Impact of 4-epi-oxytetracycline on the gut microbiota and blood metabolomics of Wistar rats

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Han, Hongxing ^a   Xiao, Hailong ^b   Zhang, Kai ^a   Lu, Zhenmei ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b Zhejiang Institute for Food and Drug Control   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4-EPI-OXYTETRACYCLINE; ANTIINFECTIVE AGENT; BIOLOGICAL MARKER; OXYTETRACYCLINE;

ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; DRUG EFFECTS; FECES; FEMALE; INTESTINE FLORA; LIPID METABOLISM; MALE; METABOLOME; MICROBIOLOGY; URINE; WISTAR RAT;

ANIMALS; ANTI-BACTERIAL AGENTS; BIOMARKERS; FECES; FEMALE; GASTROINTESTINAL MICROBIOME; LIPID METABOLISM; MALE; METABOLOME; OXYTETRACYCLINE; RATS, WISTAR;

EID: 84961779091     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep23141     Document Type: Article

References (59)

1. Modi, S. R., Collins, J. J. and Relman, D. A. Antibiotics and the gut microbiota. J. Clin. Invest. 124(10), 4212-4218 (2014).
2. Backhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A. and Gordon, J. I. Host-bacterial mutualism in the human intestine. Science 307(5717), 1915-1920 (2005).
3. Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K. and Knight, R. Diversity, stability and resilience of the human gut microbiota. Nature 489(7415), 220-230 (2012).
4. Tang, W. H. W. and Hazen, S. L. The contributory role of gut microbiota in cardiovascular disease. J. Clin. Invest. 124(10), 4204-4211 (2014).
5. Trompette, A. et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat. Med. 20(2), 159-166 (2014).
6. Swann, J. R. et al. Variation in antibiotic-induced microbial recolonization impacts on the host metabolic phenotypes of rats. J. Proteome Res. 10(8), 3590-3603 (2011).
7. Everard, A. et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc. Natl. Acad. Sci. USA 110(22), 9066-9071 (2013).
8. Tremaroli, V. and Backhed, F. Functional interactions between the gut microbiota and host metabolism. Nature 489(7415), 242-249 (2012).
9. Turnbaugh, P. J. et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444(7122), 1027-1031 (2006).
10. Xu, J. et al. Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula. ISME J 9(3), 552-562 (2015).
11. Zhang, C., Zhang, M., Pang, X. and Zhao, L. Structural resilience of the gut microbiota in adult mice under high-fat dietary perturbations. ISME J 6(10), 1848-1857 (2012).
12. David, L. A. et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 505(7484), 559 (2014).
13. Blaser, M. Stop the killing of beneficial bacteria. Nature 476(7361), 393-394 (2011).
14. Bruessow, H. Growth promotion and gut microbiota: insights from antibiotic use. Environ. Microbiol. 17(7), 2216-2227 (2015).
15. Xu, D. et al. Rifaximin alters intestinal bacteria and prevents stress-induced gut inflammation and visceral hyperalgesia in rats. Gastroenterology 146(2), 484 (2014).
16. Sommer, M. O. A., Dantas, G. and Church, G. M. Functional Characterization of the Antibiotic resistance reservoir in the human microflora. Science 325(5944), 1128-1131 (2009).
17. Dethlefsen, L. and Relman, D. A. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proc. Natl. Acad. Sci. USA 108, 4554-4561 (2011).
18. Zhang, Y., Limaye, P. B., Renaud, H. J. and Klaassen, C. D. Effect of various antibiotics on modulation of intestinal microbiota and bile acid profile in mice. Toxicol. Appl. Pharmacol. 277(2), 138-145 (2014).
19. Chopra, I., Hawkey, P. M. and Hinton, M. Tetracyclines, molecular and clinical aspects. J Antimicrob. Chemoth. 29(3), 245-277 (1992).
20. Le, T., Yu, H., Zhao, Z. and Wei, W. Development of a monoclonal antibody-based ELISA for the detection of oxytetracycline and 4-epi-oxytetracycline residues in chicken tissues. Anal. Lett. 45(4), 386-394 (2012).
21. Kemper, N. Veterinary antibiotics in the aquatic and terrestrial environment. Ecol. Indic. 2008 8(1), 1-13 (2008).
22. Bilandzic, N. et al. Veterinary drug residues determination in raw milk in Croatia. Food Control 22(12), 1941-1948 (2011).
23. Zheng, N. et al. Occurrence of several main antibiotic residues in raw milk in 10 provinces of China. Food Addit. Contam. Part B Surveill. 6(2), 84-89 (2013).
24. Zhao, L., Dong, Y. H. and Wang, H. Residues of veterinary antibiotics in manures from feedlot livestock in eight provinces of China. Sci. Total Environ 408(5), 1069-1075 (2010).
25. Navarrete, P., Mardones, P., Opazo, R., Espejo, R. and Romero, J. Oxytetracycline treatment reduces bacterial diversity of intestinal microbiota of Atlantic salmon. J. Aquat. Anim. Health 20(3), 177-183 (2008).
26. Halling-Sorensen, B., Sengelov, G. and Tjornelund, J. Toxicity of tetracyclines and tetracycline degradation products to environmentally relevant bacteria, including selected tetracycline-resistant bacteria. Arch. Environ. Contam. Toxicol. 42(3), 263-271 (2002).
27. Han, H. X., Xiao, H. L. and Lu, Z. M. Short-term toxicity assessments of an antibiotic metabolite in Wistar rats and its metabonomics analysis by ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. Toxicol. Appl. Pharm. (2016), doi: 10.1016/j.taap.2016.01.004.
28. Gill, S. R. et al. Metagenomic analysis of the human distal gut microbiome. Science 312(5778), 1355-1359 (2006).
29. Kurokawa, K. et al. Comparative metagenomics revealed commonly enriched gene sets in human gut microbiomes. DNA Res. 14(4), 169-181 (2007).
30. Turnbaugh, P. J. et al. A core gut microbiome in obese and lean twins. Nature 457(7228), 480-487 (2009).
31. Ventura, M. et al. Genomics of Actinobacteria: tracing the evolutionary history of an ancient phylura. Microbiol. Mol. Biol. Rev. 71(3), 495 (2007).
32. Cani, P. D. et al. Selective increases of Bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 50(11), 2374-2383 (2007).
33. Wang, H. et al. Bifidobacteria may be beneficial to intestinal microbiota and reduction of bacterial translocation in mice following ischaemia and reperfusion injury. Br. J. Nutr. 109(11), 1990-1998 (2013).
34. Kaakoush, N. O. et al. Detection of Helicobacteraceae in intestinal biopsies of children with Crohns disease. Helicobacter 15(6), 549-557 (2010).
35. Bohr, U. et al. A group-specific PCR assay for the detection of Helicobacteraceae in human gut. Helicobacter. 7(6), 378-383 (2002).
36. Chopra, I. and Roberts, M. Tetracycline antibiotics: Mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol. Mol. Biol. Rev. 65(2), 232 (2001).
37. Fischbach, M. A. and Walsh, C. T. Antibiotics for emerging pathogens. Science 325(5944), p. 1089-1093 (2009).
38. Beaber, J. W., Hochhut, B. and Waldor, M. K. SOS response promotes horizontal dissemination of antibiotic resistance genes. Nature 427(6969), 72-74 (2004).
39. Stokes, H. W. and Gillings, M. R. Gene flow, mobile genetic elements and the recruitment of antibiotic resistance genes into Gramnegative pathogens. FEMS Microbiol. Rev. 35(5), 790-819 (2011).
40. Roberts, M. C. Update on acquired tetracycline resistance genes. FEMS Microbiol. Lett. 245(2), 195-203 (2005).
41. Kakisaka, K. et al. Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis. Am. J. Physiol. Gastrointest. Liver Physiol. 302(1), G77-G84 (2012).
42. Kume, N., Cybulsky, M. I. and Gimbrone, Jr. M. A. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells. J. Clin. Invest. 90(3), 1138-1144 (1992).
43. Spiegel, S. and Merrill, A. H. Sphingolipid metabolism and cell growth regulation. FASEB J. 10(12), 1388-1397 (1996).
44. Nishimura, K., Lee, S. B., Park, J. H. and Park, M. H. Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development. Amino Acids 42(2-3), 703-710 (2012).
45. Hossain, G. S. et al. One-step biosynthesis of a-keto-γ -methylthiobutyric acid from L-methionine by an Escherichia coli whole-cell biocatalyst expressing an engineered L-amino acid deaminase from proteus vulgaris. Plos ONE 9(12), e114291 (2014).
46. Quinn, M. T., Parthasarathy, S. and Steinberg, D. Lysophosphatidylcholine: a chemotactic factor for human monocytes and its potential role in atherogenesis. Proc. Natl. Acad. Sci. USA 85(8), 2805-2809 (1988).
47. Farooqui, A. A., Horrocks, L. A. and Farooqui, T. Glycerophospholipids in brain: their metabolism, incorporation into membranes, functions, and involvement in neurological disorders. Chem. Phys. Lipids 106(1), 1-29 (2000).
48. Murase, T., Aoki, M., Wakisaka, T., Hase, T. and Tokimitsu, I. Anti-obesity effect of dietary diacylglycerol in C57BL/6J mice dietary diacylglycerol stimulates intestinal lipid metabolism. J. Lipid Res. 43(8), 1312-1319 (2002).
49. Ye, L., Shao, M., Zhang, T., Tong, A. H. Y. and Lok, S. Analysis of the bacterial community in a laboratory-scale nitrification reactor and a wastewater treatment plant by 454-pyrosequencing. Water Res. 45(15), 4390-4398 (2011).
50. Caporaso, J. G. et al. QIIME allows analysis of high-throughput community sequencing data. Nat. Methods 7(5), 335-336 (2010).
51. Cole, J. R. et al. The Ribosomal Database Project: improved alignments and new tools for rRNA analysis. Nucleic Acids Res. 37, D141-D145 (2009).
52. Lan, Y., Wang, Q., Cole, J. R. and Rosen, G. L. Using the RDP classifier to predict taxonomic novelty and reduce the search space for finding novel organisms. Plos ONE 7(3), e32491 (2012).
53. Schloss, P. D. et al. Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities. Appl. Environ. Microbiol. 75(23), 7537-7541 (2009).
54. Liu, B. and Pop, M. ARDB-antibiotic resistance genes database. Nucleic Acids Res. 37 (suppl 1), D443-D447 (2009).
55. Oka, H., Ito, Y. and Matsumoto, H. Chromatographic analysis of tetracycline antibiotics in foods. Journal of Chromatography A, 882(1-2), 109-133 (2000).
56. Samanidou, V. F., Giannakis, D. E. and Papadaki, A. Development and validation of an HPLC method for the determination of seven penicillin antibiotics in veterinary drugs and bovine blood plasma. J Sep Sci 32(9), 1302-1311 (2009).
57. Wang, C. et al. Metabolic profiling of urine in young obese men using ultra performance liquid chromatography and Q-TOF mass spectrometry (UPLC/Q-TOF MS). J. Chromatogr. B 879(27), 2871-2876 (2011).
58. Chiesa, L. et al. Determination of veterinary antibiotics in bovine urine by liquid chromatography-tandem mass spectrometry. Food Chemistry 185, 7-15 (2015).
59. Sanderson, H. et al. Dissipation of oxytetracycline, chlortetracycline, tetracycline and doxycycline using HPLC-UV and LC/MS/MS under aquatic semi-field microcosm conditions. Chemosphere 60(5), 619-629 (2005).