Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates

Chemistry and Biology

Volumn 19, Issue 5, 2012, Pages 579-588

  Chang, Jae Won ^a   Niphakis, Micah J ^a   Lum, Kenneth M ^a   Cognetta III, Armand B ^a   Wang, Chu ^a   Matthews, Megan L ^a   Niessen, Sherry ^a   Buczynski, Matthew W ^a   Parsons, Loren H ^a   Cravatt, Benjamin F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMIC ACID; ENDOCANNABINOID; ENZYME INHIBITOR; HYDROLASE INHIBITOR; JZL 184; KML 29; MONOACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ARTICLE; CROSS REACTION; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; RAT;

AMIDOHYDROLASES; ANIMALS; ARACHIDONIC ACIDS; CARBAMATES; ENDOCANNABINOIDS; ENZYME INHIBITORS; GLYCERIDES; HEK293 CELLS; HUMANS; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; MONOACYLGLYCEROL LIPASES; RATS; RATS, WISTAR;

EID: 84861635055     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2012.03.009     Document Type: Article

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