Celastrol prevents cadmium-induced neuronal cell death via targeting JNK and PTEN-Akt/mTOR network

Journal of Neurochemistry

Volumn 128, Issue 2, 2014, Pages 256-266

  Chen, Sujuan ^a   Gu, Chenjian ^a   Xu, Chong ^a   Zhang, Jinfei ^a   Xu, Yijiao ^a   Ren, Qian ^a   Guo, Min ^a   Huang, Shile ^b   Chen, Long ^a  

^a NANJING NORMAL UNIVERSITY   (China)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

apoptosis; c Jun N terminal kinase; cadmium; Celastrol; mammalian target of rapamycin; phosphatase and tensin homolog on chromosome 10

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CADMIUM; CASPASE 3; CELASTROL; LACTATE DEHYDROGENASE; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG TARGETING; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; FETUS; MOUSE; NERVE CELL; NEUROPROTECTION; NONHUMAN; PC12 CELL; POLYMERIZATION; PRIORITY JOURNAL; RAT; WESTERN BLOTTING; WILD TYPE;

MAMMALIA;

APOPTOSIS; C-JUN N-TERMINAL KINASE; CADMIUM; CELASTROL; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATASE AND TENSIN HOMOLOG ON CHROMOSOME 10;

ANIMALS; APOPTOSIS; CADMIUM CHLORIDE; CELL SURVIVAL; ENVIRONMENTAL POLLUTANTS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; NEUROPROTECTIVE AGENTS; PC12 CELLS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RATS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRITERPENES;

EID: 84891835356     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12474     Document Type: Article

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