Glucagon-like peptide-1 improves beta-cell antioxidant capacity via extracellular regulated kinases pathway and Nrf2 translocation

Free Radical Biology and Medicine

Volumn 95, Issue , 2016, Pages 16-26

  Fernandez Millan E ^a   Martin M A ^a,b   Goya, L ^b   Lizarraga Mollinedo E ^a,c   Escriva F ^a,c   Ramos, S ^b   Alvarez C ^a,c  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b INSTITUTE OF FOOD SCIENCE   (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Beta cell; GLP 1; Glutathione related enzymes; Oxidative stress

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUCAGON LIKE PEPTIDE 1 [7-36] AMIDE; GLUCOSE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; MITOGEN ACTIVATED PROTEIN KINASE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TERT BUTYL HYDROPEROXIDE; TRANSCRIPTION FACTOR NRF2; UNCOUPLING PROTEIN 2; ANTIOXIDANT; GLUCAGON LIKE PEPTIDE 1; GLUTATHIONE; INSULIN; ISOQUINOLINE DERIVATIVE; N-(2-(4-BROMOCINNAMYLAMINO)ETHYL)-5-ISOQUINOLINESULFONAMIDE; NFE2L2 PROTEIN, RAT; REACTIVE OXYGEN METABOLITE; SULFONAMIDE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DAMAGE; CELL DEATH; CELL LEVEL; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; GENE EXPRESSION; INSULIN RELEASE; MALE; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; GENETICS; HUMAN; INSULIN RESISTANCE; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOLOGY; SECRETION (PROCESS);

ANIMALS; ANTIOXIDANTS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIABETES MELLITUS, TYPE 2; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE; GLUTATHIONE; GLUTATHIONE REDUCTASE; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; ISOQUINOLINES; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; RATS; REACTIVE OXYGEN SPECIES; SULFONAMIDES; TERT-BUTYLHYDROPEROXIDE; UNCOUPLING PROTEIN 2;

EID: 84961203982     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2016.03.002     Document Type: Article

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