Autoreactive B cells in the marginal zone that express dual receptors

Journal of Experimental Medicine

Volumn 195, Issue 2, 2002, Pages 181-188

  Li, Yijin ^a   Li, Hui ^a   Weigert, Martin ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

Allele exclusion; Antinuclear antibody; Autoimmunity; Editing; Tolerance

Indexed keywords

ANTINUCLEAR ANTIBODY; B LYMPHOCYTE RECEPTOR; DNA ANTIBODY; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN;

ALLOTYPE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENETIC RECOMBINATION; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTIBODIES, ANTINUCLEAR; B-LYMPHOCYTES; DNA; FLOW CYTOMETRY; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN LAMBDA-CHAINS; ISOANTIGENS; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, B-CELL; RECOMBINATION, GENETIC; SPLEEN;

EID: 0037148509     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20011453     Document Type: Article

References (29)

1. Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain
2. Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression
3. Mouse kappa lightchain recombination signal sequences mediate recombination more frequently than do those of lambda light chain
4. -/- small pre-BII cells have no L chain gene rearrangements: Detection by high-efficiency single cell PCR
5. Receptor editing occurs frequently during normal B cell development
6. B lymphocytes may escape tolerance by revising their antigen receptors
7. Cellular localization of immunoglobulins with different allotypic specificities in rabbit lymphoid tissues
8. The specificities of antibodies produced by single cells
9. Receptor editing: An approach by autoreactive B cells to escape tolerance
10. Editors and editing of anti-DNA receptors
11. The site and stage of anti-DNA B-cell deletion
12. Immunoglobulin heavy chain gene replacement: A mechanism of receptor editing
13. Residues that mediate DNA binding of autoimmune antibodies
14. Mouse lambda-chain sequences
15. Evidence for selection of a population of multi-reactive B cells into the splenic marginal zone
16. Induction of self-tolerance in mature peripheral B lymphocytes
17. Effects of breeding environments on generation and activation of autoreactive B-1 cells in anti-red blood cell autoantibody transgenic mice
18. Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice
19. B-cell subsets and the mature preimmune repertoire. Marginal zone and B1 B cells as part of a "natural immune memory"
20. B1 cells: Similarities and differences with other B cell subsets
21. The role of clonal selection and somatic mutation in autoimmunity
22. Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse
23. Specificity of recombination of H and L chains from human gamma-G-myeloma proteins
24. Lymphocytes rearrange, edit and revise their antigen receptors to be useful yet safe
25. Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate
26. Ig lambda-producing B cells do not show feedback inhibition of gene rearrangement
27. Autoreactive B cells escape clonal deletion by expressing multiple antigen receptors
28. + dual receptor B cells are present in the human peripheral repertoire
29. Contribution of receptor editing to the antibody repertoire