Male and female Fmr1 knockout mice on C57 albino background exhibit spatial learning and memory impairments

Genes, Brain and Behavior

Volumn 9, Issue 6, 2010, Pages 562-574

  Baker, K B ^a   Wray, S P ^a   Ritter, R ^a   Mason, S ^a   Lanthorn, T H ^a   Savelieva, K V ^a  

^a LEXICON PHARMACEUTICALS INC   (United States)

Author keywords

Fmr1; FXS model; impairment; knockout mice; learning and memory

Indexed keywords

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; AUDITORY STIMULATION; CONDITIONING; CONTROLLED STUDY; FEAR; FEMALE; FMR1 GENE; GENE; GENOTYPE; KNOCKOUT MOUSE; LEARNING DISORDER; MALE; MEMORY DISORDER; MOUSE; NONHUMAN; OPEN FIELD BEHAVIOR; PREPULSE INHIBITION; PRIORITY JOURNAL; SOCIAL INTERACTION; SPATIAL MEMORY;

ACOUSTIC STIMULATION; ALBINISM; ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; CONDITIONING (PSYCHOLOGY); DISEASE MODELS, ANIMAL; FEAR; FEMALE; FRAGILE X MENTAL RETARDATION PROTEIN; FRAGILE X SYNDROME; MALE; MAZE LEARNING; MEMORY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; PHENOTYPE; STARTLE REACTION;

MUS;

EID: 77955139512     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2010.00585.x     Document Type: Article

References (51)

1. Alanay, Y., Unal, F., Turanli, G., Alikasifoglu, M., Alehan, D., Akyol, U., Belgin, E., Sener, C., Aktas, D., Boduroglu, K., Utine, E., Volkan-Salanci, B., Ozusta, S., Genc, A., Basar, F., Sevinc, S. Tuncbilek, E. (2007) A multidisciplinary approach to the management of individuals with fragile X syndrome. J Intellect Disabil Res 51, 151 161.
2. Bakker, C.E. & Oostra, B.A. (2003) Understanding fragile X syndrome: insights from animal models. Cytogenet Genome Res 100, 111 123.
3. Bernardet, M. Crusio, W.E. (2006) Fmr1 KO mice as a possible model of autistic features. TheScientificWorldJournal 6, 1164 1176.
4. Chen, L. Toth, M. (2001) Fragile X mice develop sensory hyperreactivity to auditory stimuli. Neuroscience 103, 1043 1050.
5. Cornish, K., Turk, J. Hagerman, R. (2008) The fragile X continuum: new advances and perspectives. J Intellect Disabil Res 52, 469 482.
6. Cornish, K.M., Munir, F. Cross, G. (1998) The nature of the spatial deficit in young females with fragile-X syndrome: a neuropsychological and molecular perspective. Neuropsychologia 36, 1239 1246.
7. D'Hooge, R., Nagels, G., Franck, F., Bakker, C.E., Reyniers, E., Storm, K., Kooy, R.F., Oostra, B.A., Willems, P.J. De Deyn, P.P. (1997) Mildly impaired water maze performance in male Fmr1 knockout mice. Neuroscience 76, 367 376.
8. Dissanayake, C., Bui, Q., Bulhak-Paterson, D., Huggins, R. Loesch, D.Z. (2009) Behavioural and cognitive phenotypes in idiopathic autism versus autism associated with fragile X syndrome. J Child Psychol Psychiatry 50, 290 299.
9. Dobkin, C., Rabe, A., Dumas, R., El Idrissi, A., Haubenstock, H. Brown, W.T. (2000) Fmr1 knockout mouse has a distinctive strain-specific learning impairment. Neuroscience 100, 423 429.
10. Elia, M., Ferri, R., Musumeci, S.A., Del Gracco, S., Bottitta, M., Scuderi, C., Miano, G., Panerai, S., Bertrand, T. Grubar, J.C. (2000) Sleep in subjects with autistic disorder: a neurophysiological and psychological study. Brain & Dev 22, 88 92.
11. Farzin, F., Whitney, D., Hagerman, R.J. Rivera, S.M. (2008) Contrast detection in infants with fragile X syndrome. Vision Res 48, 1471 1478.
12. Frankland, P.W., Wang, Y., Rosner, B., Shimizu, T., Balleine, B.W., Dykens, E.M., Ornitz, E.M. Silva, A.J. (2004) Sensorimotor gating abnormalities in young males with fragile X syndrome and Fmr1-knockout mice. Mol Psychiatry 9, 417 425.
13. Gallagher, M., Burwell, R. Burchinal, M. (1993) Severity of spatial learning impairment in aging: development of a learning index for performance in the Morris water maze. Behav Neurosc 107, 618 626.
14. Gao, F.B. (2002) Understanding fragile X syndrome: insights from retarded flies. Neuron 34, 859 862.
15. Gatto, C.L. Broadie, K. (2009) The fragile X mental retardation protein in circadian rhythmicity and memory consolidation. Mol Neurobiol 39, 107 129.
16. Green, D.G., Herreros de Tejada, P. Glover, M.J. (1994) Electrophysiological estimates of visual sensitivity in albino and pigmented mice. Vis Neurosci 11, 919 925.
17. Harvey, M.T. Kennedy, C.H. (2002) Polysomnographic phenotypes in developmental disabilities. Int J Dev Neurosci 20, 443 448.
18. Hayes, J.M. Balkema, G.W. (1993) Elevated dark-adapted thresholds in hypopigmented mice measured with a water maze screening apparatus. Behav Genet 23, 395 403.
19. Hernandez, R.N., Feinberg, R.L., Vaurio, R., Passanante, N.M., Thompson, R.E. Kaufmann, W.E. (2009) Autism spectrum disorder in fragile X syndrome: a longitudinal evaluation. Am J Med Genet 149A, 1125 1137.
20. Herreros de Tejada, P., Munoz Tedo, C. Costi, C. (1997) Behavioral estimates of absolute visual threshold in mice. Vision Res 37, 2427 2432.
21. Hinds, H.L., Ashley, C.T., Sutcliffe, J.S., Nelson, D.L., Warren, S.T., Housman, D.E. Schalling, M. (1993) Tissue specific expression of FMR-1 provides evidence for a functional role in fragile X syndrome. Nat Genet 3, 36 43.
22. Kabakus, N., Aydin, M., Akin, H., Balci, T.A., Kurt, A. Kekilli, E. (2006) Fragile X syndrome and cerebral perfusion abnormalities: single-photon emission computed tomographic study. J Child Neurol 21, 1040 1046.
23. Kooy, R.F., D'Hooge, R., Reyniers, E., Bakker, C.E., Nagels, G., De Boulle, K., Storm, K., Clincke, G., De Deyn, P.P., Oostra, B.A. Willems, P.J. (1996) Transgenic mouse model for the fragile X syndrome. Am J Med Genet 64, 241 245.
24. Levitas, A. (1996) Neuropsychiatric aspects of fragile X syndrome. Semin Clin Neuropsychiatry 1, 154 167.
25. Maei, H.R., Zaslavsky, K., Teixeira, C.M. Frankland, P.W. (2009) What is the most sensitive measure of water maze probe test performance?. Front Integr Neurosci 3, 4.
26. Maren, S., Aharonov, G. Fanselow, M.S. (1997) Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats. Behav Brain Res 88, 261 274.
27. Mazzocco, M.M., Pennington, B.F. Hagerman, R.J. (1993) The neurocognitive phenotype of female carriers of fragile X: additional evidence for specificity. J Dev Behav Pediatr 14, 328 335.
28. McNaughton, C.H., Moon, J., Strawderman, M.S., Maclean, K.N., Evans, J. Strupp, B.J. (2008) Evidence for social anxiety and impaired social cognition in a mouse model of fragile X syndrome. Behav Neurosci 122, 293 300.
29. Mineur, Y.S., Sluyter, F., de Wit, S., Oostra, B.A. Crusio, W.E. (2002) Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse. Hippocampus 12, 39 46.
30. Mineur, Y.S., Huynh, L.X. Crusio, W.E. (2006) Social behavior deficits in the Fmr1 mutant mouse. Behav Brain Res 168, 172 175.
31. Misane, I., Tovote, P., Meyer, M., Spiess, J., Ogren, S.O. Stiedl, O. (2005) Time-dependent involvement of the dorsal hippocampus in trace fear conditioning in mice. Hippocampus 15, 418 426.
32. Morris, R.G., Garrud, P., Rawlins, J.N. O'Keefe, J. (1982) Place navigation impaired in rats with hippocampal lesions. Nature 297, 681 683.
33. Moser, E.I., Krobert, K.A., Moser, M.B. Morris, R.G. (1998) Impaired spatial learning after saturation of long-term potentiation. Science 281, 2038 2042.
34. Moy, S.S., Nadler, J.J., Young, N.B., Nonneman, R.J., Grossman, A.W., Murphy, D.L., D'Ercole, A.J., Crawley, J.N., Magnuson, T.R. Lauder, J.M. (2009) Social approach in genetically engineered mouse lines relevant to autism. Genes Brain Behav 8, 129 142.
35. Nielsen, D.M., Derber, W.J., McClellan, D.A. Crnic, L.S. (2002) Alterations in the auditory startle response in Fmr1 targeted mutant mouse models of fragile X syndrome. Brain Res 927, 8 17.
36. O'Keefe, J. Conway, D.H. (1978) Hippocampal place units in the freely moving rat: why they fire where they fire. Exp Brain Res 31, 573 590.
37. Paradee, W., Melikian, H.E., Rasmussen, D.L., Kenneson, A., Conn, P.J. Warren, S.T. (1999) Fragile X mouse: strain effects of knockout phenotype and evidence suggesting deficient amygdala function. Neuroscience 94, 185 192.
38. Paylor, R., Yuva-Paylor, L.A., Nelson, D.L. Spencer, C.M. (2008) Reversal of sensorimotor gating abnormalities in Fmr1 knockout mice carrying a human Fmr1 transgene. Behav Neurosci 122, 1371 1377.
39. Peier, A.M., McIlwain, K.L., Kenneson, A., Warren, S.T., Paylor, R. Nelson, D.L. (2000) (Over)correction of FMR1 deficiency with YAC transgenics: behavioral and physical features. Human Mol Genet 9, 1145 1159.
40. Pogorelov, V.M., Lanthorn, T.H. Savelieva, K.V. (2007) Use of a platform in an automated open-field to enhance assessment of anxiety-like behaviors in mice. J Neurosci Methods 162, 222 228.
41. Qin, M., Kang, J. Smith, C.B. (2005) A null mutation for Fmr1 in female mice: effects on regional cerebral metabolic rate for glucose and relationship to behavior. Neuroscience 135, 999 1009.
42. Spencer, C.M., Alekseyenko, O., Serysheva, E., Yuva-Paylor, L.A. Paylor, R. (2005) Altered anxiety-related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome. Genes Brain Behav 4, 420 430.
43. Spencer, C.M., Graham, D.F., Yuva-Paylor, L.A., Nelson, D.L. Paylor, R. (2008) Social behavior in Fmr1 knockout mice carrying a human FMR1 transgene. Behav Neuroscience 122, 710 715.
44. The Dutch-Belgian Fragile X Consortium 1994) Fmr1 knockout mice: a model to study fragile X mental retardation. Cell 78, 23 33.
45. Van Dam, D., D'Hooge, R., Hauben, E., Reyniers, E., Gantois, I., Bakker, C.E., Oostra, B.A., Kooy, R.F. De Deyn, P.P. (2000) Spatial learning, contextual fear conditioning and conditioned emotional response in Fmr1 knockout mice. Behav Brain Res 117, 127 136.
46. Van Esch, H. (2006) The fragile X premutation: new insights and clinical consequences. Eur J Med Genet 49, 1 8.
47. de Vries, B.B., Jansen, C.C., Duits, A.A., Verheij, C., Willemsen, R., van Hemel, J.O., van den Ouweland, A.M., Niermeijer, M.F., Oostra, B.A. Halley, D.J. (1996) Variable FMR1 gene methylation of large expansions leads to variable phenotype in three males from one fragile X family. J Med Genet 33, 1007 1010.
48. Warren, S.T. (2007) The epigenetics of fragile X syndrome. Cell Stem Cell 1, 488 489.
49. Zhang, A., Shen, C.H., Ma, S.Y., Ke, Y. El Idrissi, A. (2009) Altered expression of autism-associated genes in the brain of fragile X mouse model. Biochem Biophys Res Commun 379, 920 923.
50. Zhang, J., Fang, Z., Jud, C., Vansteensel, M.J., Kaasik, K., Lee, C.C., Albrecht, U., Tamanini, F., Meijer, J.H., Oostra, B.A. Nelson, D.L. (2008) Fragile X-related proteins regulate mammalian circadian behavioral rhythms. Am J Human Genet 83, 43 52.
51. Zhao, M.G., Toyoda, H., Ko, S.W., Ding, H.K., Wu, L.J. Zhuo, M. (2005) Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome. J Neurosci 25, 7385 7392.