Monoglyceride lipase: Structure and inhibitors

Chemistry and Physics of Lipids

Volumn 197, Issue , 2016, Pages 13-24

  Scalvini, Laura ^a   Piomelli, Daniele ^b,c   Mor, Marco ^a  

^a UNIVERSITY OF PARMA   (Italy)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

Author keywords

2 Arachidonoyl sn glycerol (2 AG); Cysteines; Endocannabinoids; Inhibitors; Lid domain; Monoglyceride lipase (MGL)

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 4 [BIS(1,3 BENZODIOXOL 5 YL)HYDROXYMETHYL] 1 PIPERIDINECARBOXYLIC ACID 4 NITROPHENYL ESTER; ACYLGLYCEROL LIPASE; ACYLGLYCEROL LIPASE INHIBITOR; BENZISOTHIAZOLINONE DERIVATIVE; BETA AMYRIN; CARBAMIC ACID DERIVATIVE; CL 6 A; COMP 21; CYSTEINE; DISULFIDE; DISULFIRAM; ENDOCANNABINOID; EUPHOL; ISOTHIAZOLINONE DERIVATIVE; JJKK 048; JW 651; JZL 195; KML 29; MALEIMIDE DERIVATIVE; MJN 110; O HEXAFLUOROISOPROPYLCARBAMATE DERIVATIVE; OCTHILINONE; PRISTIMERIN; SAR 127303; SERINE; TERPENOID DERIVATIVE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; URB 602; ENZYME INHIBITOR;

ADVERSE DRUG REACTION; ARTICLE; BIOSYNTHESIS; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYMATIC DEGRADATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HUMAN; IC50; INFLAMMATION; NEOPLASM; NEUROPROTECTION; NONHUMAN; PAIN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; MOLECULAR MODEL; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MONOACYLGLYCEROL LIPASES; PROTEIN CONFORMATION;

EID: 84960815043     PISSN: 00093084     EISSN: 18732941     Source Type: Journal    
DOI: 10.1016/j.chemphyslip.2015.07.011     Document Type: Article

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