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Volumn 167, Issue 2, 2011, Pages

Targeting the JNK signaling pathway potentiates the antiproliferative efficacy of rapamycin in LS174T colon cancer cells

Author keywords

JNK; mTOR; proliferation; rapamycin; signaling; tumor

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; STRESS ACTIVATED PROTEIN KINASE;

EID: 79954618950     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2011.01.015     Document Type: Article
Times cited : (13)

References (32)
  • 1
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • S. Wullschleger, R. Loewith, and M.N. Hall TOR signaling in growth and metabolism Cell 124 2006 471
    • (2006) Cell , vol.124 , pp. 471
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 2
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • D.A. Guertin, and D.M. Sabatini Defining the role of mTOR in cancer Cancer Cell 12 2007 9
    • (2007) Cancer Cell , vol.12 , pp. 9
    • Guertin, D.A.1    Sabatini, D.M.2
  • 3
    • 33646023695 scopus 로고    scopus 로고
    • Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
    • D.D. Sarbassov, S.M. Ali, and S. Sengupta Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB Mol Cell 22 2006 159
    • (2006) Mol Cell , vol.22 , pp. 159
    • Sarbassov, D.D.1    Ali, S.M.2    Sengupta, S.3
  • 4
    • 33750072949 scopus 로고    scopus 로고
    • MTOR and cancer therapy
    • J.B. Easton, and P.J. Houghton mTOR and cancer therapy Oncogene 25 2006 6436
    • (2006) Oncogene , vol.25 , pp. 6436
    • Easton, J.B.1    Houghton, P.J.2
  • 5
    • 33746637660 scopus 로고    scopus 로고
    • Current development of mTOR inhibitors as anticancer agents
    • S. Faivre, G. Kroemer, and E. Raymond Current development of mTOR inhibitors as anticancer agents Nat Rev Drug Discov 5 2006 671
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 671
    • Faivre, S.1    Kroemer, G.2    Raymond, E.3
  • 6
    • 77951231349 scopus 로고    scopus 로고
    • MTOR and cancer: Many loops in one pathway
    • A. Efeyan, and D.M. Sabatini mTOR and cancer: Many loops in one pathway Curr Opin Cell Biol 22 2010 169
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 169
    • Efeyan, A.1    Sabatini, D.M.2
  • 7
    • 0034644522 scopus 로고    scopus 로고
    • Signal transduction by the JNK group of MAP kinases
    • R.J. Davis Signal transduction by the JNK group of MAP kinases Cell 103 2000 239
    • (2000) Cell , vol.103 , pp. 239
    • Davis, R.J.1
  • 8
  • 9
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signalling cascades
    • L. Chang, and M. Karin Mammalian MAP kinase signalling cascades Nature 410 2001 37
    • (2001) Nature , vol.410 , pp. 37
    • Chang, L.1    Karin, M.2
  • 10
  • 11
    • 67749117934 scopus 로고    scopus 로고
    • Signal integration by JNK and p38 MAPK pathways in cancer development
    • E.F. Wagner, and A.R. Nebreda Signal integration by JNK and p38 MAPK pathways in cancer development Nat Rev Cancer 9 2009 537
    • (2009) Nat Rev Cancer , vol.9 , pp. 537
    • Wagner, E.F.1    Nebreda, A.R.2
  • 12
    • 74949089952 scopus 로고    scopus 로고
    • C-Jun-NH2-kinase-1 inhibition leads to antitumor activity in ovarian cancer
    • P. Vivas-Mejia, J.M. Benito, and A. Fernandez c-Jun-NH2-kinase-1 inhibition leads to antitumor activity in ovarian cancer Clin Cancer Res 16 2010 184
    • (2010) Clin Cancer Res , vol.16 , pp. 184
    • Vivas-Mejia, P.1    Benito, J.M.2    Fernandez, A.3
  • 13
    • 52049122570 scopus 로고    scopus 로고
    • C-Jun NH(2)-terminal kinase mediates leptin-stimulated androgen-independent prostate cancer cell proliferation via signal transducer and activator of transcription 3 and Akt
    • T. Miyazaki, J.D. Bub, and Y. Iwamoto c-Jun NH(2)-terminal kinase mediates leptin-stimulated androgen-independent prostate cancer cell proliferation via signal transducer and activator of transcription 3 and Akt Biochim Biophys Acta 1782 2008 593
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 593
    • Miyazaki, T.1    Bub, J.D.2    Iwamoto, Y.3
  • 14
    • 72549119225 scopus 로고    scopus 로고
    • Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary conditions
    • H. Endo, K. Hosono, and T. Fujisawa Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary conditions Gut 58 2009 1637
    • (2009) Gut , vol.58 , pp. 1637
    • Endo, H.1    Hosono, K.2    Fujisawa, T.3
  • 15
    • 0029943605 scopus 로고    scopus 로고
    • Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
    • A. Klippel, C. Reinhard, and W.M. Kavanaugh Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways Mol Cell Biol 16 1996 4117
    • (1996) Mol Cell Biol , vol.16 , pp. 4117
    • Klippel, A.1    Reinhard, C.2    Kavanaugh, W.M.3
  • 16
    • 34249815200 scopus 로고    scopus 로고
    • Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN
    • I. Vivanco, N. Palaskas, and C. Tran Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN Cancer Cell 11 2007 555
    • (2007) Cancer Cell , vol.11 , pp. 555
    • Vivanco, I.1    Palaskas, N.2    Tran, C.3
  • 17
    • 0028329953 scopus 로고
    • JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
    • B. Derijard, M. Hibi, and I.H. Wu JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain Cell 76 1994 1025
    • (1994) Cell , vol.76 , pp. 1025
    • Derijard, B.1    Hibi, M.2    Wu, I.H.3
  • 18
    • 35548968518 scopus 로고    scopus 로고
    • Cancer: Mixing cocktails
    • C.L. Sawyers Cancer: Mixing cocktails Nature 449 2007 993
    • (2007) Nature , vol.449 , pp. 993
    • Sawyers, C.L.1
  • 19
    • 75149130051 scopus 로고    scopus 로고
    • Targeting the cancer kinome through polypharmacology
    • Z.A. Knight, H. Lin, and K.M. Shokat Targeting the cancer kinome through polypharmacology Nat Rev Cancer 10 2010 130
    • (2010) Nat Rev Cancer , vol.10 , pp. 130
    • Knight, Z.A.1    Lin, H.2    Shokat, K.M.3
  • 20
    • 77951044433 scopus 로고    scopus 로고
    • Rapamycin-mediated FOXO1 inactivation reduces the anticancer efficacy of rapamycin
    • E. Abdelnour-Berchtold, Y. Cerantola, and D. Roulin Rapamycin-mediated FOXO1 inactivation reduces the anticancer efficacy of rapamycin Anticancer Res 30 2010 799
    • (2010) Anticancer Res , vol.30 , pp. 799
    • Abdelnour-Berchtold, E.1    Cerantola, Y.2    Roulin, D.3
  • 21
    • 67349119907 scopus 로고    scopus 로고
    • Combined inhibition of Dnmt and mTOR signaling inhibits formation and growth of colorectal cancer
    • Y.J. Zhang, S.L. Zhao, and X.Q. Tian Combined inhibition of Dnmt and mTOR signaling inhibits formation and growth of colorectal cancer Int J Colorectal Dis 24 2009 629
    • (2009) Int J Colorectal Dis , vol.24 , pp. 629
    • Zhang, Y.J.1    Zhao, S.L.2    Tian, X.Q.3
  • 22
    • 51349164790 scopus 로고    scopus 로고
    • Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
    • A. Carracedo, L. Ma, and J. Teruya-Feldstein Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer J Clin Invest 118 2008 3065
    • (2008) J Clin Invest , vol.118 , pp. 3065
    • Carracedo, A.1    Ma, L.2    Teruya-Feldstein, J.3
  • 23
    • 33845227643 scopus 로고    scopus 로고
    • Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non-small-cell lung, pancreatic, colon, and breast tumors
    • E. Buck, A. Eyzaguirre, and E. Brown Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non-small-cell lung, pancreatic, colon, and breast tumors Mol Cancer Ther 5 2006 2676
    • (2006) Mol Cancer Ther , vol.5 , pp. 2676
    • Buck, E.1    Eyzaguirre, A.2    Brown, E.3
  • 24
    • 65549089078 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity
    • Y. Rong, V.E. Belozerov, and C. Tucker-Burden Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity Cancer Res 69 2009 2540
    • (2009) Cancer Res , vol.69 , pp. 2540
    • Rong, Y.1    Belozerov, V.E.2    Tucker-Burden, C.3
  • 25
    • 77951984318 scopus 로고    scopus 로고
    • Exendin-4 protects pancreatic beta cells from the cytotoxic effect of rapamycin by inhibiting JNK and p38 phosphorylation
    • Y. Kawasaki, S. Harashima, and M. Sasaki Exendin-4 protects pancreatic beta cells from the cytotoxic effect of rapamycin by inhibiting JNK and p38 phosphorylation Horm Metab Res 42 2010 311
    • (2010) Horm Metab Res , vol.42 , pp. 311
    • Kawasaki, Y.1    Harashima, S.2    Sasaki, M.3
  • 26
    • 0038094504 scopus 로고    scopus 로고
    • Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)
    • S. Huang, L. Shu, and M.B. Dilling Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1) Mol Cell 11 2003 1491
    • (2003) Mol Cell , vol.11 , pp. 1491
    • Huang, S.1    Shu, L.2    Dilling, M.B.3
  • 27
    • 4344610451 scopus 로고    scopus 로고
    • Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity
    • S. Huang, L. Shu, and J. Easton Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity J Biol Chem 279 2004 36490
    • (2004) J Biol Chem , vol.279 , pp. 36490
    • Huang, S.1    Shu, L.2    Easton, J.3
  • 28
    • 24644478136 scopus 로고    scopus 로고
    • Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
    • A.S. Nateri, B. Spencer-Dene, and A. Behrens Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development Nature 437 2005 281
    • (2005) Nature , vol.437 , pp. 281
    • Nateri, A.S.1    Spencer-Dene, B.2    Behrens, A.3
  • 29
    • 0033938194 scopus 로고    scopus 로고
    • Expression of Jun family members in human colorectal adenocarcinoma
    • H. Wang, M. Birkenbach, and J. Hart Expression of Jun family members in human colorectal adenocarcinoma Carcinogenesis 21 2000 1313
    • (2000) Carcinogenesis , vol.21 , pp. 1313
    • Wang, H.1    Birkenbach, M.2    Hart, J.3
  • 30
    • 73149122504 scopus 로고    scopus 로고
    • Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer
    • P. Gulhati, Q. Cai, and J. Li Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer Clin Cancer Res 15 2009 7207
    • (2009) Clin Cancer Res , vol.15 , pp. 7207
    • Gulhati, P.1    Cai, Q.2    Li, J.3
  • 31
    • 77952305228 scopus 로고    scopus 로고
    • Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo
    • D. Roulin, Y. Cerantola, and A. Dormond-Meuwly Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo Mol Cancer 9 2010 57
    • (2010) Mol Cancer , vol.9 , pp. 57
    • Roulin, D.1    Cerantola, Y.2    Dormond-Meuwly, A.3
  • 32
    • 68949198785 scopus 로고    scopus 로고
    • MTOR signaling pathway is a target for the treatment of colorectal cancer
    • Y.J. Zhang, Q. Dai, and D.F. Sun mTOR signaling pathway is a target for the treatment of colorectal cancer Ann Surg Oncol 16 2009 2617
    • (2009) Ann Surg Oncol , vol.16 , pp. 2617
    • Zhang, Y.J.1    Dai, Q.2    Sun, D.F.3


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