Identification of the polycomb group protein SU(Z)12 as a potential molecular target for human cancer therapy

Molecular Cancer Therapeutics

Volumn 2, Issue 1, 2003, Pages 113-121

  Kirmizis, Antonis ^a   Bartley, Stephanie M ^a   Farnham, Peggy J ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CATNB PROTEIN, MOUSE; CTNNB1 PROTEIN, HUMAN; CYTOSKELETON PROTEIN; DROSOPHILA PROTEIN; MESSENGER RNA; POLYCOMB GROUP PROTEINS; POLYCOMB PROTEIN, DROSOPHILA; PRIMER DNA; REPRESSOR PROTEIN; TRANSACTIVATOR PROTEIN;

ANIMAL; ARTICLE; BREAST TUMOR; CHROMATIN; COLON TUMOR; FEMALE; GENETIC TRANSCRIPTION; GENETICS; HELA CELL; HUMAN; LIVER TUMOR; METABOLISM; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BASE SEQUENCE; BETA CATENIN; BREAST NEOPLASMS; CHROMATIN; COLONIC NEOPLASMS; CYTOSKELETAL PROTEINS; DNA PRIMERS; DROSOPHILA PROTEINS; FEMALE; HELA CELLS; HUMANS; LIVER NEOPLASMS; MICE; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 0141576562     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Nagase, T., Seki, N., Tanaka, A., Ishikawa, K., and Nomura, N. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160). DNA Res., 2: 199-210, 1995.
2. Koontz, J. I., Soreng, A. L., Nucci, M., Kuo, F. C., Pauwels, P., van den Berghe, H., Dal Cin, P., Fletcher, J. A., and Sklar, J. Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. Proc. Natl. Acad. Sci. USA, 98: 6348-6353, 2001. (Pubitemid 32488241)
3. Birve, A., Sengupta, A. K., Beuchle, D., Larsson, J., Kennison, J. A., Rasmuson-Lestander, A., and Muller, J. Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants. Development (Camb.), 128: 3371-3379, 2001. (Pubitemid 32910389)
4. Weinmann, A. S., Bartley, S. M., Zhang, M. Q., Zhang, T., and Farnham, P. J. The use of chromatin immunoprecipitation to clone novel E2F target promoters. Mol. Cell. Biol., 21: 6820-6832, 2001. (Pubitemid 32911243)
5. Muller, H., Bracken, A. P., Vernell, R., Moroni, M. C., Christians, F., Grassilli, E., Prosperini, E., Vigo, E., Oliner, J. D., and Helin, K. E.2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev., 15: 267-285, 2001. (Pubitemid 32155143)
6. Weinmann, A. S., Yan, P. S., Oberley, M. J., Huang, T. H-M., and Farnham, P. J. Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. Genes Dev., 16: 235-244, 2002. (Pubitemid 34075815)
7. Ren, B., Cam, H., Takahashi, Y., Volkert, T., Terragni, J., Young, R. A., and Dynlacht, B. D. E.2F integrates cell cycle progression with DNA repair, replication, and G2/M checkpoints. Genes Dev., 16: 245-256, 2002. (Pubitemid 34075816)
8. Ishida, S., Huang, E., Zuzan, H., Spang, R., Leone, G., West, M., and Nevins, J. R. Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. Mol. Cell. Biol., 21: 4684-4699, 2001. (Pubitemid 32588250)
9. Nevins, J. R. The Rb/E2F pathway and cancer. Hum. Mol. Genet., 10: 699-703, 2001. (Pubitemid 32331578)
10. Johnson, L., Shen, A., Boyle, L., Kunich, J., Pandey, K., Lemmon, M., Hermiston, T., Giedlin, M., McCormick, F., and Fattaey, A. Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents. Cancer Cell, 1: 325-336, 2002.
11. Morris, E. J., and Dyson, N. J. Retinoblastoma protein partners. Adv. Cancer Res., 82: 1-54, 2001. (Pubitemid 32613381)
12. Ogawa, H., Ishiguro, K., Gaubatz, S., Livingston, D. M., and Nakatani, Y. A. complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science (Wash. DC), 296: 1132-1136, 2002. (Pubitemid 34517133)
13. Sears, R., Ohtani, K., and Nevins, J. R. Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals. Mol. Cell. Biol., 17: 5227-5235, 1997. (Pubitemid 27357621)
14. Eischen, C. M., Packham, G., Nip, J., Fee, B. E., Hiebert, S. W., Zambetti, G., and Cleveland, J. L. Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1. Oncogene, 20: 6983-6993, 2001. (Pubitemid 33052191)
15. He, T-C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., and Vogelstein, B., Kinzler, K. W. Identification of c-Myc as a target of the APC pathway. Science (Wash. DC), 281: 1509-1512, 1998. (Pubitemid 28425575)
16. Tetsu, O., and McCormick, F. β-Catenin regulates expression of cyclin DI in colon carcinoma cells. Nature (Lond.), 398: 422-426, 1999. (Pubitemid 29180374)
17. Lee, R. J., Albanese, C., Fu, M., D'Amico. M., Lin, B., Watanabe, G., Haines, G. K. 3rd, Siegel, P. M., Hung, M. C., Yarden, Y., Horowitz, J. M., Muller, W. J., and Pestell, R. G. Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signalling pathway. Mol. Cell. Biol., 20: 672-683, 2000.
18. Logan, T. J., Morberg, K. H., and Hall, D. J. Multiprotein complex formation on the c-Myc promoter. Biochem. Mol. Biol. Int., 43: 945-953, 1997. (Pubitemid 27524955)
19. Fry, C. J., and Farnham, P. J. Context-dependent transcriptional regulation. J. Biol. Chem., 274: 29583-29586, 1999.
20. Kinzler, K. W., and Vogelstein, B. Lessons from hereditary colorectal cancer. Cell, 87: 159-170, 1996. (Pubitemid 26358996)
21. Aoiki, M., Hecht, A., Kruse, U., Kemler, R., and Vogt, P. K. Nuclear endpoint of Wnt signaling: neoplastic transformation induced by transactivating lymphoid-enhancing factor 1. Proc. Natl. Acad. Sci. USA, 96: 139-144, 1999. (Pubitemid 29036066)
22. Roose, J., and Clevers, H. TCF transcription factors: molecular switches in carcinogenesis. Biochim. Biophys. Acta, 87456: M23-M37, 1999. (Pubitemid 29488713)
23. Mann, B., Gelos, M., Siedow, A., Hanski, M. L., Gratchev, A., Ilyas, M., Bodmer, W. F., Moyer, M. P., Riecken, E. O., Buhr, H. J., and Hanski, C. Target genes of β-catenin-T-cell factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc. Natl. Acad. Sci. USA, 96: 1603-1608, 1999. (Pubitemid 29098498)
24. Mei, J. M., Hord, N. G., Winterstein, D. F., Donald, S. P., and Phang, J. M. Differential expression of prostaglandin endoperoxide H synthase-2 and formation of activated β-catenin-LEF-1 transcription complex in mouse colonic epithelial cells contrasting in APC. Carcinogenesis (Lond.), 20: 737-740, 1999. (Pubitemid 29151316)
25. Crawford, H. C., Fingleton, B. M., Rudolph-Owen, L. A., Goss, K. J. H., Rubinfield, B., Polakis, P., and Matrisian, L. M. The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors. Oncogene, 18: 2883-2891, 1999. (Pubitemid 29250878)
26. Tsunoda, T., Nakamura, T., Ishimoto, K., Yamaue, H., Tanimura, H., Saijo, N., and Nishio, K. Upregulated expression of angiogenesis genes and down regulation of cell cycle genes in human colorectal cancer tissue determined by cDNA macroarray. Anticancer Res., 21: 137-143, 2001.
27. Lin, Y-M., Ono, K., Satoh, S., Ishiguro, H., Fujita, M., Miwa, N., Tanaka, T., Tsunoda, T., Yang, K-C., Nakamura, Y., and Furukawa, Y. Identification of AF17 as a downstream gene of the β-catenin/T-Cell Factor pathway and its involvement in colorectal carcinogenesis. Cancer Res., 61: 6345-6349, 2001. (Pubitemid 32783235)
28. Scherl-Mostageer, M., Sommergruber, W., Abseher, R., Hauptmann, R., Ambros, P., and Schweifer, N. Identification of a novel gene. CDCP1, overexpressed in human colorectal cancer. Oncogene, 20: 4402-4408, 2001. (Pubitemid 32726882)
29. Lukas, E. R., Bartley, S. M., Graveel, C. R., Diaz, Z. M., Dyson, N., Harlow, E., Yamasaki, L., and Farnham, P. J. No effect of loss of E2F1 on liver regeneration or hepatocarcinogenesis in C57BL/6J or C3H/HeJ mice. Mol. Carcinog., 25: 295-303, 1999. (Pubitemid 29372915)
30. Ross, J., Lemm, I., and Berberet, B. Overexpression of an mRNA-binding protein in human colorectal cancer. Oncogene, 20: 6544-6550, 2001. (Pubitemid 32980280)
31. Graveel, C. R., Jatkoe, T., Madore, S. J., Holt, A. L., and Farnham, P. J. Expression profiling and identification of novel genes in hepatocellular carcinomas. Oncogene, 20: 2704-2712, 2001. (Pubitemid 32525301)
32. Slansky, J. E., Li, Y., Kaelin, W. G., and Farnham, P. J. A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter [author's correction: Mol. Cell. Biol., 13: 7201, 1993]. Mol. Cell. Biol., 13: 1610-1618, 1993. (Pubitemid 23068099)
33. Plevy, S. E., Gemberling, J. H. M., Hsu, S., Dorner, A. J., and Smale, S. T. Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Mol. Cell. Biol., 17: 4572-4588, 1997. (Pubitemid 27318134)
34. Smale, S., and Baltimore, D. The "Initiator" as a transcription control element. Cell, 57: 103-113, 1989.
35. Wells, J., Held, P., Illenye, S., and Heintz, N. H. Protein-DNA interactions at the major and minor promoters of the divergently transcribed dhfr and rep3 genes during the Chinese hamster ovary cell cycle. Mol. Cell. Biol., 16: 634-647, 1996. (Pubitemid 26029103)
36. Korinek, V., Barker, N., Morin, P. J., van Wichen, D., de Weger, R., Kinzler, K. W., Vogelstein, B., and Clevers, H. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC -/- colon carcinoma. Science (Wash. DC), 275: 1784-1787, 1997. (Pubitemid 27136714)
37. Farnham, P. J., Abrams, J. M., and Schimke, R. T. Opposite-strand RNAs from the 5′ flanking region of the mouse dihydrofolate reductase gene. Proc. Natl. Acad. Sci., 82: 3978-3982, 1985. (Pubitemid 15052812)
38. Dong, S., Lester, L., and Johnson, L. F. Transcriptional control elements and complex initiation pattern of the TATA-less bidirectional human thymidylate synthase promoter. J. Cell. Biochem., 77: 50-64, 2000. (Pubitemid 30126894)
39. Guarguaglini, G., Battistoni, A., Pittoggi, C., Di Matteo, G., Di Fiore, B., and Lavia, P. Expression of the murine RanBP1 and Htf9-c genes is regulated from a shared bidirectional promoter during cell cycle progression. Biochem. J., 325: 277-286, 1997. (Pubitemid 27322713)
40. Adachi, N., and Lieber, M. R. Bidirectional gene organization: a common architectural feature of the human genome. Cell, 109: 807-809, 2002. (Pubitemid 34785996)
41. Marcu, K. B., Bossone, S. A., and Patel, A. J. myc function and regulation. Annu. Rev. Biochem., 61: 809-860, 1992.
42. Gong, Q., Brown, L. J., and MacDonald, M. J. Functional analysis of two promoters for the human mitochondrial glycerol phosphate dehydrogenase gene. J. Biol. Chem., 275: 38012-38021, 2000. (Pubitemid 32004924)
43. Haug, T., Skorpen, F., Aas, P. A., Malm, V., Skjelbred, C., and Krokan, H. E. Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase. Nucleic Acids Res., 26: 1449-1457, 1998. (Pubitemid 28291620)
44. Adams, M. R., Sears, R., Nuckolls, F., Leone, G., and Nevins, J. R. Complex transcriptional regulatory mechanisms control expression of the E2F3 locus. Mol. Cell. Biol., 20: 3633-3639, 2000. (Pubitemid 30243909)
45. Albig, W., Trappe, R., Kardalinou, E., Eick, S., and Doenecke, D. The human H2A and H2B histone gene complement. Biol. Chem., 380: 7-18, 1999. (Pubitemid 29057406)
46. Hovanes, K., Li, T. W. H., Munguia, J. E., Truong, T., Milovanovic, T., Marsh, J. L., Holcombe, R. F., and Waterman, M. L. B-Catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer. Nat. Genet., 28: 53-57, 2001. (Pubitemid 32405817)
47. Lin, S-Y., Xia, W., Wnag, J. C., Kwong, K. Y., Spohn, B., Wen, Y., Pestell, R. G., and Hung, M-C. β-Catenin, a novel prognostic marker for breast cancer: its role in cyclin D1 expression and cancer progression. Proc. Natl. Acad. Sci. USA, 97: 4262-4266, 2000. (Pubitemid 30226121)
48. Buendia, M. A. Genetics of hepatocellular carcinoma. Semin. Cancer Biol., 10: 185-200, 2000.
49. Brantjes, H., Roose, J., van de Wetering, M., and Clevers, H. All Tcf HMG box transcription factors interact with groucho-related co-repressors. Nucleic Acid Res., 29: 1410-1419, 2001. (Pubitemid 32288486)
50. Muller, J., Hart, C. M., Francis, N. J., Vargas, M. L., Sengupta, A., Wild, B., Miller, E. L., O'Connor. M. B., Kingston, R. E., and Simon, J. A. Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell, 111: 197-208, 2002. (Pubitemid 35292440)
51. Cao, R., Wang, L., Wang, H., Xia, L., Erdjument-Bromage, H., Tempst, P., Jones, R. S., and Zhang, Y. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science (Wash. DC), 298: 1039-1043, 2002. (Pubitemid 35247314)
52. Varambally, S., Dhanasekaran, S. M., Zhou, M., Barrette, T. R., Kumar-Sinha, C., Sanda, M. G., Ghosh, D., Pienta, K. J., Sewalt, R. G. A. B., Otte, A. P., Rubin, M. A., and Chinnalyan, A. M. The Polycomb group protein EZH2 is involved in progression of prostate cancer. Nature (Lond.), 419: 624-629, 2002.
53. Notterman, D. A., Alon, U., Sierk, A. J., and Levine, A. J. Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays. Cancer Res., 61: 3124-3130, 2001. (Pubitemid 32691964)
54. Kuzmichev, A., Nishioka, K., Erdjument-Bromage, H., Tempst, P., and Reinberg, D. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev., 16: 2893-2905, 2002. (Pubitemid 35334738)