Dual Regulation of Cadmium-Induced Apoptosis by mTORC1 through Selective Induction of IRE1 Branches in Unfolded Protein Response

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Kato, Hironori ^a   Katoh, Ryohei ^a   Kitamura, Masanori ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; CADMIUM; INITIATION FACTOR 2ALPHA; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN IRE1; PROTEIN KINASE; PROTEIN KINASE LIKE ENDOPLASMIC RETICULUM KINASE; RAPAMYCIN; RAPTOR PROTEIN; REACTIVE OXYGEN METABOLITE; REGULATOR PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TUBERIN; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; KIDNEY TUBULE CELL; MALE; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

ANIMALS; APOPTOSIS; CADMIUM; CELL LINE; KIDNEY TUBULES; MICE; MICE, INBRED C57BL; MULTIPROTEIN COMPLEXES; RATS; REACTIVE OXYGEN SPECIES; TOR SERINE-THREONINE KINASES; UNFOLDED PROTEIN RESPONSE;

EID: 84877805530     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064344     Document Type: Article

References (43)

1. Lind Y, Engman J, Jorhem L, Glynn AW, (1997) Cadmium accumulation in liver and kidney of mice exposed to the same weekly cadmium dose continuously or once a week. Food Chem Toxicol 35: 891-895.
2. Jarup L, Akesson A, (2009) Current status of cadmium as an environmental health problem. Toxicol Appl Pharmaco 238: 201-208.
3. Bernard A, (2004) Renal dysfunction induced by cadmium: biomarkers of critical effects. Bio Metals 17: 519-523.
4. Oh SH, Lim SC, (2006) A rapid and transient ROS generation by cadmium triggers apoptosis via caspase-dependent pathway in HepG2 cells and this is inhibited through N-acetylcysteine-mediated catalase upregulation. Toxicol Appl Pharmacol 212: 212-223.
5. Pathak N, Khandelwal S, (2006) Oxidative stress and apoptotic changes in murine splenocytes exposed to cadmium. Toxicology 220: 26-36.
6. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M, (2006) Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 160: 1-40.
7. Ognjanović BI, Marković SD, Ethordević NZ, Trbojević IS, Stajn AS, et al. (2006) Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: protective role of coenzyme Q(10) and vitamin E. Reprod Toxicol 29: 191-197.
8. Stohs SJ, Bagchi D, (1995) Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med 18: 321-336.
9. Figueiredo-Pereira ME, Yakushin S, Cohen G, (1998) Disruption of the intracellular sulfhydryl homeostasis by cadmium-induced oxidative stress leads to protein thiolation and ubiquitination in neuronal cells. J Biol Chem 273: 12703-12709.
10. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, et al. (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39: 44-84.
11. Yokouchi M, Hiramatsu N, Hayakawa K, Kasai A, Takano Y, et al. (2007) Atypical, bidirectional regulation of cadmium-induced apoptosis via distinct signaling of unfolded protein response. Cell Death Differ 14: 1467-1474.
12. Lee AS, (2002) The glucose-regulated proteins: stress induction and clinical applications. Trends Biochem Sci 26: 504-510.
13. Kaufman RJ, (2002) Orchestrating the unfolded protein response in health and disease. J Clin Invest 110: 1389-1398.
14. Kim R, Emi M, Tanabe K, Murakami S, (2006) Role of the unfolded protein response in cell death. Apoptosis 11: 5-13.
15. Ron D, Walter P, (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8: 519-529.
16. Rutkowski DT, Kaufman RJ, (2004) A trip to the ER: coping with stress. Trends Cell Biol 14: 20-28.
17. Wullschleger S, Loewith R, Hall MN, (2006) TOR signaling in growth and metabolism. Cell 124: 471-484.
18. Laplante M, Sabatini DM, (2009) mTOR signaling at a glance. J Cell Sci 122: 3589-3594.
19. Chen L, Liu L, Luo Y, Huang S, (2008) MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem 105: 251-261.
20. Park HR, Tomida A, Sato S, Tsukumo Y, Yun J, et al. (2004) Effect on tumor cells of blocking survival response to glucose deprivation. J Natl Cancer Inst 96: 1300-1310.
21. Lee AH, Iwakoshi NN, Anderson KC, Glimcher LH, (2003) Proteasome inhibitors disrupt the unfolded protein response in myeloma cells. Proc Natl Acad Sci USA 100: 9946-9951.
22. Iwawaki T, Akai R, Kohno K, Miura M, (2004) A transgenic mouse model for monitoring endoplasmic reticulum stress. Nat Med 10: 98-102.
23. Ogata M, Hino S, Saito A, Morikawa K, Kondo S, et al. (2006) Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 26: 9220-9231.
24. Dérijard B, Hibi M, Wu IH, Barrett T, Su B, et al. (1994) JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76: 1025-1037.
25. Piao X, Kobayashi T, Wang L, Shiono M, Takagi Y, et al. (2009) Regulation of folliculin (the BHD gene product) phosphorylation by Tsc2-mTOR pathway. Biochem Biophys Res Commun 389: 16-21.
26. Kato H, Nakajima S, Saito Y, Takahashi S, Katoh R, et al. (2012) mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway. Cell Death Differ 19: 310-320.
27. Liu J, Qu W, Kadiiska MB, (2009) Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol Appl Pharmacol 238: 209-214.
28. Sugawara M, Sugawara Y, Wen K, Giulivi C, (2002) Generation of oxygen free radicals in thyroid cells and inhibition of thyroid peroxidase. Exp Biol Med 227: 141-146.
29. Criddle DN, Gillies S, Baumgartner-Wilson HK, Jaffar M, Chinje EC, et al. (2006) Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells. J Biol Chem 281: 40485-40492.
30. Yamada T, Egashira N, Bando A, Nishime Y, Tonogai Y, et al. (2012) Activation of p38 MAPK by oxidative stress underlying epirubicin-induced vascular endothelial cell injury. Free Radic Biol Med 52: 1285-1293.
31. Yokouchi M, Hiramatsu N, Hayakawa K, Okamura M, Du S, et al. (2008) Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response. J Biol Chem 283: 4252-4260.
32. Nishitoh H, Matsuzawa A, Tobiume K, Saegusa K, Takeda K, et al. (2002) ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev 16: 1345-1355.
33. Inoki K, Li Y, Zhu T, Wu J, Guan KL, (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling. Nat Cell Biol 4: 648-657.
34. Zeng L, Zampetaki A, Margariti A, Pepe AE, Alam S, et al. (2009) Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow. Proc Natl Acad Sci USA 106: 8326-8331.
35. Yu C, Minemoto Y, Zhang J, Liu J, Tang F, et al. (2004) JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell 13: 329-340.
36. Wang Z, Wang H, Xu ZM, Ji YL, Chen YH, et al. (2012) Cadmium-induced teratogenicity: association with ROS-mediated endoplasmic reticulum stress in placenta. Toxicol Appl Pharmacol 259: 236-247.
37. Chen L, Xu B, Liu L, Luo Y, Zhou H, et al. (2011) Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death. Free Radic Biol Med 50: 624-632.
38. Hetz C, Bernasconi P, Fisher J, Lee AH, Bassik MC, et al. (2006) Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1α. Science 312: 572-576.
39. Hetz C, Glimcher LH, (2009) Fine-tuning of the unfolded protein response: Assembling the IRE1α interactome. Mol Cell 35: 551-561.
40. Klee M, Pallauf K, Alcalá S, Fleischer A, Pimentel-Muiños FX, (2009) Mitochondrial apoptosis induced by BH3-only molecules in the exclusive presence of endoplasmic reticular Bak. EMBO J 28: 1757-1768.
41. Lam D, Dickens D, Reid EB, Loh SH, Moisoi N, et al. (2009) MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins. Proc Natl Acad Sci USA 106: 11978-11983.
42. Lin JH, Li H, Yasumura D, Cohen HR, Zhang C, et al. (2007) IRE1 signaling affects cell fate during the unfolded protein response. Science 318: 944-949.
43. Rutkowski DT, Kaufman RJ, (2007) That which does not kill me makes me stronger: adapting to chronic ER stress. Trends Biochem Sci 32: 469-476.