-
1
-
-
0025201012
-
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins
-
Ballester R., Marchuk D., Boguski M., Saulino A., Letcher R., Wigler M., and Collins F. The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell 63 (1990) 851-859
-
(1990)
Cell
, vol.63
, pp. 851-859
-
-
Ballester, R.1
Marchuk, D.2
Boguski, M.3
Saulino, A.4
Letcher, R.5
Wigler, M.6
Collins, F.7
-
2
-
-
33749354937
-
The Ras inhibitor farnesylthiosalicylic acid as a potential therapy for neurofibromatosis type 1
-
Barkan B., Starinsky S., Friedman E., Stein R., and Kloog Y. The Ras inhibitor farnesylthiosalicylic acid as a potential therapy for neurofibromatosis type 1. Clin. Cancer Res. 12 (2006) 5533-5542
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 5533-5542
-
-
Barkan, B.1
Starinsky, S.2
Friedman, E.3
Stein, R.4
Kloog, Y.5
-
3
-
-
0033531955
-
Characterization of Rac and Cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases
-
Benard V., Bohl B.P., and Bokoch G.M. Characterization of Rac and Cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases. J. Biol. Chem. 274 (1999) 13198-13204
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 13198-13204
-
-
Benard, V.1
Bohl, B.P.2
Bokoch, G.M.3
-
4
-
-
3042796979
-
GAP control: regulating the regulators of small GTPases
-
Bernards A., and Settleman J. GAP control: regulating the regulators of small GTPases. Trends Cell Biol. 14 (2004) 377-385
-
(2004)
Trends Cell Biol.
, vol.14
, pp. 377-385
-
-
Bernards, A.1
Settleman, J.2
-
5
-
-
27144556152
-
Stringent doxycycline-dependent control of gene activities using an episomal one-vector system
-
Bornkamm G.W., Berens C., Kuklik-Roos C., Bechet J.M., Laux G., Bachl J., Korndoerfer M., Schlee M., Holzel M., Malamoussi A., Chapman R.D., Nimmerjahn F., Mautner J., Hillen W., Bujard H., and Feuillard J. Stringent doxycycline-dependent control of gene activities using an episomal one-vector system. Nucleic Acids Res. 33 (2005) e137
-
(2005)
Nucleic Acids Res.
, vol.33
-
-
Bornkamm, G.W.1
Berens, C.2
Kuklik-Roos, C.3
Bechet, J.M.4
Laux, G.5
Bachl, J.6
Korndoerfer, M.7
Schlee, M.8
Holzel, M.9
Malamoussi, A.10
Chapman, R.D.11
Nimmerjahn, F.12
Mautner, J.13
Hillen, W.14
Bujard, H.15
Feuillard, J.16
-
6
-
-
0025010979
-
The GTPase superfamily: a conserved switch for diverse cell functions
-
Bourne H.R., Sanders D.A., and McCormick F. The GTPase superfamily: a conserved switch for diverse cell functions. Nature 348 (1990) 125-132
-
(1990)
Nature
, vol.348
, pp. 125-132
-
-
Bourne, H.R.1
Sanders, D.A.2
McCormick, F.3
-
7
-
-
0025152970
-
Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and IRA-2 negative regulators of the RAS cyclic AMP pathway
-
Buchberg A.M., Cleveland L.S., Jenkins N.A., and Copeland N.G. Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and IRA-2 negative regulators of the RAS cyclic AMP pathway. Nature 347 (1990) 291-294
-
(1990)
Nature
, vol.347
, pp. 291-294
-
-
Buchberg, A.M.1
Cleveland, L.S.2
Jenkins, N.A.3
Copeland, N.G.4
-
8
-
-
0035936783
-
NF1 tumor suppressor gene function: narrowing the GAP
-
Cichowski K., and Jacks T. NF1 tumor suppressor gene function: narrowing the GAP. Cell 104 (2001) 593-604
-
(2001)
Cell
, vol.104
, pp. 593-604
-
-
Cichowski, K.1
Jacks, T.2
-
9
-
-
0037443055
-
Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor
-
Cichowski K., Santiago S., Jardim M., Johnson B.W., and Jacks T. Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor. Genes Dev. 17 (2003) 449-454
-
(2003)
Genes Dev.
, vol.17
, pp. 449-454
-
-
Cichowski, K.1
Santiago, S.2
Jardim, M.3
Johnson, B.W.4
Jacks, T.5
-
10
-
-
0242380337
-
NF1 modulates the effects of Ras oncogenes: evidence of other NF1 function besides its GAP activity
-
Corral T., Jimenez M., Hernandez-Munoz I., Perez de Castro I., and Pellicer A. NF1 modulates the effects of Ras oncogenes: evidence of other NF1 function besides its GAP activity. J. Cell. Physiol. 197 (2003) 214-224
-
(2003)
J. Cell. Physiol.
, vol.197
, pp. 214-224
-
-
Corral, T.1
Jimenez, M.2
Hernandez-Munoz, I.3
Perez de Castro, I.4
Pellicer, A.5
-
11
-
-
0031055415
-
Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras
-
de Rooij J., and Bos J.L. Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras. Oncogene 14 (1997) 623-625
-
(1997)
Oncogene
, vol.14
, pp. 623-625
-
-
de Rooij, J.1
Bos, J.L.2
-
12
-
-
0033194037
-
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
-
Edwards D.C., Sanders L.C., Bokoch G.M., and Gill G.N. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat. Cell Biol. 1 (1999) 253-259
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 253-259
-
-
Edwards, D.C.1
Sanders, L.C.2
Bokoch, G.M.3
Gill, G.N.4
-
13
-
-
0032717429
-
Targeting of K-Ras 4B by S-trans,trans-farnesyl thiosalicylic acid
-
Elad G., Paz A., Haklai R., Marciano D., Cox A., and Kloog Y. Targeting of K-Ras 4B by S-trans,trans-farnesyl thiosalicylic acid. Biochim. Biophys. Acta 1452 (1999) 228-242
-
(1999)
Biochim. Biophys. Acta
, vol.1452
, pp. 228-242
-
-
Elad, G.1
Paz, A.2
Haklai, R.3
Marciano, D.4
Cox, A.5
Kloog, Y.6
-
14
-
-
32144442590
-
In vitro assay of primary astrocyte migration as a tool to study Rho GTPase function in cell polarization
-
Etienne-Manneville S. In vitro assay of primary astrocyte migration as a tool to study Rho GTPase function in cell polarization. Methods Enzymol. 406 (2006) 565-578
-
(2006)
Methods Enzymol.
, vol.406
, pp. 565-578
-
-
Etienne-Manneville, S.1
-
15
-
-
0033924917
-
Minor lesion mutational spectrum of the entire NF1 gene does not explain its high mutability but points to a functional domain upstream of the GAP-related domain
-
Fahsold R., Hoffmeyer S., Mischung C., Gille C., Ehlers C., Kucukceylan N., Abdel-Nour M., Gewies A., Peters H., Kaufmann D., Buske A., Tinschert S., and Nurnberg P. Minor lesion mutational spectrum of the entire NF1 gene does not explain its high mutability but points to a functional domain upstream of the GAP-related domain. Am. J. Hum. Genet. 66 (2000) 790-818
-
(2000)
Am. J. Hum. Genet.
, vol.66
, pp. 790-818
-
-
Fahsold, R.1
Hoffmeyer, S.2
Mischung, C.3
Gille, C.4
Ehlers, C.5
Kucukceylan, N.6
Abdel-Nour, M.7
Gewies, A.8
Peters, H.9
Kaufmann, D.10
Buske, A.11
Tinschert, S.12
Nurnberg, P.13
-
16
-
-
33645516549
-
PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility
-
Fiordalisi J.J., Keller P.J., and Cox A.D. PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility. Cancer Res. 66 (2006) 3153-3161
-
(2006)
Cancer Res.
, vol.66
, pp. 3153-3161
-
-
Fiordalisi, J.J.1
Keller, P.J.2
Cox, A.D.3
-
17
-
-
33645116938
-
Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras
-
Hannan F., Ho I., Tong J.J., Zhu Y., Nurnberg P., and Zhong Y. Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras. Hum. Mol. Genet. 15 (2006) 1087-1098
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 1087-1098
-
-
Hannan, F.1
Ho, I.2
Tong, J.J.3
Zhu, Y.4
Nurnberg, P.5
Zhong, Y.6
-
19
-
-
0034598363
-
Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo
-
Ingram D.A., Yang F.C., Travers J.B., Wenning M.J., Hiatt K., New S., Hood A., Shannon K., Williams D.A., and Clapp D.W. Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo. J. Exp. Med. 191 (2000) 181-188
-
(2000)
J. Exp. Med.
, vol.191
, pp. 181-188
-
-
Ingram, D.A.1
Yang, F.C.2
Travers, J.B.3
Wenning, M.J.4
Hiatt, K.5
New, S.6
Hood, A.7
Shannon, K.8
Williams, D.A.9
Clapp, D.W.10
-
20
-
-
0030615004
-
p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions
-
Ishizaki T., Naito M., Fujisawa K., Maekawa M., Watanabe N., Saito Y., and Narumiya S. p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions. FEBS Lett. 404 (1997) 118-124
-
(1997)
FEBS Lett.
, vol.404
, pp. 118-124
-
-
Ishizaki, T.1
Naito, M.2
Fujisawa, K.3
Maekawa, M.4
Watanabe, N.5
Saito, Y.6
Narumiya, S.7
-
21
-
-
0033605480
-
Plexiform neurofibromas
-
Korf B.R. Plexiform neurofibromas. Am. J. Med. Genet. 89 (1999) 31-37
-
(1999)
Am. J. Med. Genet.
, vol.89
, pp. 31-37
-
-
Korf, B.R.1
-
22
-
-
0033799930
-
Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma
-
Lau N., Feldkamp M.M., Roncari L., Loehr A.H., Shannon P., Gutmann D.H., and Guha A. Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma. J. Neuropathol. Exp. Neurol. 59 (2000) 759-767
-
(2000)
J. Neuropathol. Exp. Neurol.
, vol.59
, pp. 759-767
-
-
Lau, N.1
Feldkamp, M.M.2
Roncari, L.3
Loehr, A.H.4
Shannon, P.5
Gutmann, D.H.6
Guha, A.7
-
23
-
-
0033529620
-
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
-
Maekawa M., Ishizaki T., Boku S., Watanabe N., Fujita A., Iwamatsu A., Obinata T., Ohashi K., Mizuno K., and Narumiya S. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 285 (1999) 895-898
-
(1999)
Science
, vol.285
, pp. 895-898
-
-
Maekawa, M.1
Ishizaki, T.2
Boku, S.3
Watanabe, N.4
Fujita, A.5
Iwamatsu, A.6
Obinata, T.7
Ohashi, K.8
Mizuno, K.9
Narumiya, S.10
-
24
-
-
0033214846
-
In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells
-
Mahgoub N., Taylor B.R., Gratiot M., Kohl N.E., Gibbs J.B., Jacks T., and Shannon K.M. In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells. Blood 94 (1999) 2469-2476
-
(1999)
Blood
, vol.94
, pp. 2469-2476
-
-
Mahgoub, N.1
Taylor, B.R.2
Gratiot, M.3
Kohl, N.E.4
Gibbs, J.B.5
Jacks, T.6
Shannon, K.M.7
-
25
-
-
32244437769
-
Phosphorylation of neurofibromin by PKC is a possible molecular switch in EGF receptor signaling in neural cells
-
Mangoura D., Sun Y., Li C., Singh D., Gutmann D.H., Flores A., Ahmed M., and Vallianatos G. Phosphorylation of neurofibromin by PKC is a possible molecular switch in EGF receptor signaling in neural cells. Oncogene 25 (2006) 735-745
-
(2006)
Oncogene
, vol.25
, pp. 735-745
-
-
Mangoura, D.1
Sun, Y.2
Li, C.3
Singh, D.4
Gutmann, D.H.5
Flores, A.6
Ahmed, M.7
Vallianatos, G.8
-
26
-
-
0026319619
-
cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product
-
Marchuk D.A., Saulino A.M., Tavakkol R., Swaroop M., Wallace M.R., Andersen L.B., Mitchell A.L., Gutmann D.H., Boguski M., and Collins F.S. cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product. Genomics 11 (1991) 931-940
-
(1991)
Genomics
, vol.11
, pp. 931-940
-
-
Marchuk, D.A.1
Saulino, A.M.2
Tavakkol, R.3
Swaroop, M.4
Wallace, M.R.5
Andersen, L.B.6
Mitchell, A.L.7
Gutmann, D.H.8
Boguski, M.9
Collins, F.S.10
-
27
-
-
0028981375
-
Selective inhibition of Ras-dependent cell growth by farnesylthiosalicylic acid
-
Marom M., Haklai R., Ben-Baruch G., Marciano D., Egozi Y., and Kloog Y. Selective inhibition of Ras-dependent cell growth by farnesylthiosalicylic acid. J. Biol. Chem. 270 (1995) 22263-22270
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 22263-22270
-
-
Marom, M.1
Haklai, R.2
Ben-Baruch, G.3
Marciano, D.4
Egozi, Y.5
Kloog, Y.6
-
28
-
-
0025251137
-
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21
-
Martin G.A., Viskochil D., Bollag G., McCabe P.C., Crosier W.J., Haubruck H., Conroy L., Clark R., O'Connell P., Cawthon R.M., et al. The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21. Cell 63 (1990) 843-849
-
(1990)
Cell
, vol.63
, pp. 843-849
-
-
Martin, G.A.1
Viskochil, D.2
Bollag, G.3
McCabe, P.C.4
Crosier, W.J.5
Haubruck, H.6
Conroy, L.7
Clark, R.8
O'Connell, P.9
Cawthon, R.M.10
-
29
-
-
28244469687
-
The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway
-
Ozawa T., Araki N., Yunoue S., Tokuo H., Feng L., Patrakitkomjorn S., Hara T., Ichikawa Y., Matsumoto K., Fujii K., and Saya H. The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway. J. Biol. Chem. 280 (2005) 39524-39533
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 39524-39533
-
-
Ozawa, T.1
Araki, N.2
Yunoue, S.3
Tokuo, H.4
Feng, L.5
Patrakitkomjorn, S.6
Hara, T.7
Ichikawa, Y.8
Matsumoto, K.9
Fujii, K.10
Saya, H.11
-
30
-
-
0037459075
-
Cellular motility driven by assembly and disassembly of actin filaments
-
Pollard T.D., and Borisy G.G. Cellular motility driven by assembly and disassembly of actin filaments. Cell 112 (2003) 453-465
-
(2003)
Cell
, vol.112
, pp. 453-465
-
-
Pollard, T.D.1
Borisy, G.G.2
-
31
-
-
0345731237
-
Cell migration: Rho GTPases lead the way
-
Raftopoulou M., and Hall A. Cell migration: Rho GTPases lead the way. Dev. Biol. 265 (2004) 23-32
-
(2004)
Dev. Biol.
, vol.265
, pp. 23-32
-
-
Raftopoulou, M.1
Hall, A.2
-
33
-
-
34249887660
-
LIM kinases: function, regulation and association with human disease
-
Scott R.W., and Olson M.F. LIM kinases: function, regulation and association with human disease. J. Mol. Med. 85 (2007) 555-568
-
(2007)
J. Mol. Med.
, vol.85
, pp. 555-568
-
-
Scott, R.W.1
Olson, M.F.2
-
34
-
-
34247330161
-
The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways
-
Shapira S., Barkan B., Friedman E., Kloog Y., and Stein R. The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways. Cell Death Differ. 14 (2007) 895-906
-
(2007)
Cell Death Differ.
, vol.14
, pp. 895-906
-
-
Shapira, S.1
Barkan, B.2
Friedman, E.3
Kloog, Y.4
Stein, R.5
-
35
-
-
41149133470
-
Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1
-
Yan J., Chen S., Zhang Y., Li X., Li Y., Wu X., Yuan J., Robling A.G., Kapur R., Chan R.J., and Yang F.C. Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1. Hum. Mol. Genet. 17 (2008) 936-948
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 936-948
-
-
Yan, J.1
Chen, S.2
Zhang, Y.3
Li, X.4
Li, Y.5
Wu, X.6
Yuan, J.7
Robling, A.G.8
Kapur, R.9
Chan, R.J.10
Yang, F.C.11
|