Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 52, 2012, Pages 21516-21521

  Wang, I Ting Judy ^a   Allen, Megan ^a   Goffin, Darren ^a   Zhu, Xinjian ^a,b   Fairless, Andrew H ^a   Brodkin, Edward S ^a   Siegel, Steve J ^a   Marsh, Eric D ^a,b   Blendy, Julie A ^a   Zhou, Zhaolan ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 5; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ARTICLE; AUTISM; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; EVENT RELATED POTENTIAL; FEAR; GENE DISRUPTION; KNOCKOUT MOUSE; LEARNING DISORDER; LOSS OF FUNCTION MUTATION; MEMORY; MOTOR DYSFUNCTION; MOUSE; NEUROPHYSIOLOGY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SOCIAL INTERACTION;

ANIMALS; ANXIETY; AUTISTIC DISORDER; BEHAVIOR, ANIMAL; ELECTROENCEPHALOGRAPHY; EVOKED POTENTIALS; HYPERKINESIS; MEMORY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; PROTEOME; PROTO-ONCOGENE PROTEINS C-AKT; SEIZURES; SIGNAL TRANSDUCTION; SOCIAL BEHAVIOR; TOR SERINE-THREONINE KINASES;

MAMMALIA; MUS;

EID: 84871837838     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1216988110     Document Type: Article

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