91893-4
164. Yao, S., Hu, M., Hao, T., Li, W., Xue, X., Xue, M., et al. (2015). MiRNA-891a-5p mediates HIV-1 Tat and KSHV Orf-K1 synergistic induction of angiogenesis by activating NF-kappaB signaling. Nucleic Acids Res. 43, 9362-9378. doi: 10.1093/nar/gkv988
165. Ye, F., Lei, X., and Gao, S. J. (2011). Mechanisms of Kaposi's sarcoma-associated herpesvirus latency and reactivation. Adv. Virol. 2011, 193860. doi: 10.1155/2011/193860
166. Younas, M., Psomas, C., Reynes, J., and Corbeau, P. (2016). Immune activation in the course of HIV-1 infection: causes, phenotypes and persistence under therapy. HIV Med. 17, 89-105. doi: 10.1111/hiv.12310
167. 2, and SUV39H1 to promote Kaposi's sarcoma-associated herpesvirus replication. J. Virol. 88, 4466-4479. doi: 10.1128/JVI.03326-13
168. Zeng, Y., Zhang, X., Huang, Z., Cheng, L., Yao, S., Qin, D., et al. (2007). Intracellular Tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus: role of JAK/STAT signaling. J. Virol. 81, 2401-2417. doi: 10.1128/JVI.02024-06
169. Zerr, D. M., Corey, L., Kim, H. W., Huang, M. L., Nguy, L., and Boeckh, M. (2005). Clinical outcomes of human herpesvirus 6 reactivation after hematopoietic stem cell transplantation. Clin. Infect. Dis. 40, 932-940. doi: 10.1086/428060
170. Zhou, F., Xue, M., Qin, D., Zhu, X., Wang, C., Zhu, J., et al. (2013). HIV-1 Tat promotes Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K/PTEN/AKT/GSK-3beta signaling pathway. PLoS ONE 8:e53145. doi: 10.1371/journal.pone.0053145b