Classification of HHV-6A and HHV-6B as distinct viruses

Archives of Virology

Volumn 159, Issue 5, 2014, Pages 863-870

  Ablashi, Dharam ^a   Agut, Henri ^b   Alvarez Lafuente, Roberto ^c   Clark, Duncan A ^d   Dewhurst, Stephen ^e   DiLuca, Dario ^f   Flamand, Louis ^g   Frenkel, Niza ^h   Gallo, Robert ⁱ   Gompels, Ursula A ^j   Höllsberg, Per ^k   Jacobson, Steven ^l   Luppi, Mario ^m   Lusso, Paolo ⁿ   Malnati, Mauro ^o   Medveczky, Peter ^p   Mori, Yasuko ^q   Pellett, Philip E ^r   Pritchett, Joshua C ^a   Yamanishi, Koichi ^t   Yoshikawa, Tetsushi ^s   more..

^a The HHV 6 Foundation   (United States)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^d BARTS HEALTH NHS TRUST   (United Kingdom)

^e UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^f UNIVERSITY OF FERRARA   (Italy)

^g UNIVERSITÉ LAVAL   (Canada)

^h TEL AVIV UNIVERSITY   (Israel)

ⁱ UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^j LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^k AARHUS UNIVERSITY   (Denmark)

^l NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^m UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

ⁿ NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^o OSR Scientific Institute   (Italy)

^p UNIVERSITY OF SOUTH FLORIDA   (United States)

^q KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^r WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^s FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^t The Research Foundation for Microbial Diseases of Osaka University   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN HERPESVIRUS 6;

CLASSIFICATION; EXANTHEMA SUBITUM; GENETIC VARIABILITY; GENETICS; HUMAN; HUMAN HERPESVIRUS 6; IMMUNOLOGY; REVIEW; VIROLOGY;

GENETIC VARIATION; HERPESVIRUS 6, HUMAN; HUMANS; ROSEOLOVIRUS INFECTIONS;

EID: 84899935021     PISSN: 03048608     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00705-013-1902-5     Document Type: Review

References (134)

1. Ablashi D, Agut H, Berneman Z, Campadelli-Fiume G, Carrigan D, Ceccerini-Nelli L, Chandran B, Chou S, Collandre H, Cone R (1993) Human herpesvirus-6 strain groups: a nomenclature. Arch Virol 129: 363-366.
2. Ablashi DV, Salahuddin SZ, Josephs SF, Imam F, Lusso P, Gallo RC, Hung C, Lemp J, Markham PD (1987) HBLV (or HHV-6) in human cell lines. Nature 329: 207.
3. Ablashi DV, Lusso P, Hung CL, Salahuddin SZ, Josephs SF, Llana T, Kramarsky B, Biberfeld P, Markham PD, Gallo RC (1988) Utilization of human hematopoietic cell lines for the propagation and characterization of HBLV (human herpesvirus 6). Int J Cancer 42: 787-791.
4. Ablashi DV, Balachandran N, Josephs SF, Hung CL, Krueger GR, Kramarsky B, Salahuddin SZ, Gallo RC (1991) Genomic polymorphism, growth properties, and immunologic variations in human herpesvirus-6 isolates. Virology 184: 545-552.
5. Achour A, Malet I, Le Gal F, Dehee A, Gautheret-Dejean A, Bonnafous P, Agut H (2008) Variability of gB and gH genes of human herpesvirus-6 among clinical specimens. J Med Virol 80: 1211-1221.
6. Adams MJ, Carstens EB (2012) Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2012). Arch Virol 157: 1411-1422.
7. Ahlqvist J, Fotheringham J, Akhyani N, Yao K, Fogdell-Hahn A, Jacobson S (2005) Differential tropism of human herpesvirus 6 (HHV-6) variants and induction of latency by HHV-6A in oligodendrocytes. J Neurovirol 11: 384-394.
8. Akhyani N, Berti R, Brennan MB, Soldan SS, Eaton JM, McFarland HF, Jacobson S (2000) Tissue distribution and variant characterization of human herpesvirus (HHV)-6: increased prevalence of HHV-6A in patients with multiple sclerosis. J Infect Dis 182: 1321-1325.
9. Alvarez-Lafuente R, De las Heras V, Bartolome M, Picazo JJ, Arroyo R (2004) Relapsing-remitting multiple sclerosis and human herpesvirus 6 active infection. Arch Neurol 61: 1523-1527.
10. Alvarez-Lafuente R, De Las Heras V, Bartolome M, Garcia-Montojo M, Arroyo R (2006) Human herpesvirus 6 and multiple sclerosis: a one-year follow-up study. Brain Pathol 16: 20-27.
11. Alvarez-Lafuente R, Garcia-Montojo M, De las Heras V, Bartolome M, Arroyo R (2006) Clinical parameters and HHV-6 active replication in relapsing-remitting multiple sclerosis patients. J Clin Virol 37(Suppl 1): 24-26.
12. Alvarez-Lafuente R, de las Heras V, Garcia-Montojo M, Bartolome M, Arroyo R (2007) Human herpesvirus-6 and multiple sclerosis: relapsing-remitting versus secondary progressive. Mult Scler 13: 578-583.
13. Alvarez-Lafuente R, Garcia-Montojo M, De Las Heras V, Bartolome M, Arroyo R (2007) JC virus in cerebrospinal fluid samples of multiple sclerosis patients at the first demyelinating event. Mult Scler 13: 590-595.
14. Alvarez-Lafuente R, Martinez A, Garcia-Montojo M, Mas A, De Las Heras V, Dominguez-Mozo MI, Maria Del Carmen C, Lopez-Cavanillas M, Bartolome M, Gomez de la Concha E, Urcelay E, Arroyo R (2010) MHC2TA rs4774C and HHV-6A active replication in multiple sclerosis patients. Eur J Neurol 17: 129-135.
15. Arsenault S, Gravel A, Gosselin J, Flamand L (2003) Generation and characterization of a monoclonal antibody specific for human herpesvirus 6 variant A immediate-early 2 protein. J Clin Virol 28: 284-290.
16. Aubin JT, Collandre H, Candotti D, Ingrand D, Rouzioux C, Burgard M, Richard S, Huraux JM, Agut H (1991) Several groups among human herpesvirus 6 strains can be distinguished by Southern blotting and polymerase chain reaction. J Clin Microbiol 29: 367-372.
17. Aubin JT, Agut H, Collandre H, Yamanishi K, Chandran B, Montagnier L, Huraux JM (1993) Antigenic and genetic differentiation of the two putative types of human herpes virus 6. J Virol Methods 41: 223-234.
18. Bates M, Monze M, Bima H, Kapambwe M, Clark D, Kasolo FC, Gompels UA (2009) Predominant human herpesvirus 6 variant A infant infections in an HIV-1 endemic region of Sub-Saharan Africa. J Med Virol 81: 779-789.
19. Biancotto A, Grivel JC, Lisco A, Vanpouille C, Markham PD, Gallo RC, Margolis LB, Lusso P (2009) Evolution of SIV toward RANTES resistance in macaques rapidly progressing to AIDS upon coinfection with HHV-6A. Retrovirology 6: 61.
20. Blanco-Kelly F, Alvarez-Lafuente R, Alcina A, Abad-Grau MM, De Las Heras V, Lucas M, de la Concha EG, Fernandez O, Arroyo R, Matesanz F, Urcelay E (2011) Members 6B and 14 of the TNF receptor superfamily in multiple sclerosis predisposition. Genes Immun 12: 145-148.
21. Boutolleau D, Duros C, Bonnafous P, Caiola D, Karras A, Castro ND, Ouachee M, Narcy P, Gueudin M, Agut H, Gautheret-Dejean A (2006) Identification of human herpesvirus 6 variants A and B by primer-specific real-time PCR may help to revisit their respective role in pathology. J Clin Virol 35: 257-263.
22. Braun DK, Dominguez G, Pellett PE (1997) Human herpesvirus 6. Clin Microbiol Rev 10: 521-567.
23. Burbelo PD, Bayat A, Wagner J, Nutman TB, Baraniuk JN, Iadarola MJ (2012) No serological evidence for a role of HHV-6 infection in chronic fatigue syndrome. Am J Transl Res 4: 443-451.
24. Campadelli-Fiume G, Mirandola P, Menotti L (1999) Human herpesvirus 6: An emerging pathogen. Emerg Infect Dis 5: 353-366.
25. Caselli E, Zatelli MC, Rizzo R, Benedetti S, Martorelli D, Trasforini G, Cassai E, degli Uberti EC, Di Luca D, Dolcetti R (2012) Virologic and immunologic evidence supporting an association between HHV-6 and Hashimoto's thyroiditis. PLoS Pathog 8: e1002951.
26. Cassina G, Russo D, De Battista D, Broccolo F, Lusso P, Malnati MS (2013) Calibrated real-time polymerase chain reaction for specific quantitation of HHV-6A and HHV-6B in clinical samples. J Virol Methods 189: 172-179.
27. Catusse J, Parry CM, Dewin DR, Gompels UA (2007) Inhibition of HIV-1 infection by viral chemokine U83A via high-affinity CCR5 interactions that block human chemokine-induced leukocyte chemotaxis and receptor internalization. Blood 109: 3633-3639.
28. Chapenko S, Trociukas I, Donina S, Chistyakov M, Sultanova A, Gravelsina S, Lejniece S, Murovska M (2012) Relationship between beta-herpesviruses reactivation and development of complications after autologous peripheral blood stem cell transplantation. J Med Virol 84: 1953-1960.
29. Cheng FW, Lee V, Leung WK, Chan PK, Leung TF, Shing MK, Li CK (2010) HHV-6 encephalitis in pediatric unrelated umbilical cord transplantation: a role for ganciclovir prophylaxis? Pediatr Transplant 14: 483-487.
30. Chi J, Gu B, Zhang C, Peng G, Zhou F, Chen Y, Zhang G, Guo Y, Guo D, Qin J, Wang J, Li L, Wang F, Liu G, Xie F, Feng D, Zhou H, Huang X, Lu S, Liu Y, Hu W, Yao K (2012) Human herpesvirus 6 latent infection in patients with glioma. J Infect Dis 206: 1394-1398.
31. Chi J, Wang F, Li L, Feng D, Qin J, Xie F, Zhou F, Chen Y, Wang J, Yao K (2012) The role of MAPK in CD4(+) T cells toll-like receptor 9-mediated signaling following HHV-6 infection. Virology 422: 92-98.
32. Clark DA (2000) Human herpesvirus 6. Rev Med Virol 10: 155-173.
33. Clark DJ, Catusse J, Stacey A, Borrow P, Gompels U (2013) Activation of CCR2+ human proinflammatory monocytes by human herpesvirus-6B chemokine N-terminal peptide. J Gen Virol. doi: 10. 1099/vir. 0. 050153-0.
34. Cohen JI, Fahle G, Kemp MA, Apakupakul K, Margolis TP (2010) Human herpesvirus 6-A, 6-B, and 7 in vitreous fluid samples. J Med Virol 82: 996-999.
35. Comar M, Grasso D, dal Molin G, Zocconi E, Campello C (2010) HHV-6 infection of tonsils and adenoids in children with hypertrophy and upper airway recurrent infections. Int J Pediatr Otorhinolaryngol 74: 47-49.
36. Cone RW, Huang ML, Hackman RC, Corey L (1996) Coinfection with human herpesvirus 6 variants A and B in lung tissue. J Clin Microbiol 34: 877-881.
37. Crawford JR, Kadom N, Santi MR, Mariani B, Lavenstein BL (2007) Human herpesvirus 6 rhombencephalitis in immunocompetent children. J Child Neurol 22: 1260-1268.
38. Crawford JR, Santi MR, Thorarinsdottir HK, Cornelison R, Rushing EJ, Zhang H, Yao K, Jacobson S, Macdonald TJ (2009) Detection of human herpesvirus-6 variants in pediatric brain tumors: association of viral antigen in low grade gliomas. J Clin Virol 46: 37-42.
39. Dagna L, Pritchett JC, and Lusso P (2013) Immunomodulation and immunosuppression by human herpesvirus 6A and 6B. Future Virol 8(3): 273-287.
40. De Bolle L, Naesens L, De Clercq E (2005) Update on human herpesvirus 6 biology, clinical features, and therapy. Clin Microbiol Rev 18: 217-245.
41. De Filippis L, Foglieni C, Silva S, Vescovi AL, Lusso P, Malnati MS (2006) Differentiated human neural stem cells: a new ex vivo model to study HHV-6 infection of the central nervous system. J Clin Virol 37(Suppl 1): 27-32.
42. de Pagter PJ, Schuurman R, de Vos NM, Mackay W, van Loon AM (2010) Multicenter external quality assessment of molecular methods for detection of human herpesvirus 6. J Clin Microbiol 48: 2536-2540.
43. Dewhurst S, McIntyre K, Schnabel K, Hall CB (1993) Human herpesvirus 6 (HHV-6) variant B accounts for the majority of symptomatic primary HHV-6 infections in a population of US infants. J Clin Microbiol 31: 416-418.
44. Dewin DR, Catusse J, Gompels UA (2006) Identification and characterization of U83A viral chemokine, a broad and potent beta-chemokine agonist for human CCRs with unique selectivity and inhibition by spliced isoform. J Immunol 176: 544-556.
45. Di Luca D, Dolcetti R, Mirandola P, De Re V, Secchiero P, Carbone A, Boiocchi M, Cassai E (1994) Human herpesvirus 6: a survey of presence and variant distribution in normal peripheral lymphocytes and lymphoproliferative disorders. J Infect Dis 170: 211-215.
46. Dietrich J, Blumberg BM, Roshal M, Baker JV, Hurley SD, Mayer-Proschel M, Mock DJ (2004) Infection with an endemic human herpesvirus disrupts critical glial precursor cell properties. J Neurosci 24: 4875-4883.
47. Dominguez G, Dambaugh TR, Stamey FR, Dewhurst S, Inoue N, Pellett PE (1999) Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A. J Virol 73: 8040-8052.
48. Dominguez-Mozo MI, Garcia-Montojo M, Delh V, Garcia-Martinez A, Arias-Leal AM, Casanova I, Arroyo R, Alvarez-Lafuente R (2012) MHC2TA mRNA levels and human herpesvirus 6 in multiple sclerosis patients treated with interferon beta along two-year follow-up. BMC Neurol 12: 107.
49. Donati D, Martinelli E, Cassiani-Ingoni R, Ahlqvist J, Hou J, Major EO, Jacobson S (2005) Variant-specific tropism of human herpesvirus 6 in human astrocytes. J Virol 79: 9439-9448.
50. Downing RG, Sewankambo N, Serwadda D, Honess R, Crawford D, Jarrett R, Griffin BE (1987) Isolation of human lymphotropic herpesviruses from Uganda. Lancet 2: 390.
51. Enders G, Biber M, Meyer G, Helftenbein E (1990) Prevalence of antibodies to human herpesvirus 6 in different age groups, in children with exanthema subitum, other acute exanthematous childhood diseases, Kawasaki syndrome, and acute infections with other herpesviruses and HIV. Infection 18: 12-15.
52. Epstein LG, Shinnar S, Hesdorffer DC, Nordli DR, Hamidullah A, Benn EK, Pellock JM, Frank LM, Lewis DV, Moshe SL, Shinnar RC, Sun S, FEBSTAT study team (2012) Human herpesvirus 6 and 7 in febrile status epilepticus: the FEBSTAT study. Epilepsia 53: 1481-1488.
53. Faten N, Agnes GD, Nadia BF, Nabil AB, Monia Z, Abderrahim K, Henri A, Salma F, Mahjoub A (2012) Quantitative analysis of human herpesvirus-6 genome in blood and bone marrow samples from Tunisian patients with acute leukemia: a follow-up study. Infect Agent Cancer 7: 31.
54. Ferreira DC, Paiva SS, Carmo FL, Rocas IN, Rosado AS, Santos KR, Siqueira JF Jr (2011) Identification of herpesviruses types 1 to 8 and human papillomavirus in acute apical abscesses. J Endod 37: 10-16.
55. Flamand L, Gravel A, Boutolleau D, Alvarez-Lafuente R, Jacobson S, Malnati MS, Kohn D, Tang YW, Yoshikawa T, Ablashi D (2008) Multicenter comparison of PCR assays for detection of human herpesvirus 6 DNA in serum. J Clin Microbiol 46: 2700-2706.
56. French C, Menegazzi P, Nicholson L, Macaulay H, DiLuca D, Gompels UA (1999) Novel, nonconsensus cellular splicing regulates expression of a gene encoding a chemokine-like protein that shows high variation and is specific for human herpesvirus 6. Virology 262: 139-151.
57. Geraudie B, Charrier M, Bonnafous P, Heurte D, Desmonet M, Bartoletti MA, Penasse C, Agut H, Gautheret-Dejean A (2012) Quantitation of human herpesvirus-6A, -6B and -7 DNAs in whole blood, mononuclear and polymorphonuclear cell fractions from healthy blood donors. J Clin Virol 53: 151-155.
58. Gompels UA, Nicholas J, Lawrence G, Jones M, Thomson BJ, Martin ME, Efstathiou S, Craxton M, Macaulay HA (1995) The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution. Virology 209: 29-51.
59. Gravel A, Gosselin J, Flamand L (2002) Human Herpesvirus 6 immediate-early 1 protein is a sumoylated nuclear phosphoprotein colocalizing with promyelocytic leukemia protein-associated nuclear bodies. J Biol Chem 277: 19679-19687.
60. Grivel JC, Santoro F, Chen S, Faga G, Malnati MS, Ito Y, Margolis L, Lusso P (2003) Pathogenic effects of human herpesvirus 6 in human lymphoid tissue ex vivo. J Virol 77: 8280-8289.
61. Gu B, Zhang GF, Li LY, Zhou F, Feng DJ, Ding CL, Chi J, Zhang C, Guo DD, Wang JF, Zhou H, Yao K, Hu WX (2011) Human herpesvirus 6A induces apoptosis of primary human fetal astrocytes via both caspase-dependent and -independent pathways. Virol J 8: 530.
62. Hall CB, Caserta MT, Schnabel KC, Long C, Epstein LG, Insel RA, Dewhurst S (1998) Persistence of human herpesvirus 6 according to site and variant: possible greater neurotropism of variant A. Clin Infect Dis 26: 132-137.
63. Hall CB, Caserta MT, Schnabel KC, McDermott MP, Lofthus GK, Carnahan JA, Gilbert LM, Dewhurst S (2006) Characteristics and acquisition of human herpesvirus (HHV) 7 infections in relation to infection with HHV-6. J Infect Dis 193: 1063-1069.
64. Higashimoto Y, Ohta A, Nishiyama Y, Ihira M, Sugata K, Asano Y, Peterson DL, Ablashi DV, Lusso P, Yoshikawa T (2012) Development of a human herpesvirus 6 species-specific immunoblotting assay. J Clin Microbiol 50: 1245-1251.
65. Hudnall SD, Chen T, Allison P, Tyring SK, Heath A (2008) Herpesvirus prevalence and viral load in healthy blood donors by quantitative real-time polymerase chain reaction. Transfusion 48: 1180-1187.
66. Ihira M, Enomoto Y, Kawamura Y, Nakai H, Sugata K, Asano Y, Tsuzuki M, Emi N, Goto T, Miyamura K, Matsumoto K, Kato K, Takahashi Y, Kojima S, Yoshikawa T (2012) Development of quantitative RT-PCR assays for detection of three classes of HHV-6B gene transcripts. J Med Virol 84: 1388-1395.
67. Isegawa Y, Mukai T, Nakano K, Kagawa M, Chen J, Mori Y, Sunagawa T, Kawanishi K, Sashihara J, Hata A, Zou P, Kosuge H, Yamanishi K (1999) Comparison of the complete DNA sequences of human herpesvirus 6 variants A and B. J Virol 73: 8053-8063.
68. Iyengar S, Levine PH, Ablashi D, Neequaye J, Pearson GR (1991) Sero-epidemiological investigations on human herpesvirus 6 (HHV-6) infections using a newly developed early antigen assay. Int J Cancer 49: 551-557.
69. Jarrett RF, Gallagher A, Gledhill S, Jones MD, Teo I, Griffin BE (1989) Variation in restriction map of MHV-6 genome. Lancet 1: 448-449.
70. Jaworska J, Gravel A, Flamand L (2010) Divergent susceptibilities of human herpesvirus 6 variants to type I interferons. Proc Natl Acad Sci USA 107: 8369-8374.
71. Josephs SF, Ablashi DV, Salahuddin SZ, Kramarsky B, Franza BR Jr, Pellett P, Buchbinder A, Memon S, Wong-Staal F, Gallo RC (1988) Molecular studies of HHV-6. J Virol Methods 21: 179-190.
72. Kasolo FC, Mpabalwani E, Gompels UA (1997) Infection with AIDS-related herpesviruses in human immunodeficiency virus-negative infants and endemic childhood Kaposi's sarcoma in Africa. J Gen Virol 78(Pt 4): 847-855.
73. Kawabata A, Oyaizu H, Maeki T, Tang H, Yamanishi K, Mori Y (2011) Analysis of a neutralizing antibody for human herpesvirus 6B reveals a role for glycoprotein Q1 in viral entry. J Virol 85: 12962-12971.
74. Lautenschlager I, Razonable RR (2012) Human herpesvirus-6 infections in kidney, liver, lung, and heart transplantation: review. Transpl Int 25: 493-502.
75. Leibovitch E, Wohler JE, Cummings Macri SM, Motanic K, Harberts E, Gaitan MI, Maggi P, Ellis M, Westmoreland S, Silva A, Reich DS, Jacobson S (2013) Novel marmoset (Callithrix jacchus) model of human Herpesvirus 6A and 6B infections: immunologic, virologic and radiologic characterization. PLoS Pathog 9: e1003138.
76. Lempinen M, Halme L, Arola J, Honkanen E, Salmela K, Lautenschlager I (2012) HHV-6B is frequently found in the gastrointestinal tract in kidney transplantation patients. Transpl Int 25: 776-782.
77. Li JM, Lei D, Peng F, Zeng YJ, Li L, Xia ZL, Xia XQ, Zhou D (2011) Detection of human herpes virus 6B in patients with mesial temporal lobe epilepsy in West China and the possible association with elevated NF-kappaB expression. Epilepsy Res 94: 1-9.
78. Li L, Gu B, Zhou F, Chi J, Wang F, Peng G, Xie F, Qing J, Feng D, Lu S, Yao K (2011) Human herpesvirus 6 suppresses T cell proliferation through induction of cell cycle arrest in infected cells in the G2/M phase. J Virol 85: 6774-6783.
79. Loginov R, Karlsson T, Hockerstedt K, Ablashi D, Lautenschlager I (2010) Quantitative HHV-6B antigenemia test for the monitoring of transplant patients. Eur J Clin Microbiol Infect Dis 29: 881-886.
80. Lopez C, Pellett P, Stewart J, Goldsmith C, Sanderlin K, Black J, Warfield D, Feorino P (1988) Characteristics of human herpesvirus-6. J Infect Dis 157: 1271-1273.
81. Lou J, Wu Y, Cai M, Wu X, Shang S (2011) Subtype-specific, probe-based, real-time PCR for detection and typing of human herpesvirus-6 encephalitis from pediatric patients under the age of 2 years. Diagn Microbiol Infect Dis 70: 223-229.
82. Luppi M, Barozzi P, Maiorana A, Marasca R, Torelli G (1994) Human herpesvirus 6 infection in normal human brain tissue. J Infect Dis 169: 943-944.
83. Lusso P, Markham PD, Tschachler E, di Marzo Veronese F, Salahuddin SZ, Ablashi DV, Pahwa S, Krohn K, Gallo RC (1988) In vitro cellular tropism of human B-lymphotropic virus (human herpesvirus-6). J Exp Med 167: 1659-1670.
84. Lusso P, De Maria A, Malnati M, Lori F, DeRocco SE, Baseler M, Gallo RC (1991) Induction of CD4 and susceptibility to HIV-1 infection in human CD8+ T lymphocytes by human herpesvirus 6. Nature 349: 533-535.
85. Lusso P, Malnati MS, Garzino-Demo A, Crowley RW, Long EO, Gallo RC (1993) Infection of natural killer cells by human herpesvirus 6. Nature 362: 458-462.
86. Lusso P, Garzino-Demo A, Crowley RW, Malnati MS (1995) Infection of gamma/delta T lymphocytes by human herpesvirus 6: transcriptional induction of CD4 and susceptibility to HIV infection. J Exp Med 181: 1303-1310.
87. Lusso P, Crowley RW, Malnati MS, Di Serio C, Ponzoni M, Biancotto A, Markham PD, Gallo RC (2007) Human herpesvirus 6A accelerates AIDS progression in macaques. Proc Natl Acad Sci USA 104: 5067-5072.
88. Luttichau HR, Clark-Lewis I, Jensen PO, Moser C, Gerstoft J, Schwartz TW (2003) A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6. J Biol Chem 278: 10928-10933.
89. Maeki T, Mori Y (2012) Features of Human Herpesvirus-6A and -6B Entry. Adv Virol 2012: 384069.
90. Martin LK, Schub A, Dillinger S, Moosmann A (2012) Specific CD8(+) T cells recognize human herpesvirus 6B. Eur J Immunol 42: 2901-2912.
91. Martinez A, Alvarez-Lafuente R, Mas A, Bartolome M, Garcia-Montojo M, de Las Heras V, de la Concha EG, Arroyo R, Urcelay E (2007) Environment-gene interaction in multiple sclerosis: human herpesvirus 6 and MHC2TA. Hum Immunol 68: 685-689.
92. Mirandola P, Menegazzi P, Merighi S, Ravaioli T, Cassai E, Di Luca D (1998) Temporal mapping of transcripts in herpesvirus 6 variants. J Virol 72: 3837-3844.
93. Mori Y, Seya T, Huang HL, Akkapaiboon P, Dhepakson P, Yamanishi K (2002) Human herpesvirus 6 variant A but not variant B induces fusion from without in a variety of human cells through a human herpesvirus 6 entry receptor, CD46. J Virol 76: 6750-6761.
94. Mori Y, Yang X, Akkapaiboon P, Okuno T, Yamanishi K (2003) Human herpesvirus 6 variant A glycoprotein H-glycoprotein L-glycoprotein Q complex associates with human CD46. J Virol 77: 4992-4999.
95. Mori Y (2009) Recent topics related to human herpesvirus 6 cell tropism. Cell Microbiol 11: 1001-1006.
96. Nastke MD, Becerra A, Yin L, Dominguez-Amorocho O, Gibson L, Stern LJ, Calvo-Calle JM (2012) Human CD4+ T cell response to human herpesvirus 6. J Virol 86: 4776-4792.
97. Nitsche A, Muller CW, Radonic A, Landt O, Ellerbrok H, Pauli G, Siegert W (2001) Human herpesvirus 6A DNA Is detected frequently in plasma but rarely in peripheral blood leukocytes of patients after bone marrow transplantation. J Infect Dis 183: 130-133.
98. Oyaizu H, Tang H, Ota M, Takenaka N, Ozono K, Yamanishi K, Mori Y (2012) Complementation of the function of glycoprotein H of human herpesvirus 6 variant A by glycoprotein H of variant B in the virus life cycle. J Virol 86: 8492-8498.
99. Pedersen SM, Oster B, Bundgaard B, Hollsberg P (2006) Induction of cell-cell fusion from without by human herpesvirus 6B. J Virol 80: 9916-9920.
100. Pellett PE, Lindquester GJ, Feorino P, Lopez C (1990) Genomic heterogeneity of human herpesvirus 6 isolates. Adv Exp Med Biol 278: 9-18.
101. Pellett PE, Sanchez-Martinez D, Dominguez G, Black JB, Anton E, Greenamoyer C, Dambaugh TR (1993) A strongly immunoreactive virion protein of human herpesvirus 6 variant B strain Z29: identification and characterization of the gene and mapping of a variant-specific monoclonal antibody reactive epitope. Virology 195: 521-531.
102. Pfeiffer B, Berneman ZN, Neipel F, Chang CK, Tirwatnapong S, Chandran B (1993) Identification and mapping of the gene encoding the glycoprotein complex gp82-gp105 of human herpesvirus 6 and mapping of the neutralizing epitope recognized by monoclonal antibodies. J Virol 67: 4611-4620.
103. Pfeiffer B, Thomson B, Chandran B (1995) Identification and characterization of a cDNA derived from multiple splicing that encodes envelope glycoprotein gp105 of human herpesvirus 6. J Virol 69: 3490-3500.
104. Portolani M, Pecorari M, Tamassia MG, Gennari W, Beretti F, Guaraldi G (2001) Case of fatal encephalitis by HHV-6 variant A. J Med Virol 65: 133-137.
105. Portolani M, Tamassia MG, Gennari W, Pecorari M, Beretti F, Alu M, Maiorana A, Migaldi M (2005) Post-mortem diagnosis of encephalitis in a 75-year-old man associated with human herpesvirus-6 variant A. J Med Virol 77: 244-248.
106. Potenza L, Luppi M, Barozzi P, Rossi G, Cocchi S, Codeluppi M, Pecorari M, Masetti M, Di Benedetto F, Gennari W, Portolani M, Gerunda GE, Lazzarotto T, Landini MP, Schulz TF, Torelli G, Guaraldi G (2008) HHV-6A in syncytial giant-cell hepatitis. N Engl J Med 359: 593-602.
107. Rapp JC, Krug LT, Inoue N, Dambaugh TR, Pellett PE (2000) U94, the human herpesvirus 6 homolog of the parvovirus nonstructural gene, is highly conserved among isolates and is expressed at low mRNA levels as a spliced transcript. Virology 268: 504-516.
108. Reddy S, Manna P (2005) Quantitative detection and differentiation of human herpesvirus 6 subtypes in bone marrow transplant patients by using a single real-time polymerase chain reaction assay. Biol Blood Marrow Transplant 11: 530-541.
109. Robert C, Aubin JT, Visse B, Fillet AM, Huraux JM, Agut H (1996) Difference in permissiveness of human fibroblast cells to variants A and B of human herpesvirus-6. Res Virol 147: 219-225.
110. Rotola A, Merlotti I, Caniatti L, Caselli E, Granieri E, Tola MR, Di Luca D, Cassai E (2004) Human herpesvirus 6 infects the central nervous system of multiple sclerosis patients in the early stages of the disease. Mult Scler 10: 348-354.
111. Salahuddin SZ, Ablashi DV, Markham PD, Josephs SF, Sturzenegger S, Kaplan M, Halligan G, Biberfeld P, Wong-Staal F, Kramarsky B et al (1986) Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 234: 596-601.
112. Santoro F, Kennedy PE, Locatelli G, Malnati MS, Berger EA, Lusso P (1999) CD46 is a cellular receptor for human herpesvirus 6. Cell 99: 817-827.
113. Schirmer EC, Wyatt LS, Yamanishi K, Rodriguez WJ, Frenkel N (1991) Differentiation between two distinct classes of viruses now classified as human herpesvirus 6. Proc Natl Acad Sci USA 88: 5922-5926.
114. Secchiero P, Carrigan DR, Asano Y, Benedetti L, Crowley RW, Komaroff AL, Gallo RC, Lusso P (1995) Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction. J Infect Dis 171: 273-280.
115. Soldan SS, Berti R, Salem N, Secchiero P, Flamand L, Calabresi PA, Brennan MB, Maloni HW, McFarland HF, Lin HC, Patnaik M, Jacobson S (1997) Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA. Nat Med 3: 1394-1397.
116. Stanton R, Wilkinson GW, Fox JD (2003) Analysis of human herpesvirus-6 IE1 sequence variation in clinical samples. J Med Virol 71: 578-584.
117. Sugita S, Shimizu N, Watanabe K, Ogawa M, Maruyama K, Usui N, Mochizuki M (2012) Virological analysis in patients with human herpes virus 6-associated ocular inflammatory disorders. Invest Ophthalmol Vis Sci 53: 4692-4698.
118. Takahashi K, Sonoda S, Higashi K, Kondo T, Takahashi H, Takahashi M, Yamanishi K (1989) Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus. J Virol 63: 3161-3163.
119. Takeda K, Haque M, Sunagawa T, Okuno T, Isegawa Y, Yamanishi K (1997) Identification of a variant B-specific neutralizing epitope on glycoprotein H of human herpesvirus-6. J Gen Virol 78(Pt 9): 2171-2178.
120. Tang H, Kawabata A, Yoshida M, Oyaizu H, Maeki T, Yamanishi K, Mori Y (2010) Human herpesvirus 6 encoded glycoprotein Q1 gene is essential for virus growth. Virology 407: 360-367.
121. Tang H, Mori Y (2010) Human herpesvirus-6 entry into host cells. Future Microbiol 5: 1015-1023.
122. Tang H, Hayashi M, Maeki T, Yamanishi K, Mori Y (2011) Human herpesvirus 6 glycoprotein complex formation is required for folding and trafficking of the gH/gL/gQ1/gQ2 complex and its cellular receptor binding. J Virol 85: 11121-11130.
123. Tang H, Serada S, Kawabata A, Ota M, Hayashi E, Naka T, Yamanishi K, Mori Y (2013) CD134 is a cellular receptor specific for human herpesvirus-6B entry. Proc Natl Acad Sci USA 110: 9096-9099.
124. Tedder RS, Briggs M, Cameron CH, Honess R, Robertson D, Whittle H (1987) A novel lymphotropic herpesvirus. Lancet 2: 390-392.
125. Thader-Voigt A, Jacobs E, Lehmann W, Bandt D (2011) Development of a microwell adapted immunoblot system with recombinant antigens for distinguishing human herpesvirus (HHV)6A and HHV6B and detection of human cytomegalovirus. Clin Chem Lab Med 49: 1891-1898.
126. Theodore WH, Epstein L, Gaillard WD, Shinnar S, Wainwright MS, Jacobson S (2008) Human herpes virus 6B: a possible role in epilepsy? Epilepsia 49: 1828-1837.
127. Tomoiu A, Flamand L (2007) Epitope mapping of a monoclonal antibody specific for human herpesvirus 6 variant A immediate-early 2 protein. J Clin Virol 38: 286-291.
128. Wang LR, Dong LJ, Zhang MJ, Lu DP (2006) The impact of human herpesvirus 6B reactivation on early complications following allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 12: 1031-1037.
129. Wyatt LS, Balachandran N, Frenkel N (1990) Variations in the replication and antigenic properties of human herpesvirus 6 strains. J Infect Dis 162: 852-857.
130. Yamamoto T, Mukai T, Kondo K, Yamanishi K (1994) Variation of DNA sequence in immediate-early gene of human herpesvirus 6 and variant identification by PCR. J Clin Microbiol 32: 473-476.
131. Yao K, Gagnon S, Akhyani N, Williams E, Fotheringham J, Frohman E, Stuve O, Monson N, Racke MK, Jacobson S (2008) Reactivation of human herpesvirus-6 in natalizumab treated multiple sclerosis patients. PLoS One 3: e2028.
132. Yasukawa M, Yakushijin Y, Furukawa M, Fujita S (1993) Specificity analysis of human CD4+ T-cell clones directed against human herpesvirus 6 (HHV-6), HHV-7, and human cytomegalovirus. J Virol 67: 6259-6264.
133. Yoshikawa T, Asano Y, Akimoto S, Ozaki T, Iwasaki T, Kurata T, Goshima F, Nishiyama Y (2002) Latent infection of human herpesvirus 6 in astrocytoma cell line and alteration of cytokine synthesis. J Med Virol 66: 497-505.
134. Zerr DM, Meier AS, Selke SS, Frenkel LM, Huang ML, Wald A, Rhoads MP, Nguy L, Bornemann R, Morrow RA, Corey L (2005) A population-based study of primary human herpesvirus 6 infection. N Engl J Med 352: 768-776.