Elevated fetal steroidogenic activity in autism

Molecular Psychiatry

Volumn 20, Issue 3, 2015, Pages 369-376

  Baron Cohen, S ^a   Auyeung, B ^a,b   Norgaard Pedersen B ^c   Hougaard, D M ^c   Abdallah, M W ^c,d,e   Melgaard, L ^c   Cohen, A S ^c   Chakrabarti, B ^a,f   Ruta, L ^a,g   Lombardo, M V ^a,h  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c STATENS SERUM INSTITUT   (Denmark)

^d ROSTOCK UNIVERSITY MEDICAL CENTER   (Germany)

^e AARHUS UNIVERSITY   (Denmark)

^f UNIVERSITY OF READING   (United Kingdom)

^g DEPARTMENT OF DEVELOPMENTAL NEUROSCIENCE   (Italy)

^h UNIVERSITY OF CYPRUS   (Cyprus)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTENEDIONE; HYDROCORTISONE; HYDROXYPROGESTERONE; PROGESTERONE; SEX HORMONE; TESTOSTERONE; STEROID;

ADULT; ARTICLE; ASPERGER SYNDROME; AUTISM; CONTROLLED STUDY; DIAGNOSTIC TEST; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; FETUS; HORMONE BLOOD LEVEL; HUMAN; HYDROCORTISONE BLOOD LEVEL; ICD-10; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY; MAJOR CLINICAL STUDY; MALE; NEWBORN; PATHOPHYSIOLOGY; PERVASIVE DEVELOPMENTAL DISORDER NOT OTHERWISE SPECIFIED; PREDICTIVE VALUE; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; SAMPLE SIZE; STEROIDOGENESIS; TANDEM MASS SPECTROMETRY; TESTOSTERONE BLOOD LEVEL; ANALYSIS OF VARIANCE; BLOOD; CASE CONTROL STUDY; COHORT ANALYSIS; DENMARK; GESTATIONAL AGE; LIQUID CHROMATOGRAPHY; METABOLISM;

ANALYSIS OF VARIANCE; ASPERGER SYNDROME; AUTISTIC DISORDER; CASE-CONTROL STUDIES; CHROMATOGRAPHY, LIQUID; COHORT STUDIES; DENMARK; FEMALE; FETUS; GESTATIONAL AGE; HUMANS; HYDROCORTISONE; MALE; PRINCIPAL COMPONENT ANALYSIS; STEROIDS; TANDEM MASS SPECTROMETRY;

EID: 84924743530     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2014.48     Document Type: Article

References (48)

1. Baird G, Simonoff E, Pickles A, Chandler S, Loucas T, Meldrum D, et al. Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). Lancet 2006; 368: 210-215
2. Baron-Cohen S, Lombardo MV, Auyeung B, Ashwin E, Chakrabarti B, Knickmeyer R. Why are autism spectrum conditions more prevalent in males? PLoS Biol 2011; 9: e1001081
3. Baron-Cohen S. The extreme male brain theory of autism. Trends Cogn Sci 2002; 6: 248-254
4. Jessen HM, Auger AP. Sex differences in epigenetic mechanisms may underlie risk and resilience for mental health disorders. Epigenetics 2011; 6: 857-861
5. Morgan CP, Bale TL. Sex differences in microRNA regulation of gene expression: no smoke, just miRs. Biol Sex Differ 2012; 3: 22
6. Nugent BM, McCarthy MM. Epigenetic underpinnings of developmental sex differences in the brain. Neuroendocrinology 2011; 93: 150-158
7. Phoenix CH, Goy RW, Gerall AA, Young WC. Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology 1959; 65: 369-382
8. Geschwind N, Galaburda AM. Cerebral lateralization. Biological mechanisms, associations, and pathology: I. A hypothesis and a program for research. Arch Neurol 1985; 42: 428-459
9. Lombardo MV, Ashwin E, Auyeung B, Chakrabarti B, Lai MC, Taylor K, et al. Fetal programming effects of testosterone on the reward system and behavioral approach tendencies in humans. Biol Psychiatry 2012; 72: 839-847
10. Glover V. Annual Research Review: prenatal stress and the origins of psychopathology: an evolutionary perspective. J Child Psychol Psychiatry 2011; 52: 356-367
11. Auyeung B, Lombardo MV, Baron-Cohen S. Prenatal and postnatal hormone effects on the human brain and cognition. Pflugers Archiv 2013; 465: 557-571
12. Lombardo MV, Ashwin E, Auyeung B, Chakrabarti B, Taylor K, Hackett G, et al. Fetal testosterone influences sexually dimorphic gray matter in the human brain. J Neurosci 2012; 32: 674-680
13. Chakrabarti B, Dudbridge F, Kent L, Wheelwright S, Hill-Cawthorne G, Allison C, et al. Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. Autism Res 2009; 2: 157-177
14. Simonoff E, Pickles A, Charman T, Chandler S, Loucas T, Baird G. Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample. J Am Acad Child Adolesc Psychiatry 2008; 47: 921-929
15. Gitau R, Adams D, Fisk NM, Glover V. Fetal plasma testosterone correlates positively with cortisol. Arch Dis Child Fetal Neonatal Ed 2005; 90: F166-F169
16. Sarkar P, Bergman K, Fisk NM, O'Connor TG, Glover V. Amniotic fluid testosterone: relationship with cortisol and gestational age. Clin Endocrinol (Oxf) 2007; 67: 743-747
17. Abdallah MW, Greaves-Lord K, Grove J, Norgaard-Pedersen B, Hougaard DM, Mortensen EL. Psychiatric comorbidities in autism spectrum disorders: findings from a Danish Historic Birth Cohort. Eur Child Adolesc Psychiatry 2011; 20: 599-601
18. Norgaard-Pedersen B, Hougaard DM. Storage policies and use of the Danish Newborn Screening Biobank. J Inherit Metab Dis 2007; 30: 530-536
19. Kugler K, Hackl W, Mueller L, Fiegl H, Graber A, Pfeiffer R. The impact of sample storage time on estimates of association in biomarker discovery studies. J Clin Bioinforma 2011; 1: 1-8
20. van de Beek C, Thijssen JH, Cohen-Kettenis PT, van Goozen SH, Buitelaar JK. Relationships between sex hormones assessed in amniotic fluid, and maternal and umbilical cord serum: what is the best source of information to investigate the effects of fetal hormonal exposure? Horm Behav 2004; 46: 663-669
21. Glover V, Bergman K, Sarkar P, O'Connor TG. Association between maternal and amniotic fluid cortisol is moderated by maternal anxiety. Psychoneuroendocrinology 2009; 34: 430-435
22. Sarkar P, Bergman K, Fisk NM, O'Connor TG, Glover V. Ontogeny of foetal exposure to maternal cortisol using midtrimester amniotic fluid as a biomarker. Clin Endocrinol (Oxf) 2007; 66: 636-640
23. Escobar JC, Patel SS, Beshay VE, Suzuki T, Carr BR. The human placenta expresses CYP17 and generates androgens de novo. J Clin Endocrinol Metab 2011; 96: 1385-1392
24. Strauss JF3rd, Martinez F, Kiriakidou M. Placental steroid hormone synthesis: unique features and unanswered questions. Biol Reprod 1996; 54: 303-311
25. Hertz-Picciotto I. Environmental risk factors in autism: results from large-scale epidemiological studies. In: Amaral DG, Dawson G, Geschwind DH (eds). Autism Spectrum Disorders. Oxford University Press: New York, NY, USA, 2011, pp 827-862
26. Lenz KM, Nugent BM, Haliyur R, McCarthy MM. Microglia are essential to masculinization of brain and behavior. J Neurosci 2013; 33: 2761-2772
27. McCarthy MM, Arnold AP. Reframing sexual differentiation of the brain. Nat Neurosci 2011; 14: 677-683
28. Mulholland DJ, Dedhar S, Coetzee GA, Nelson CC. Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know? Endocr Rev 2005; 26: 898-915
29. Williams EL, Casanova MF. Above genetics: lessons from cerebral development in autism. Transl Neurosci 2011; 2: 1-15
30. Spooren W, Lindemann L, Ghosh A, Santarelli L. Synapse dysfunction in autism: a molecular medicine approach to drug discovery in neurodevelopmental disorders. Trends Pharmacol Sci 2012; 33: 669-684
31. Kang HJ, Kawasawa YI, Cheng F, Zhu Y, Xu X, Li M, et al. Spatio-Temporal transcriptome of the human brain. Nature 2011; 478: 483-489
32. McCarthy MM, Auger AP, Perrot-Sinal TS. Getting excited about GABA and sex differences in the brain. Trends Neurosci 2002; 25: 307-312
33. Rubenstein JL. Developmental neurobiology of autism spectrum disorders. In: Amaral DG, Dawson G, Geschwind DH (eds). Autism Spectrum Disorders. Oxford University Press: New York, NY, USA, 2011 pp 527-538
34. Warrier V, Baron-Cohen S, Chakrabarti B. Genetic variation in GABRB3 is associated with Asperger syndrome and multiple endophenotypes relevant to autism. Mol Autism 2013; 4: 48
35. Goines P, Van de Water J. The immune system's role in the biology of autism. Curr Opin Neurol 2010; 23: 111-117
36. Abdallah MW, Larsen N, Grove J, Norgaard-Pedersen B, Thorsen P, Mortensen EL, et al. Amniotic fluid inflammatory cytokines: potential markers of immunologic dysfunction in autism spectrum disorders. World J Biol Psychiatry 2011; 14: 528-538
37. Abdallah MW, Larsen N, Grove J, Nørgaard-Pedersen B, Thorsen P, Mortensen EL, et al. Amniotic fluid chemokines and autism spectrum disorders: an exploratory study utilizing a Danish Historic Birth Cohort. Brain Behav Immun 2012; 26: 170-176
38. Abdallah MW, Larsen N, Mortensen EL, Atladottir HO, Norgaard-Pedersen B, Bonefeld-Jorgensen EC, et al. Neonatal levels of cytokines and risk of autism spectrum disorders: an exploratory register-based historic birth cohort study utilizing the Danish Newborn Screening Biobank. J Neuroimmunol 2012; 252: 75-82
39. Kinney DK, Miller AM, Crowley DJ, Huang E, Gerber E. Autism prevalence following prenatal exposure to hurricanes and tropical storms in Louisiana. J Autism Dev Disord 2008; 38: 481-488
40. Li J, Vestergaard M, Obel C, Christensen J, Precht DH, Lu M, et al. A nationwide study on the risk of autism after prenatal stress exposure to maternal bereavement. Pediatrics 2009; 123: 1102-1107
41. Sarkar P, Bergman K, O'Connor TG, Glover V. Maternal antenatal anxiety and amniotic fluid cortisol and testosterone: possible implications for foetal programming. J Neuroendocrinol 2008; 20: 489-496
42. Geier DA, Geier MR. A clinical trial of combined anti-Androgen and anti-heavy metal therapy in autistic disorders. Neuroendocrinol Lett 2006; 27: 833-838
43. Lauritsen MB, Jorgensen M, Madsen KM, Lemcke S, Toft S, Grove J, et al. Validity of childhood autism in the Danish Psychiatric Central Register: findings from a cohort sample born 1990-1999. J Autism Dev Disord 2010; 40: 139-148
44. Parner ET, Schendel DE, Thorsen P. Autism prevalence trends over time in Denmark: changes in prevalence and age at diagnosis. Arch Pediatr Adolesc Med 2008; 162: 1150-1156
45. Wu MV, Manoli DS, Fraser EJ, Coats JK, Tollkuhn J, Honda SI, et al. Estrogen masculinizes neural pathways and sex-specific behaviors. Cell 2009; 139: 61-72
46. Sarachana T, Xu M, Wu RC, Hu VW. Sex hormones in autism: androgens and estrogens differentially and reciprocally regulate RORA, a novel candidate gene for autism. PLoS One 2011; 6: e17116
47. Sarachana T, Hu VW. Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder. Mol Autism 2013; 4: 14
48. O'Connor TG, Heron J, Golding J, Glover V. Maternal antenatal an xiety and behavioural/emotional problems in children: a test of a programming hypothesis. J Child Psychol Psychiatry 2003; 44: 1025-1036