메뉴 건너뛰기




Volumn 67, Issue , 2016, Pages 9-24

Genes and sex hormones interaction in neurodevelopmental disorders

Author keywords

Androgen; Animal models; Behavior; Estradiol; Estrogens; FMRP; MeCP2; Neuroactive steroids; Reelin; Trisomy 21

Indexed keywords

ANDROGEN; CYCLIN DEPENDENT KINASE 5; ESTRADIOL; ESTROGEN; FRAGILE X MENTAL RETARDATION PROTEIN; METHYL CPG BINDING PROTEIN 2; NEUROSTEROID; REELIN; RETINOID RELATED ORPHAN RECEPTOR ALPHA; SEX HORMONE; TESTOSTERONE;

EID: 84961815202     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2016.02.019     Document Type: Review
Times cited : (34)

References (199)
  • 1
    • 84978146913 scopus 로고    scopus 로고
    • A.P.A., 2013. Diagnostic and Statistical Manual of Mental Disorders (DSM-5, 5th edition).
    • A.P.A., 2013. Diagnostic and Statistical Manual of Mental Disorders (DSM-5, 5th edition).
  • 3
    • 0032830639 scopus 로고    scopus 로고
    • Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
    • Amir, R.E., Van den Veyver, I.B., Wan, M., Tran, C.Q., Francke, U., Zoghbi, H.Y., Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat. Genet. 23 (1999), 185–188.
    • (1999) Nat. Genet. , vol.23 , pp. 185-188
    • Amir, R.E.1    Van den Veyver, I.B.2    Wan, M.3    Tran, C.Q.4    Francke, U.5    Zoghbi, H.Y.6
  • 4
    • 4344685681 scopus 로고    scopus 로고
    • Sex chromosomes and brain gender
    • Arnold, A.P., Sex chromosomes and brain gender. Nat. Rev. Neurosci. 5 (2004), 701–708.
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 701-708
    • Arnold, A.P.1
  • 5
    • 65549139630 scopus 로고    scopus 로고
    • The organizational–activational hypothesis as the foundation for a unified theory of sexual differentiation of all mammalian tissues
    • Arnold, A.P., The organizational–activational hypothesis as the foundation for a unified theory of sexual differentiation of all mammalian tissues. Horm. Behav. 55 (2009), 570–578.
    • (2009) Horm. Behav. , vol.55 , pp. 570-578
    • Arnold, A.P.1
  • 6
    • 79952746951 scopus 로고    scopus 로고
    • Epigenetic control of vasopressin expression is maintained by steroid hormones in the adult male rat brain
    • Auger, C.J., Coss, D., Auger, A.P., Forbes-Lorman, R.M., Epigenetic control of vasopressin expression is maintained by steroid hormones in the adult male rat brain. Proc. Natl. Acad. Sci. U. S. A. 108 (2011), 4242–4247.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 4242-4247
    • Auger, C.J.1    Coss, D.2    Auger, A.P.3    Forbes-Lorman, R.M.4
  • 8
    • 84860202594 scopus 로고    scopus 로고
    • CDKL5-related disorders: from clinical description to molecular genetics
    • Bahi-Buisson, N., Bienvenu, T., CDKL5-related disorders: from clinical description to molecular genetics. Mol. Syndromol. 2 (2012), 137–152.
    • (2012) Mol. Syndromol. , vol.2 , pp. 137-152
    • Bahi-Buisson, N.1    Bienvenu, T.2
  • 9
    • 77955139512 scopus 로고    scopus 로고
    • Male and female Fmr1 knockout mice on C57 albino background exhibit spatial learning and memory impairments
    • Baker, K.B., Wray, S.P., Ritter, R., Mason, S., Lanthorn, T.H., Savelieva, K.V., Male and female Fmr1 knockout mice on C57 albino background exhibit spatial learning and memory impairments. Genes Brain Behav. 9 (2010), 562–574.
    • (2010) Genes Brain Behav. , vol.9 , pp. 562-574
    • Baker, K.B.1    Wray, S.P.2    Ritter, R.3    Mason, S.4    Lanthorn, T.H.5    Savelieva, K.V.6
  • 12
    • 0036606475 scopus 로고    scopus 로고
    • The extreme male brain theory of autism
    • Baron-Cohen, S., The extreme male brain theory of autism. Trends Cogn. Sci. 6 (2002), 248–254.
    • (2002) Trends Cogn. Sci. , vol.6 , pp. 248-254
    • Baron-Cohen, S.1
  • 15
    • 62149119249 scopus 로고    scopus 로고
    • Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation
    • Belichenko, N.P., Belichenko, P.V., Mobley, W.C., Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation. Neurobiol. Dis. 34 (2009), 71–77.
    • (2009) Neurobiol. Dis. , vol.34 , pp. 71-77
    • Belichenko, N.P.1    Belichenko, P.V.2    Mobley, W.C.3
  • 18
    • 38149016287 scopus 로고    scopus 로고
    • Low-level neonatal thimerosal exposure: further evaluation of altered neurotoxic potential in SJL mice
    • Berman, R.F., Pessah, I.N., Mouton, P.R., Mav, D., Harry, J., Low-level neonatal thimerosal exposure: further evaluation of altered neurotoxic potential in SJL mice. Toxicol. Sci. 101 (2008), 294–309.
    • (2008) Toxicol. Sci. , vol.101 , pp. 294-309
    • Berman, R.F.1    Pessah, I.N.2    Mouton, P.R.3    Mav, D.4    Harry, J.5
  • 20
    • 1642399711 scopus 로고    scopus 로고
    • Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice
    • Bielsky, I.F., Hu, S.B., Szegda, K.L., Westphal, H., Young, L.J., Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice. Neuropsychopharmacology 29 (2004), 483–493.
    • (2004) Neuropsychopharmacology , vol.29 , pp. 483-493
    • Bielsky, I.F.1    Hu, S.B.2    Szegda, K.L.3    Westphal, H.4    Young, L.J.5
  • 22
    • 84880060135 scopus 로고    scopus 로고
    • Sexual dimorphism in estrogen-induced synaptogenesis in the adult hippocampus
    • Brandt, N., Vierk, R., Rune, G.M., Sexual dimorphism in estrogen-induced synaptogenesis in the adult hippocampus. Int. J. Dev. Biol. 57 (2013), 351–356.
    • (2013) Int. J. Dev. Biol. , vol.57 , pp. 351-356
    • Brandt, N.1    Vierk, R.2    Rune, G.M.3
  • 23
    • 34047271756 scopus 로고    scopus 로고
    • MeCP2 in Rett syndrome: transcriptional repressor or chromatin architectural protein?
    • Chadwick, L.H., Wade, P.A., MeCP2 in Rett syndrome: transcriptional repressor or chromatin architectural protein?. Curr. Opin. Genet. Dev. 17 (2007), 121–125.
    • (2007) Curr. Opin. Genet. Dev. , vol.17 , pp. 121-125
    • Chadwick, L.H.1    Wade, P.A.2
  • 24
    • 45849105557 scopus 로고    scopus 로고
    • MeCP2, a key contributor to neurological disease, activates and represses transcription
    • Chahrour, M., Jung, S.Y., Shaw, C., Zhou, X., Wong, S.T., Qin, J., Zoghbi, H.Y., MeCP2, a key contributor to neurological disease, activates and represses transcription. Science 320 (2008), 1224–1229.
    • (2008) Science , vol.320 , pp. 1224-1229
    • Chahrour, M.1    Jung, S.Y.2    Shaw, C.3    Zhou, X.4    Wong, S.T.5    Qin, J.6    Zoghbi, H.Y.7
  • 25
    • 35648978121 scopus 로고    scopus 로고
    • The story of Rett syndrome: from clinic to neurobiology
    • Chahrour, M., Zoghbi, H.Y., The story of Rett syndrome: from clinic to neurobiology. Neuron 56 (2007), 422–437.
    • (2007) Neuron , vol.56 , pp. 422-437
    • Chahrour, M.1    Zoghbi, H.Y.2
  • 26
    • 33749254952 scopus 로고    scopus 로고
    • En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder
    • Cheh, M.A., Millonig, J.H., Roselli, L.M., Ming, X., Jacobsen, E., Kamdar, S., Wagner, G.C., En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder. Brain Res. 1116 (2006), 166–176.
    • (2006) Brain Res. , vol.1116 , pp. 166-176
    • Cheh, M.A.1    Millonig, J.H.2    Roselli, L.M.3    Ming, X.4    Jacobsen, E.5    Kamdar, S.6    Wagner, G.C.7
  • 27
    • 77957196807 scopus 로고    scopus 로고
    • CDKL5, a protein associated with rett syndrome, regulates neuronal morphogenesis via Rac1 signaling
    • Chen, Q., Zhu, Y.C., Yu, J., Miao, S., Zheng, J., Xu, L., Zhou, Y., Li, D., Zhang, C., Tao, J., Xiong, Z.Q., CDKL5, a protein associated with rett syndrome, regulates neuronal morphogenesis via Rac1 signaling. J. Neurosci. 30 (2010), 12777–12786.
    • (2010) J. Neurosci. , vol.30 , pp. 12777-12786
    • Chen, Q.1    Zhu, Y.C.2    Yu, J.3    Miao, S.4    Zheng, J.5    Xu, L.6    Zhou, Y.7    Li, D.8    Zhang, C.9    Tao, J.10    Xiong, Z.Q.11
  • 29
    • 0033407499 scopus 로고    scopus 로고
    • Motor dysfunction in a mouse model for Down syndrome
    • Costa, A.C., Walsh, K., Davisson, M.T., Motor dysfunction in a mouse model for Down syndrome. Physiol. Behav. 68 (1999), 211–220.
    • (1999) Physiol. Behav. , vol.68 , pp. 211-220
    • Costa, A.C.1    Walsh, K.2    Davisson, M.T.3
  • 30
    • 84907969262 scopus 로고    scopus 로고
    • Dysregulation of estrogen receptor beta (ERbeta), aromatase (CYP19A1), and ER co-activators in the middle frontal gyrus of autism spectrum disorder subjects
    • Crider, A., Thakkar, R., Ahmed, A.O., Pillai, A., Dysregulation of estrogen receptor beta (ERbeta), aromatase (CYP19A1), and ER co-activators in the middle frontal gyrus of autism spectrum disorder subjects. Mol. Autism, 5, 2014, 46.
    • (2014) Mol. Autism , vol.5 , pp. 46
    • Crider, A.1    Thakkar, R.2    Ahmed, A.O.3    Pillai, A.4
  • 32
    • 33845386437 scopus 로고    scopus 로고
    • It is not all hormones: alternative explanations for sexual differentiation of the brain
    • Davies, W., Wilkinson, L.S., It is not all hormones: alternative explanations for sexual differentiation of the brain. Brain Res. 1126 (2006), 36–45.
    • (2006) Brain Res. , vol.1126 , pp. 36-45
    • Davies, W.1    Wilkinson, L.S.2
  • 38
    • 1642417533 scopus 로고    scopus 로고
    • Prevalence of sleep-disordered breathing in children with Down syndrome: polygraphic findings in 108 children
    • de Miguel-Diez, J., Villa-Asensi, J.R., Alvarez-Sala, J.L., Prevalence of sleep-disordered breathing in children with Down syndrome: polygraphic findings in 108 children. Sleep 26 (2003), 1006–1009.
    • (2003) Sleep , vol.26 , pp. 1006-1009
    • de Miguel-Diez, J.1    Villa-Asensi, J.R.2    Alvarez-Sala, J.L.3
  • 39
    • 53049099496 scopus 로고    scopus 로고
    • Steroids, sex and the cerebellar cortex: implications for human disease
    • Dean, S.L., McCarthy, M.M., Steroids, sex and the cerebellar cortex: implications for human disease. Cerebellum 7 (2008), 38–47.
    • (2008) Cerebellum , vol.7 , pp. 38-47
    • Dean, S.L.1    McCarthy, M.M.2
  • 40
    • 78650414129 scopus 로고    scopus 로고
    • A novel social proximity test suggests patterns of social avoidance and gaze aversion-like behavior in BTBR T+ tf/J mice
    • Defensor, E.B., Pearson, B.L., Pobbe, R.L., Bolivar, V.J., Blanchard, D.C., Blanchard, R.J., A novel social proximity test suggests patterns of social avoidance and gaze aversion-like behavior in BTBR T+ tf/J mice. Behav. Brain Res. 217 (2011), 302–308.
    • (2011) Behav. Brain Res. , vol.217 , pp. 302-308
    • Defensor, E.B.1    Pearson, B.L.2    Pobbe, R.L.3    Bolivar, V.J.4    Blanchard, D.C.5    Blanchard, R.J.6
  • 41
    • 38049013294 scopus 로고    scopus 로고
    • Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder
    • DeLorey, T.M., Sahbaie, P., Hashemi, E., Homanics, G.E., Clark, J.D., Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder. Behav. Brain Res. 187 (2008), 207–220.
    • (2008) Behav. Brain Res. , vol.187 , pp. 207-220
    • DeLorey, T.M.1    Sahbaie, P.2    Hashemi, E.3    Homanics, G.E.4    Clark, J.D.5
  • 42
    • 84902682356 scopus 로고    scopus 로고
    • Behavioral analysis of male and female Fmr1 knockout mice on C57BL/6 background
    • Ding, Q., Sethna, F., Wang, H., Behavioral analysis of male and female Fmr1 knockout mice on C57BL/6 background. Behav. Brain Res. 271 (2014), 72–78.
    • (2014) Behav. Brain Res. , vol.271 , pp. 72-78
    • Ding, Q.1    Sethna, F.2    Wang, H.3
  • 44
  • 45
    • 34250178749 scopus 로고    scopus 로고
    • Object recognition memory is conserved in Ts1Cje, a mouse model of Down syndrome
    • Fernandez, F., Garner, C.C., Object recognition memory is conserved in Ts1Cje, a mouse model of Down syndrome. Neurosci. Lett. 421 (2007), 137–141.
    • (2007) Neurosci. Lett. , vol.421 , pp. 137-141
    • Fernandez, F.1    Garner, C.C.2
  • 47
    • 31144444162 scopus 로고    scopus 로고
    • Epidemiology of autistic disorder and other pervasive developmental disorders
    • Fombonne, E., Epidemiology of autistic disorder and other pervasive developmental disorders. J. Clin. Psychiatry 66:Suppl. 10 (2005), 3–8.
    • (2005) J. Clin. Psychiatry , vol.66 , pp. 3-8
    • Fombonne, E.1
  • 48
    • 84891742491 scopus 로고    scopus 로고
    • MeCP2 regulates GFAP expression within the developing brain
    • Forbes-Lorman, R.M., Kurian, J.R., Auger, A.P., MeCP2 regulates GFAP expression within the developing brain. Brain Res. 1543 (2014), 151–158.
    • (2014) Brain Res. , vol.1543 , pp. 151-158
    • Forbes-Lorman, R.M.1    Kurian, J.R.2    Auger, A.P.3
  • 49
    • 84858242057 scopus 로고    scopus 로고
    • Neonatal MeCP2 is important for the organization of sex differences in vasopressin expression
    • Forbes-Lorman, R.M., Rautio, J.J., Kurian, J.R., Auger, A.P., Auger, C.J., Neonatal MeCP2 is important for the organization of sex differences in vasopressin expression. Epigenetics 7 (2012), 230–238.
    • (2012) Epigenetics , vol.7 , pp. 230-238
    • Forbes-Lorman, R.M.1    Rautio, J.J.2    Kurian, J.R.3    Auger, A.P.4    Auger, C.J.5
  • 51
    • 64549126454 scopus 로고    scopus 로고
    • Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome
    • Galante, M., Jani, H., Vanes, L., Daniel, H., Fisher, E.M., Tybulewicz, V.L., Bliss, T.V., Morice, E., Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome. Hum. Mol. Genet. 18 (2009), 1449–1463.
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 1449-1463
    • Galante, M.1    Jani, H.2    Vanes, L.3    Daniel, H.4    Fisher, E.M.5    Tybulewicz, V.L.6    Bliss, T.V.7    Morice, E.8
  • 53
    • 37849023607 scopus 로고    scopus 로고
    • A prospective assessment of androgen levels in patients with autistic spectrum disorders: biochemical underpinnings and suggested therapies
    • Geier, D.A., Geier, M.R., A prospective assessment of androgen levels in patients with autistic spectrum disorders: biochemical underpinnings and suggested therapies. Neuroendocrinol. Lett. 28 (2007), 565–573.
    • (2007) Neuroendocrinol. Lett. , vol.28 , pp. 565-573
    • Geier, D.A.1    Geier, M.R.2
  • 56
    • 84920085294 scopus 로고    scopus 로고
    • Implications of prenatal steroid perturbations for neurodevelopment, behavior, and autism
    • Gore, A.C., Martien, K.M., Gagnidze, K., Pfaff, D., Implications of prenatal steroid perturbations for neurodevelopment, behavior, and autism. Endocr. Rev. 35 (2014), 961–991.
    • (2014) Endocr. Rev. , vol.35 , pp. 961-991
    • Gore, A.C.1    Martien, K.M.2    Gagnidze, K.3    Pfaff, D.4
  • 58
    • 0345874735 scopus 로고    scopus 로고
    • Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome
    • Granholm, A.C., Sanders, L., Seo, H., Lin, L., Ford, K., Isacson, O., Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome. Hippocampus 13 (2003), 905–914.
    • (2003) Hippocampus , vol.13 , pp. 905-914
    • Granholm, A.C.1    Sanders, L.2    Seo, H.3    Lin, L.4    Ford, K.5    Isacson, O.6
  • 60
    • 0036270792 scopus 로고    scopus 로고
    • Clinical manifestations and stages of Rett syndrome
    • Hagberg, B., Clinical manifestations and stages of Rett syndrome. Ment. Retard. Dev. Disabil. Res. Rev. 8 (2002), 61–65.
    • (2002) Ment. Retard. Dev. Disabil. Res. Rev. , vol.8 , pp. 61-65
    • Hagberg, B.1
  • 61
    • 0020507697 scopus 로고
    • A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: report of 35 cases
    • Hagberg, B., Aicardi, J., Dias, K., Ramos, O., A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: report of 35 cases. Ann. Neurol. 14 (1983), 471–479.
    • (1983) Ann. Neurol. , vol.14 , pp. 471-479
    • Hagberg, B.1    Aicardi, J.2    Dias, K.3    Ramos, O.4
  • 67
    • 84909993043 scopus 로고    scopus 로고
    • Nest building is impaired in the Ts65Dn mouse model of Down syndrome and rescued by blocking 5HT2a receptors
    • Heller, H.C., Salehi, A., Chuluun, B., Das, D., Lin, B., Moghadam, S., Garner, C.C., Colas, D., Nest building is impaired in the Ts65Dn mouse model of Down syndrome and rescued by blocking 5HT2a receptors. Neurobiol. Learn. Mem. 116 (2014), 162–171.
    • (2014) Neurobiol. Learn. Mem. , vol.116 , pp. 162-171
    • Heller, H.C.1    Salehi, A.2    Chuluun, B.3    Das, D.4    Lin, B.5    Moghadam, S.6    Garner, C.C.7    Colas, D.8
  • 69
    • 1942440875 scopus 로고    scopus 로고
    • Impairment of verbal memory and learning in antipsychotic-naive patients with first-episode schizophrenia
    • Hill, S.K., Beers, S.R., Kmiec, J.A., Keshavan, M.S., Sweeney, J.A., Impairment of verbal memory and learning in antipsychotic-naive patients with first-episode schizophrenia. Schizophr. Res. 68 (2004), 127–136.
    • (2004) Schizophr. Res. , vol.68 , pp. 127-136
    • Hill, S.K.1    Beers, S.R.2    Kmiec, J.A.3    Keshavan, M.S.4    Sweeney, J.A.5
  • 70
    • 33847296112 scopus 로고    scopus 로고
    • Neonatal serotonin depletion alters behavioral responses to spatial change and novelty
    • Hohmann, C.F., Walker, E.M., Boylan, C.B., Blue, M.E., Neonatal serotonin depletion alters behavioral responses to spatial change and novelty. Brain Res. 1139 (2007), 163–177.
    • (2007) Brain Res. , vol.1139 , pp. 163-177
    • Hohmann, C.F.1    Walker, E.M.2    Boylan, C.B.3    Blue, M.E.4
  • 71
    • 0036075389 scopus 로고    scopus 로고
    • Androgens and environmental antiandrogens affect reproductive development and play behavior in the Sprague–Dawley rat
    • Hotchkiss, A.K., Ostby, J.S., Vandenburgh, J.G., Gray, L.E. Jr., Androgens and environmental antiandrogens affect reproductive development and play behavior in the Sprague–Dawley rat. Environ. Health Perspect. 110:Suppl 3 (2002), 435–439.
    • (2002) Environ. Health Perspect. , vol.110 , pp. 435-439
    • Hotchkiss, A.K.1    Ostby, J.S.2    Vandenburgh, J.G.3    Gray, L.E.4
  • 72
    • 84931044581 scopus 로고    scopus 로고
    • Investigation of sex differences in the expression of RORA and its transcriptional targets in the brain as a potential contributor to the sex bias in autism
    • Hu, V.W., Sarachana, T., Sherrard, R.M., Kocher, K.M., Investigation of sex differences in the expression of RORA and its transcriptional targets in the brain as a potential contributor to the sex bias in autism. Mol. Autism, 6, 2015, 6.
    • (2015) Mol. Autism , vol.6 , pp. 6
    • Hu, V.W.1    Sarachana, T.2    Sherrard, R.M.3    Kocher, K.M.4
  • 74
    • 3042521332 scopus 로고    scopus 로고
    • Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen
    • Hunter, C.L., Bimonte-Nelson, H.A., Nelson, M., Eckman, C.B., Granholm, A.C., Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen. Neurobiol. Aging 25 (2004), 873–884.
    • (2004) Neurobiol. Aging , vol.25 , pp. 873-884
    • Hunter, C.L.1    Bimonte-Nelson, H.A.2    Nelson, M.3    Eckman, C.B.4    Granholm, A.C.5
  • 81
    • 84881064386 scopus 로고    scopus 로고
    • The malep revalence in autism spectrum disorders: hypotheses on its neurobiological basis
    • G.J. Blatt Springer Verlag
    • Keller, F., Ruta, L., The malep revalence in autism spectrum disorders: hypotheses on its neurobiological basis. Blatt, G.J., (eds.) The Neurochemical Basis of Autism, 2010, Springer, Verlag.
    • (2010) The Neurochemical Basis of Autism
    • Keller, F.1    Ruta, L.2
  • 84
    • 84863475944 scopus 로고    scopus 로고
    • Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists
    • Kleschevnikov, A.M., Belichenko, P.V., Faizi, M., Jacobs, L.F., Htun, K., Shamloo, M., Mobley, W.C., Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists. J. Neurosci. 32 (2012), 9217–9227.
    • (2012) J. Neurosci. , vol.32 , pp. 9217-9227
    • Kleschevnikov, A.M.1    Belichenko, P.V.2    Faizi, M.3    Jacobs, L.F.4    Htun, K.5    Shamloo, M.6    Mobley, W.C.7
  • 85
    • 15844431969 scopus 로고    scopus 로고
    • Foetal testosterone, social relationships, and restricted interests in children
    • Knickmeyer, R., Baron-Cohen, S., Raggatt, P., Taylor, K., Foetal testosterone, social relationships, and restricted interests in children. J. Child Psychol. Psychiatry 46 (2005), 198–210.
    • (2005) J. Child Psychol. Psychiatry , vol.46 , pp. 198-210
    • Knickmeyer, R.1    Baron-Cohen, S.2    Raggatt, P.3    Taylor, K.4
  • 86
    • 33750627525 scopus 로고    scopus 로고
    • Fetal testosterone and sex differences in typical social development and in autism
    • Knickmeyer, R.C., Baron-Cohen, S., Fetal testosterone and sex differences in typical social development and in autism. J. Child Neurol. 21 (2006), 825–845.
    • (2006) J. Child Neurol. , vol.21 , pp. 825-845
    • Knickmeyer, R.C.1    Baron-Cohen, S.2
  • 87
    • 84907859640 scopus 로고    scopus 로고
    • Sex differences in animal models of psychiatric disorders
    • Kokras, N., Dalla, C., Sex differences in animal models of psychiatric disorders. Br. J. Pharmacol. 171 (2014), 4595–4619.
    • (2014) Br. J. Pharmacol. , vol.171 , pp. 4595-4619
    • Kokras, N.1    Dalla, C.2
  • 88
    • 0035523297 scopus 로고    scopus 로고
    • Sex ratio in Down syndrome: Studies in patients with confirmed trisomy 21
    • Kovaleva, N.V., Butomo, I.V., Korblein, A., Sex ratio in Down syndrome: Studies in patients with confirmed trisomy 21. Tsitol. Genet. 35 (2001), 43–49.
    • (2001) Tsitol. Genet. , vol.35 , pp. 43-49
    • Kovaleva, N.V.1    Butomo, I.V.2    Korblein, A.3
  • 93
    • 36749090131 scopus 로고    scopus 로고
    • Sex difference in mecp2 expression during a critical period of rat brain development
    • Kurian, J.R., Forbes-Lorman, R.M., Auger, A.P., Sex difference in mecp2 expression during a critical period of rat brain development. Epigenetics 2 (2007), 173–178.
    • (2007) Epigenetics , vol.2 , pp. 173-178
    • Kurian, J.R.1    Forbes-Lorman, R.M.2    Auger, A.P.3
  • 94
    • 0033595202 scopus 로고    scopus 로고
    • APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome
    • Lai, F., Kammann, E., Rebeck, G.W., Anderson, A., Chen, Y., Nixon, R.A., APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome. Neurology 53 (1999), 331–336.
    • (1999) Neurology , vol.53 , pp. 331-336
    • Lai, F.1    Kammann, E.2    Rebeck, G.W.3    Anderson, A.4    Chen, Y.5    Nixon, R.A.6
  • 95
    • 85084749025 scopus 로고    scopus 로고
    • Understanding autism in the light of sex/gender
    • Lai, M.C., Baron-Cohen, S., Buxbaum, J.D., Understanding autism in the light of sex/gender. Mol Autism, 6, 2015, 24.
    • (2015) Mol Autism , vol.6 , pp. 24
    • Lai, M.C.1    Baron-Cohen, S.2    Buxbaum, J.D.3
  • 98
    • 2942566293 scopus 로고    scopus 로고
    • Neurobehavioral evaluation of Reln-rl-orl mutant mice and correlations with cytochrome oxidase activity
    • Lalonde, R., Hayzoun, K., Derer, M., Mariani, J., Strazielle, C., Neurobehavioral evaluation of Reln-rl-orl mutant mice and correlations with cytochrome oxidase activity. Neurosci. Res. 49:3 (2004), 297–305.
    • (2004) Neurosci. Res. , vol.49 , Issue.3 , pp. 297-305
    • Lalonde, R.1    Hayzoun, K.2    Derer, M.3    Mariani, J.4    Strazielle, C.5
  • 100
    • 61849135475 scopus 로고    scopus 로고
    • Gene-environment interaction during early development in the heterozygous reeler mouse: clues for modelling of major neurobehavioral syndromes
    • Laviola, G., Ognibene, E., Romano, E., Adriani, W., Keller, F., Gene-environment interaction during early development in the heterozygous reeler mouse: clues for modelling of major neurobehavioral syndromes. Neurosci. Biobehav. Rev. 33 (2009), 560–572.
    • (2009) Neurosci. Biobehav. Rev. , vol.33 , pp. 560-572
    • Laviola, G.1    Ognibene, E.2    Romano, E.3    Adriani, W.4    Keller, F.5
  • 101
    • 78149498422 scopus 로고    scopus 로고
    • Sex-dependent behavioral effects of Mthfr deficiency and neonatal GABA potentiation in mice
    • Levav-Rabkin, T., Blumkin, E., Galron, D., Golan, H.M., Sex-dependent behavioral effects of Mthfr deficiency and neonatal GABA potentiation in mice. Behav. Brain Res. 216 (2011), 505–513.
    • (2011) Behav. Brain Res. , vol.216 , pp. 505-513
    • Levav-Rabkin, T.1    Blumkin, E.2    Galron, D.3    Golan, H.M.4
  • 103
    • 58549101513 scopus 로고    scopus 로고
    • Autistic phenotypes and genetic testing: state-of-the-art for the clinical geneticist
    • Lintas, C., Persico, A.M., Autistic phenotypes and genetic testing: state-of-the-art for the clinical geneticist. J. Med. Genet. 46 (2009), 1–8.
    • (2009) J. Med. Genet. , vol.46 , pp. 1-8
    • Lintas, C.1    Persico, A.M.2
  • 106
    • 77956614292 scopus 로고    scopus 로고
    • Perseverative responding and neuroanatomical alterations in adult heterozygous reeler mice are mitigated by neonatal estrogen administration
    • Macri, S., Biamonte, F., Romano, E., Marino, R., Keller, F., Laviola, G., Perseverative responding and neuroanatomical alterations in adult heterozygous reeler mice are mitigated by neonatal estrogen administration. Psychoneuroendocrinology 35 (2010), 1374–1387.
    • (2010) Psychoneuroendocrinology , vol.35 , pp. 1374-1387
    • Macri, S.1    Biamonte, F.2    Romano, E.3    Marino, R.4    Keller, F.5    Laviola, G.6
  • 107
    • 0037151272 scopus 로고    scopus 로고
    • Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome
    • Martinez-Cue, C., Baamonde, C., Lumbreras, M., Paz, J., Davisson, M.T., Schmidt, C., Dierssen, M., Florez, J., Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome. Behav. Brain Res. 134 (2002), 185–200.
    • (2002) Behav. Brain Res. , vol.134 , pp. 185-200
    • Martinez-Cue, C.1    Baamonde, C.2    Lumbreras, M.3    Paz, J.4    Davisson, M.T.5    Schmidt, C.6    Dierssen, M.7    Florez, J.8
  • 108
    • 84865448239 scopus 로고    scopus 로고
    • Epigenetic mechanisms are involved in sexual differentiation of the brain
    • Matsuda, K.I., Mori, H., Kawata, M., Epigenetic mechanisms are involved in sexual differentiation of the brain. Rev. Endocr. Metab. Disord. 13 (2012), 163–171.
    • (2012) Rev. Endocr. Metab. Disord. , vol.13 , pp. 163-171
    • Matsuda, K.I.1    Mori, H.2    Kawata, M.3
  • 110
    • 84875757666 scopus 로고    scopus 로고
    • Using as a tool to identify Pharmacological Therapies for Fragile X Syndrome
    • McBride, S.M., Holloway, S.L., Jongens, T.A., Using as a tool to identify Pharmacological Therapies for Fragile X Syndrome. Drug Discov. Today Technol. 10 (2012), e129–e136.
    • (2012) Drug Discov. Today Technol. , vol.10 , pp. e129-e136
    • McBride, S.M.1    Holloway, S.L.2    Jongens, T.A.3
  • 111
    • 79960816743 scopus 로고    scopus 로고
    • Reframing sexual differentiation of the brain
    • McCarthy, M.M., Arnold, A.P., Reframing sexual differentiation of the brain. Nat. Neurosci. 14 (2011), 677–683.
    • (2011) Nat. Neurosci. , vol.14 , pp. 677-683
    • McCarthy, M.M.1    Arnold, A.P.2
  • 112
    • 23744481466 scopus 로고    scopus 로고
    • When is a sex difference not a sex difference?
    • McCarthy, M.M., Konkle, A.T., When is a sex difference not a sex difference?. Front. Neuroendocrinol. 26 (2005), 85–102.
    • (2005) Front. Neuroendocrinol. , vol.26 , pp. 85-102
    • McCarthy, M.M.1    Konkle, A.T.2
  • 113
    • 84940194236 scopus 로고    scopus 로고
    • At the frontier of epigenetics of brain sex differences
    • McCarthy, M.M., Nugent, B.M., At the frontier of epigenetics of brain sex differences. Front. Behav. Neurosci., 9, 2015, 221.
    • (2015) Front. Behav. Neurosci. , vol.9 , pp. 221
    • McCarthy, M.M.1    Nugent, B.M.2
  • 114
    • 45549091029 scopus 로고    scopus 로고
    • Mechanisms mediating oestradiol modulation of the developing brain
    • McCarthy, M.M., Schwarz, J.M., Wright, C.L., Dean, S.L., Mechanisms mediating oestradiol modulation of the developing brain. J. Neuroendocrinol. 20 (2008), 777–783.
    • (2008) J. Neuroendocrinol. , vol.20 , pp. 777-783
    • McCarthy, M.M.1    Schwarz, J.M.2    Wright, C.L.3    Dean, S.L.4
  • 116
    • 33845287975 scopus 로고    scopus 로고
    • Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome
    • McGill, B.E., Bundle, S.F., Yaylaoglu, M.B., Carson, J.P., Thaller, C., Zoghbi, H.Y., Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome. Proc. Natl. Acad. Sci. U. S. A. 103 (2006), 18267–18272.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 18267-18272
    • McGill, B.E.1    Bundle, S.F.2    Yaylaoglu, M.B.3    Carson, J.P.4    Thaller, C.5    Zoghbi, H.Y.6
  • 117
    • 0021443753 scopus 로고
    • Animal models of depression: an overview
    • McKinney, W.T., Animal models of depression: an overview. Psychiatr. Dev. 2 (1984), 77–96.
    • (1984) Psychiatr. Dev. , vol.2 , pp. 77-96
    • McKinney, W.T.1
  • 118
    • 0024064517 scopus 로고
    • Molecular biology of steroid hormone synthesis
    • Miller, W.L., Molecular biology of steroid hormone synthesis. Endocr. Rev. 9 (1988), 295–318.
    • (1988) Endocr. Rev. , vol.9 , pp. 295-318
    • Miller, W.L.1
  • 121
    • 12744261491 scopus 로고    scopus 로고
    • Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome
    • Moretti, P., Bouwknecht, J.A., Teague, R., Paylor, R., Zoghbi, H.Y., Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome. Hum. Mol. Genet. 14 (2005), 205–220.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 205-220
    • Moretti, P.1    Bouwknecht, J.A.2    Teague, R.3    Paylor, R.4    Zoghbi, H.Y.5
  • 122
    • 47549096987 scopus 로고    scopus 로고
    • Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome
    • Morice, E., Andreae, L.C., Cooke, S.F., Vanes, L., Fisher, E.M., Tybulewicz, V.L., Bliss, T.V., Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome. Learn. Mem. 15 (2008), 492–500.
    • (2008) Learn. Mem. , vol.15 , pp. 492-500
    • Morice, E.1    Andreae, L.C.2    Cooke, S.F.3    Vanes, L.4    Fisher, E.M.5    Tybulewicz, V.L.6    Bliss, T.V.7
  • 126
    • 33846059754 scopus 로고    scopus 로고
    • Impulsivity-anxiety-related behavior and profiles of morphine-induced analgesia in heterozygous reeler mice
    • Ognibene, E., Adriani, W., Granstrem, O., Pieretti, S., Laviola, G., Impulsivity-anxiety-related behavior and profiles of morphine-induced analgesia in heterozygous reeler mice. Brain Res. 1131 (2007), 173–180.
    • (2007) Brain Res. , vol.1131 , pp. 173-180
    • Ognibene, E.1    Adriani, W.2    Granstrem, O.3    Pieretti, S.4    Laviola, G.5
  • 128
    • 0035964263 scopus 로고    scopus 로고
    • Effect of menopause on cognitive performance in women with Down syndrome
    • Patel, B.N., Seltzer, G.B., Wu, H.S., Schupf, N., Effect of menopause on cognitive performance in women with Down syndrome. Neuroreport 12 (2001), 2659–2662.
    • (2001) Neuroreport , vol.12 , pp. 2659-2662
    • Patel, B.N.1    Seltzer, G.B.2    Wu, H.S.3    Schupf, N.4
  • 129
    • 0036471969 scopus 로고    scopus 로고
    • Maternal infection: window on neuroimmune interactions in fetal brain development and mental illness
    • Patterson, P.H., Maternal infection: window on neuroimmune interactions in fetal brain development and mental illness. Curr. Opin. Neurobiol. 12 (2002), 115–118.
    • (2002) Curr. Opin. Neurobiol. , vol.12 , pp. 115-118
    • Patterson, P.H.1
  • 130
    • 0000104755 scopus 로고
    • Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig
    • Phoenix, C.H., Goy, R.W., Gerall, A.A., Young, W.C., Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology 65 (1959), 369–382.
    • (1959) Endocrinology , vol.65 , pp. 369-382
    • Phoenix, C.H.1    Goy, R.W.2    Gerall, A.A.3    Young, W.C.4
  • 131
    • 84906937993 scopus 로고    scopus 로고
    • Testosterone down regulates the expression of Fmr-1 gene in the cerebral cortex of gonadectomized old male mice
    • Prasad, S., Singh, K., Testosterone down regulates the expression of Fmr-1 gene in the cerebral cortex of gonadectomized old male mice. Biogerontology 15 (2014), 503–515.
    • (2014) Biogerontology , vol.15 , pp. 503-515
    • Prasad, S.1    Singh, K.2
  • 132
    • 84893376436 scopus 로고    scopus 로고
    • Female mice liberated for inclusion in neuroscience and biomedical research
    • Prendergast, B.J., Onishi, K.G., Zucker, I., Female mice liberated for inclusion in neuroscience and biomedical research. Neurosci. Biobehav. Rev. 40 (2014), 1–5.
    • (2014) Neurosci. Biobehav. Rev. , vol.40 , pp. 1-5
    • Prendergast, B.J.1    Onishi, K.G.2    Zucker, I.3
  • 133
    • 26044460532 scopus 로고    scopus 로고
    • A null mutation for Fmr1 in female mice: effects on regional cerebral metabolic rate for glucose and relationship to behavior
    • Qin, M., Kang, J., Smith, C.B., A null mutation for Fmr1 in female mice: effects on regional cerebral metabolic rate for glucose and relationship to behavior. Neuroscience 135 (2005), 999–1009.
    • (2005) Neuroscience , vol.135 , pp. 999-1009
    • Qin, M.1    Kang, J.2    Smith, C.B.3
  • 138
    • 0014011176 scopus 로고
    • On a unusual brain atrophy syndrome in hyperammonemia in childhood
    • Rett, A., On a unusual brain atrophy syndrome in hyperammonemia in childhood. Wien. Med. Wochenschr. 116 (1966), 723–726.
    • (1966) Wien. Med. Wochenschr. , vol.116 , pp. 723-726
    • Rett, A.1
  • 139
    • 58149340280 scopus 로고    scopus 로고
    • Mouse models of Rett syndrome: from behavioural phenotyping to preclinical evaluation of new therapeutic approaches
    • Ricceri, L., De Filippis, B., Laviola, G., Mouse models of Rett syndrome: from behavioural phenotyping to preclinical evaluation of new therapeutic approaches. Behav. Pharmacol. 19 (2008), 501–517.
    • (2008) Behav. Pharmacol. , vol.19 , pp. 501-517
    • Ricceri, L.1    De Filippis, B.2    Laviola, G.3
  • 140
    • 84875221023 scopus 로고    scopus 로고
    • Rett syndrome treatment in mouse models: searching for effective targets and strategies
    • Ricceri, L., De Filippis, B., Laviola, G., Rett syndrome treatment in mouse models: searching for effective targets and strategies. Neuropharmacology 68 (2013), 106–115.
    • (2013) Neuropharmacology , vol.68 , pp. 106-115
    • Ricceri, L.1    De Filippis, B.2    Laviola, G.3
  • 143
    • 84856596122 scopus 로고    scopus 로고
    • Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of Fragile X Syndrome
    • Rotschafer, S.E., Trujillo, M.S., Dansie, L.E., Ethell, I.M., Razak, K.A., Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of Fragile X Syndrome. Brain Res. 1439 (2012), 7–14.
    • (2012) Brain Res. , vol.1439 , pp. 7-14
    • Rotschafer, S.E.1    Trujillo, M.S.2    Dansie, L.E.3    Ethell, I.M.4    Razak, K.A.5
  • 144
    • 84862333723 scopus 로고    scopus 로고
    • Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities
    • 584071
    • Rueda, N., Florez, J., Martinez-Cue, C., Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities. Neural Plast., 2012 584071.
    • (2012) Neural Plast.
    • Rueda, N.1    Florez, J.2    Martinez-Cue, C.3
  • 145
    • 57649148768 scopus 로고    scopus 로고
    • CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail
    • Rusconi, L., Salvatoni, L., Giudici, L., Bertani, I., Kilstrup-Nielsen, C., Broccoli, V., Landsberger, N., CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail. J. Biol. Chem. 283 (2008), 30101–30111.
    • (2008) J. Biol. Chem. , vol.283 , pp. 30101-30111
    • Rusconi, L.1    Salvatoni, L.2    Giudici, L.3    Bertani, I.4    Kilstrup-Nielsen, C.5    Broccoli, V.6    Landsberger, N.7
  • 147
    • 77953363689 scopus 로고    scopus 로고
    • 2+ -dependent activator protein for secretion 2 and autistic-like phenotypes
    • 2+ -dependent activator protein for secretion 2 and autistic-like phenotypes. Neurosci. Res. 67 (2010), 197–202.
    • (2010) Neurosci. Res. , vol.67 , pp. 197-202
    • Sadakata, T.1    Furuichi, T.2
  • 150
    • 0033756144 scopus 로고    scopus 로고
    • Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome
    • Sago, H., Carlson, E.J., Smith, D.J., Rubin, E.M., Crnic, L.S., Huang, T.T., Epstein, C.J., Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome. Pediatr. Res. 48 (2000), 606–613.
    • (2000) Pediatr. Res. , vol.48 , pp. 606-613
    • Sago, H.1    Carlson, E.J.2    Smith, D.J.3    Rubin, E.M.4    Crnic, L.S.5    Huang, T.T.6    Epstein, C.J.7
  • 151
    • 84870016257 scopus 로고    scopus 로고
    • Female Mecp2(+/−) mice display robust behavioral deficits on two different genetic backgrounds providing a framework for pre-clinical studies
    • Samaco, R.C., McGraw, C.M., Ward, C.S., Sun, Y., Neul, J.L., Zoghbi, H.Y., Female Mecp2(+/−) mice display robust behavioral deficits on two different genetic backgrounds providing a framework for pre-clinical studies. Hum. Mol. Genet. 22 (2013), 96–109.
    • (2013) Hum. Mol. Genet. , vol.22 , pp. 96-109
    • Samaco, R.C.1    McGraw, C.M.2    Ward, C.S.3    Sun, Y.4    Neul, J.L.5    Zoghbi, H.Y.6
  • 152
    • 84907713894 scopus 로고    scopus 로고
    • Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us
    • Santos, A.R., Kanellopoulos, A.K., Bagni, C., Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us. Learn. Mem. 21 (2014), 543–555.
    • (2014) Learn. Mem. , vol.21 , pp. 543-555
    • Santos, A.R.1    Kanellopoulos, A.K.2    Bagni, C.3
  • 154
    • 79951876357 scopus 로고    scopus 로고
    • Sex hormones in autism: androgens and estrogens differentially and reciprocally regulate RORA, a novel candidate gene for autism
    • Sarachana, T., Xu, M., Wu, R.C., Hu, V.W., Sex hormones in autism: androgens and estrogens differentially and reciprocally regulate RORA, a novel candidate gene for autism. PLoS One, 6, 2011, e17116.
    • (2011) PLoS One , vol.6 , pp. e17116
    • Sarachana, T.1    Xu, M.2    Wu, R.C.3    Hu, V.W.4
  • 156
    • 78751692683 scopus 로고    scopus 로고
    • Unusual repertoire of vocalizations in adult BTBR T + tf/J mice during three types of social encounters
    • Scattoni, M.L., Ricceri, L., Crawley, J.N., Unusual repertoire of vocalizations in adult BTBR T + tf/J mice during three types of social encounters. Genes Brain Behav. 10 (2011), 44–56.
    • (2011) Genes Brain Behav. , vol.10 , pp. 44-56
    • Scattoni, M.L.1    Ricceri, L.2    Crawley, J.N.3
  • 157
    • 84903773296 scopus 로고    scopus 로고
    • Etiologies underlying sex differences in Autism Spectrum Disorders
    • Schaafsma, S.M., Pfaff, D.W., Etiologies underlying sex differences in Autism Spectrum Disorders. Front. Neuroendocrinol. 35 (2014), 255–271.
    • (2014) Front. Neuroendocrinol. , vol.35 , pp. 255-271
    • Schaafsma, S.M.1    Pfaff, D.W.2
  • 158
    • 84936943540 scopus 로고    scopus 로고
    • Emerging pharmacologic treatment options for fragile X syndrome
    • Schaefer, T.L., Davenport, M.H., Erickson, C.A., Emerging pharmacologic treatment options for fragile X syndrome. Appl. Clin. Genet. 8 (2015), 75–93.
    • (2015) Appl. Clin. Genet. , vol.8 , pp. 75-93
    • Schaefer, T.L.1    Davenport, M.H.2    Erickson, C.A.3
  • 159
    • 46249109052 scopus 로고    scopus 로고
    • Gender-specific behavioral and immunological alterations in an animal model of autism induced by prenatal exposure to valproic acid
    • Schneider, T., Roman, A., Basta-Kaim, A., Kubera, M., Budziszewska, B., Schneider, K., Przewlocki, R., Gender-specific behavioral and immunological alterations in an animal model of autism induced by prenatal exposure to valproic acid. Psychoneuroendocrinology 33 (2008), 728–740.
    • (2008) Psychoneuroendocrinology , vol.33 , pp. 728-740
    • Schneider, T.1    Roman, A.2    Basta-Kaim, A.3    Kubera, M.4    Budziszewska, B.5    Schneider, K.6    Przewlocki, R.7
  • 162
    • 33748172357 scopus 로고    scopus 로고
    • Bioavailable estradiol and age at onset of Alzheimer's disease in postmenopausal women with Down syndrome
    • Schupf, N., Winsten, S., Patel, B., Pang, D., Ferin, M., Zigman, W.B., Silverman, W., Mayeux, R., Bioavailable estradiol and age at onset of Alzheimer's disease in postmenopausal women with Down syndrome. Neurosci. Lett. 406 (2006), 298–302.
    • (2006) Neurosci. Lett. , vol.406 , pp. 298-302
    • Schupf, N.1    Winsten, S.2    Patel, B.3    Pang, D.4    Ferin, M.5    Zigman, W.B.6    Silverman, W.7    Mayeux, R.8
  • 163
    • 44149109113 scopus 로고    scopus 로고
    • Cellular mechanisms of estradiol-mediated masculinization of the brain
    • Schwarz, J.M., McCarthy, M.M., Cellular mechanisms of estradiol-mediated masculinization of the brain. J. Steroid Biochem. Mol. Biol. 109 (2008), 300–306.
    • (2008) J. Steroid Biochem. Mol. Biol. , vol.109 , pp. 300-306
    • Schwarz, J.M.1    McCarthy, M.M.2
  • 164
    • 0037081840 scopus 로고    scopus 로고
    • Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation
    • Shahbazian, M.D., Antalffy, B., Armstrong, D.L., Zoghbi, H.Y., Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation. Hum. Mol. Genet. 11 (2002), 115–124.
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 115-124
    • Shahbazian, M.D.1    Antalffy, B.2    Armstrong, D.L.3    Zoghbi, H.Y.4
  • 166
    • 0037218688 scopus 로고    scopus 로고
    • Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring
    • Shi, L., Fatemi, S.H., Sidwell, R.W., Patterson, P.H., Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. J. Neurosci. 23 (2003), 297–302.
    • (2003) J. Neurosci. , vol.23 , pp. 297-302
    • Shi, L.1    Fatemi, S.H.2    Sidwell, R.W.3    Patterson, P.H.4
  • 167
    • 77953800799 scopus 로고    scopus 로고
    • Behavioural phenotyping assays for mouse models of autism
    • Silverman, J.L., Yang, M., Lord, C., Crawley, J.N., Behavioural phenotyping assays for mouse models of autism. Nat. Rev. Neurosci. 11 (2010), 490–502.
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 490-502
    • Silverman, J.L.1    Yang, M.2    Lord, C.3    Crawley, J.N.4
  • 168
    • 77953468577 scopus 로고    scopus 로고
    • The potential for estrogens in preventing Alzheimer's disease and vascular dementia
    • Simpkins, J.W., Perez, E., Wang, X., Yang, S., Wen, Y., Singh, M., The potential for estrogens in preventing Alzheimer's disease and vascular dementia. Ther. Adv. Neurol. Disord. 2 (2009), 31–49.
    • (2009) Ther. Adv. Neurol. Disord. , vol.2 , pp. 31-49
    • Simpkins, J.W.1    Perez, E.2    Wang, X.3    Yang, S.4    Wen, Y.5    Singh, M.6
  • 169
    • 56049123847 scopus 로고    scopus 로고
    • Age- and sex-related analysis of methylation of 5’-upstream sequences of Fmr-1 gene in mouse brain and modulation by sex steroid hormones
    • Singh, K., Prasad, S., Age- and sex-related analysis of methylation of 5’-upstream sequences of Fmr-1 gene in mouse brain and modulation by sex steroid hormones. Biogerontology 9 (2008), 455–465.
    • (2008) Biogerontology , vol.9 , pp. 455-465
    • Singh, K.1    Prasad, S.2
  • 170
    • 57349198786 scopus 로고    scopus 로고
    • Differential expression of Fmr-1 mRNA and FMRP in female mice brain during aging
    • Singh, K., Prasad, S., Differential expression of Fmr-1 mRNA and FMRP in female mice brain during aging. Mol. Biol. Rep. 35 (2008), 677–684.
    • (2008) Mol. Biol. Rep. , vol.35 , pp. 677-684
    • Singh, K.1    Prasad, S.2
  • 172
    • 26444548563 scopus 로고    scopus 로고
    • Altered anxiety-related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome
    • Spencer, C.M., Alekseyenko, O., Serysheva, E., Yuva-Paylor, L.A., Paylor, R., Altered anxiety-related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome. Genes Brain Behav. 4 (2005), 420–430.
    • (2005) Genes Brain Behav. , vol.4 , pp. 420-430
    • Spencer, C.M.1    Alekseyenko, O.2    Serysheva, E.3    Yuva-Paylor, L.A.4    Paylor, R.5
  • 173
  • 174
    • 33947227299 scopus 로고    scopus 로고
    • Chronobiometry of behavioral activity in the Ts65Dn model of Down syndrome
    • Stewart, L.S., Persinger, M.A., Cortez, M.A., Snead, O.C. 3rd, Chronobiometry of behavioral activity in the Ts65Dn model of Down syndrome. Behav. Genet. 37 (2007), 388–398.
    • (2007) Behav. Genet. , vol.37 , pp. 388-398
    • Stewart, L.S.1    Persinger, M.A.2    Cortez, M.A.3    Snead, O.C.4
  • 176
    • 84941179779 scopus 로고    scopus 로고
    • Sex differences in structural organization of motor systems and their dissociable links with repetitive/restricted behaviors in children with autism
    • Supekar, K., Menon, V., Sex differences in structural organization of motor systems and their dissociable links with repetitive/restricted behaviors in children with autism. Mol. Autism, 6, 2015, 50.
    • (2015) Mol. Autism , vol.6 , pp. 50
    • Supekar, K.1    Menon, V.2
  • 178
    • 35148858044 scopus 로고    scopus 로고
    • A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice
    • Tabuchi, K., Blundell, J., Etherton, M.R., Hammer, R.E., Liu, X., Powell, C.M., Sudhof, T.C., A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science 318 (2007), 71–76.
    • (2007) Science , vol.318 , pp. 71-76
    • Tabuchi, K.1    Blundell, J.2    Etherton, M.R.3    Hammer, R.E.4    Liu, X.5    Powell, C.M.6    Sudhof, T.C.7
  • 179
    • 2642541787 scopus 로고    scopus 로고
    • Is fever suppression involved in the etiology of autism and neurodevelopmental disorders?
    • Torres, A.R., Is fever suppression involved in the etiology of autism and neurodevelopmental disorders?. BMC Pediatr., 3, 2003, 9.
    • (2003) BMC Pediatr. , vol.3 , pp. 9
    • Torres, A.R.1
  • 180
    • 8644255888 scopus 로고    scopus 로고
    • Expression of three zebrafish orthologs of human FMR1-related genes and their phylogenetic relationships
    • Tucker, B., Richards, R., Lardelli, M., Expression of three zebrafish orthologs of human FMR1-related genes and their phylogenetic relationships. Dev. Genes Evol. 214 (2004), 567–574.
    • (2004) Dev. Genes Evol. , vol.214 , pp. 567-574
    • Tucker, B.1    Richards, R.2    Lardelli, M.3
  • 182
    • 34447297311 scopus 로고    scopus 로고
    • MECP2 mutations in males
    • Villard, L., MECP2 mutations in males. J. Med. Genet. 44 (2007), 417–423.
    • (2007) J. Med. Genet. , vol.44 , pp. 417-423
    • Villard, L.1
  • 183
    • 3543004163 scopus 로고    scopus 로고
    • Infections, toxic chemicals and dietary peptides binding to lymphocyte receptors and tissue enzymes are major instigators of autoimmunity in autism
    • Vojdani, A., Pangborn, J.B., Vojdani, E., Cooper, E.L., Infections, toxic chemicals and dietary peptides binding to lymphocyte receptors and tissue enzymes are major instigators of autoimmunity in autism. Int. J. Immunopathol. Pharmacol. 16 (2003), 189–199.
    • (2003) Int. J. Immunopathol. Pharmacol. , vol.16 , pp. 189-199
    • Vojdani, A.1    Pangborn, J.B.2    Vojdani, E.3    Cooper, E.L.4
  • 186
    • 84874939983 scopus 로고    scopus 로고
    • Sex differences in autism spectrum disorders
    • Werling, D.M., Geschwind, D.H., Sex differences in autism spectrum disorders. Curr. Opin. Neurol. 26 (2013), 146–153.
    • (2013) Curr. Opin. Neurol. , vol.26 , pp. 146-153
    • Werling, D.M.1    Geschwind, D.H.2
  • 188
    • 84874189927 scopus 로고    scopus 로고
    • Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes
    • Wolstenholme, J.T., Rissman, E.F., Bekiranov, S., Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes. Genes Brain Behav. 12 (2013), 166–180.
    • (2013) Genes Brain Behav. , vol.12 , pp. 166-180
    • Wolstenholme, J.T.1    Rissman, E.F.2    Bekiranov, S.3
  • 193
    • 84925678760 scopus 로고    scopus 로고
    • Increased coupling of caveolin-1 and estrogen receptor alpha contributes to the fragile X syndrome
    • Yang, Q., Yang, L., Zhang, K., Guo, Y.Y., Liu, S.B., Wu, Y.M., Li, X.Q., Song, Q., Zhuo, M., Zhao, M.G., Increased coupling of caveolin-1 and estrogen receptor alpha contributes to the fragile X syndrome. Ann. Neurol. 77 (2015), 618–636.
    • (2015) Ann. Neurol. , vol.77 , pp. 618-636
    • Yang, Q.1    Yang, L.2    Zhang, K.3    Guo, Y.Y.4    Liu, S.B.5    Wu, Y.M.6    Li, X.Q.7    Song, Q.8    Zhuo, M.9    Zhao, M.G.10
  • 194
    • 77952323012 scopus 로고    scopus 로고
    • Animal model of autism using GSTM1 knockout mice and early post-natal sodium valproate treatment
    • Yochum, C.L., Bhattacharya, P., Patti, L., Mirochnitchenko, O., Wagner, G.C., Animal model of autism using GSTM1 knockout mice and early post-natal sodium valproate treatment. Behav. Brain Res. 210 (2010), 202–210.
    • (2010) Behav. Brain Res. , vol.210 , pp. 202-210
    • Yochum, C.L.1    Bhattacharya, P.2    Patti, L.3    Mirochnitchenko, O.4    Wagner, G.C.5
  • 196
    • 78349236906 scopus 로고    scopus 로고
    • Resistance to change and vulnerability to stress: autistic-like features of GAP43-deficient mice
    • Zaccaria, K.J., Lagace, D.C., Eisch, A.J., McCasland, J.S., Resistance to change and vulnerability to stress: autistic-like features of GAP43-deficient mice. Genes Brain Behav. 9 (2010), 985–996.
    • (2010) Genes Brain Behav. , vol.9 , pp. 985-996
    • Zaccaria, K.J.1    Lagace, D.C.2    Eisch, A.J.3    McCasland, J.S.4
  • 197
    • 84894358674 scopus 로고    scopus 로고
    • Ultrasonic vocalizations during male-female interaction in the mouse model of Down syndrome Ts65Dn
    • Zampieri, B.L., Fernandez, F., Pearson, J.N., Stasko, M.R., Costa, A.C., Ultrasonic vocalizations during male-female interaction in the mouse model of Down syndrome Ts65Dn. Physiol. Behav. 128 (2014), 119–125.
    • (2014) Physiol. Behav. , vol.128 , pp. 119-125
    • Zampieri, B.L.1    Fernandez, F.2    Pearson, J.N.3    Stasko, M.R.4    Costa, A.C.5
  • 199
    • 79951972628 scopus 로고    scopus 로고
    • Analysis of the parental origin of de novo MECP2 mutations and X chromosome inactivation in fifteen sporadic cases with Rett syndrome
    • Zhu, X.W., Pan, H., Li, M.R., Bao, X.H., Zhang, J.J., Wu, X.R., Analysis of the parental origin of de novo MECP2 mutations and X chromosome inactivation in fifteen sporadic cases with Rett syndrome. Zhonghua Er Ke Za Zhi 47 (2009), 565–569.
    • (2009) Zhonghua Er Ke Za Zhi , vol.47 , pp. 565-569
    • Zhu, X.W.1    Pan, H.2    Li, M.R.3    Bao, X.H.4    Zhang, J.J.5    Wu, X.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.