Linking the Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to human malignancies

Methods in Molecular Biology

Volumn 471, Issue , 2009, Pages 387-407

  Kalt, Inna ^a   Masa, Shiri Rivka ^a   Sarid, Ronit ^a  

^a BAR ILAN UNIVERSITY   (Israel)

Author keywords

Human herpesvirus 8 (HHV 8); Kaposi's sarcoma (KS); Kaposi's sarcoma associated herpesvirus (KSHV); Multicentric Castleman's disease (MCD); Primary effusion lymphoma (PEL)

Indexed keywords

ANGIOFOLLICULAR LYMPH NODE HYPERPLASIA; HOST PATHOGEN INTERACTION; HUMAN; HUMAN HERPESVIRUS 8; KAPOSI SARCOMA; PATHOLOGY; PHYSIOLOGY; PRIMARY EFFUSION LYMPHOMA; REVIEW; VIROLOGY;

GIANT LYMPH NODE HYPERPLASIA; HERPESVIRUS 8, HUMAN; HOST-PATHOGEN INTERACTIONS; HUMANS; LYMPHOMA, PRIMARY EFFUSION; SARCOMA, KAPOSI;

HUMAN HERPESVIRUS 8;

EID: 60349122854     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-59745-416-2_19     Document Type: Review

References (132)

1. Kaposi, M. (1872) Idiopathisches Multiples Pigmentsarkom Der Haut. 3, 265-273.
2. Iscovich, J., Boffetta, P., Franceschi, S., Azizi, E., and Sarid, R. (2000) Classic Kaposi sarcoma: epidemiology and risk factors. 88, 500-517.
3. Cohen, A., Wolf, D. G., Guttman-Yassky, E., and Sarid, R. (2005) Kaposi's sarcoma-associated herpesvirus: clinical, diagnostic, and epidemiological aspects. 42, 101-153.
4. Dourmishev, L. A., Dourmishev, A. L., Palmeri, D., Schwartz, R. A., and Lukac, D. M. (2003) Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis. 67, 175-212.
5. Cook-Mozaffari, P., Newton, R., Beral, V., and Burkitt, D. P. (1998) The geographical distribution of Kaposi's sarcoma and of lymphomas in Africa before the aids epidemic. 78, 1521-1528.
6. Sitas, F. and Newton, R. (2001) Kaposi's sarcoma in South Africa. 1-4.
7. Sissolak, G. and Mayaud, P. (2005) AIDS-related Kaposi's sarcoma: epidemiological, diagnostic, treatment and control aspects in sub-Saharan Africa. 10, 981-992.
8. Zmonarski, S. C., Boratynska, M., Puziewicz-Zmonarska, A., Kazimierczak, K., and Klinger, M. (2005) Kaposi's sarcoma in renal transplant recipients. 10, 59-65.
9. Marcelin, A. G., Calvez, V., and Dussaix, E. (2007) KSHV after an organ transplant: should we screen? 312, 245-62.
10. Goedert, J. J. (2000) The epidemiology of acquired immunodeficiency syndrome malignancies. 27, 390-401.
11. Cheung, T. W. (2004) AIDS-related cancer in the era of highly active antiretroviral therapy (HAART): a model of the interplay of the immune system, virus, and cancer. "On the offensive - the Trojan horse is being destroyed" - part A: Kaposi's sarcoma. 22, 774-786.
12. Bower, M., Palmieri, C., and Dhillon, T. (2006) AIDS-related malignancies: changing epidemiology and the impact of highly active antiretroviral therapy. 19, 14-19.
13. Cheung, M. C., Pantanowitz, L., and Dezube, B. J. (2005) AIDS-related malignancies: emerging challenges in the era of highly active antiretroviral therapy. 10, 412-426.
14. Beral, V., Peterman, T. A., Berkelman, R. L., and Jaffe, H. W. (1990) Kaposi's sarcoma among persons with aids: a sexually transmitted infection? 335, 123-128.
15. Archibald, C. P., Schechter, M. T., Le, T. N., Craib, K. J., Montaner, J. S., and O'shaughnessy, M. V. (1992) Evidence For a sexually transmitted cofactor for AIDS-related Kaposi's sarcoma in a cohort of homosexual men. 3, 203-209.
16. Vogel, J., Hinrichs, S. H., Reynolds, R. K., Luciw, P. A., and Jay, G. (1988) The HIV Tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice. 335, 606-611.
17. Ensoli, B., Salahuddin, S. Z., and Gallo, R. C. (1989) AIDS-associated Kaposi's sarcoma: a molecular model for its pathogenesis. 1, 93-96.
18. Chang, Y., Cesarman, E., Pessin, M. S., Lee, F., Culpepper, J., Knowles, D. M., and Moore, P. S. (1994) Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. 266, 1865-1869.
19. Russo, J. J., Bohenzky, R. A., Chien, M. C., Chen, J., Yan, M., Maddalena, D., Parry, J. P., Peruzzi, D., Edelman, I. S., Chang, Y., and Moore, P. S. (1996) Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). 93, 14862-14867.
20. Moore, P. S. and Chang, Y. (1995) Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and without HIV infection. 332, 1181-1185.
21. Cesarman, E., Chang, Y., Moore, P. S., Said, J. W., and Knowles, D. M. (1995) Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. 332, 1186-1191.
22. Soulier, J., Grollet, L., Oksenhendler, E., Cacoub, P., Cazals-Hatem, D., Babinet, P., D'agay, M. F., Clauvel, J. P., Raphael, M., and Degos, L. (1995) Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. 86, 1276-1280.
23. Codish, S., Abu-Shakra, M., Ariad, S., Zirkin, H. J., Yermiyahu, T., Dupin, N., Boshoff, C., and Sukenik, S. (2000) Manifestations of three HHV-8-related diseases in an HIV-negative patient: immunoblastic variant multicentric Castleman's disease, primary effusion lymphoma, and Kaposi's sarcoma. 65, 310-314.
24. Ascoli, V., Signoretti, S., Onetti-Muda, A., Pescarmona, E., Della-Rocca, C., Nardi, F., Mastroianni, C. M., Gastaldi, R., Pistilli, A., Gaidano, G., Carbone, A., and Lo-Coco, F. (2001) Primary effusion lymphoma in HIV-infected patients with multicentric Castleman's disease. 193, 200-209.
25. Sukpanichnant, S., Sivayathorn, A., Visudhiphan, S., and Ngowthammatas, W. (2002) Multicentric Castleman's disease, non-Hodgkin's lymphoma, and Kaposi's sarcoma: a rare simultaneous occurrence. 20, 127-133.
26. Kasolo, F. C., Mpabalwani, E., and Gompels, U. A. (1997) Infection with AIDS-related herpesviruses in human immunodeficiency virus-negative infants and endemic childhood Kaposi's sarcoma in Africa. 78 (4), 847-855.
27. Sarmati, L. (2004) HHV-8 infection in African children. 11, 50-53.
28. Andreoni, M., El-Sawaf, G., Rezza, G., Ensoli, B., Nicastri, E., Ventura, L., Ercoli, L., Sarmati, L., and Rocchi, G. (1999) High seroprevalence of antibodies to human herpesvirus-8 in Egyptian children: evidence of nonsexual transmission. 91, 465-469.
29. Wang, Q. J., Jenkins, F. J., Jacobson, L. P., Kingsley, L. A., Day, R. D., Zhang, Z. W., Meng, Y. X., Pellett, P. E., Kousoulas, K. G., Baghian, A., and Rinaldo, C. R., Jr. (2001) Primary human herpesvirus 8 infection generates a broadly specific cd8(+) T-cell response to viral lytic cycle proteins. 97, 2366-2373.
30. Luppi, M., Barozzi, P., Schulz, T. F., Setti, G., Staskus, K., Trovato, R., Narni, F., Donelli, A., Maiorana, A., Marasca, R., Sandrini, S., and Torelli, G. (2000) Bone marrow failure associated with human herpesvirus 8 infection after transplantation. 343, 1378-1385.
31. Sarid, R., Pizov, G., Rubinger, D., Backenroth, R., Friedlaender, M. M., Schwartz, F., and Wolf, D. G. (2001) Detection of human herpesvirus-8 DNA in kidney allografts prior to the development of Kaposi's sarcoma. 32, 1502-1505.
32. Marcelin, A. G., Roque-Afonso, A. M., Hurtova, M., Dupin, N., Tulliez, M., Sebagh, M., Arkoub, Z. A., Guettier, C., Samuel, D., Calvez, V., and Dussaix, E. (2004) Fatal disseminated Kaposi's sarcoma following human herpesvirus 8 primary infections in liver-transplant recipients. 10, 295-300.
33. Renne, R., Zhong, W., Herndier, B., Mcgrath, M., Abbey, N., Kedes, D., and Ganem, D. (1996) Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. 2, 342-346.
34. Sarid, R., Flore, O., Bohenzky, R. A., Chang, Y., and Moore, P. S. (1998) Transcription mapping of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genome in a body cavity-based lymphoma cell line (Bc-1). 72, 1005-1012.
35. Krishnan, H. H., Naranatt, P.P., Smith, M. S., Zeng, L., Bloomer, C., and Chandran, B. (2004) Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent decline of lytic gene expression. 78, 3601-3620.
36. Grundhoff, A. and Ganem, D. (2004) Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis. 113, 124-136.
37. Chen, J., Ueda, K., Sakakibara, S., Okuno, T., Parravicini, C., Corbellino, M., and Yamanishi, K. (2001) Activation of latent Kaposi's sarcoma-associated herpesvirus by demethylation of the promoter of the lytic transactivator. 98, 4119-4124.
38. Chang, J., Renne, R., Dittmer, D., and Ganem, D. (2000) Inflammatory cytokines and the reactivation of Kaposi's sarcoma-associated herpesvirus lytic replication. 266, 17-25.
39. Davis, D. A., Rinderknecht, A. S., Zoeteweij, J. P., Aoki, Y., Read-Connole, E. L., Tosato, G., Blauvelt, A., and Yarchoan, R. (2001) Hypoxia induces lytic replication of Kaposi sarcoma-associated herpesvirus. 97, 3244-3250.
40. Deutsch, E., Cohen, A., Kazimirsky, G., Dovrat, S., Rubinfeld, H., Brodie, C., and Sarid, R. (2004) Role of protein kinase c delta in reactivation of Kaposi's sarcoma-associated herpesvirus. 78, 10187-10192.
41. Sgarbanti, M., Arguello, M., Tenoever, B. R., Battistini, A., Lin, R., and Hiscott, J. (2004) A requirement for NF-kappaB induction in the production of replication-competent HHV-8 virions. 23, 5770-5780.
42. Mcallister, S. C., Hansen, S. G., Messaoudi, I., Nikolich-Zugich, J., and Moses, A. V. (2005) Increased efficiency of phorbol ester-induced lytic reactivation of Kaposi's sarcoma-associated herpesvirus during S phase. 79, 2626-2630.
43. Brown, H. J., Mcbride, W. H., Zack, J. A., and Sun, R. (2005) Prostratin and bortezomib are novel inducers of latent Kaposi's sarcoma-associated herpesvirus. 10, 745-751.
44. Chang, M., Brown, H. J., Collado-Hidalgo, A., Arevalo, J. M., Galic, Z., Symensma, T. L., Tanaka, L., Deng, H., Zack, J. A., Sun, R., and Cole, S. W. (2005) Beta-adreno-receptors reactivate Kaposi's sarcoma-associated herpesvirus lytic replication via PKA-dependent control of viral RTA. 79, 13538-13547.
45. Morris, T. L., Arnold, R. R., and Webster-Cyriaque, J. (2007) Signaling cascades triggered by bacterial metabolic end-products during KSHV reactivation. J. Virol.
46. Staudt, M. R. and Dittmer, D. P. (2007) The RTA/ORF50 transactivator proteins of the gamma-Herpesviridae. 312, 71-100.
47. Whitby, D., Marshall, V. A., Bagni, R. K., Miley, W. J., Mccloud, T. G., Hines-Boykin, R., Goedert, J. J., Conde, B. A., Nagashima, K., Mikovits, J., Dittmer, D. P., and Newman, D. J. (2007) Reactivation of Kaposi's sarcoma-associated herpesvirus by natural products from Kaposi's sarcoma endemic regions. 120, 321-328.
48. Aoki, Y. and Tosato, G. (2007) Interactions between HIV-1 Tat and KSHV. 312, 309-326.
49. Parravicini, C., Olsen, S. J., Capra, M., Poli, F., Sirchia, G., Gao, S. J., Berti, E., Nocera,A., Rossi, E., Bestetti, G., Pizzuto, M., Galli, M., Moroni, M., Moore, P. S., and Corbellino, M. (1997) Risk of Kaposi's sarcoma-associated herpes virus transmission from donor allografts among Italian posttransplant Kaposi's sarcoma patients. 90, 2826-2829.
50. Campbell, T. B., Borok, M., Gwanzura, L., Mawhinney, S., White, I. E., Ndemera, B., Gudza, I., Fitzpatrick, L., and Schooley, R.T. (2000) Relationship of human herpesvirus 8 peripheral blood virus load and Kaposi's sarcoma clinical stage. 14, 2109-2116.
51. Quinlivan, E. B., Zhang, C., Stewart, P. W., Komoltri, C., Davis, M. G., and Wehbie, R. S. (2002) Elevated virus loads of Kaposi's sarcoma-associated human herpesvirus 8 predict Kaposi's sarcoma disease progression, but elevated levels of human immunodeficiency virus type 1 do not. 185, 1736-1744.
52. Tedeschi, R., Enbom, M., Bidoli, E., Linde, A., De Paoli, P., and Dillner, J. (2001) Viral load of human herpesvirus 8 in peripheral blood of human immunodeficiency virus-infected patients with Kaposi's sarcoma. 39, 4269-4273.
53. Polstra, A. M., Cornelissen, M., Goudsmit, J., and Van Der Kuyl, A. C. (2004) Retrospective, longitudinal analysis of serum human herpesvirus-8 viral DNA load in aids-related Kaposi's sarcoma patients before and after diagnosis. 74, 390-396.
54. Pellet, C., Chevret, S., Frances, C., Euvrard, S., Hurault, M., Legendre, C., Dalac, S., Farge, D., Antoine, C., Hiesse, C., Peraldi, M.N., Lang, P., Samuel, D., Calmus, Y., Agbalika, F., Morel, P., Calvo, F., and Lebbe, C. (2002) Prognostic value of quantitative Kaposi sarcoma - associated herpesvirus load in posttransplantation Kaposi sarcoma. 186, 110-113.
55. Gessain, A. and Duprez, R. (2005) Spindle cells and their role in Kaposi's sarcoma. 37, 2457-2465.
56. Montaner, S., Sodhi, A., Molinolo, A., Bugge, T. H., Sawai, E. T., He, Y., Li, Y., Ray, P. E., and Gutkind, J. S. (2003) Endothelial infection with KSHV genes in vivo reveals that vgpcr initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. 3, 23-36.
57. Guo, H. G., Sadowska, M., Reid, W., Tschachler, E., Hayward, G., and Reitz, M. (2003) Kaposi's sarcoma-like tumors in a human herpesvirus 8 orf74 transgenic mouse. 77, 2631-2639.
58. Grisotto, M. G., Garin, A., Martin, A. P., Jensen, K. K., Chan, P., Sealfon, S. C., and Lira, S. A. (2006) The human herpesvirus 8 chemokine receptor vgpcr triggers autonomous proliferation of endothelial cells. 116, 1264-1273.
59. Mutlu, A. D., Cavallin, L. E., Vincent, L., Chiozzini, C., Eroles, P., Duran, E. M., Asgari, Z., Hooper, A. T., La Perle, K. M., Hilsher, C., Gao, S. J., Dittmer, D. P., Rafii, S., snd Mesri, E. A. (2007) In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma. 11, 245-258.
60. Brown, E. E., Whitby, D., Vitale, F., Marshall, V., Mbisa, G., Gamache, C., Lauria, C., Alberg, A. J., Serraino, D., Cordiali-Fei, P., Messina, A., and Goedert, J. J. (2006) Virologic, hematologic, and immunologic risk factors for classic Kaposi sarcoma. 107, 2282-2290.
61. Hengge, U. R., Ruzicka, T., Tyring, S. K., Stuschke, M., Roggendorf, M., Schwartz, R. A., and Seeber, S. (2002) Update on Kaposi's sarcoma and other hhv8 associated diseases. Part 2: pathogenesis, Castleman's disease, and pleural effusion lymphoma. 2, 344-352.
62. Cesarman, E. and Mesri, E. A. (2007) Kaposi sarcoma-associated herpesvirus and other viruses in human lymphomagenesis. 312, 263-87., 263-287.
63. Casper, C. (2005) The aetiology and management of Castleman disease at 50 years: translating pathophysiology to patient care. 129, 3-17.
64. Whitby, D., Howard, M. R., Tenant-Flowers, M., Brink, N. S., Copas, A., Boshoff, C., Hatzioannou, T., Suggett, F. E., Aldam, D. M., and Denton, A. S. (1995) Detection of Kaposi sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi's sarcoma. 346, 799-802.
65. Widmer, I. C., Erb, P., Grob, H., Itin, P., Baumann, M., Stalder, A., Weber, R., and Cathomas, G. (2006) Human herpesvirus 8 oral shedding in HIV-infected men with and without Kaposi sarcoma. 42, 420-425.
66. Boldogh, I., Szaniszlo, P., Bresnahan, W. A., Flaitz, C. M., Nichols, M. C., and Albrecht, T. (1996) Kaposi's Sarcoma herpesvirus-like DNA sequences in the saliva of individuals infected with human immunodeficiency virus. 23, 406-407.
67. Blackbourn, D. J., Lennette, E. T., Ambroziak, J., Mourich, D. V., and Levy, J. A. (1998) Human herpesvirus 8 detection in nasal secretions and saliva. 177, 213-216.
68. Pauk, J., Huang, M. L., Brodie, S. J., Wald, A., Koelle, D. M., Schacker, T., Celum, C., Selke, S., and Corey, L. (2000) Mucosal shedding of human herpesvirus 8 in men. 343, 1369-1377.
69. Pellett, P. E., Spira, T. J., Bagasra, O., Boshoff, C., Corey, L., De Lellis, L., Huang, M. L., Lin, J. C., Matthews, S., Monini, P., Rimessi, P., Sosa, C., Wood, C., and Stewart, J. A. (1999) Multicenter comparison of PCR assays for detection of human herpesvirus 8 DNA in semen. 37, 1298-1301.
70. Diamond, C., Brodie, S. J., Krieger, J. N., Huang, M. L., Koelle, D. M., Diem, K., Muthui, D., and Corey, L. (1998) Human herpesvirus 8 in the prostate glands of men with Kaposi's sarcoma. 72, 6223-6227.
71. Cerimele, F., Curreli, F., Ely, S., Friedman-Kien, A. E., Cesarman, E., and Flore, O. (2001) Kaposi's sarcoma-associated herpesvirus can productively infect primary human keratinocytes and alter their growth properties. 75, 2435-2443.
72. Akula, S. M., Wang, F. Z., Vieira, J., and Chandran, B. (2001) Human herpesvirus 8 interaction with target cells involves heparan sulfate. 282, 245-255.
73. Krishnan, H. H., Sharma-Walia, N., Zeng, L., Gao, S. J., and Chandran, B. (2005) Envelope glycoprotein gb of Kaposi's sarcoma-associated herpesvirus is essential for egress from infected cells. 79, 10952-10967.
74. Martin, J. N., Ganem, D. E., Osmond, D. H., Page-Shafer, K. A., Macrae, D., and Kedes, D. H. (1998) Sexual transmission and the natural history of human herpesvirus 8 infection. 338, 948-954.
75. Blackbourn, D. J., Osmond, D., Levy, J. A., and Lennette, E. T. (1999) Increased human herpesvirus 8 seroprevalence in young homosexual men who have multiple sex contacts with different partners. 179, 237-239.
76. Grulich, A. E., Kaldor, J. M., Hendry, O., Luo, K., Bodsworth, N. J., and Cooper, D. A. (1997) Risk of Kaposi's sarcoma and oroanal sexual contact. 145, 673-679.
77. Smith, N. A., Sabin, C. A., Gopal, R., Bourboulia, D., Labbet, W., Boshoff, C., Barlow, D., Band, B., Peters, B. S., De Ruiter, A., Brown, D. W., Weiss R. A., Best, J. M., and Whitby, D. (1999) Serologic evidence of human herpesvirus 8 transmission by homosexual but not heterosexual sex. 180, 600-606.
78. Osmond, D. H., Buchbinder, S., Cheng, A., Graves, A., Vittinghoff, E., Cossen, C. K., Forghani, B., and Martin, J. N. (2002) Prevalence of Kaposi sarcoma-associated herpesvirus infection in homosexual men at beginning of and during the HIV epidemic. 287, 221-225.
79. Mayama, S., Cuevas, L. E., Sheldon, J., Omar, O.H., Smith, D. H., Okong, P., Silvel, B., Hart, C. A., and Schulz, T. F. (1998) Prevalence and transmission of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in Ugandan children and adolescents. 77, 817-820.
80. Gessain, A., Mauclere, P., Van Beveren, M., Plancoulaine, S., Ayouba, A., Essame-Oyono, J. L., Martin, P. M., and De The, G. (1999) Human herpesvirus 8 primary infection occurs during childhood in Cameroon, Central Africa. 81, 189-192.
81. Bourboulia, D., Whitby, D., Boshoff, C., Newton, R., Beral, V., Carrara, H., Lane, A., and Sitas, F. (1998) Serologic evidence for mother-to-child transmission of Kaposi sarcoma-associated herpesvirus infection (letter). 280, 31-32.
82. Plancoulaine, S., Abel, L., Van Beveren, M., Tregouet, D. A., Joubert, M., Tortevoye, P., De The, G., and Gessain, A. (2000) Human herpesvirus 8 transmission from mother to child and between siblings in an endemic population. 356, 1062-1065.
83. Sarmati, L., Carlo, T., Rossella, S., Montano, M., Adalgisa, P., Rezza, G., and Andreoni, M. (2004) Human herpesvirus-8 infection in pregnancy and labor: lack of evidence of vertical transmission. 72, 462-466.
84. Angeloni, A., Heston, L., Uccini, S., Sirianni, M. C., Cottoni, F., Masala, M. V., Cerimele, D., Lin, S. F., Sun, R., Rigsby, M., Faggioni, A., and Miller, G. (1998) High prevalence of antibodies to human herpesvirus 8 in relatives of patients with classic Kaposi's sarcoma from Sardinia. 177, 1715-1718.
85. Guttman-Yassky, E., Kra-Oz, Z., Dubnov, J., Friedman-Birnbaum, R., Segal, I., Zaltzman, N., Roth, T., Schwartz, F., Linn, S., Rozenman, D., David, M., Silbermann, M., Barchana, M., Bergman, R., and Sarid, R. (2005) Infection with Kaposi's sarcoma-associated herpesvirus among families of patients with classic Kaposi's sarcoma. 141, 1429-1434.
86. Davidovici, B., Karakis, I., Bourboulia, D., Ariad, S., Zong, J. C., Benharroch, D., Dupin,N., Weiss, R., Hayward, G., Sarov, B., and Boshoff, C. (2001) Seroepidemiology and molecular epidemiology of Kaposi's sarcoma-associated herpesvirus among Jewish population groups in Israel. 93, 194-202.
87. Plancoulaine, S., Abel, L., Tregouet, D., Duprez, R., Van Beveren, M., Tortevoye, P., Froment, A., and Gessain, A. (2004) Respective roles of serological status and blood specific antihuman herpesvirus 8 antibody levels in human herpesvirus 8 intra-familial transmission in a highly endemic area. 64, 8782-8787.
88. Mbulaiteye, S. M., Biggar, R. J., Bakaki, P. M., Pfeiffer, R. M., Whitby, D., Owor, A. M., Katongole-Mbidde, E., Goedert, J. J., Ndugwa, C. M., and Engels, E. A. (2003) Human herpesvirus 8 infection and transfusion history in children with sickle-cell disease in Uganda. 95, 1330-1335.
89. Hladik, W., Dollard, S. C., Mermin, J., Fowlkes, A. L., Downing, R., Amin, M. M., Banage, F., Nzaro, E., Kataaha, P., Dondero, T. J., Pellett, P.E., and Lackritz, E. M. (2006) Transmission of human herpesvirus 8 by blood transfusion. 355, 1331-1338.
90. Barozzi, P., Luppi, M., Facchetti, F., Mecucci, C., Alu, M., Sarid, R., Rasini, V., Ravazzini,L., Rossi, E., Festa, S., Crescenzi, B., Wolf, D. G., Schulz, T. F., and Torelli, G. (2003) Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors. 9, 554-561.
91. Parkin, D. M., Whelan, S. L., Ferlay, J., Raymond, L., and Young, J. (2003) Cancer Incidence In Five Continents, Vol. VIII. IARC Scientific Publications, Lyon, France.
92. Gao, S. J., Kingsley, L., Li, M., Zheng, W., Parravicini, C., Ziegler, J., Newton, R., Rinaldo, C. R., Saah, A., Phair, J., Detels, R., Chang, Y., and Moore, P. S. (1996) KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. 2, 925-928.
93. Gao, S. J., Kingsley, L., Hoover, D. R., Spira, T. J., Rinaldo, C. R., Saah, A., Phair, J., Detels, R., Parry, P., Chang, Y., and Moore, P. S. (1996) Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma. 335, 233-241.
94. Kedes, D. H., Operskalski, E., Busch, M., Kohn, R., Flood, J., and Ganem, D. (1996) The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. 2, 918-924.
95. Simpson, G. R., Schulz, T. F., Whitby, D., Cook, P. M., Boshoff, C., Rainbow, L., Howard, M. R., Gao, S. J., Bohenzky, R. A., Simmonds, P., Lee, C., De Ruiter, A., Hatzakis, A., Tedder, R. S., Weller, I. V., Weiss, R. A., and Moore, P. S. (1996) Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen. 348, 1133-1138.
96. Laney, A. S., Peters, J. S., Manzi, S. M., Kingsley, L. A., Chang, Y., and Moore, P. S. (2006) Use of a multiantigen detection algorithm for diagnosis of Kaposi's sarcoma-associated herpesvirus infection. 44, 3734-3741.
97. Dukers, N. H. and Rezza, G. (2003) Human herpesvirus 8 epidemiology: what we do and do not know. 17, 1717-1730.
98. Mohanna, S., Maco, V., Bravo, F., and Gotuzzo, E. (2005) Epidemiology and clinical characteristics of classic Kaposi's sarcoma, seroprevalence, and variants of human herpesvirus 8 in South America: a critical review of an old disease. 9, 239-250.
99. Dedicoat, M. and Newton, R. (2003) Review of the distribution of Kaposi's sarcoma-associated herpesvirus (KSHV) in Africa in relation to the incidence of Kaposi's sarcoma. 88, 1-3.
100. Plancoulaine, S., Gessain, A., Van Beveren, M., Tortevoye, P., and Abel, L. (2003) Evidence for a recessive major gene predisposing to human herpesvirus 8 (HHV-8) infection in a population in which HHV-8 is endemic. 187, 1944-1950.
101. Ariyoshi, K., Schim, V. D. L., Cook, P., Whitby, D., Corrah, T., Jaffar, S., Cham, F., Sabally, S., O'donovan, D., Weiss, R. A., Schulz, T. F., and Whittle, H. (1998) Kaposi's sarcoma in The Gambia, West Africa is less frequent in human immunodeficiency virus type 2 than in human immunodeficiency virus type 1 infection despite a high prevalence of human herpesvirus 8. 1, 193-199.
102. He, F., Wang, X., He, B., Feng, Z., Lu, X., Zhang, Y., Zhao, S., Lin, R., Hui, Y., Bao, Y., Zhang, Z., and Wen, H. (2007) Human herpesvirus 8: serovprevalence and correlates in tumor patients from Xinjiang, China. 79, 161-166.
103. Biggar, R. J., Whitby, D., Marshall, V., Linhares, A. C., and Black, F. (2000) Human herpesvirus 8 in Brazilian Amerindians: a hyperendemic population with a new subtype. 181, 1562-1568.
104. Grossman, Z., Iscovich, J., Schwartz, F., Azizi, E., Klepfish, A., Schattner, A., and Sarid, R. (2002) Absence of Kaposi sarcoma among Ethiopian immigrants to Israel despite high seroprevalence of human herpesvirus 8. 77, 905-909.
105. Cottoni, E., Masia, I. M., Masala, M. V., Mulargia, M., and Contu, L. (1996) Familial Kaposi's sarcoma: case reports and review of the literature. 76, 59-61.
106. Guttman-Yassky, E., Cohen, A., Kra-Oz, Z., Friedman-Birnbaum, R., Sprecher, E., Zaltzman, N., Friedman, E., Silbermann, M., Rubin, D., Linn, S., Whitby, D., Gideoni, O., Pollack, S., Bergman, R., and Sarid, R. (2004) Familial clustering of classic Kaposi sarcoma. 189, 2023-2026.
107. Hayward, G. S. and Zong, J. C. (2007) Modern evolutionary history of the human KSHV genome. 312, 1-42.
108. Sarid, R., Olsen, S. J., and Moore, P. S (1999) Kaposi's sarcoma-associated herpesvirus epidemiology, virology, and molecular biology. 52, 139-232.
109. Vitale, F., Briffa, D. V., Whitby, D., Maida, I., Grochowska, A., Levin, A., Romano, N., and Goedert, J. J. (2001) Kaposi's Sarcoma herpes virus and Kaposi's sarcoma in the elderly populations of 3 Mediterranean islands. 91, 588-591.
110. Woodle, E. S., Hanaway, M., Buell, J., Gross, T., First, M. R., Trofe, J., and Beebe, T. (2001) Kaposi sarcoma: an analysis of the us and international experiences from The Israel Penn International Transplant Tumor Registry. 33, 3660-3661.
111. Renwick, N., Halaby, T., Weverling, G. J., Dukers, N. H., Simpson, G. R., Coutinho, R. A., Lange, J. M., Schulz, T. F., and Goudsmit, J. (1998) Seroconversion for human herpesvirus 8 during HIV infection is highly predictive of Kaposi's sarcoma. 12, 2481-2488.
112. Dorak, M. T., Yee, L. J., Tang, J., Shao, W., Lobashevsky ,E. S., Jacobson, L. P., and Kaslow, R. A. (2005) Hla-B, -Drb1/3/4/5, and -Dqb1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma. 76, 302-310.
113. Gaya, A., Esteve, A., Casabona, J., Mccarthy, J. J., Martorell, J., Schulz, T. F., and Whitby, D. (2004) Amino acid residue at position 13 in HLA-dr beta chain plays a critical role in the development of Kaposi's sarcoma in AIDS patients. 18, 199-204.
114. Cottoni, F., Masala, M. V., Santarelli, R., Carcassi, C., Uccini, S., Montesu, M. A., Satta, R., Angeloni, A., Faggioni, A., and Cerimele, D. (2004) Susceptibility to human herpesvirus-8 infection in a healthy population from Sardinia is not directly correlated with the expression of HLA-dr alleles. 151, 247-249.
115. Foster ,C. B., Lehrnbecher, T., Samuels, S., Stein, S., Mol, F., Metcalf, J. A., Wyvill, K., Steinberg, S. M., Kovacs, J., Blauvelt, A., Yarchoan, R., and Chanock, S. J. (2000) An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus. 96, 2562-2567.
116. Lehrnbecher, T. L., Foster, C. B., Zhu, S., Venzon, D., Steinberg, S. M., Wyvill, K., Metcalf, J. A., Cohen, S. S., Kovacs, J., Yarchoan,R., Blauvelt, A., and Chanock, S. J. (2000) Variant genotypes of fcgammariiia influence the development of Kaposi's sarcoma in HIV-infected men. 95, 2386-2390.
117. Brown, E. E., Fallin, D., Ruczinski, I., Hutchinson, A., Staats, B., Vitale, F., Lauria, C., Serraino, D., Rezza, G., Mbisa, G., Whitby, D., Messina, A., Goedert, J. J., and Chanock, S. J. (2006) Associations of classic Kaposi sarcoma with common variants in genes that modulate host immunity. 15, 926-934.
118. Simonart, T. (2006) Role of environmental factors in the pathogenesis of classic and African-endemic Kaposi sarcoma. 244, 1-7.
119. Montella, M., Serraino, D., Crispo, A., Rezza, G., Carbone, S., and Tamburini, M. (2000) Is volcanic soil a cofactor for classic Kaposi's sarcoma? 16, 1185-1186.
120. Nawar, E., Mbulaiteye, S. M., Gallant, J. E., Wohl, D. A., Ardini, M., Hendershot, T., Goedert, J. J., and Rabkin, C. S. (2005) Risk factors for Kaposi's sarcoma among hhv-8 seropositive homosexual men with AIDS. 115, 296-300.
121. Goedert, J. J., Vitale, F., Lauria, C., Serraino, D., Tamburini, M., Montella, M., Messina, A., Brown, E. E., Rezza, G., Gafa, L., and Romano, N. (2002) Risk factors for classical Kaposi's sarcoma. 94, 1712-1718.
122. Guttman-Yassky, E., Dubnov, J., Kra-Oz, Z., Friedman-Birnbaum, R., Silbermann, M., Barchana, M., Bergman, R., and Sarid, R. (2006) Classic Kaposi sarcoma which KSHV-seropositive individuals are at risk? 106, 413-419.
123. Pfeffer, S., Sewer, A., Lagos-Quintana, M., Sheridan, R., Sander, C., Grasser, F. A., Van Dyk, L. F., Ho, C. K., Shuman, S., Chien, M., Russo, J. J., Ju, J., Randall, G., Lindenbach, B. D., Rice, C. M., Simon, V., Ho, D. D., Zavolan, M., and Tuschl,T. (2005) Identification of micrornas of the herpesvirus family. 2, 269-276.
124. Cai, X., Lu, S., Zhang, Z., Gonzalez, C. M., Damania, B., and Cullen, B. R. (2005) Kaposi's sarcoma-associated herpesvirus expresses an array of viral micrornas in latently infected cells. 102, 5570-5575.
125. Samols, M. A., Hu, J., Skalsky, R. L., and Renne, R. (2005) Cloning and identification of a microrna cluster within the latency-associated region of Kaposi's sarcoma-associated herpesvirus. 79, 9301-9305.
126. Grundhoff, A., Sullivan, C. S., and Ganem, D. (2006) A combined computational and microarray-based approach identifies novel micrornas encoded by human gamma-herpesviruses. 12, 733-750.
127. Moore, P. S. and Chang, Y. (2003) Kaposi's sarcoma-associated herpesvirus immunoevasion and tumorigenesis: two sides of the same coin? 57, 609-39., 609-639.
128. Schulz, T. F. (2006) The pleiotropic effects of Kaposi's sarcoma herpesvirus. 208, 187-198.
129. Jarviluoma, A. and Ojala, P. M. (2006) Cell signaling pathways engaged by KSHV. 1766, 140-158.
130. Rezaee, S. A., Cunningham, C., Davison, A. J., and Blackbourn, D. J. (2006) Kaposi's sarcoma-associated herpesvirus immune modulation: an overview. 87, 1781-1804.
131. Sodhi,A., Montaner,S., And Gutkind,J.S. (2004) Does dysregulated expression of a deregulated viral gpcr trigger Kaposi's sarcomagenesis? 18, 422-427.
132. Boshoff,C. (2003) Kaposi Virus Scores Cancer Coup. 9, 261-262.