Modulation of Rho GTPases rescues brain mitochondrial dysfunction, cognitive deficits and aberrant synaptic plasticity in female mice modeling Rett syndrome

European Neuropsychopharmacology

Volumn 25, Issue 6, 2015, Pages 889-901

  De Filippis, Bianca ^a   Valenti, Daniela ^b   Chiodi, Valentina ^a   Ferrante, Antonella ^a   de Bari, Lidia ^b   Fiorentini, Carla ^a   Domenici, Maria Rosaria ^a   Ricceri, Laura ^a   Vacca, Rosa Anna ^b   Fabbri, Alessia ^a   Laviola, Giovanni ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b CNR   (Italy)

Author keywords

Behavioral phenotyping; Energy metabolism; Intellectual disabilities; Neural plasticity; NMDA receptors; Transgenic mice

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOTOXIC NECROTIZING FACTOR 1; GLUN2B PROTEIN; PEPTIDES AND PROTEINS; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; BACTERIAL TOXIN; ESCHERICHIA COLI PROTEIN; GLUTAMATE RECEPTOR; MECP2 PROTEIN, MOUSE; METHYL CPG BINDING PROTEIN 2; MULTIENZYME COMPLEX;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BARNES MAZE TEST; BRAIN MITOCHONDRION; CELL ENERGY; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENERGY METABOLISM; ENERGY YIELD; FEMALE; HIPPOCAMPUS; INTELLECTUAL IMPAIRMENT; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REFERENCE MEMORY; RETT SYNDROME; SPATIAL MEMORY; SPATIAL MEMORY TEST; VISUAL ACUITY; ANIMAL; BRAIN; COGNITION DISORDERS; COMPLICATION; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; GENETICS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MAZE TEST; METABOLISM; MITOCHONDRIAL DISEASES; MITOCHONDRION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; BACTERIAL TOXINS; BRAIN; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; ESCHERICHIA COLI PROTEINS; FEMALE; HIPPOCAMPUS; INJECTIONS, INTRAVENTRICULAR; MAZE LEARNING; METHYL-CPG-BINDING PROTEIN 2; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIAL DISEASES; NEURONAL PLASTICITY; RECEPTORS, GLUTAMATE; RETT SYNDROME; RHO GTP-BINDING PROTEINS; VISUAL ACUITY;

EID: 84930273339     PISSN: 0924977X     EISSN: 18737862     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2015.03.012     Document Type: Article

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