Heavy metal poisoning: The effects of cadmium on the kidney

BioMetals

Volumn 23, Issue 5, 2010, Pages 783-792

  Johri, Nikhil ^a   Jacquillet, Grégory ^a   Unwin, Robert ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Cadmium; Fanconi syndrome; Kidney; Low molecular weight protein; Nephrotoxicity; Proximal tubule

Indexed keywords

CADMIUM; LEAD; METALLOTHIONEIN; REACTIVE OXYGEN METABOLITE; RETINOL BINDING PROTEIN;

ACUTE TOXICITY; BLOOD LEVEL; BREAST CANCER; CARDIOVASCULAR RISK; CHRONIC KIDNEY DISEASE; CHRONIC TOXICITY; COMORBIDITY; CYTOSOL; DIABETES MELLITUS; ENDOCYTOSIS; ENDOMETRIUM CANCER; ENDOSOME; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL IMPACT; FANCONI RENOTUBULAR SYNDROME; FRACTURE; HEAVY METAL POISONING; HUMAN; HYPERTENSION; INFERTILITY; KIDNEY CANCER; KIDNEY FAILURE; KIDNEY PROXIMAL TUBULE; LUNG CANCER; LYSOSOME; NEPHROTOXICITY; NONHUMAN; OSTEOMALACIA; PROSTATE CANCER; PROTEINURIA; REVIEW; RICKETS; SCREENING; STOMACH CANCER; URINE LEVEL;

BONE AND BONES; CADMIUM; CADMIUM POISONING; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; HUMANS; KIDNEY; KIDNEY TUBULES, PROXIMAL; METALS, HEAVY; MODELS, BIOLOGICAL;

EID: 78349306576     PISSN: 09660844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10534-010-9328-y     Document Type: Review

References (80)

1. A Akesson T Lundh M Vahter P Bjellerup J Lidfeldt C Nerbrand G Samsioe U Stromberg S Skerfving 2005 Tubular and glomerular kidney effects in Swedish women with low environmental cadmium exposure Environ Health Perspect 113 1627 1631 10.1289/ehp.8033 16263522 (Pubitemid 41614922)
2. S Arpadjan G Celik S Taskesen S Gucer 2008 Arsenic, cadmium and lead in medicinal herbs and their fractionation Food Chem Toxicol 46 2871 2875 10.1016/j.fct.2008.05.027 18614270 1:CAS:528:DC%2BD1cXoslCnt78%3D
3. D Bagchi M Bagchi EA Hassoun SJ Stohs 1996 Cadmium-induced excretion of urinary lipid metabolites, DNA damage, glutathione depletion, and hepatic lipid peroxidation in Sprague-Dawley rats Biol Trace Elem Res 52 143 154 10.1007/BF02789456 8773755 1:CAS:528:DyaK28XjsFansr8%3D
4. A Bernard 2008 Biomarkers of metal toxicity in population studies: research potential and interpretation issues J Toxicol Environ Health A 71 1259 1265 10.1080/15287390802211885 18654897 1:CAS:528:DC%2BD1cXovFWku7s%3D
5. A Bernard R Lauwerys 1990 Early markers of cadmium nephrotoxicity: biological significance and predictive value Toxicol Environ Chem 27 65 72 10.1080/02772249009357558 1:CAS:528:DyaK3cXhsFeis7k%3D
6. AM Bernard AA Vyskocil P Mahieu RR Lauwerys 1987 Assessment of urinary retinol-binding protein as an index of proximal tubular injury Clin Chem 33 775 779 3297418 1:CAS:528:DyaL2sXksFGiu70%3D
7. AM Bernard H Roels A Cardenas R Lauwerys 1990 Assessment of urinary protein 1 and transferrin as early markers of cadmium nephrotoxicity Br J Ind Med 47 559 565 2203466 1:STN:280:DyaK3czms1Gntg%3D%3D
8. A Bernard N Thielemans H Roels R Lauwerys 1995 Association between NAG-B and cadmium in urine with no evidence of a threshold Occup Environ Med 52 177 180 10.1136/oem.52.3.177 7735390 1:CAS:528:DyaK2MXlslCjtbc%3D
9. MH Bhattacharyya NA Sacco-Gibson DP Peterson 1992 Cadmium-induced bone loss: increased susceptibility in female beagles after ovariectomy IARC Sci Publ 118 279 286 1303952 1:CAS:528:DyaK3sXltlejtLo%3D
10. JP Buchet R Lauwerys H Roels A Bernard P Bruaux F Claeys G Ducoffre P De Plaen J Staessen A Amery 1990 Renal effects of cadmium body burden of the general population Lancet 336 699 702 10.1016/0140-6736(90)92201-R 1975890 1:STN:280:DyaK3czns1ymuw%3D%3D (Pubitemid 20309126)
11. L Chen L Lei T Jin M Nordberg GF Nordberg 2006 Plasma metallothionein antibody, urinary cadmium, and renal dysfunction in a Chinese type 2 diabetic population Diabetes Care 29 2682 2687 10.2337/dc06-1003 17130205 1:CAS:528:DC%2BD2sXhtVGgsg%3D%3D (Pubitemid 44912199)
12. PG Davey P Gosling 1982 Beta 2-microglobulin instability in pathological urine Clin Chem 28 1330 1333 6176371 1:CAS:528:DyaL38Xkt1Wksb8%3D
13. C de Burbure JP Buchet A Leroyer C Nisse JM Haguenoer A Mutti Z Smerhovsky M Cikrt M Trzcinka-Ochocka G Razniewska M Jakubowski A Bernard 2006 Renal and neurologic effects of cadmium, lead, mercury, and arsenic in children: evidence of early effects and multiple interactions at environmental exposure levels Environ Health Perspect 114 584 590 10.1289/ehp.8202 16581550 1:CAS:528:DC%2BD28Xktlens74%3D
14. S Desagher JC Martinou 2000 Mitochondria as the central control point of apoptosis Trends Cell Biol 10 369 377 10.1016/S0962-8924(00)01803-1 10932094 1:CAS:528:DC%2BD3cXls1CktLk%3D (Pubitemid 30612469)
15. Dreisbach RH (1983) Handbook of poisoning: prevention, diagnosis and treatment, 11 edn. Lange Medical Publications
16. CG Elinder T Kjellstrom B Lind L Linnman M Piscator K Sundstedt 1983 Cadmium exposure from smoking cigarettes: variations with time and country where purchased Environ Res 32 220 227 10.1016/0013-9351(83)90209-8 6617614 1:CAS:528:DyaL3sXlslWitbs%3D
17. CJ Everett IL Frithsen 2008 Association of urinary cadmium and myocardial infarction Environ Res 106 284 286 10.1016/j.envres.2007.10.009 18053980 1:CAS:528:DC%2BD1cXhsVCmurk%3D (Pubitemid 351162984)
18. PR Flanagan JS McLellan J Haist G Cherian MJ Chamberlain LS Valberg 1978 Increased dietary cadmium absorption in mice and human subjects with iron deficiency Gastroenterology 74 841 846 640339 1:CAS:528:DyaE1cXktVCqtbo%3D
19. L Friberg 1952 Further investigations on chronic cadmium poisoning; a study on rabbits with radioactive cadmium AMA Arch Ind Hyg Occup Med 5 30 36 1:CAS:528:DyaG38Xmt1Wgtw%3D%3D
20. PR Greipp JA Katzmann WM O'Fallon RA Kyle 1988 Value of beta 2-microglobulin level and plasma cell labeling indices as prognostic factors in patients with newly diagnosed myeloma Blood 72 219 223 3291982 1:STN:280:DyaL1c3mvFyhsg%3D%3D
21. H Gunshin B Mackenzie UV Berger Y Gunshin MF Romero WF Boron S Nussberger JL Gollan MA Hediger 1997 Cloning and characterization of a mammalian proton-coupled metal-ion transporter Nature 388 482 488 10.1038/41343 9242408 1:CAS:528:DyaK2sXltFGqtbY%3D (Pubitemid 27328927)
22. T Halatek J Gromadzinska W Wasowicz K Rydzynski 2005 Serum clara-cell protein and beta2-microglobulin as early markers of occupational exposure to nitric oxides Inhal Toxicol 17 87 97 10.1080/08958370590899460 15764486 1:CAS:528:DC%2BD2MXovV2ksg%3D%3D
23. M Haswell-Elkins S Satarug P O'Rourke M Moore J Ng V McGrath M Walmby 2008 Striking association between urinary cadmium level and albuminuria among Torres Strait Islander people with diabetes Environ Res 106 379 383 10.1016/j.envres.2007.10.004 18045586 1:CAS:528:DC%2BD1cXivVaqs7w%3D (Pubitemid 351296206)
24. L Hellstrom CG Elinder B Dahlberg M Lundberg L Jarup B Persson O Axelson 2001 Cadmium exposure and end-stage renal disease Am J Kidney Dis 38 1001 1008 10.1053/ajkd.2001.28589 11684553 1:CAS:528:DC%2BD3MXovVGgu7s%3D
25. DJ Hendrick 1996 Occupational and chronic obstructive pulmonary disease (COPD) Thorax 51 947 955 10.1136/thx.51.9.947 8984710 1:STN:280: DyaK2s7gsFKitw%3D%3D
26. F Hong T Jin A Zhang 2004 Risk assessment on renal dysfunction caused by co-exposure to arsenic and cadmium using benchmark dose calculation in a Chinese population Biometals 17 573 580 10.1023/B:BIOM.0000045741.22924.d8 15688868 1:CAS:528:DC%2BD2cXovVOjsbo%3D (Pubitemid 41214272)
27. H Horiguchi M Sato N Konno M Fukushima 1996 Long-term cadmium exposure induces anemia in rats through hypoinduction of erythropoietin in the kidneys Arch Toxicol 71 11 19 10.1007/s002040050352 9010580 1:CAS:528: DyaK2sXns1KnsA%3D%3D (Pubitemid 26402864)
28. H Horiguchi E Oguma S Sasaki K Miyamoto Y Ikeda M Machida F Kayama 2004 Comprehensive study of the effects of age, iron deficiency, diabetes mellitus, and cadmium burden on dietary cadmium absorption in cadmium-exposed female Japanese farmers Toxicol Appl Pharmacol 196 114 123 10.1016/j.taap.2003.11.024 15050413 1:CAS:528:DC%2BD2cXisFyrsbY%3D (Pubitemid 38393699)
29. D Il'yasova GG Schwartz 2005 Cadmium and renal cancer Toxicol Appl Pharmacol 207 179 186 10.1016/j.taap.2004.12.005 16102569 1:CAS:528: DC%2BD2MXos1Wqsr8%3D (Pubitemid 41133504)
30. T Inaba E Kobayashi Y Suwazono M Uetani M Oishi H Nakagawa K Nogawa 2005 Estimation of cumulative cadmium intake causing Itai-itai disease Toxicol Lett 159 192 201 10.1016/j.toxlet.2005.05.011 16006079 1:CAS:528:DC%2BD2MXhtVart77J (Pubitemid 41330937)
31. G Jacquillet O Barbier M Cougnon M Tauc MC Namorado D Martin JL Reyes P Poujeol 2006 Zinc protects renal function during cadmium intoxication in the rat Am J Physiol 290 F127 F137 1:CAS:528:DC%2BD28XhsVKitb8%3D
32. G Jacquillet O Barbier I Rubera M Tauc A Borderie MC Namorado D Martin G Sierra JL Reyes P Poujeol M Cougnon 2007 Cadmium causes delayed effects on renal function in the offspring of cadmium-contaminated pregnant female rats Am J Physiol 293 F1450 F1460 10.1152/ajprenal.00223.2007 1:CAS:528:DC%2BD2sXhtlGhtrzI (Pubitemid 350085980)
33. L Jarup CG Elinder 1993 Incidence of renal stones among cadmium exposed battery workers Br J Ind Med 50 598 602 8343420 1:STN:280:DyaK3szksVartg%3D%3D (Pubitemid 23243761)
34. L Jarup A Rogenfelt CG Elinder K Nogawa T Kjellstrom 1983 Biological half-time of cadmium in the blood of workers after cessation of exposure Scand J Work Environ Health 9 327 331 6635611 1:STN:280:DyaL2c%2FksVKgug%3D%3D
35. L Jarup B Persson CG Elinder 1995 Decreased glomerular filtration rate in solderers exposed to cadmium Occup Environ Med 52 818 822 10.1136/oem.52.12.818 8563845 1:STN:280:DyaK287msFWgsA%3D%3D
36. L Jarup M Berglund CG Elinder G Nordberg M Vahter 1998 Health effects of cadmium exposure-a review of the literature and a risk estimate Scand J Work Environ Health 24 Suppl 1 1 51 9569444
37. A Jensen F Bro-Rasmussen 1992 Environmental cadmium in Europe Rev Environ Contam Toxicol 125 101 181 1509176 1:CAS:528:DyaK38Xhsl2qtL0%3D
38. T Jin X Wu Y Tang M Nordberg A Bernard T Ye Q Kong NG Lundstrom GF Nordberg 2004 Environmental epidemiological study and estimation of benchmark dose for renal dysfunction in a cadmium-polluted area in China Biometals 17 525 530 10.1023/B:BIOM.0000045732.91261.e2 15688857 1:CAS:528:DC%2BD2cXovVOjtrk%3D (Pubitemid 41214261)
39. MM Jones MA Basinger RJ Topping GR Gale SG Jones MA Holscher 1988 Meso-2,3-dimercaptosuccinic acid and sodium N-benzyl-N-dithiocarboxy-d-glucamine as antagonists for cadmium intoxication Arch Toxicol 62 29 36 10.1007/BF00316253 2847690 1:CAS:528:DyaL1cXlvVGisrc%3D
40. G Kazantzis 2004 Cadmium, osteoporosis and calcium metabolism Biometals 17 493 498 10.1023/B:BIOM.0000045727.76054.f3 15688852 1:CAS:528: DC%2BD2cXovVOjt70%3D (Pubitemid 41214255)
41. E Kinne-Saffran M Hulseweh C Pfaff RK Kinne 1993 Inhibition of Na, K-ATPase by cadmium: different mechanisms in different species Toxicol Appl Pharmacol 121 22 29 10.1006/taap.1993.1124 8393220 1:CAS:528:DyaK3sXltleitL8%3D (Pubitemid 23221269)
42. R Lauwerys A Bernard JP Buchet H Roels P Bruaux F Claeys G Ducoffre P De Plaen J Staessen A Amery 1991 Does environmental exposure to cadmium represent a health risk? Conclusions from the Cadmibel study Acta Clin Belg 46 219 225 1659089 1:STN:280:DyaK38%2FlslertQ%3D%3D
43. RR Lauwerys AM Bernard HA Roels JP Buchet 1994 Cadmium: exposure markers as predictors of nephrotoxic effects Clin Chem 40 1391 1394 8013125 1:CAS:528:DyaK2cXkslGnsrs%3D
44. AS Levey J Coresh E Balk AT Kausz A Levin MW Steffes RJ Hogg RD Perrone J Lau G Eknoyan 2003 National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification Ann Intern Med 139 137 147 12859163
45. J Liu Y Liu SM Habeebu MP Waalkes CD Klaassen 2000 Chronic combined exposure to cadmium and arsenic exacerbates nephrotoxicity, particularly in metallothionein-I/II null mice Toxicology 147 157 166 10.1016/S0300-483X(00) 00194-3 10924798 1:CAS:528:DC%2BD3cXlt1KgtLw%3D (Pubitemid 30618874)
46. Z Liu H Li M Soleimani K Girijashanker JM Reed L He TP Dalton DW Nebert 2008 Cd2+ versus Zn2+ uptake by the ZIP8 HCO3-dependent symporter: kinetics, electrogenicity and trafficking Biochem Biophys Res Commun 365 814 820 10.1016/j.bbrc.2007.11.067 18037372 1:CAS:528:DC%2BD2sXhsVCks7bN (Pubitemid 350234863)
47. KR Mahaffey BA Fowler 1977 Effects of concurrent administration of lead, cadmium, and arsenic in the rat Environ Health Perspect 19 165 171 10.2307/3428470 198203 1:CAS:528:DyaE2sXlvFCqtro%3D
48. W Manzar MR Raghavan AR Aroor KR Keshavamurthy 1992 Evaluation of serum beta 2-microglobulin in oral cancer Aust Dent J 37 39 42 10.1111/j.1834-7819. 1992.tb00832.x 1567293 1:STN:280:DyaK383jtFOjtw%3D%3D
49. I Meyer J Heinrich U Lippold 1999 Factors affecting lead and cadmium levels in house dust in industrial areas of eastern Germany Sci Total Environ 234 25 36 10.1016/S0048-9697(99)00164-3 10507145 1:CAS:528:DyaK1MXlsFOrsL8%3D (Pubitemid 29392987)
50. J Moriguchi Y Inoue S Kamiyama M Horiguchi K Murata S Sakuragi Y Fukui F Ohashi M Ikeda 2009 N-acetyl-beta-d-glucosaminidase (NAG) as the most sensitive marker of tubular dysfunction for monitoring residents in non-polluted areas Toxicol Lett 190 1 8 10.1016/j.toxlet.2009.05.009 19467302 1:CAS:528: DC%2BD1MXhtVSgtbjK
51. H Nakagawa M Nishijo Y Morikawa K Miura K Tawara J Kuriwaki T Kido A Ikawa E Kobayashi K Nogawa 2006 Urinary cadmium and mortality among inhabitants of a cadmium-polluted area in Japan Environ Res 100 323 329 10.1016/j.envres. 2005.08.014 16221470 1:CAS:528:DC%2BD28Xhs1Sgtbg%3D (Pubitemid 43234247)
52. A Navas-Acien M Tellez-Plaza E Guallar P Muntner E Silbergeld B Jaar V Weaver 2009 Blood cadmium and lead and chronic kidney disease in US adults: a joint analysis Am J Epidemiol 170 1156 1164 10.1093/aje/kwp248 19700501
53. T Nawrot M Plusquin J Hogervorst HA Roels H Celis L Thijs J Vangronsveld HE Van JA Staessen 2006 Environmental exposure to cadmium and risk of cancer: a prospective population-based study Lancet Oncol 7 119 126 10.1016/S1470-2045(06) 70545-9 16455475 1:CAS:528:DC%2BD28XhtFWiu70%3D (Pubitemid 43159497)
54. K Nogawa N Hagino A Ishizaki M Fukushima 1975 Itai-itai disease Nippon Eiseigaku Zasshi 30 76 166226 1:STN:280:DyaE2M7nt12gtQ%3D%3D
55. K Nogawa A Ishizaki M Fukushima I Shibata N Hagino 1975 Studies on the women with acquired Fanconi syndrome observed in the Ichi river basin polluted by cadmium. Is this Itai-itai disease? Environ Res 10 280 307 10.1016/0013-9351(75)90090-0 172326 1:STN:280:DyaE28%2Fms1SisA%3D%3D
56. CW Noonan SM Sarasua D Campagna SJ Kathman JA Lybarger PW Mueller 2002 Effects of exposure to low levels of environmental cadmium on renal biomarkers Environ Health Perspect 110 151 155 10.1289/ehp.02110151 11836143 1:CAS:528:DC%2BD38Xit1ansL8%3D
57. GF Nordberg 2009 Historical perspectives on cadmium toxicology Toxicol Appl Pharmacol 238 192 200 10.1016/j.taap.2009.03.015 19341754 1:CAS:528:DC%2BD1MXosVaqsr4%3D
58. E Obi DN Akunyili B Ekpo OE Orisakwe 2006 Heavy metal hazards of Nigerian herbal remedies Sci Total Environ 369 35 41 10.1016/j.scitotenv.2006.04.024 16759683 1:CAS:528:DC%2BD28XptVOmtb4%3D (Pubitemid 44292218)
59. B Okuda Y Iwamoto H Tachibana M Sugita 1997 Parkinsonism after acute cadmium poisoning Clin Neurol Neurosurg 99 263 265 10.1016/S0303-8467(97)00090-5 9491302 1:STN:280:DyaK1c7lt1SjsA%3D%3D (Pubitemid 28045421)
60. J Parizek Z Zahor 1956 Effect of cadmium salts on testicular tissue Nature 177 1036 13322022 1:CAS:528:DyaG28XnsFSisw%3D%3D
61. JD Park NJ Cherrington CD Klaassen 2002 Intestinal absorption of cadmium is associated with divalent metal transporter 1 in rats Toxicol Sci 68 288 294 10.1093/toxsci/68.2.288 12151624 1:CAS:528:DC%2BD38Xmt1ykurk%3D (Pubitemid 34919170)
62. PA Peterson PE Evrin I Berggard 1969 Differentiation of glomerular, tubular, and normal proteinuria: determinations of urinary excretion of beta-2-macroglobulin, albumin, and total protein J Clin Invest 48 1189 1198 10.1172/JCI106083 4978446 1:CAS:528:DyaF1MXks1yksLY%3D
63. WC Prozialeck PC Lamar SM Lynch 2003 Cadmium alters the localization of N-cadherin, E-cadherin, and beta-catenin in the proximal tubule epithelium Toxicol Appl Pharmacol 189 180 195 10.1016/S0041-008X(03)00130-3 12791303 1:CAS:528:DC%2BD3sXkt1yjsb8%3D (Pubitemid 36677530)
64. CS Rose PG Heywood RM Costanzo 1992 Olfactory impairment after chronic occupational cadmium exposure J Occup Med 34 600 605 1619490 1:STN:280:DyaK38zhvVSmtw%3D%3D
65. GG Schwartz D Il'yasova A Ivanova 2003 Urinary cadmium, impaired fasting glucose, and diabetes in the NHANES III Diabetes Care 26 468 470 10.2337/diacare.26.2.468 12547882 1:CAS:528:DC%2BD3sXhs1ynu7s%3D (Pubitemid 36929075)
66. ZA Shaikh TT Vu K Zaman 1999 Oxidative stress as a mechanism of chronic cadmium-induced hepatotoxicity and renal toxicity and protection by antioxidants Toxicol Appl Pharmacol 154 256 263 10.1006/taap.1998.8586 9931285 1:CAS:528:DyaK1MXhtlOktr8%3D (Pubitemid 29085237)
67. FZ Sheabar S Yannai 1989 Extracorporeal complexation and haemodialysis for the treatment of cadmium poisoning. I. Effects of four chelators on the in vitro elimination of cadmium from human blood Pharmacol Toxicol 64 257 261 10.1111/j.1600-0773.1989.tb00642.x 2498863 1:CAS:528:DyaL1MXitF2jtrs%3D
68. C Spieker W Zidek H Zumkley 1987 Cadmium and hypertension Nephron 47 Suppl 1 34 36 10.1159/000184550 3696347 1:CAS:528:DyaL2sXlslSjsrc%3D
69. SJ Stohs D Bagchi E Hassoun M Bagchi 2000 Oxidative mechanisms in the toxicity of chromium and cadmium ions J Environ Pathol Toxicol Oncol 19 201 213 10983887 1:CAS:528:DC%2BD3cXmvFKmtb8%3D
70. W Tang ZA Shaikh 2001 Renal cortical mitochondrial dysfunction upon cadmium metallothionein administration to Sprague-Dawley rats J Toxicol Environ Health A 63 221 235 10.1080/15287390151101583 11405417 1:CAS:528: DC%2BD3MXktFajtbg%3D (Pubitemid 32493563)
71. F Thevenod 2003 Nephrotoxicity and the proximal tubule. Insights from cadmium Nephron Physiol 93 87 93 10.1159/000070241 1:CAS:528: DC%2BD3sXktFSms7o%3D (Pubitemid 37475739)
72. F Thevenod JM Friedmann AD Katsen IA Hauser 2000 Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis J Biol Chem 275 1887 1896 10.1074/jbc.275.3.1887 10636889 1:CAS:528:DC%2BD3cXotFWqtA%3D%3D (Pubitemid 30060813)
73. MJ Thun AM Osorio S Schober WH Hannon B Lewis W Halperin 1989 Nephropathy in cadmium workers: assessment of risk from airborne occupational exposure to cadmium Br J Ind Med 46 689 697 2818957 1:CAS:528:DyaK3cXltValsrw%3D
74. KN Tzirogiannis GI Panoutsopoulos MD Demonakou RI Hereti KN Alexandropoulou AC Basayannis MG Mykoniatis 2003 Time-course of cadmium-induced acute hepatotoxicity in the rat liver: the role of apoptosis Arch Toxicol 77 694 701 10.1007/s00204-003-0499-y 13680093 1:CAS:528:DC%2BD3sXptleks7k%3D (Pubitemid 38085100)
75. T Uno E Kobayashi Y Suwazono Y Okubo K Miura K Sakata A Okayama H Ueshima H Nakagawa K Nogawa 2005 Health effects of cadmium exposure in the general environment in Japan with special reference to the lower limit of the benchmark dose as the threshold level of urinary cadmium Scand J Work Environ Health 31 307 315 16161714 1:CAS:528:DC%2BD2MXhtVGiu7nI
76. Van Assche F, Ciarletta P (1993) Environmental exposure to cadmium in Belgium: decreasing trends during the 1980s. In: Heavy metals in the environment, vol 1. CEP consultants, Pub. Edinburg, UK, pp 34-37
77. Y Wang J Fang SS Leonard KM Rao 2004 Cadmium inhibits the electron transfer chain and induces reactive oxygen species Free Radic Biol Med 36 1434 1443 10.1016/j.freeradbiomed.2004.03.010 15135180 1:CAS:528:DC%2BD2cXjvVags74%3D (Pubitemid 38596803)
78. NA Wolff M Abouhamed PJ Verroust F Thevenod 2006 Megalin-dependent internalization of cadmium-metallothionein and cytotoxicity in cultured renal proximal tubule cells J Pharmacol Exp Ther 318 782 791 10.1124/jpet.106.102574 16690719 1:CAS:528:DC%2BD28XnslOltrs%3D (Pubitemid 44061252)
79. T Yanagiya N Imura S Enomoto Y Kondo S Himeno 2000 Suppression of a high-affinity transport system for manganese in cadmium-resistant metallothionein-null cells J Pharmacol Exp Ther 292 1080 1086 10688626 1:CAS:528:DC%2BD3cXhslWku78%3D
80. DH Yates KP Goldman 1990 Acute cadmium poisoning in a foreman plater welder Br J Ind Med 47 429 431 2378822 1:CAS:528:DyaK3MXitlChsbc%3D