메뉴 건너뛰기




Volumn 358, Issue 2, 2014, Pages 343-358

The effect of glucagon-like peptide-1 in the management of diabetes mellitus: cellular and molecular mechanisms

Author keywords

Diabetes mellitus; Exenatide; Gene expression; GLP 1; Glucagon; Glucose; Insulin; Rats; Streptozotocin

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CATALASE; EXENDIN 4; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCOSE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HEAT SHOCK PROTEIN 70; INSULIN; INSULIN RECEPTOR; UREA; URIC ACID; GLUCOSE BLOOD LEVEL; LIPID; PEPTIDE; VENOM;

EID: 84919946463     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-014-1959-9     Document Type: Article
Times cited : (17)

References (62)
  • 1
    • 0033081848 scopus 로고    scopus 로고
    • Effect of subcutaneous pancreatic tissue transplants on streptozotocin-induced diabetes in rats. I. Morphological studies on normal, diabetic and transplanted pancreatic tissues
    • PID: 10368987, COI: 1:STN:280:DyaK1M3pslektA%3D%3D
    • Adeghate E (1999) Effect of subcutaneous pancreatic tissue transplants on streptozotocin-induced diabetes in rats. I. Morphological studies on normal, diabetic and transplanted pancreatic tissues. Tissue Cell 31:66–72
    • (1999) Tissue Cell , vol.31 , pp. 66-72
    • Adeghate, E.1
  • 2
    • 0036083399 scopus 로고    scopus 로고
    • Ghrelin stimulates insulin secretion from the pancreas of normal and diabetic rats
    • PID: 12121492, COI: 1:CAS:528:DC%2BD38XltF2gurc%3D
    • Adeghate E, Ponery AS (2002) Ghrelin stimulates insulin secretion from the pancreas of normal and diabetic rats. J Neuroendocrinol 14:555–560
    • (2002) J Neuroendocrinol , vol.14 , pp. 555-560
    • Adeghate, E.1    Ponery, A.S.2
  • 3
    • 13644265663 scopus 로고    scopus 로고
    • Diabetes mellitus influences the degree of co-localization of calcitonin-gene-related-peptide with insulin and somatostatin in the rat pancreas
    • PID: 15502648, COI: 1:CAS:528:DC%2BD2cXhtVKnt7zN
    • Adeghate E, Ponery AS (2004) Diabetes mellitus influences the degree of co-localization of calcitonin-gene-related-peptide with insulin and somatostatin in the rat pancreas. Pancreas 29:311–319
    • (2004) Pancreas , vol.29 , pp. 311-319
    • Adeghate, E.1    Ponery, A.S.2
  • 5
    • 77952796951 scopus 로고    scopus 로고
    • When and how to evaluate mildly elevated liver enzymes in apparently healthy patients
    • PID: 20200170
    • Aragon G, Younossi ZM (2010) When and how to evaluate mildly elevated liver enzymes in apparently healthy patients. Cleve Clin J Med 77(3):195–204
    • (2010) Cleve Clin J Med , vol.77 , Issue.3 , pp. 195-204
    • Aragon, G.1    Younossi, Z.M.2
  • 6
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • COI: 1:CAS:528:DC%2BD2sXmsVynsrY%3D
    • Baggio LL, Drucker DJ (2007) Biology of incretins: GLP-1 and GIP. Gastroenterol 132:2131–2157
    • (2007) Gastroenterol , vol.132 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 7
    • 62049084407 scopus 로고    scopus 로고
    • Prevalence of diagnosed and undiagnosed diabetes mellitus and its risk factors in a population-based study of Qatar
    • PID: 19261345
    • Bener A, Zirie M, Janahi IM, Al-Hamaq AO, Musallam M, Wareham NJ (2009) Prevalence of diagnosed and undiagnosed diabetes mellitus and its risk factors in a population-based study of Qatar. Diabetes Res Clin Pract 84(1):99–106
    • (2009) Diabetes Res Clin Pract , vol.84 , Issue.1 , pp. 99-106
    • Bener, A.1    Zirie, M.2    Janahi, I.M.3    Al-Hamaq, A.O.4    Musallam, M.5    Wareham, N.J.6
  • 8
    • 25444455671 scopus 로고    scopus 로고
    • Regulation of pancreatic beta-cell mass
    • PID: 16183912, COI: 1:CAS:528:DC%2BD2MXhtFeqsr3J
    • Bouwens L, Rooman I (2005) Regulation of pancreatic beta-cell mass. Physiol Rev 85(4):1255–1270
    • (2005) Physiol Rev , vol.85 , Issue.4 , pp. 1255-1270
    • Bouwens, L.1    Rooman, I.2
  • 10
    • 67651043975 scopus 로고    scopus 로고
    • Association of Exenatide with liver enzymes in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BD1MXnsVahurc%3D
    • Bulchandani D, Nachnani J, Eaton C, Hamburg M (2009) Association of Exenatide with liver enzymes in patients with type 2 diabetes. Curr Opin Endocrinol Diabetes Obes 19(3):114–115
    • (2009) Curr Opin Endocrinol Diabetes Obes , vol.19 , Issue.3 , pp. 114-115
    • Bulchandani, D.1    Nachnani, J.2    Eaton, C.3    Hamburg, M.4
  • 11
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • PID: 19515413, COI: 1:CAS:528:DC%2BD1MXotFCgtb4%3D
    • Buse JB, Rosenstock J, Sesti G, Schmidt WE, Montanya E, Brett JH, Zychma M, Blonde L (2009) Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet 374(4):39–47
    • (2009) Lancet , vol.374 , Issue.4 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3    Schmidt, W.E.4    Montanya, E.5    Brett, J.H.6    Zychma, M.7    Blonde, L.8
  • 12
    • 2942568445 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 prevents beta cell glucolipotoxicity
    • PID: 15095038, COI: 1:CAS:528:DC%2BD2cXksFGitb4%3D
    • Buteau J, El-Assaad W, Rhodes CJ, Rosenberg L, Joly E, Prentki M (2004) Glucagon-like peptide-1 prevents beta cell glucolipotoxicity. Diabetologia 47:806–815
    • (2004) Diabetologia , vol.47 , pp. 806-815
    • Buteau, J.1    El-Assaad, W.2    Rhodes, C.J.3    Rosenberg, L.4    Joly, E.5    Prentki, M.6
  • 13
    • 34548634696 scopus 로고    scopus 로고
    • Diet-induced obesity in gravid rats engenders early hyperadiposity in the offspring
    • PID: 17884457, COI: 1:CAS:528:DC%2BD2sXhtVOgu7vM
    • Caluwaerts S, Lambin S, van Bree R, Peeters H, Vergote I, Verhaeghe J (2007) Diet-induced obesity in gravid rats engenders early hyperadiposity in the offspring. Metabolism 56:1431–1438
    • (2007) Metabolism , vol.56 , pp. 1431-1438
    • Caluwaerts, S.1    Lambin, S.2    van Bree, R.3    Peeters, H.4    Vergote, I.5    Verhaeghe, J.6
  • 14
    • 69649084224 scopus 로고    scopus 로고
    • Immunomodulatory role of prolactin in diabetes development
    • PID: 19248843, COI: 1:CAS:528:DC%2BD1MXhtleitbbK
    • Cejkova P, Fojtikova M, Cerna M (2009) Immunomodulatory role of prolactin in diabetes development. Autoimmun Rev 9(1):23–27
    • (2009) Autoimmun Rev , vol.9 , Issue.1 , pp. 23-27
    • Cejkova, P.1    Fojtikova, M.2    Cerna, M.3
  • 15
    • 79959774265 scopus 로고    scopus 로고
    • Therapy in the early stage: incretins
    • PID: 21525466, COI: 1:CAS:528:DC%2BC3MXntlKksLs%3D
    • Cernea S, Raz I (2011) Therapy in the early stage: incretins. Diabetes Care 34(2):S264–S271
    • (2011) Diabetes Care , vol.34 , Issue.2 , pp. S264-S271
    • Cernea, S.1    Raz, I.2
  • 16
    • 33645967809 scopus 로고    scopus 로고
    • Therapeutic strategic based on GLP-1 pathway
    • Druker DJ (2005) Therapeutic strategic based on GLP-1 pathway. Adv Stud Med 5(10E):S1069–S1073
    • (2005) Adv Stud Med , vol.5 , Issue.10E , pp. S1069-S1073
    • Druker, D.J.1
  • 17
    • 0029028687 scopus 로고
    • The effects of glucagon-like peptide-I (GLP-I) on hormone secretion from isolated human pancreatic islets
    • PID: 7479679, COI: 1:STN:280:DyaK28%2FotlaksA%3D%3D
    • Fehmann HC, Hering BJ, Wolf MJ, Brandhorst H, Brandhorst D, Bretzel RG, Federlin K, Göke B (1995) The effects of glucagon-like peptide-I (GLP-I) on hormone secretion from isolated human pancreatic islets. Pancreas 11:196–200
    • (1995) Pancreas , vol.11 , pp. 196-200
    • Fehmann, H.C.1    Hering, B.J.2    Wolf, M.J.3    Brandhorst, H.4    Brandhorst, D.5    Bretzel, R.G.6    Federlin, K.7    Göke, B.8
  • 18
    • 10344234243 scopus 로고    scopus 로고
    • Signaling pathways: the benefits of good communication
    • PID: 15589136, COI: 1:CAS:528:DC%2BD2cXhtVKrtbrM
    • Fisher TL, White MF (2004) Signaling pathways: the benefits of good communication. Curr Biol 14:R1005–R1007
    • (2004) Curr Biol , vol.14 , pp. R1005-R1007
    • Fisher, T.L.1    White, M.F.2
  • 20
    • 79959803070 scopus 로고    scopus 로고
    • Incretin effects on β-cell function, replication, and mass
    • PID: 21525465, COI: 1:CAS:528:DC%2BC3MXntlKksLo%3D
    • Garber AJ (2011) Incretin effects on β-cell function, replication, and mass. Diabetes Care 34(2):S258–S263
    • (2011) Diabetes Care , vol.34 , Issue.2 , pp. S258-S263
    • Garber, A.J.1
  • 21
    • 68049099973 scopus 로고    scopus 로고
    • Exendin-4 exerts its effects through the NGF/p75NTR system in diabetic mouse pancreas
    • PID: 19767827, COI: 1:CAS:528:DC%2BD1MXhtVSjsrvI
    • Gezginci-Oktayoglu S, Bolkent S (2009) Exendin-4 exerts its effects through the NGF/p75NTR system in diabetic mouse pancreas. Biochem Cell Biol 87(4):641–651
    • (2009) Biochem Cell Biol , vol.87 , Issue.4 , pp. 641-651
    • Gezginci-Oktayoglu, S.1    Bolkent, S.2
  • 22
    • 57149083860 scopus 로고    scopus 로고
    • The incretins: from the concept to their use in the treatment of type 2 diabetes. Part A: incretins: concept and physiological functions
    • PID: 19036624, COI: 1:CAS:528:DC%2BD1MXitVWntLw%3D
    • Girard J (2008) The incretins: from the concept to their use in the treatment of type 2 diabetes. Part A: incretins: concept and physiological functions. Diabetes Metab 34:550–559
    • (2008) Diabetes Metab , vol.34 , pp. 550-559
    • Girard, J.1
  • 23
    • 84877763148 scopus 로고    scopus 로고
    • Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells
    • PID: 23519462, COI: 1:CAS:528:DC%2BC3sXnsFGjsLY%3D
    • Habib AM, Richards P, Rogers GJ, Reimann F, Gribble FM (2013) Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells. Diabetologia 56:1413–1416
    • (2013) Diabetologia , vol.56 , pp. 1413-1416
    • Habib, A.M.1    Richards, P.2    Rogers, G.J.3    Reimann, F.4    Gribble, F.M.5
  • 24
    • 79959633497 scopus 로고    scopus 로고
    • Influence of cell cycle on responses of MCF-7 cells to benzo[a]pyrene
    • COI: 1:CAS:528:DC%2BC3MXovVaisro%3D
    • Hamouchene H, Arlt VM, Giddings I, Phillips DH (2011) Influence of cell cycle on responses of MCF-7 cells to benzo[a]pyrene. BMC Med Genom 12:333
    • (2011) BMC Med Genom , vol.12 , pp. 333
    • Hamouchene, H.1    Arlt, V.M.2    Giddings, I.3    Phillips, D.H.4
  • 25
    • 77954250537 scopus 로고    scopus 로고
    • The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action
    • PID: 20150286, COI: 1:CAS:528:DC%2BC3cXpsVOlsL4%3D
    • Hare KJ, Vilsbøll T, Asmar M, Deacon CF, Knop FK, Holst JJ (2010) The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action. Diabetes 59:1765–1770
    • (2010) Diabetes , vol.59 , pp. 1765-1770
    • Hare, K.J.1    Vilsbøll, T.2    Asmar, M.3    Deacon, C.F.4    Knop, F.K.5    Holst, J.J.6
  • 26
    • 0030975613 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide I receptor expression in glucagon-producing alpha-cells of the rat endocrine pancreas
    • PID: 9133545, COI: 1:CAS:528:DyaK2sXjtVGntL8%3D
    • Heller RS, Kieffer TJ, Habener JF (1997) Insulinotropic glucagon-like peptide I receptor expression in glucagon-producing alpha-cells of the rat endocrine pancreas. Diabetes 46(5):785–791
    • (1997) Diabetes , vol.46 , Issue.5 , pp. 785-791
    • Heller, R.S.1    Kieffer, T.J.2    Habener, J.F.3
  • 27
    • 47649086665 scopus 로고    scopus 로고
    • The physiology and pharmacology of incretins in type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BD1cXhtVCqtrvO
    • Holst JJ (2008) The physiology and pharmacology of incretins in type 2 diabetes mellitus. Diabetes Obes Metab 10:14–21
    • (2008) Diabetes Obes Metab , vol.10 , pp. 14-21
    • Holst, J.J.1
  • 28
    • 68649100255 scopus 로고    scopus 로고
    • The proteostasis boundary in misfolding diseases of membrane traffic
    • PID: 19708088, COI: 1:CAS:528:DC%2BD1MXhtVent7nO
    • Hutt DM, Powers ET, Balch WE (2009) The proteostasis boundary in misfolding diseases of membrane traffic. FEBS Lett 583:2639–2646
    • (2009) FEBS Lett , vol.583 , pp. 2639-2646
    • Hutt, D.M.1    Powers, E.T.2    Balch, W.E.3
  • 29
    • 77953920801 scopus 로고    scopus 로고
    • Calcium signaling in the islets
    • PID: 20217501, COI: 1:CAS:528:DC%2BC3cXhsFyjsLnN
    • Islam MS (2010) Calcium signaling in the islets. Adv Exp Med Biol 654:235–259
    • (2010) Adv Exp Med Biol , vol.654 , pp. 235-259
    • Islam, M.S.1
  • 30
    • 37549011770 scopus 로고    scopus 로고
    • Curcumin treatment enhances islet recovery by induction of heat shock response proteins, Hsp70 and heme oxygenase-1, during cryopreservation
    • Kanitkara M, Bhonde RR (2008) Curcumin treatment enhances islet recovery by induction of heat shock response proteins, Hsp70 and heme oxygenase-1, during cryopreservation. Life Sci 82(3–4):182–189
    • (2008) Life Sci , vol.82 , Issue.3-4 , pp. 182-189
    • Kanitkara, M.1    Bhonde, R.R.2
  • 31
    • 64149130125 scopus 로고    scopus 로고
    • Functional pancreatic beta-cell mass: involvement in type 2 diabetes and therapeutic intervention
    • PID: 19251449, COI: 1:CAS:528:DC%2BD1MXmtVKqtbc%3D
    • Karaca M, Magnan C, Kargar C (2009) Functional pancreatic beta-cell mass: involvement in type 2 diabetes and therapeutic intervention. Diabetes Metab 35:77–84
    • (2009) Diabetes Metab , vol.35 , pp. 77-84
    • Karaca, M.1    Magnan, C.2    Kargar, C.3
  • 32
    • 70449713491 scopus 로고    scopus 로고
    • Problems associated with glucose toxicity: role of hyperglycemia-induced oxidative stress
    • PID: 19725147, COI: 1:CAS:528:DC%2BD1MXhtFSju77J
    • Kawahito S, Kitahata H, Oshita S (2009) Problems associated with glucose toxicity: role of hyperglycemia-induced oxidative stress. World J Gastroenterol 15(33):4137–4142
    • (2009) World J Gastroenterol , vol.15 , Issue.33 , pp. 4137-4142
    • Kawahito, S.1    Kitahata, H.2    Oshita, S.3
  • 33
    • 0037974530 scopus 로고    scopus 로고
    • Insulin receptor knockout mice
    • PID: 12471165, COI: 1:CAS:528:DC%2BD3sXjt1Glt7c%3D
    • Kitamura T, Kahn CR, Accili D (2003) Insulin receptor knockout mice. Annu Rev Physiol 65:313–332
    • (2003) Annu Rev Physiol , vol.65 , pp. 313-332
    • Kitamura, T.1    Kahn, C.R.2    Accili, D.3
  • 34
    • 0037312821 scopus 로고    scopus 로고
    • The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects
    • PID: 12540611, COI: 1:CAS:528:DC%2BD3sXhtFans7w%3D
    • Kjems LL, Holst JJ, Vølund A, Madsbad S (2003) The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects. Diabetes 52:380–386
    • (2003) Diabetes , vol.52 , pp. 380-386
    • Kjems, L.L.1    Holst, J.J.2    Vølund, A.3    Madsbad, S.4
  • 35
    • 3442880065 scopus 로고    scopus 로고
    • Diabetes mellitus and other disorders of metabolism
    • Kumar PJ, Clark ML, (eds), Saunders, London:
    • Kumar PJ, Clark ML (2007) Diabetes mellitus and other disorders of metabolism. In: Kumar PJ, Clark ML (eds) Clinical medicine, 6th edn. Saunders, London, pp 1069–1121
    • (2007) Clinical medicine , pp. 1069-1121
    • Kumar, P.J.1    Clark, M.L.2
  • 36
    • 70449808042 scopus 로고    scopus 로고
    • Beta-cell function and mass in type 2 diabetes
    • Larsen MO (2009) Beta-cell function and mass in type 2 diabetes. Dan Med J 56:153–164
    • (2009) Dan Med J , vol.56 , pp. 153-164
    • Larsen, M.O.1
  • 37
    • 0035265835 scopus 로고    scopus 로고
    • Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells
    • PID: 11463381, COI: 1:CAS:528:DC%2BD3MXivVCmt7g%3D
    • Leibiger B, Leibiger IB, Moede T, Kemper S, Kulkarni RN, Kahn CR, de Vargas LM, Berggren P-O (2001) Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells. Mol Cell 7(3):559–570
    • (2001) Mol Cell , vol.7 , Issue.3 , pp. 559-570
    • Leibiger, B.1    Leibiger, I.B.2    Moede, T.3    Kemper, S.4    Kulkarni, R.N.5    Kahn, C.R.6    de Vargas, L.M.7    Berggren, P.-O.8
  • 38
    • 77955106477 scopus 로고    scopus 로고
    • The exenatide analogue AC3174 attenuates hypertension, insulin resistance, and renal dysfunction in Dahl salt-sensitive rats
    • Liu Q, Adams L, Broyde A, Fernandez R, Baron AD, Parkes DG (2010) The exenatide analogue AC3174 attenuates hypertension, insulin resistance, and renal dysfunction in Dahl salt-sensitive rats. Cardiovasc Diabetol 9(32):1–10
    • (2010) Cardiovasc Diabetol , vol.9 , Issue.32 , pp. 1-10
    • Liu, Q.1    Adams, L.2    Broyde, A.3    Fernandez, R.4    Baron, A.D.5    Parkes, D.G.6
  • 39
    • 84894309436 scopus 로고    scopus 로고
    • Mechanism of the beneficial and protective effects of exenatide in diabetic rats
    • PID: 24353307, COI: 1:CAS:528:DC%2BC2cXmtVGmu7w%3D
    • Lotfy M, Singh J, Rashed H, Tariq S, Zilahi E, Adeghate E (2014) Mechanism of the beneficial and protective effects of exenatide in diabetic rats. J Endocrinol 220(3):291–304
    • (2014) J Endocrinol , vol.220 , Issue.3 , pp. 291-304
    • Lotfy, M.1    Singh, J.2    Rashed, H.3    Tariq, S.4    Zilahi, E.5    Adeghate, E.6
  • 40
    • 79955932942 scopus 로고    scopus 로고
    • Multiple-labelling immunoEM using different sizes of colloidal gold: alternative approaches to test for differential distribution and colocalization in subcellular structures
    • PID: 21327857, COI: 1:CAS:528:DC%2BC3MXivFClu78%3D
    • Mayhew TM, Lucocq JM (2011) Multiple-labelling immunoEM using different sizes of colloidal gold: alternative approaches to test for differential distribution and colocalization in subcellular structures. Histochem Cell Biol 135:317–326
    • (2011) Histochem Cell Biol , vol.135 , pp. 317-326
    • Mayhew, T.M.1    Lucocq, J.M.2
  • 41
    • 0030820630 scopus 로고    scopus 로고
    • Overexpression of glucagon-like peptide-1 receptor in an insulin-secreting cell line enhances glucose responsiveness
    • PID: 9220027, COI: 1:CAS:528:DyaK2sXktlCiurY%3D
    • Montrose-Rafizadeh C, Wang Y, Janczewski AM, Henderson TE, Egan JM (1997) Overexpression of glucagon-like peptide-1 receptor in an insulin-secreting cell line enhances glucose responsiveness. Mol Cell Endocrinol 130(1–2):109–117
    • (1997) Mol Cell Endocrinol , vol.130 , Issue.1-2 , pp. 109-117
    • Montrose-Rafizadeh, C.1    Wang, Y.2    Janczewski, A.M.3    Henderson, T.E.4    Egan, J.M.5
  • 42
    • 77649102941 scopus 로고    scopus 로고
    • Effects of incretin hormones on β-cell mass and function, body weight, and hepatic and myocardial function
    • PID: 20206728, COI: 1:CAS:528:DC%2BC3cXivFalsL4%3D
    • Mudaliar S, Henry RR (2010) Effects of incretin hormones on β-cell mass and function, body weight, and hepatic and myocardial function. Am J Med 123(3):S19–S27
    • (2010) Am J Med , vol.123 , Issue.3 , pp. S19-S27
    • Mudaliar, S.1    Henry, R.R.2
  • 43
    • 33644850386 scopus 로고    scopus 로고
    • Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function
    • PID: 16272563, COI: 1:CAS:528:DC%2BD28Xit1SjsA%3D%3D
    • Park S, Dong X, Fisher TL, Dunn S, Omer AK, Weir G, White MF (2006) Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function. J Biol Chem 281(2):1159–1168
    • (2006) J Biol Chem , vol.281 , Issue.2 , pp. 1159-1168
    • Park, S.1    Dong, X.2    Fisher, T.L.3    Dunn, S.4    Omer, A.K.5    Weir, G.6    White, M.F.7
  • 44
    • 33747605065 scopus 로고    scopus 로고
    • Glucagon like peptide-1: a new therapeutic target for diabetes mellitus
    • COI: 1:CAS:528:DC%2BD28XhtVCmsb7I
    • Patel SK, Goyal RK, Anand IS, Shah JS, Patel HU, Patel CN (2006) Glucagon like peptide-1: a new therapeutic target for diabetes mellitus. Indian J Pharmacol 38(4):231–237
    • (2006) Indian J Pharmacol , vol.38 , Issue.4 , pp. 231-237
    • Patel, S.K.1    Goyal, R.K.2    Anand, I.S.3    Shah, J.S.4    Patel, H.U.5    Patel, C.N.6
  • 45
    • 0034522773 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats
    • Perfeitti R, Zhou J, Doyle ME, Egan J (2000) Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinol 141(12):4600–4605
    • (2000) Endocrinol , vol.141 , Issue.12 , pp. 4600-4605
    • Perfeitti, R.1    Zhou, J.2    Doyle, M.E.3    Egan, J.4
  • 46
    • 80052766495 scopus 로고    scopus 로고
    • Activation of the GLP-1 receptor signalling pathway: a relevant strategy to repair a deficient beta-cell mass
    • PID: 21716694
    • Portha B, Tourrel-Cuzin C, Movassat J (2011) Activation of the GLP-1 receptor signalling pathway: a relevant strategy to repair a deficient beta-cell mass. Exp Diabetes Res 2011:376509
    • (2011) Exp Diabetes Res , vol.2011 , pp. 376509
    • Portha, B.1    Tourrel-Cuzin, C.2    Movassat, J.3
  • 47
    • 84873403513 scopus 로고    scopus 로고
    • An emerging role of glucagon-like peptide-1 in preventing advanced-glycation-end-product-mediated damages in diabetes
    • Puddu A, Mach F, Nencioni A, Viviani GL, Montecucco F (2013) An emerging role of glucagon-like peptide-1 in preventing advanced-glycation-end-product-mediated damages in diabetes. Mediat Inflamm 2013:591056
    • (2013) Mediat Inflamm , vol.2013 , pp. 591056
    • Puddu, A.1    Mach, F.2    Nencioni, A.3    Viviani, G.L.4    Montecucco, F.5
  • 48
    • 34447504557 scopus 로고    scopus 로고
    • Pancreatic islet β-cell and oxidative stress: the importance of glutathione peroxidase
    • PID: 17433304, COI: 1:CAS:528:DC%2BD2sXotlaisbw%3D
    • Robertson RP, Harmon JS (2007) Pancreatic islet β-cell and oxidative stress: the importance of glutathione peroxidase. FEBS Lett 581:3743–3748
    • (2007) FEBS Lett , vol.581 , pp. 3743-3748
    • Robertson, R.P.1    Harmon, J.S.2
  • 49
    • 84874626634 scopus 로고    scopus 로고
    • Pulmonary GLP-1 receptor increases at birth and exogenous GLP-1 receptor agonists augmented surfactant-protein levels in litters from normal and nitrofen-treated pregnant rats
    • Romaní-Pérez M, Outeiriño-Iglesias V, Gil-Lozano M, González-Matías LC, Mallo F, Vigo E (2013) Pulmonary GLP-1 receptor increases at birth and exogenous GLP-1 receptor agonists augmented surfactant-protein levels in litters from normal and nitrofen-treated pregnant rats. Endocrinol 154(3):1144–1155
    • (2013) Endocrinol , vol.154 , Issue.3 , pp. 1144-1155
    • Romaní-Pérez, M.1    Outeiriño-Iglesias, V.2    Gil-Lozano, M.3    González-Matías, L.C.4    Mallo, F.5    Vigo, E.6
  • 50
    • 43549114067 scopus 로고    scopus 로고
    • Targeting β-cell mass in type 2 diabetes: promise and limitations of new drugs based on incretins
    • PID: 18292465, COI: 1:CAS:528:DC%2BD1cXntV2lsbY%3D
    • Salehi M, Aulinger BA, D’Alessio DA (2008) Targeting β-cell mass in type 2 diabetes: promise and limitations of new drugs based on incretins. Endocr Rev 29(3):367–379
    • (2008) Endocr Rev , vol.29 , Issue.3 , pp. 367-379
    • Salehi, M.1    Aulinger, B.A.2    D’Alessio, D.A.3
  • 51
    • 77956230708 scopus 로고    scopus 로고
    • Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitus
    • PID: 20557887, COI: 1:CAS:528:DC%2BC3cXhtFams77M
    • Schwartz EA, Koska J, Mullin MP, Syoufi I, Schwenke DC, Reaven PD (2010) Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitus. Atherosclerosis 212(1):217–222
    • (2010) Atherosclerosis , vol.212 , Issue.1 , pp. 217-222
    • Schwartz, E.A.1    Koska, J.2    Mullin, M.P.3    Syoufi, I.4    Schwenke, D.C.5    Reaven, P.D.6
  • 52
    • 79955134104 scopus 로고    scopus 로고
    • AGEs decrease insulin synthesis in pancreatic β-cell by repressing Pdx-1 protein expression at the post-translational level
    • PID: 21533167, COI: 1:CAS:528:DC%2BC3MXlt12is7c%3D
    • Shu T, Zhu Y, Wang H, Lin Y, Ma Z, Han X (2011) AGEs decrease insulin synthesis in pancreatic β-cell by repressing Pdx-1 protein expression at the post-translational level. PLoS ONE 6(4):e18782
    • (2011) PLoS ONE , vol.6 , Issue.4 , pp. e18782
    • Shu, T.1    Zhu, Y.2    Wang, H.3    Lin, Y.4    Ma, Z.5    Han, X.6
  • 54
    • 34249279490 scopus 로고    scopus 로고
    • Animal models in type 2 diabetes research: an overview
    • PID: 17496368, COI: 1:STN:280:DC%2BD2s3os12jsA%3D%3D
    • Srinivasan K, Ramarao P (2007) Animal models in type 2 diabetes research: an overview. Indian J Med Res 125:451–472
    • (2007) Indian J Med Res , vol.125 , pp. 451-472
    • Srinivasan, K.1    Ramarao, P.2
  • 55
    • 25444514533 scopus 로고    scopus 로고
    • Hormonal regulation of food intake
    • PID: 16183909, COI: 1:CAS:528:DC%2BD2MXhtFeqsr3O
    • Stanley S, Wynne K, McGowan B, Bloom S (2005) Hormonal regulation of food intake. Physiol Rev 85:1131–1158
    • (2005) Physiol Rev , vol.85 , pp. 1131-1158
    • Stanley, S.1    Wynne, K.2    McGowan, B.3    Bloom, S.4
  • 56
    • 39649092092 scopus 로고    scopus 로고
    • PDZ-domain containing-2 (PDZD2) is a novel factor that affects the growth and differentiation of human fetal pancreatic progenitor cells
    • PID: 18037333, COI: 1:CAS:528:DC%2BD1cXivVOlsrk%3D
    • Suen PM, Zou C, Zhang YA, Lau TK, Chan J, Yao KM, Leung PS (2008) PDZ-domain containing-2 (PDZD2) is a novel factor that affects the growth and differentiation of human fetal pancreatic progenitor cells. Int J Biochem Cell Biol 40:789–803
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 789-803
    • Suen, P.M.1    Zou, C.2    Zhang, Y.A.3    Lau, T.K.4    Chan, J.5    Yao, K.M.6    Leung, P.S.7
  • 57
    • 0011057938 scopus 로고    scopus 로고
    • A decade of diabetes research and development
    • Townsend T (2000) A decade of diabetes research and development. Int J Diabetes Metab 8:88–92
    • (2000) Int J Diabetes Metab , vol.8 , pp. 88-92
    • Townsend, T.1
  • 59
    • 58749090731 scopus 로고    scopus 로고
    • Narrative review: effect of bariatric surgery on type 2 diabetes mellitus
    • PID: 19153412
    • Vetter ML, Cardillo S, Rickels MR, Iqbal N (2009) Narrative review: effect of bariatric surgery on type 2 diabetes mellitus. Ann Intern Med 150:94–103
    • (2009) Ann Intern Med , vol.150 , pp. 94-103
    • Vetter, M.L.1    Cardillo, S.2    Rickels, M.R.3    Iqbal, N.4
  • 60
    • 80555157690 scopus 로고    scopus 로고
    • White A. Processing of proglucagon to GLP-1 in pancreatic α-cells: is this a paracrine mechanism enabling GLP-1 to act on β-cells?
    • PID: 21795304, COI: 1:CAS:528:DC%2BC3MXhtlyiurfE
    • Whalley NM, Pritchard LE, Smith DM (2011) White A. Processing of proglucagon to GLP-1 in pancreatic α-cells: is this a paracrine mechanism enabling GLP-1 to act on β-cells? J Endocrinol 211:99–106
    • (2011) J Endocrinol , vol.211 , pp. 99-106
    • Whalley, N.M.1    Pritchard, L.E.2    Smith, D.M.3
  • 61
    • 12244299202 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide as a regulator of beta cell function and fate
    • PID: 15655709, COI: 1:CAS:528:DC%2BD2MXnvFWksQ%3D%3D
    • Wideman RD, Kieffer TJ (2004) Glucose-dependent insulinotropic polypeptide as a regulator of beta cell function and fate. Horm Metab Res 36:782–786
    • (2004) Horm Metab Res , vol.36 , pp. 782-786
    • Wideman, R.D.1    Kieffer, T.J.2
  • 62
    • 24944534978 scopus 로고    scopus 로고
    • Real-time PCR for mRNA quantitation
    • COI: 1:CAS:528:DC%2BD2MXmtlCnur4%3D
    • Wong ML, Medrano JF (2005) Real-time PCR for mRNA quantitation. BioTech 39:75–85
    • (2005) BioTech , vol.39 , pp. 75-85
    • Wong, M.L.1    Medrano, J.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.