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Volumn 52, Issue , 2016, Pages 39-46

Neurofibromatosis type 1: Fundamental insights into cell signalling and cancer

Author keywords

Cancer; MPNST; Neurofibromin; NF1; Tumour suppressor

Indexed keywords

COLLAPSIN RESPONSE MEDIATOR PROTEIN 2; FOCAL ADHESION KINASE 1; MICRORNA; NEUROFIBROMIN; PROTEIN TYROSINE KINASE; STAT3 PROTEIN;

EID: 84961207132     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2016.02.007     Document Type: Review
Times cited : (63)

References (65)
  • 1
    • 0019741677 scopus 로고
    • Translation of case reports in Ueber die multiplen Fibrome der Haut und ihre Beziehung zu den multiplen Neuromen by F. v. Recklinghausen
    • (accessed 20.07.15)
    • Crump T. Translation of case reports in Ueber die multiplen Fibrome der Haut und ihre Beziehung zu den multiplen Neuromen by F. v. Recklinghausen. Adv. Neurol. 1981, 29:259-275. http://www.ncbi.nlm.nih.gov/pubmed/6798841 (accessed 20.07.15).
    • (1981) Adv. Neurol. , vol.29 , pp. 259-275
    • Crump, T.1
  • 3
    • 33846319400 scopus 로고    scopus 로고
    • Neurofibromatosis 1
    • Ferner R.E. Neurofibromatosis 1. Eur. J. Hum. Genet. 2007, 15:131-138. 10.1038/sj.ejhg.5201676.
    • (2007) Eur. J. Hum. Genet. , vol.15 , pp. 131-138
    • Ferner, R.E.1
  • 4
    • 84977986196 scopus 로고    scopus 로고
    • Facial plexiform neurofibromatosis: a surgical challenge
    • Dogra B.B., Rana K.S. Facial plexiform neurofibromatosis: a surgical challenge. Indian Dermatol. Online J. 2013, 4:195--198. 10.4103/2229-5178.115515.
    • (2013) Indian Dermatol. Online J. , vol.4 , pp. 195-198
    • Dogra, B.B.1    Rana, K.S.2
  • 5
    • 0023244033 scopus 로고
    • Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17
    • (accessed 22.07.15)
    • Barker D., Wright E., Nguyen K., Cannon L., Fain P., Goldgar D., et al. Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17. Science 1987, 236:1100-1102. http://www.ncbi.nlm.nih.gov/pubmed/3107130 (accessed 22.07.15).
    • (1987) Science , vol.236 , pp. 1100-1102
    • Barker, D.1    Wright, E.2    Nguyen, K.3    Cannon, L.4    Fain, P.5    Goldgar, D.6
  • 6
    • 0023645022 scopus 로고
    • Genetic linkage of von Recklinghausen neurofibromatosis to the nerve growth factor receptor gene
    • Seizinger B.R., Rouleau G.A., Ozelius L.J., Lane A.H., Faryniarz A.G., Chao M.V., et al. Genetic linkage of von Recklinghausen neurofibromatosis to the nerve growth factor receptor gene. Cell 1987, 49:589-594. 10.1016/0092-8674(87) 90534-4.
    • (1987) Cell , vol.49 , pp. 589-594
    • Seizinger, B.R.1    Rouleau, G.A.2    Ozelius, L.J.3    Lane, A.H.4    Faryniarz, A.G.5    Chao, M.V.6
  • 7
    • 0025297599 scopus 로고
    • Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients
    • (accessed 22.07.15)
    • Wallace M.R., Marchuk D.A., Andersen L.B., Letcher R., Odeh H.M., Saulino A.M., et al. Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients. Science 1990, 249:181-186. http://www.ncbi.nlm.nih.gov/pubmed/2134734 (accessed 22.07.15).
    • (1990) Science , vol.249 , pp. 181-186
    • Wallace, M.R.1    Marchuk, D.A.2    Andersen, L.B.3    Letcher, R.4    Odeh, H.M.5    Saulino, A.M.6
  • 8
    • 0024461393 scopus 로고
    • Refined physical and genetic mapping of the NF1 region on chromosome 17
    • (accessed 22.07.15)
    • Fain P.R., Goldgar D.E., Wallace M.R., Collins F.S., Wright E., Nguyen K., et al. Refined physical and genetic mapping of the NF1 region on chromosome 17. Am. J. Hum. Genet. 1989, 45:721-728. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1683433&tool=pmcentrez&rendertype=abstract (accessed 22.07.15).
    • (1989) Am. J. Hum. Genet. , vol.45 , pp. 721-728
    • Fain, P.R.1    Goldgar, D.E.2    Wallace, M.R.3    Collins, F.S.4    Wright, E.5    Nguyen, K.6
  • 9
    • 0023637513 scopus 로고
    • Cases of neurofibromatosis with rearrangements of chromosome 17 involving band 17q11.2
    • Schmidt M.A., Michels V.V., Dewald G.W., Opitz J.M., Reynolds J.F. Cases of neurofibromatosis with rearrangements of chromosome 17 involving band 17q11.2. Am. J. Med. Genet. 1987, 28:771-777. 10.1002/ajmg.1320280333.
    • (1987) Am. J. Med. Genet. , vol.28 , pp. 771-777
    • Schmidt, M.A.1    Michels, V.V.2    Dewald, G.W.3    Opitz, J.M.4    Reynolds, J.F.5
  • 10
    • 0024380841 scopus 로고
    • Progress towards identifying the neurofibromatosis (NF1) gene
    • (accessed 22.07.15)
    • Collins F.S., O'Connell P., Ponder B.A., Seizinger B.R. Progress towards identifying the neurofibromatosis (NF1) gene. Trends Genet. 1989, 5:217-221. http://www.ncbi.nlm.nih.gov/pubmed/2506682 (accessed 22.07.15).
    • (1989) Trends Genet. , vol.5 , pp. 217-221
    • Collins, F.S.1    O'Connell, P.2    Ponder, B.A.3    Seizinger, B.R.4
  • 11
    • 0024712191 scopus 로고
    • Characterization of a translocation within the von Recklinghausen neurofibromatosis region of chromosome 17
    • (accessed 22.07.15)
    • Menon A.G., Ledbetter D.H., Rich D.C., Seizinger B.R., Rouleau G.A., Michels V.F., et al. Characterization of a translocation within the von Recklinghausen neurofibromatosis region of chromosome 17. Genomics 1989, 5:245-249. http://www.ncbi.nlm.nih.gov/pubmed/2507442 (accessed 22.07.15).
    • (1989) Genomics , vol.5 , pp. 245-249
    • Menon, A.G.1    Ledbetter, D.H.2    Rich, D.C.3    Seizinger, B.R.4    Rouleau, G.A.5    Michels, V.F.6
  • 12
    • 0025326726 scopus 로고
    • A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations
    • (accessed 22.06.15)
    • Cawthon R.M., Weiss R., Xu G.F., Viskochil D., Culver M., Stevens J., et al. A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations. Cell 1990, 62:193-201. http://www.ncbi.nlm.nih.gov/pubmed/2114220 (accessed 22.06.15).
    • (1990) Cell , vol.62 , pp. 193-201
    • Cawthon, R.M.1    Weiss, R.2    Xu, G.F.3    Viskochil, D.4    Culver, M.5    Stevens, J.6
  • 13
    • 0025369709 scopus 로고
    • Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus
    • Viskochil D., Buchberg a M., Xu G., Cawthon R.M., Stevens J., Wolff R.K., et al. Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus. Cell 1990, 62:187-192. 10.1016/0092-8674(90)90252-A.
    • (1990) Cell , vol.62 , pp. 187-192
    • Viskochil, D.1    Buchberg, A.M.2    Xu, G.3    Cawthon, R.M.4    Stevens, J.5    Wolff, R.K.6
  • 14
    • 84872617743 scopus 로고    scopus 로고
    • Risk of benign tumours of nervous system, and of malignant neoplasms, in people with neurofibromatosis: population-based record-linkage study
    • Seminog O.O., Goldacre M.J. Risk of benign tumours of nervous system, and of malignant neoplasms, in people with neurofibromatosis: population-based record-linkage study. Br. J. Cancer 2013, 108:193-198. 10.1038/bjc.2012.535.
    • (2013) Br. J. Cancer , vol.108 , pp. 193-198
    • Seminog, O.O.1    Goldacre, M.J.2
  • 15
    • 84928583796 scopus 로고    scopus 로고
    • A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor
    • Ratner N., Miller S.J. A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor. Nat. Rev. Cancer 2015, 15:290-301. 10.1038/nrc3911.
    • (2015) Nat. Rev. Cancer , vol.15 , pp. 290-301
    • Ratner, N.1    Miller, S.J.2
  • 16
    • 22744445886 scopus 로고    scopus 로고
    • Signaling interplay in Ras superfamily function
    • Mitin N., Rossman K.L., Der C.J. Signaling interplay in Ras superfamily function. Curr. Biol. 2005, 15:R563-R574. 10.1016/j.cub.2005.07.010.
    • (2005) Curr. Biol. , vol.15 , pp. R563-R574
    • Mitin, N.1    Rossman, K.L.2    Der, C.J.3
  • 17
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • Downward J. Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer 2003, 3:11-22. 10.1038/nrc969.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 18
    • 0033056764 scopus 로고    scopus 로고
    • The molecular perspective: the ras oncogene
    • (accessed 09.06.15)
    • Goodsell D.S. The molecular perspective: the ras oncogene. Oncologist. 1999, 4:263-264. http://theoncologist.alphamedpress.org/content/4/3/263 (accessed 09.06.15).
    • (1999) Oncologist. , vol.4 , pp. 263-264
    • Goodsell, D.S.1
  • 19
    • 84938742098 scopus 로고    scopus 로고
    • The RAS-binding domain of human BRAF protein serine/threonine kinase exhibits allosteric conformational changes upon binding HRAS
    • Aramini J.M., Vorobiev S.M., Tuberty L.M., Janjua H., Campbell E.T., Seetharaman J., et al. The RAS-binding domain of human BRAF protein serine/threonine kinase exhibits allosteric conformational changes upon binding HRAS. Structure 2015, 10.1016/j.str.2015.06.003.
    • (2015) Structure
    • Aramini, J.M.1    Vorobiev, S.M.2    Tuberty, L.M.3    Janjua, H.4    Campbell, E.T.5    Seetharaman, J.6
  • 20
    • 84929077789 scopus 로고    scopus 로고
    • Regulation of RAF protein kinases in ERK signalling
    • Lavoie H., Therrien M. Regulation of RAF protein kinases in ERK signalling. Nat. Rev. Mol. Cell Biol. 2015, 16:281-298. 10.1038/nrm3979.
    • (2015) Nat. Rev. Mol. Cell Biol. , vol.16 , pp. 281-298
    • Lavoie, H.1    Therrien, M.2
  • 21
    • 79551567002 scopus 로고    scopus 로고
    • Structural and biochemical consequences of NF1 associated nontruncating mutations in the Sec14-pH module of neurofibromin
    • Welti S., Kühn S., D'Angelo I., Brügger B., Kaufmann D., Scheffzek K. Structural and biochemical consequences of NF1 associated nontruncating mutations in the Sec14-pH module of neurofibromin. Hum. Mutat. 2011, 32:191-197. 10.1002/humu.21405.
    • (2011) Hum. Mutat. , vol.32 , pp. 191-197
    • Welti, S.1    Kühn, S.2    D'Angelo, I.3    Brügger, B.4    Kaufmann, D.5    Scheffzek, K.6
  • 22
    • 22144479017 scopus 로고    scopus 로고
    • Ras plasma membrane signalling platforms
    • Hancock J.F., Parton R.G. Ras plasma membrane signalling platforms. Biochem. J. 2005, 389:1-11. 10.1042/BJ20050231.
    • (2005) Biochem. J. , vol.389 , pp. 1-11
    • Hancock, J.F.1    Parton, R.G.2
  • 25
    • 84939884427 scopus 로고    scopus 로고
    • MTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3
    • Dodd K.M., Yang J., Shen M.H., Sampson J.R., Tee a R. mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3. Oncogene 2014, 1-12. 10.1038/onc.2014.164.
    • (2014) Oncogene , pp. 1-12
    • Dodd, K.M.1    Yang, J.2    Shen, M.H.3    Sampson, J.R.4    Tee, A.R.5
  • 26
    • 28244469687 scopus 로고    scopus 로고
    • The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway
    • Ozawa T., Araki N., Yunoue S., Tokuo H., Feng L., Patrakitkomjorn S., et al. The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway. J. Biol. Chem. 2005, 280:39524--39533. 10.1074/jbc.M503707200.
    • (2005) J. Biol. Chem. , vol.280 , pp. 39524-39533
    • Ozawa, T.1    Araki, N.2    Yunoue, S.3    Tokuo, H.4    Feng, L.5    Patrakitkomjorn, S.6
  • 27
    • 84867648473 scopus 로고    scopus 로고
    • Nf1 RasGAP Inhibition of LIMK2 Mediates a New Cross-Talk between Ras and Rho Pathways
    • Vallée B., Doudeau M., Godin F., Gombault A., Tchalikian A., de Tauzia M., et al. Nf1 RasGAP Inhibition of LIMK2 Mediates a New Cross-Talk between Ras and Rho Pathways. PLoS One 2012, 7:e47283. 10.1371/journal.pone.0047283.
    • (2012) PLoS One , vol.7 , pp. e47283
    • Vallée, B.1    Doudeau, M.2    Godin, F.3    Gombault, A.4    Tchalikian, A.5    de Tauzia, M.6
  • 28
    • 70350749407 scopus 로고    scopus 로고
    • The pre-GAP-related domain of neurofibromin regulates cell migration through the LIM kinase/cofilin pathway
    • Starinsky-Elbaz S., Faigenbloom L., Friedman E., Stein R., Kloog Y. The pre-GAP-related domain of neurofibromin regulates cell migration through the LIM kinase/cofilin pathway. Mol. Cell. Neurosci. 2009, 42:278-287. 10.1016/j.mcn.2009.07.014.
    • (2009) Mol. Cell. Neurosci. , vol.42 , pp. 278-287
    • Starinsky-Elbaz, S.1    Faigenbloom, L.2    Friedman, E.3    Stein, R.4    Kloog, Y.5
  • 29
    • 0027320496 scopus 로고
    • Neurofibromatosis type 1 gene product (neurofibromin) associates with microtubules
    • (accessed 27.07.15)
    • Gregory P.E., Gutmann D.H., Mitchell A., Park S., Boguski M., Jacks T., et al. Neurofibromatosis type 1 gene product (neurofibromin) associates with microtubules. Somat. Cell Mol. Genet. 1993, 19:265-274. http://www.ncbi.nlm.nih.gov/pubmed/8332934 (accessed 27.07.15).
    • (1993) Somat. Cell Mol. Genet. , vol.19 , pp. 265-274
    • Gregory, P.E.1    Gutmann, D.H.2    Mitchell, A.3    Park, S.4    Boguski, M.5    Jacks, T.6
  • 30
    • 70350435471 scopus 로고    scopus 로고
    • Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase
    • Kweh F., Zheng M., Kurenova E., Wallace M., Golubovskaya V., Cance W.G. Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase. Mol. Carcinog. 2009, 48:1005-1017. 10.1002/mc.20552.
    • (2009) Mol. Carcinog. , vol.48 , pp. 1005-1017
    • Kweh, F.1    Zheng, M.2    Kurenova, E.3    Wallace, M.4    Golubovskaya, V.5    Cance, W.G.6
  • 31
    • 84867919905 scopus 로고    scopus 로고
    • Neurofibromin Mediates FAK Signaling in Confining Synapse Growth at Drosophila Neuromuscular Junctions
    • 10.1523/JNEUROSCI.1756-12.2012.
    • Tsai P.-I., Wang M., Kao H.-H., Cheng Y.-J., Walker J.A., Chen R.-H., et al. Neurofibromin Mediates FAK Signaling in Confining Synapse Growth at Drosophila Neuromuscular Junctions. J. Neurosci. 2012, 32:16971-16981. 10.1523/JNEUROSCI.1756-12.2012.
    • (2012) J. Neurosci. , vol.32 , pp. 16971-16981
    • Tsai, P.-I.1    Wang, M.2    Kao, H.-H.3    Cheng, Y.-J.4    Walker, J.A.5    Chen, R.-H.6
  • 32
    • 1642573162 scopus 로고    scopus 로고
    • PKA phosphorylation and 14-3-3 interaction regulate the function of neurofibromatosis type I tumor suppressor, neurofibromin
    • (accessed 19.10.15)
    • Feng L., Yunoue S., Tokuo H., Ozawa T., Zhang D., Patrakitkomjorn S., et al. PKA phosphorylation and 14-3-3 interaction regulate the function of neurofibromatosis type I tumor suppressor, neurofibromin. FEBS Lett. 2004, 557:275--282. http://www.ncbi.nlm.nih.gov/pubmed/14741381 (accessed 19.10.15).
    • (2004) FEBS Lett. , vol.557 , pp. 275-282
    • Feng, L.1    Yunoue, S.2    Tokuo, H.3    Ozawa, T.4    Zhang, D.5    Patrakitkomjorn, S.6
  • 33
    • 44049084687 scopus 로고    scopus 로고
    • Neurofibromatosis type 1 (NF1) tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein, CRMP-2
    • Patrakitkomjorn S., Kobayashi D., Morikawa T., Wilson M.M., Tsubota N., Irie A., et al. Neurofibromatosis type 1 (NF1) tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein, CRMP-2. J. Biol. Chem. 2008, 283:9399-9413. 10.1074/jbc.M708206200.
    • (2008) J. Biol. Chem. , vol.283 , pp. 9399-9413
    • Patrakitkomjorn, S.1    Kobayashi, D.2    Morikawa, T.3    Wilson, M.M.4    Tsubota, N.5    Irie, A.6
  • 34
    • 0033674591 scopus 로고    scopus 로고
    • Malignancy in neurofibromatosis type 1
    • Korf B.R. Malignancy in neurofibromatosis type 1. Oncologist 2000, 5:477-485. 10.1634/theoncologist.5-6-477.
    • (2000) Oncologist , vol.5 , pp. 477-485
    • Korf, B.R.1
  • 35
    • 84882475880 scopus 로고    scopus 로고
    • Chemotherapy for the treatment of malignant peripheral nerve sheath tumors in neurofibromatosis 1: a 10-year institutional review
    • Zehou O., Fabre E., Zelek L., Sbidian E., Ortonne N., Banu E., et al. Chemotherapy for the treatment of malignant peripheral nerve sheath tumors in neurofibromatosis 1: a 10-year institutional review. Orphanet J. Rare Dis. 2013, 8:127. 10.1186/1750-1172-8-127.
    • (2013) Orphanet J. Rare Dis. , vol.8 , pp. 127
    • Zehou, O.1    Fabre, E.2    Zelek, L.3    Sbidian, E.4    Ortonne, N.5    Banu, E.6
  • 36
    • 84925014236 scopus 로고    scopus 로고
    • Radiation therapy in management of sporadic and neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors
    • Kahn J., Gillespie A., Tsokos M., Ondos J., Dombi E., Camphausen K., et al. Radiation therapy in management of sporadic and neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors. Front. Oncol. 2014, 4:324. 10.3389/fonc.2014.00324.
    • (2014) Front. Oncol. , vol.4 , pp. 324
    • Kahn, J.1    Gillespie, A.2    Tsokos, M.3    Ondos, J.4    Dombi, E.5    Camphausen, K.6
  • 37
    • 0031962230 scopus 로고    scopus 로고
    • Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity
    • (accessed 31.08.15)
    • Yang J.C., Chang A.E., Baker A.R., Sindelar W.F., Danforth D.N., Topalian S.L., et al. Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J. Clin. Oncol. 1998, 16:197-203. http://www.ncbi.nlm.nih.gov/pubmed/9440743 (accessed 31.08.15).
    • (1998) J. Clin. Oncol. , vol.16 , pp. 197-203
    • Yang, J.C.1    Chang, A.E.2    Baker, A.R.3    Sindelar, W.F.4    Danforth, D.N.5    Topalian, S.L.6
  • 39
    • 84858277359 scopus 로고    scopus 로고
    • Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis
    • Upadhyaya M., Spurlock G., Thomas L., Thomas N.S.T., Richards M., Mautner V.-F., et al. Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis. Hum. Mutat. 2012, 33:763-776. 10.1002/humu.22044.
    • (2012) Hum. Mutat. , vol.33 , pp. 763-776
    • Upadhyaya, M.1    Spurlock, G.2    Thomas, L.3    Thomas, N.S.T.4    Richards, M.5    Mautner, V.-F.6
  • 41
    • 84890253771 scopus 로고    scopus 로고
    • Genomic amplification and high expression of EGFR are key targetable oncogenic events in malignant peripheral nerve sheath tumor
    • Du X., Yang J., Ylipä A., Zhu Z. Genomic amplification and high expression of EGFR are key targetable oncogenic events in malignant peripheral nerve sheath tumor. J. Hematol. Oncol. 2013, 6:93. 10.1186/1756-8722-6-93.
    • (2013) J. Hematol. Oncol. , vol.6 , pp. 93
    • Du, X.1    Yang, J.2    Ylipä, A.3    Zhu, Z.4
  • 42
    • 39749203515 scopus 로고    scopus 로고
    • High-resolution DNA copy number profiling of malignant peripheral nerve sheath tumors using targeted microarray-based comparative genomic hybridization
    • Mantripragada K.K., Spurlock G., Kluwe L., Chuzhanova N., Ferner R.E., Frayling I.M., et al. High-resolution DNA copy number profiling of malignant peripheral nerve sheath tumors using targeted microarray-based comparative genomic hybridization. Clin. Cancer Res. 2008, 14:1015-1024. 10.1158/1078-0432.CCR-07-1305.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 1015-1024
    • Mantripragada, K.K.1    Spurlock, G.2    Kluwe, L.3    Chuzhanova, N.4    Ferner, R.E.5    Frayling, I.M.6
  • 43
    • 79959226237 scopus 로고    scopus 로고
    • Activated MET is a molecular prognosticator and potential therapeutic target for malignant peripheral nerve sheath tumors
    • Torres K.E., Zhu Q.-S., Bill K., Lopez G., Ghadimi M.P., Xie X., et al. Activated MET is a molecular prognosticator and potential therapeutic target for malignant peripheral nerve sheath tumors. Clin. Cancer Res. 2011, 17:3943-3955. 10.1158/1078-0432.CCR-11-0193.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 3943-3955
    • Torres, K.E.1    Zhu, Q.-S.2    Bill, K.3    Lopez, G.4    Ghadimi, M.P.5    Xie, X.6
  • 44
    • 84876974448 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits cell growth of malignant peripheral nerve sheath tumors in vitro and in vivo through suppression of PDGFR-β
    • Ohishi J., Aoki M., Nabeshima K., Suzumiya J., Takeuchi T., Ogose A., et al. Imatinib mesylate inhibits cell growth of malignant peripheral nerve sheath tumors in vitro and in vivo through suppression of PDGFR-β. BMC Cancer 2013, 13:224. 10.1186/1471-2407-13-224.
    • (2013) BMC Cancer , vol.13 , pp. 224
    • Ohishi, J.1    Aoki, M.2    Nabeshima, K.3    Suzumiya, J.4    Takeuchi, T.5    Ogose, A.6
  • 45
    • 46749109971 scopus 로고    scopus 로고
    • Metastatic chest wall malignant schwannoma responding to sorafenib: case report and literature review
    • (accessed 13.10.15)
    • Gudena V., Verma N., Post G., Kizziah M., Fenning R., Montero A.J. Metastatic chest wall malignant schwannoma responding to sorafenib: case report and literature review. Cancer Biol. Ther. 2008, 7:810-813. http://www.ncbi.nlm.nih.gov/pubmed/18376142 (accessed 13.10.15).
    • (2008) Cancer Biol. Ther. , vol.7 , pp. 810-813
    • Gudena, V.1    Verma, N.2    Post, G.3    Kizziah, M.4    Fenning, R.5    Montero, A.J.6
  • 46
    • 42249087305 scopus 로고    scopus 로고
    • Sorafenib inhibits growth and mitogen-activated protein kinase signaling in malignant peripheral nerve sheath cells
    • Ambrosini G., Cheema H.S., Seelman S., Teed A., Sambol E.B., Singer S., et al. Sorafenib inhibits growth and mitogen-activated protein kinase signaling in malignant peripheral nerve sheath cells. Mol. Cancer Ther. 2008, 7:890-896. 10.1158/1535-7163.MCT-07-0518.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 890-896
    • Ambrosini, G.1    Cheema, H.S.2    Seelman, S.3    Teed, A.4    Sambol, E.B.5    Singer, S.6
  • 47
    • 84927752713 scopus 로고    scopus 로고
    • Evaluation of copy number variation and gene expression in neurofibromatosis type-1-associated malignant peripheral nerve sheath tumours
    • Thomas L.E., Winston J., Rad E., Mort M., Dodd K.M., Tee A.R., et al. Evaluation of copy number variation and gene expression in neurofibromatosis type-1-associated malignant peripheral nerve sheath tumours. Hum. Genomics 2015, 9:3. 10.1186/s40246-015-0025-3.
    • (2015) Hum. Genomics , vol.9 , pp. 3
    • Thomas, L.E.1    Winston, J.2    Rad, E.3    Mort, M.4    Dodd, K.M.5    Tee, A.R.6
  • 49
    • 77958177947 scopus 로고    scopus 로고
    • The role of angiogenesis in the transformation of plexiform neurofibroma into malignant peripheral nerve sheath tumors in children with neurofibromatosis type 1
    • Gesundheit B., Parkin P., Greenberg M., Baruchel S., Senger C., Kapelushnik J., et al. The role of angiogenesis in the transformation of plexiform neurofibroma into malignant peripheral nerve sheath tumors in children with neurofibromatosis type 1. J. Pediatr. Hematol. Oncol. 2010, 32:548-553. 10.1097/MPH.0b013e3181e887c7.
    • (2010) J. Pediatr. Hematol. Oncol. , vol.32 , pp. 548-553
    • Gesundheit, B.1    Parkin, P.2    Greenberg, M.3    Baruchel, S.4    Senger, C.5    Kapelushnik, J.6
  • 50
    • 84942346009 scopus 로고    scopus 로고
    • STAT3 and HIF1α signaling drives oncogenic cellular phenotypes in malignant peripheral nerve sheath tumors
    • Rad E., Dodd K., Thomas L., Upadhyaya M., Tee A. STAT3 and HIF1α signaling drives oncogenic cellular phenotypes in malignant peripheral nerve sheath tumors. Mol. Cancer Res. 2015, 13:1149-1160. 10.1158/1541-7786.MCR-14-0182.
    • (2015) Mol. Cancer Res. , vol.13 , pp. 1149-1160
    • Rad, E.1    Dodd, K.2    Thomas, L.3    Upadhyaya, M.4    Tee, A.5
  • 51
    • 84878868657 scopus 로고    scopus 로고
    • Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance
    • Watson A.L., Rahrmann E.P., Moriarity B.S., Choi K., Conboy C.B., Greeley A.D., et al. Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance. Cancer Discov. 2013, 3:674-689. 10.1158/2159-8290.CD-13-0081.
    • (2013) Cancer Discov. , vol.3 , pp. 674-689
    • Watson, A.L.1    Rahrmann, E.P.2    Moriarity, B.S.3    Choi, K.4    Conboy, C.B.5    Greeley, A.D.6
  • 53
    • 84876442920 scopus 로고    scopus 로고
    • Impaired Pten expression in human malignant peripheral nerve sheath tumours
    • Bradtmöller M., Hartmann C., Zietsch J., Jäschke S., Mautner V.-F., Kurtz A., et al. Impaired Pten expression in human malignant peripheral nerve sheath tumours. PLoS One 2012, 7:e47595. 10.1371/journal.pone.0047595.
    • (2012) PLoS One , vol.7 , pp. e47595
    • Bradtmöller, M.1    Hartmann, C.2    Zietsch, J.3    Jäschke, S.4    Mautner, V.-F.5    Kurtz, A.6
  • 54
    • 84908321120 scopus 로고    scopus 로고
    • PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies
    • De Raedt T., Beert E., Pasmant E., Luscan A., Brems H., Ortonne N., et al. PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature 2014, 514:247-251. 10.1038/nature13561.
    • (2014) Nature , vol.514 , pp. 247-251
    • De Raedt, T.1    Beert, E.2    Pasmant, E.3    Luscan, A.4    Brems, H.5    Ortonne, N.6
  • 55
    • 0141576562 scopus 로고    scopus 로고
    • Identification of the polycomb group protein SU(Z) 12 as a potential molecular target for human cancer therapy
    • (accessed 25.09.15)
    • Kirmizis A., Bartley S.M., Farnham P.J. Identification of the polycomb group protein SU(Z) 12 as a potential molecular target for human cancer therapy. Mol. Cancer Ther. 2003, 2:113-121. http://www.ncbi.nlm.nih.gov/pubmed/12533679 (accessed 25.09.15).
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 113-121
    • Kirmizis, A.1    Bartley, S.M.2    Farnham, P.J.3
  • 56
    • 84869225502 scopus 로고    scopus 로고
    • SUZ12 promotes human epithelial ovarian cancer by suppressing apoptosis via silencing HRK
    • Li H., Cai Q., Wu H., Vathipadiekal V., Dobbin Z.C., Li T., et al. SUZ12 promotes human epithelial ovarian cancer by suppressing apoptosis via silencing HRK. Mol. Cancer Res. 2012, 10:1462-1472. 10.1158/1541-7786.MCR-12-0335.
    • (2012) Mol. Cancer Res. , vol.10 , pp. 1462-1472
    • Li, H.1    Cai, Q.2    Wu, H.3    Vathipadiekal, V.4    Dobbin, Z.C.5    Li, T.6
  • 57
    • 78651474656 scopus 로고    scopus 로고
    • Identification of genes potentially involved in the increased risk of malignancy in NF1-microdeleted patients
    • Pasmant E., Masliah-Planchon J., Lévy P., Laurendeau I., Ortonne N., Parfait B., et al. Identification of genes potentially involved in the increased risk of malignancy in NF1-microdeleted patients. Mol. Med. 2016, 17:79-87. 10.2119/molmed.2010.00079.
    • (2016) Mol. Med. , vol.17 , pp. 79-87
    • Pasmant, E.1    Masliah-Planchon, J.2    Lévy, P.3    Laurendeau, I.4    Ortonne, N.5    Parfait, B.6
  • 58
    • 84904726416 scopus 로고    scopus 로고
    • SUZ12 is involved in progression of non-small cell lung cancer by promoting cell proliferation and metastasis
    • Liu C., Shi X., Wang L., Wu Y., Jin F., Bai C., et al. SUZ12 is involved in progression of non-small cell lung cancer by promoting cell proliferation and metastasis. Tumor Biol. 2014, 35:6073-6082. 10.1007/s13277-014-1804-5.
    • (2014) Tumor Biol. , vol.35 , pp. 6073-6082
    • Liu, C.1    Shi, X.2    Wang, L.3    Wu, Y.4    Jin, F.5    Bai, C.6
  • 59
    • 84925394779 scopus 로고    scopus 로고
    • Diverse involvement of EZH2 in cancer epigenetics
    • (accessed 29.09.15)
    • Völkel P., Dupret B., Le Bourhis X., Angrand P.-O. Diverse involvement of EZH2 in cancer epigenetics. Am. J. Transl. Res. 2015, 7:175-193. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4399085&tool=pmcentrez&rendertype=abstract (accessed 29.09.15).
    • (2015) Am. J. Transl. Res. , vol.7 , pp. 175-193
    • Völkel, P.1    Dupret, B.2    Le Bourhis, X.3    Angrand, P.-O.4
  • 60
    • 84876577533 scopus 로고    scopus 로고
    • An emerging role for microRNAs in NF1 tumorigenesis
    • Sedani A., Cooper D.N., Upadhyaya M. An emerging role for microRNAs in NF1 tumorigenesis. Hum. Genomics 2012, 6:23. 10.1186/1479-7364-6-23.
    • (2012) Hum. Genomics , vol.6 , pp. 23
    • Sedani, A.1    Cooper, D.N.2    Upadhyaya, M.3
  • 61
    • 84880113353 scopus 로고    scopus 로고
    • MicroRNAome profiling in benign and malignant neurofibromatosis type 1-associated nerve sheath tumors: evidences of PTEN pathway alterations in early NF1 tumorigenesis
    • Masliah-Planchon J., Pasmant E., Luscan A., Laurendeau I., Ortonne N., Hivelin M., et al. MicroRNAome profiling in benign and malignant neurofibromatosis type 1-associated nerve sheath tumors: evidences of PTEN pathway alterations in early NF1 tumorigenesis. BMC Genomics 2013, 14:473. 10.1186/1471-2164-14-473.
    • (2013) BMC Genomics , vol.14 , pp. 473
    • Masliah-Planchon, J.1    Pasmant, E.2    Luscan, A.3    Laurendeau, I.4    Ortonne, N.5    Hivelin, M.6
  • 62
    • 12144290519 scopus 로고    scopus 로고
    • Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
    • Calin G.A., Sevignani C., Dumitru C.D., Hyslop T., Noch E., Yendamuri S., et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:2999-3004. 10.1073/pnas.0307323101.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 2999-3004
    • Calin, G.A.1    Sevignani, C.2    Dumitru, C.D.3    Hyslop, T.4    Noch, E.5    Yendamuri, S.6
  • 63
    • 84875221767 scopus 로고    scopus 로고
    • MicroRNA profiling of peripheral nerve sheath tumours identifies miR-29c as a tumour suppressor gene involved in tumour progression
    • Presneau N., Eskandarpour M., Shemais T., Henderson S., Halai D., Tirabosco R., et al. MicroRNA profiling of peripheral nerve sheath tumours identifies miR-29c as a tumour suppressor gene involved in tumour progression. Br. J. Cancer 2013, 108:964--972. 10.1038/bjc.2012.518.
    • (2013) Br. J. Cancer , vol.108 , pp. 964-972
    • Presneau, N.1    Eskandarpour, M.2    Shemais, T.3    Henderson, S.4    Halai, D.5    Tirabosco, R.6
  • 64
    • 73649129263 scopus 로고    scopus 로고
    • Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours
    • Subramanian S., Thayanithy V., West R.B., Lee C.-H., Beck A.H., Zhu S., et al. Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours. J. Pathol. 2010, 220:58-70. 10.1002/path.2633.
    • (2010) J. Pathol. , vol.220 , pp. 58-70
    • Subramanian, S.1    Thayanithy, V.2    West, R.B.3    Lee, C.-H.4    Beck, A.H.5    Zhu, S.6
  • 65
    • 84864674258 scopus 로고    scopus 로고
    • MicroRNA-204 critically regulates carcinogenesis in malignant peripheral nerve sheath tumors
    • Gong M., Ma J., Li M., Zhou M., Hock J.M., Yu X. MicroRNA-204 critically regulates carcinogenesis in malignant peripheral nerve sheath tumors. Neuro. Oncol. 2012, 14:1007-1017. 10.1093/neuonc/nos124.
    • (2012) Neuro. Oncol. , vol.14 , pp. 1007-1017
    • Gong, M.1    Ma, J.2    Li, M.3    Zhou, M.4    Hock, J.M.5    Yu, X.6


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