Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A

Neuropharmacology

Volumn 105, Issue , 2016, Pages 270-284

  Xu, Chong ^a   Wang, Xiaoxue ^a   Zhu, Yu ^a   Dong, Xiaoqing ^a   Liu, Chunxiao ^a   Zhang, Hai ^a   Liu, Lei ^b   Huang, Shile ^b   Chen, Long ^a  

^a NANJING NORMAL UNIVERSITY   (China)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Apoptosis; Cadmium; MAPK; PP2A; Rapamycin; ROS

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN C JUN; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; 1,3 BUTADIENE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ANTHRACENE DERIVATIVE; CADMIUM; NITRILE; PHOSPHOPROTEIN PHOSPHATASE 2; PYRAZOLANTHRONE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FETUS; MOUSE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; WILD TYPE; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENETICS; MAPK SIGNALING; METABOLISM; MITOCHONDRION; NERVE CELL; ONCOGENE; PC12 CELL LINE; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTHRACENES; APOPTOSIS; BUTADIENES; CADMIUM; GENES, JUN; MAP KINASE SIGNALING SYSTEM; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; NITRILES; PC12 CELLS; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SIROLIMUS;

EID: 84961301074     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2016.01.030     Document Type: Article

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