Dysregulation of estrogen receptor beta (ERβ), aromatase (CYP19A1), and ER co-activators in the middle frontal gyrus of autism spectrum disorder subjects

Molecular Autism

Volumn 5, Issue 1, 2014, Pages

  Crider, Amanda ^a   Thakkar, Roshni ^a   Ahmed, Anthony O ^a   Pillai, Anilkumar ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Aromatase; Autism; Estrogen; Receptor; Sex

Indexed keywords

AROMATASE; ESTROGEN RECEPTOR BETA; MESSENGER RNA; NUCLEAR RECEPTOR COACTIVATOR 2; RECEPTOR INTERACTING PROTEIN 140; SILENCING MEDIATOR OF RETINOID AND THYROID HORMONE RECEPTOR; STEROID RECEPTOR COACTIVATOR 3;

ARTICLE; AUTISM; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; MALE; MIDDLE FRONTAL GYRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 84907969262     PISSN: None     EISSN: 20402392     Source Type: Journal    
DOI: 10.1186/2040-2392-5-46     Document Type: Article

References (41)

1. Gillberg C, Cederlund M, Lamberg K, Zeijlon L: Brief report: "the autism epidemic": the registered prevalence of autism in a Swedish urban area. J Autism Dev Disord 2006, 36(3):429-435.
2. Auyeung B, Knickmeyer R, Ashwin E, Taylor K, Hackett G, Baron-Cohen S: Effects of fetal testosterone on visuospatial ability. Arch Sex Behav 2012, 41(3):571-581.
3. Pfaff DW, Rapin I, Goldman S: Male predominance in autism: neuroendocrine influences on arousal and social anxiety. Autism Res 2011, 4(3):163-176.
4. Amin Z, Canli T, Epperson CN: Effect of estrogen - serotonin interactions on mood and cognition. Behav Cogn Neurosci Rev 2005, 4:43-58.
5. Berman KF, Schmidt PJ, Rubinow DR, Danaceau MA, Van Horn JD, Esposito G, Ostrem JL, Weinberger DR: Modulation of cognition-specific cortical activity by gonadal steroids: a positron-emission tomography study in women. Proc Natl Acad Sci U S A 1997, 94:8836-8841.
6. Mueller SO, Korach KS: Estrogen receptors and endocrine diseases: lessons from estrogen receptor knockout mice. Curr Opin Pharmacol 2001, 1:613-619.
7. Herynk MH, Fuqua SA: Estrogen receptor mutations in human disease. Endocr Rev 2004, 25:869-898.
8. Shang Y, Hu X, DiRenzo J, Lazar MA, Brown M: Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 2000, 103(6):843-852.
9. Mendelsohn ME, Karas RH: Rapid progress for non-nuclear estrogen receptor signaling. J Clin Invest 2010, 120(7):2277-2279.
10. Östlund H, Keller E, Hurd YL: Estrogen receptor gene expression in relation to neuropsychiatric disorders. Ann N Y Acad Sci 2003, 1007:54-63.
11. Österlund MK, Hurd YL: Estrogen receptors in the human forebrain and the relation to neuropsychiatric disorders. Prog Neurobiol 2001, 64:251-267.
12. Herrington DM, Howard TD, Hawkins GA, Reboussin DM, Xu J, Zheng SL, Brosnihan KB, Meyers DA, Bleecker ER: Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease. N Engl J Med 2002, 346:967-974.
13. Bodo C, Rissman EF: New roles for estrogen receptor beta in behavior and neuroendocrinology. Front Neuroendocrinol 2006, 27(2):217-232.
14. Chakrabarti B, Dudbridge F, Kent L, Wheelwright S, Hill-Cawthorne G, Allison C, Banerjee-Basu S, Baron-Cohen S: Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. Autism Res 2009, 2(3):157-177.
15. Krezel W, Dupont S, Krust A, Chambon P, Chapman PF: Increased anxiety and synaptic plasticity in estrogen receptor beta -deficient mice. Proc Natl Acad Sci U S A 2001, 98(21):12278-12282.
16. Carper RA, Courchesne E: Localized enlargement of the frontal cortex in early autism. Biol Psychiatry 2005, 57(2):126-133.
17. Barendse EM, Hendriks MP, Jansen JF, Backes WH, Hofman PA, Thoonen G, Kessels RP, Aldenkamp AP: Working memory deficits in high-functioning adolescents with autism spectrum disorders: neuropsychological and neuroimaging correlates. J Neurodev Disord 2013, 5(1):14.
18. Zikopoulos B, Barbas H: Altered neural connectivity in excitatory and inhibitory cortical circuits in autism. Front Hum Neurosci 2013, 7:609.
19. Goldstein JM, Seidman LJ, Horton NJ, Makris N, Kennedy DN, Caviness VS Jr, Faraone SV, Tsuang MT: Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging. Cereb Cortex 2001, 11(6):490-497.
20. Guo L, Hou X, Dilimina Y, Wang B: Expression of ERβ, ERα and Her-2 and distribution of molecular subtypes in Uygur and Han patients with breast cancer. Exp Ther Med 2014, 7(5):1077-1082.
21. Tam A, Wadsworth S, Dorscheid D, Man SF, Sin DD: Estradiol increases mucus synthesis in bronchial epithelial cells. PLoS One 2014, 9(6):e100633.
22. Mitra SW, Hoskin E, Yudkovitz J, Pear L, Wilkinson HA, Hayashi S, Pfaff DW, Ogawa S, Rohrer SP, Schaeffer JM, McEwen BS, Alves SE: Immunolocalization of estrogen receptor beta in the mouse brain: comparison with estrogen receptor alpha. Endocrinology 2003, 144:2055-2067.
23. Wang L, Andersson S, Warner M, Gustafsson JA: Estrogen receptor (ER)beta knockout mice reveal a role for ERbeta in migration of cortical neurons in the developing brain. Proc Natl Acad Sci U S A 2003, 100(2):703-708.
24. Behl C: Oestrogen as a neuroprotective hormone. Nat Rev Neurosci 2002, 3:433-442.
25. Rocha BA, Fleischer R, Schaeffer JM, Rohrer SP, Hickey GJ: 17β-estradiolinduced antidepressant-like effect in the forced swim test is absent in estrogen receptor-β knockout (BERKO) mice. Psychopharmacology (Berl) 2005, 179:637-643.
26. Weiser MJ, Foradori CD, Handa RJ: Estrogen receptor β in the brain: from form to function. Brain Res Rev 2008, 57:309-320.
27. Weiser MJ, Wu TJ, Handa RJ: Estrogen receptor-β agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress. Endocrinology 2009, 150:1817-1825.
28. Walf AA, Frye CA: Administration of estrogen receptor β-specific selective estrogen receptor modulators to the hippocampus decrease anxiety and depressive behavior of ovariectomized rats. Pharmacol Biochem Behav 2007, 2007(86):407-414.
29. Srivastava DP, Woolfrey KM, Liu F, Brandon NJ, Penzes P: Estrogen receptor β activity modulates synaptic signaling and structure. J Neurosci 2010, 30(40):13454-13460.
30. Nojima D, Li LC, Dharia A, Perinchery G, Ribeiro-Filho L, Yen TS, Dahiya R: CpG hypermethylation of the promoter region inactivates the estrogen receptor-beta gene in patients with prostate carcinoma. Cancer 2001, 92(8):2076-2083.
31. Lanz RB, McKenna NJ, Onate SA, Albrecht U, Wong J, Tsai SY, Tsai MJ, O'Malley BW: A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. Cell 1999, 97(1):17-27.
32. Shibata H, Spencer TE, Onate SA, Jenster G, Tsai SY, Tsai MJ, O'Malley BW: Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action. Recent Prog Horm Res 1997, 52:141-164.
33. Torchia J, Glass C, Rosenfeld MG: Co-activators and co-repressors in the integration of transcriptional responses. Curr Opin Cell Biol 1998, 10:373-383.
34. Parker MG: Transcriptional activation by oestrogen receptors. Biochem Soc Symp 1998, 63:45-50.
35. Matthews J, Gustafsson JA: Estrogen signaling: a subtle balance between ER alpha and ER beta. Mol Intervent 2003, 3:281-292.
36. Matthews J, Wihlen B, Tujague M, Wan J, Strom A, Gustafsson JA˚: Estrogen receptor (ER) beta modulates ER-alpha-mediated transcriptional activation by altering the recruitment of c-Fos and c-Jun to estrogen-responsive promoters. Mol Endocrinol 2006, 20:534-543.
37. Yague JG, Muñoz A, de Monasterio-Schrader P, Defelipe J, Garcia-Segura LM, Azcoitia I: Aromatase expression in the human temporal cortex. Neuroscience 2006, 138(2):389-401.
38. Balthazart J, Ball GF: Is brain estradiol a hormone or a neurotransmitter? Trends Neurosci 2006, 29(5):241-249.
39. Baron-Cohen S, Lombardo MV, Auyeung B, Ashwin E, Chakrabarti B, Knickmeyer R: Why are autism spectrum conditions more prevalent in males? PLoS Biol 2011, 9(6):e1001081.
40. Sarachana T, Xu M, Wu R-C, Hu VW: Sex hormones in autism: androgens and estrogens differentially and reciprocally regulate RORA, a novel candidate gene for autism. PLoS One 2011, 6(2):e17116.
41. Henningsson S, Jonsson L, Ljunggren E, Westberg L, Gillberg C, Ra˚stam M, Anckarsäter H, Nygren G, Landén M, Thuresson K, Betancur C, Leboyer M, Gillberg C, Eriksson E, Melke J: Possible association between the androgen receptor gene and autism spectrum disorder. Psychoneuroendocrinology 2009, 34(5):752-761.