Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development

Amino Acids

Volumn 42, Issue 2-3, 2012, Pages 703-710

  Nishimura, Kazuhiro ^a,b   Lee, Seung Bum ^a   Park, Jong Hwan ^a   Park, Myung Hee ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

Deoxyhypusine synthase; EIF5A; Gene knockout; Hypusine; Polyamine; Spermidine

Indexed keywords

DEOXYHYPUSINE SYNTHASE; GENOMIC DNA; INITIATION FACTOR 5A; INITIATION FACTOR; OXIDOREDUCTASE; PRIMER DNA; RNA BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLASTOCYST; CONTROLLED STUDY; DEOXYHYPUSINE SYNTHASE GENE; EMBRYO; EMBRYO CULTURE; EMBRYO DEVELOPMENT; EUKARYOTIC TRANSLATION INITIATION FACTOR 5A GENE; FEMALE; GENE; GENE FUNCTION; GENE INACTIVATION; GROWTH DISORDER; HETEROZYGOTE; HOMOZYGOTE; KNOCKOUT MOUSE; LETHALITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; WILD TYPE; ANIMAL; CELL LINE; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE;

EUKARYOTA; MAMMALIA; MUS;

ANIMALS; BASE SEQUENCE; CELL LINE; DNA PRIMERS; EMBRYONIC DEVELOPMENT; MICE; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; PEPTIDE INITIATION FACTORS; RNA-BINDING PROTEINS;

EID: 84861197887     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-011-0986-z     Document Type: Article

References (37)

1. Benne R, Hershey JW (1978) The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes. J Biol Chem 253:3078-3087 (Pubitemid 8353180)
2. Byers TL, Lakanen JR, Coward JK, Pegg AE (1994) The role of hypusine depletion in cytostasis induced by S-adenosyl-Lmethionine decarboxylase inhibition: new evidence provided by 1- methylspermidine and 1, 12-dimethylspermine. Biochem J 303:363-368 (Pubitemid 24317312)
3. Cano VS, Medrano FJ, Park MH, Valentini SR (2009) Evidence for conformational changes in the yeast deoxyhypusine hydroxylase Lia1 upon iron displacement from its active site. Amino Acids 38:479-490
4. Chatterjee I, Gross SR, Kinzy TG, Chen KY (2006) Rapid depletion of mutant eukaryotic initiation factor 5A at restrictive temperature reveals connections to actin cytoskeleton and cell cycle progression. Mol Genet Genomics 275:264-276 (Pubitemid 43357663)
5. Chattopadhyay MK, Park MH, Tabor H (2008) Hypusine modification for growth is the major function of spermidine in Saccharomyces cerevisiae polyamine auxotrophs grown in limiting spermidine. Proc Natl Acad Sci U. S. A 105:6554-6559 (Pubitemid 351754545)
6. Chen KY, Liu AY (1997) Biochemistry and function of hypusine formation on eukaryotic initiation factor 5A. Biol Signals 6:105-109 (Pubitemid 27380000)
7. Clement PM, Johansson HE, Wolff EC, Park MH (2006) Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells. Febs J 273:1102-1114 (Pubitemid 43345032)
8. Gregio AP, Cano VP, Avaca JS, Valentini SR, Zanelli CF (2009) eIF5A has a function in the elongation step of translation in yeast. Biochem Biophys Res Commun 380:785-790
9. Guan XY, Fung JM, Ma NF, Lau SH, Tai LS, Xie D, Zhang Y, Hu L, Wu QL, Fang Y, Sham JS (2004) Oncogenic role of eIF-5A2 in the development of ovarian cancer. Cancer Res 64:4197-4200 (Pubitemid 38802423)
10. Hanauske-Abel HM, Park MH, Hanauske AR, Popowicz AM, Lalande M, Folk JE (1994) Inhibition of the G1-S transition of the cell cycle by inhibitors of deoxyhypusine hydroxylation. Biochim Biophys Acta 1221:115-124 (Pubitemid 24103809)
11. Hoque M, Hanauske-Abel HM, Palumbo P, Saxena D, D'Alliessi Gandolfi D, Park MH, Pe'ery T, Mathews MB (2009) Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A. Retrovirology 6:90
12. Jao DL, Chen KY (2006) Tandem affinity purification revealed the hypusine-dependent binding of eukaryotic initiation factor 5A to the translating 80S ribosomal complex. J Cell Biochem 97:583-598 (Pubitemid 43265317)
13. Joe YA, Wolff EC, Park MH (1995) Cloning and expression of human deoxyhypusine synthase cDNA. Structure- function studies with the recombinant enzyme and mutant proteins. J Biol Chem 270:22386-22392
14. Kemper WM, Berry KW, Merrick WC (1976) Purification and properties of rabbit reticulocyte protein synthesis initiation factors M2Balpha and M2Bbeta. J Biol Chem 251:5551-5557
15. Landau G, Bercovich Z, Park MH, Kahana C (2010) The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation. J Biol Chem 285:12474-12481
16. Maier B, Ogihara T, Trace AP, Tersey SA, Robbins RD, Chakrabarti SK, Nunemaker CS, Stull ND, Taylor CA, Thompson JE, Dondero RS, Lewis EC, Dinarello CA, Nadler JL, Mirmira RG (2010) The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice. J Clin Invest 120:2156-2170
17. Nishimura K, Nakatsu F, Kashiwagi K, Ohno H, Saito T, Igarashi K (2002) Essential role of S-adenosylmethionine decarboxylase in mouse embryonic development. Genes Cells 7:41-47 (Pubitemid 34121304)
18. Nishimura K, Murozumi K, Shirahata A, Park MH, Kashiwagi K, Igarashi K (2005) Independent roles of eIF5A and polyamines in cell proliferation. Biochem J 385:779-785 (Pubitemid 40208839)
19. Park MH (2006) The post-translational synthesis of a polyaminederived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A). J Biochem (Tokyo) 139:161-169
20. Park MH, Cooper HL, Folk JE (1981) Identification of hypusine, an unusual amino acid, in a protein from human lymphocytes and of spermidine as its biosynthetic precursor. Proc Natl Acad Sci U S A 78:2869-2873
21. Park MH, Wolff EC, Lee YB, Folk JE (1994) Antiproliferative effects of inhibitors of deoxyhypusine synthase. Inhibition of growth of Chinese hamster ovary cells by guanyl diamines. J Biol Chem 269:27827-27832
22. Park J-H, Aravind L, Wolff EC, Kaevel J, Kim YS, Park MH (2006) Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme. Proc Natl Acad Sci U S A 103:51-56 (Pubitemid 43076103)
23. Park MH, Nishimura K, Zanelli CF, Valentini SR (2010) Functional significance of eIF5A and its hypusine modification in eukaryotes. Amino Acids 38:491-500
24. Patel PH, Costa-Mattioli M, Schulze KL, Bellen HJ (2009) The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy. J Cell Biol 185:1181-1194
25. Ruhl M, Himmelspach M, Bahr GM, Hammerschmid F, Jaksche H, Wolff B, Aschauer H, Farrington GK, Probst H, Bevec D et al (1993) Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation. J Cell Biol 123:1309-1320 (Pubitemid 24012012)
26. Saini P, Eyler DE, Green R, Dever TE (2009) Hypusine-containing protein eIF5A promotes translation elongation. Nature 459: 118-121
27. Schrader R, Young C, Kozian D, Hoffmann R, Lottspeich F (2006) Temperature-sensitive eIF5A mutant accumulates transcripts targeted to the nonsense-mediated decay pathway. J Biol Chem 281:35336-35346 (Pubitemid 46036572)
28. Spradling AC, Stern D, Beaton A, Rhem EJ, Laverty T, Mozden N, Misra S, Rubin GM (1999) The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes. Genetics 153:135-177 (Pubitemid 29434774)
29. Sugimoto A, Hakuba N, Gyo K (2004) Reconstruction of mastoid cortex defect using bone morphogenetic protein: an experimental study in the guinea pig. Acta Otolaryngol 124:253-257 (Pubitemid 38580853)
30. Tong Y, Park I, Hong BS, Nedyalkova L, Tempel W, Park HW (2009) Crystal structure of human eIF5A1: insight into functional similarity of human eIF5A1 and eIF5A2. Proteins 75:1040-1045
31. Truett GE, Heeger P, Mynatt RL, Truett AA, Walker JA, Warman ML (2000) Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT). Biotechniques 29:52-54 (Pubitemid 30439416)
32. Valentini SR, Casolari JM, Oliveira CC, Silver PA, McBride AE (2002) Genetic interactions of yeast eukaryotic translation initiation factor 5A (eIF5A) reveal connections to poly(A)- binding protein and protein kinase C signaling. Genetics 160: 393-405 (Pubitemid 34194516)
33. Weir BA, Yaffe MP (2004) Mmd1p, a novel, conserved protein essential for normal mitochondrial morphology and distribution in the fission yeast Schizosaccharomyces pombe. Mol Biol Cell 15:1656-1665 (Pubitemid 38401816)
34. Wolff EC, Kang KR, Kim YS, Park MH (2007) Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification. Amino Acids 33:341-350 (Pubitemid 47222971)
35. Xie D, Ma NF, Pan ZZ, Wu HX, Liu YD, Wu GQ, Kung HF, Guan XY (2008) Overexpression of EIF-5A2 is associated with metastasis of human colorectal carcinoma. Hum Pathol 39:80-86 (Pubitemid 350216163)
36. Zanelli CF, Maragno AL, Gregio AP, Komili S, Pandolfi JR, Mestriner CA, Lustri WR, Valentini SR (2006) eIF5A binds to translational machinery components and affects translation in yeast. Biochem Biophys Res Commun 348:1358-1366 (Pubitemid 44291350)
37. Zuk D, Jacobson A (1998) A single amino acid substitution in yeast eIF-5A results in mRNA stabilization. EMBO J 17:2914-2925