Rapamycin prevents cadmium-induced neuronal cell death via targeting both mTORC1 and mTORC2 pathways

Neuropharmacology

Volumn 97, Issue , 2015, Pages 35-45

  Xu, Chong ^a   Liu, Chunxiao ^a   Liu, Lei ^b   Zhang, Ruijie ^a   Zhang, Hai ^a   Chen, Sujuan ^a   Luo, Yan ^b   Chen, Long ^a,b   Huang, Shile ^b  

^a NANJING NORMAL UNIVERSITY   (China)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Apoptosis; Cadmium; mTOR; Neuronal cells; Rapamycin

Indexed keywords

CADMIUM; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PROTEIN KINASE B; RAPAMYCIN; S6 KINASE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; NEUROPROTECTIVE AGENT; RIBOSOMAL PROTEIN S6 KINASE, 70KD, POLYPEPTIDE 1; S6K1 PROTEIN, RAT; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DOWN REGULATION; DRUG INHIBITION; HUMAN; HUMAN CELL; NERVE CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS REGULATION; PROTEIN TARGETING; RAT; SIGNAL TRANSDUCTION; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; PC12 CELL LINE; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; CADMIUM; CELL DEATH; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MULTIPROTEIN COMPLEXES; NEURONS; NEUROPROTECTIVE AGENTS; PC12 CELLS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RIBOSOMAL PROTEIN S6 KINASES; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84930634663     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.05.008     Document Type: Article

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